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  1. Book ; Online: Evolving Concepts in Insulin Resistance

    Infante, Marco

    2022  

    Keywords Endocrinology ; Clinical & internal medicine
    Language English
    Size 1 electronic resource (190 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030377626
    ISBN 9781803555034 ; 1803555033
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Acerca de la segunda evaluación de la estratégia AP-21: marco estratégico para la mejora de la Atención Primaria en España 2007-2012.

    Infante, Alberto / Aguiar, Adriana

    Ciencia & saude coletiva

    2013  Volume 18, Issue 5, Page(s) 1513–1514

    Title translation With respect to the second assessment of the AP-21 strategy: the strategic benchmark for the enhancement of Primary Health Care in Spain 2007-2012.
    MeSH term(s) Evaluation Studies as Topic ; Health Care Reform ; Humans ; Primary Health Care/standards ; Spain ; Time Factors
    Language Spanish
    Publishing date 2013-05
    Publishing country Brazil
    Document type Letter
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1413-8123
    ISSN (online) 1678-4561
    ISSN 1413-8123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The unique pathophysiological features of diabetes mellitus secondary to total pancreatectomy: proposal for a new classification distinct from diabetes of the exocrine pancreas.

    Infante, Marco / Ricordi, Camillo

    Expert review of endocrinology & metabolism

    2023  Volume 18, Issue 1, Page(s) 19–32

    Abstract: Introduction: Diabetes of the exocrine pancreas (DEP; a.k.a. pancreatic diabetes or pancreatogenic diabetes or type 3c diabetes mellitus or T3cDM) refers to different diabetes types resulting from disorders of the exocrine pancreas. DEP is characterized ...

    Abstract Introduction: Diabetes of the exocrine pancreas (DEP; a.k.a. pancreatic diabetes or pancreatogenic diabetes or type 3c diabetes mellitus or T3cDM) refers to different diabetes types resulting from disorders of the exocrine pancreas. DEP is characterized by the structural and functional loss of glucose-normalizing insulin secretion in the context of exocrine pancreatic dysfunction. Among these forms, new-onset diabetes mellitus secondary to total pancreatectomy (TP) has unique pathophysiological and clinical features, for which we propose a new nomenclature such as post-total pancreatectomy diabetes mellitus (PTPDM).
    Areas covered: TP results in the complete loss of pancreatic parenchyma, with subsequent absolute insulinopenia and lifelong need for exogenous insulin therapy. Patients with PTPDM also exhibit deficiency of glucagon, amylin and pancreatic polypeptide. These endocrine abnormalities, coupled with increased peripheral insulin sensitivity, deficiency of pancreatic enzymes and TP-related modifications of gastrointestinal anatomy, can lead to marked glucose variability and increased risk of iatrogenic (insulin-induced) severe hypoglycemic episodes ('brittle diabetes').
    Expert opinion: We believe that diabetes mellitus secondary to TP should not be included in the DEP spectrum in light of its peculiar pathophysiological and clinical features. Therefore, we propose a new classification for this entity, that would likely provide more accurate prognosis and treatment strategies.
    MeSH term(s) Humans ; Pancreas, Exocrine ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Pancreas ; Insulin/therapeutic use ; Glucose ; Diabetes Mellitus/therapy
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1080/17446651.2023.2168645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties.

    Infante, Raffaele / Infante, Marco / Pastore, Donatella / Pacifici, Francesca / Chiereghin, Francesca / Malatesta, Gina / Donadel, Giulia / Tesauro, Manfredi / Della-Morte, David

    International journal of molecular sciences

    2023  Volume 24, Issue 24

    Abstract: Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, ...

    Abstract Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, among others. These health benefits are partly mediated by the high-quality extra virgin olive oil (EVOO), which is produced mostly in Mediterranean countries and is directly made from olives, the fruit of the olive tree (
    MeSH term(s) Humans ; Olive Oil/analysis ; Antioxidants/pharmacology ; Polyphenols ; Olea ; Diet, Mediterranean ; Anti-Inflammatory Agents
    Chemical Substances oleocanthal (AC7QO6038O) ; Olive Oil ; Antioxidants ; Polyphenols ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-12-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind.

    Infante, Marco / Leoni, Martina / Caprio, Massimiliano / Fabbri, Andrea

    World journal of diabetes

    2021  Volume 12, Issue 7, Page(s) 916–931

    Abstract: To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent, ...

    Abstract To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent, being prescribed to more than 100 million people worldwide, including patients with prediabetes, insulin resistance, and polycystic ovary syndrome. However, over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 deficiency. Of note, evidence suggests that long-term and high-dose metformin therapy impairs vitamin B12 status. Vitamin B12 (also referred to as cobalamin) is a water-soluble vitamin that is mainly obtained from animal-sourced foods. At the cellular level, vitamin B12 acts as a cofactor for enzymes that play a critical role in DNA synthesis and neuroprotection. Thus, vitamin B12 deficiency can lead to a number of clinical consequences that include hematologic abnormalities (
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v12.i7.916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Efficacy and safety of finerenone for treatment of diabetic kidney disease: current knowledge and future perspective.

    Marzolla, Vincenzo / Infante, Marco / Armani, Andrea / Rizzo, Manfredi / Caprio, Massimiliano

    Expert opinion on drug safety

    2022  Volume 21, Issue 9, Page(s) 1161–1170

    Abstract: Introduction: Diabetic kidney disease (DKD) represents a leading cause of morbidity and mortality in subjects with diabetes and develops in more than one third of diabetic patients. Steroidal mineralocorticoid receptor antagonists (MRAs - eplerenone and ...

    Abstract Introduction: Diabetic kidney disease (DKD) represents a leading cause of morbidity and mortality in subjects with diabetes and develops in more than one third of diabetic patients. Steroidal mineralocorticoid receptor antagonists (MRAs - eplerenone and spironolactone) reduce mortality in patients with heart failure with reduced ejection fraction (HFrEF). However, in clinical practice the use of steroidal MRAs is limited by the significant risk of hyperkalemia, especially in patients with impaired renal function. Finerenone, a novel nonsteroidal MRA, shows a higher selectivity and binding affinity for mineralocorticoid receptor (MR) compared to steroidal MRAs and has been shown to reduce chronic kidney disease (CKD) progression and cardiovascular mortality in patients with CKD and T2DM.
    Areas covered: This review summarizes the current evidence on efficacy and safety of finerenone in the treatment of patients with CKD and T2DM, and discusses its mechanisms of action investigated in preclinical studies.
    Expert opinion: Pharmacological properties of finerenone and its unique tissue distribution are responsible for a lower risk of hyperkalemia. Therefore, finerenone represents a valuable therapeutic tool in patients with CKD/diabetic kidney disease (DKD). Recent studies have shown that finerenone delays the progression of CKD and reduce cardiovascular events in patients with DKD, highlighting its safety and efficacy in this high-risk population.
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/drug therapy ; Eplerenone/therapeutic use ; Heart Failure/drug therapy ; Humans ; Hyperkalemia/chemically induced ; Mineralocorticoid Receptor Antagonists/adverse effects ; Naphthyridines ; Receptors, Mineralocorticoid/therapeutic use ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Spironolactone/adverse effects ; Stroke Volume
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Naphthyridines ; Receptors, Mineralocorticoid ; finerenone ; Spironolactone (27O7W4T232) ; Eplerenone (6995V82D0B)
    Language English
    Publishing date 2022-10-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2022.2130889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6096: Show issues Location:
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  7. Article ; Online: Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i).

    Pinheiro, Marcelo Maia / Fabbri, Andrea / Infante, Marco

    Immunotherapy

    2021  Volume 13, Issue 9, Page(s) 753–765

    Abstract: A dysregulated immune response characterized by the hyperproduction of several pro-inflammatory cytokines (a.k.a. 'cytokine storm') plays a central role in the pathophysiology of severe coronavirus disease 2019 (COVID-19) caused by the severe acute ... ...

    Abstract A dysregulated immune response characterized by the hyperproduction of several pro-inflammatory cytokines (a.k.a. 'cytokine storm') plays a central role in the pathophysiology of severe coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this Perspective article we discuss the evidence for synergistic anti-inflammatory and immunomodulatory properties exerted by vitamin D and dipeptidyl peptidase-4 (DPP-4) inhibitors, the latter being a class of antihyperglycemic agents used for the treatment of Type 2 diabetes, which have also been reported as immunomodulators. Then, we provide the rationale for investigation of vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i) as an immunomodulation strategy to ratchet down the virulence of SARS-CoV-2, prevent disease progression and modulate the cytokine storm in COVID-19.
    MeSH term(s) COVID-19/immunology ; COVID-19/therapy ; COVID-19/virology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/metabolism ; Cytokine Release Syndrome/prevention & control ; Cytokines/immunology ; Cytokines/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/immunology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Drug Therapy, Combination ; Humans ; Immunotherapy/methods ; Outcome Assessment, Health Care ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Vitamin D/immunology ; Vitamin D/therapeutic use
    Chemical Substances Cytokines ; Dipeptidyl-Peptidase IV Inhibitors ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Journal Article
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt-2020-0349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties

    Raffaele Infante / Marco Infante / Donatella Pastore / Francesca Pacifici / Francesca Chiereghin / Gina Malatesta / Giulia Donadel / Manfredi Tesauro / David Della-Morte

    International Journal of Molecular Sciences, Vol 24, Iss 24, p

    2023  Volume 17323

    Abstract: Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, ...

    Abstract Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, among others. These health benefits are partly mediated by the high-quality extra virgin olive oil (EVOO), which is produced mostly in Mediterranean countries and is directly made from olives, the fruit of the olive tree ( Olea europaea L.). Preclinical evidence supports the existence of antioxidant and anti-inflammatory properties exerted by the polyphenol oleocanthal, which belongs to the EVOO minor polar compound subclass of secoiridoids (like oleuropein). This narrative review aims to describe the antioxidant and anti-inflammatory properties of oleocanthal, as well as the potential anticancer and neuroprotective actions of this polyphenol. Based on recent evidence, we also discuss the reasons underlying the need to include the concentrations of oleocanthal and other polyphenols in the EVOO’s nutrition facts label. Finally, we report our personal experience in the production of a certified organic EVOO with a “Protected Designation of Origin” (PDO), which was obtained from olives of three different cultivars ( Rotondella , Frantoio, and Leccino ) harvested in geographical areas located a short distance from one another (villages’ names: Gorga and Camella) within the Southern Italy “Cilento, Vallo di Diano and Alburni National Park” of the Campania Region (Province of Salerno, Italy).
    Keywords extra virgin olive oil ; EVOO ; polyphenols ; oleocanthal ; cancer ; anticancer activity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Osseodensification: An Alternative to Conventional Osteotomy in Implant Site Preparation: A Systematic Review.

    Fontes Pereira, João / Costa, Rosana / Nunes Vasques, Miguel / Salazar, Filomena / Mendes, José Manuel / Infante da Câmara, Marco

    Journal of clinical medicine

    2023  Volume 12, Issue 22

    Abstract: Osseodensification is an innovative method of preparing the implant osteotomy using drills that promote bone self-compaction. The main objective of this technique is to promote peri-implant bone densification and compaction of autologous bone and to ... ...

    Abstract Osseodensification is an innovative method of preparing the implant osteotomy using drills that promote bone self-compaction. The main objective of this technique is to promote peri-implant bone densification and compaction of autologous bone and to increase the primary stability of the implant due to the viscoelastic characteristics of the alveolar bone using Densah
    Language English
    Publishing date 2023-11-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12227046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Antihyperglycemic properties of hydroxychloroquine in patients with diabetes: Risks and benefits at the time of COVID-19 pandemic.

    Infante, Marco / Ricordi, Camillo / Fabbri, Andrea

    Journal of diabetes

    2020  Volume 12, Issue 9, Page(s) 659–667

    Abstract: The antimalarial drug hydroxychloroquine (HCQ) has long been used as a disease-modifying antirheumatic drug for the treatment of several inflammatory rheumatic diseases. Over the last three decades, various studies have shown that HCQ also plays a role ... ...

    Abstract The antimalarial drug hydroxychloroquine (HCQ) has long been used as a disease-modifying antirheumatic drug for the treatment of several inflammatory rheumatic diseases. Over the last three decades, various studies have shown that HCQ also plays a role in the regulation of glucose homeostasis. Although the mechanisms of action underlying the glucose-lowering properties of HCQ are still not entirely clear, evidence suggests that this drug may exert multifaceted effects on glucose regulation, including improvement of insulin sensitivity, increase of insulin secretion, reduction of hepatic insulin clearance, and reduction of systemic inflammation. Preliminary studies have shown the safety and efficacy of HCQ (at a dose ranging from 400 to 600 mg/day) in patients with type 2 diabetes over a short-term period. In 2014, HCQ has been approved in India as an add-on hypoglycemic agent for patients with uncontrolled type 2 diabetes. However, large randomized controlled trials are needed to establish the safety and efficacy profile of HCQ in patients with type 2 diabetes over a long-term period. With regard to the COVID-19 pandemic, several medications (including HCQ) have been used as off-label drugs because of the lack of proven effective therapies. However, emerging evidence shows limited benefit from HCQ use in COVID-19 in general. The aim of this manuscript is to comprehensively summarize the current knowledge on the antihyperglycemic properties of HCQ and to critically evaluate the potential risks and benefits related to HCQ use in patients with diabetes, even in light of the current pandemic scenario.
    MeSH term(s) Antiviral Agents ; COVID-19 ; Coronavirus Infections/drug therapy ; Diabetes Complications/drug therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Pandemics ; Pneumonia, Viral
    Chemical Substances Antiviral Agents ; Hypoglycemic Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2503337-2
    ISSN 1753-0407 ; 1753-0393
    ISSN (online) 1753-0407
    ISSN 1753-0393
    DOI 10.1111/1753-0407.13053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6791: Show issues Location:
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