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  1. Article ; Online: Alterations of Prostanoid Expression and Intestinal Epithelial Barrier Functions in Ileus.

    Bessard, Anne / Cardaillac, Claire / Oullier, Thibauld / Cenac, Nicolas / Rolli-Derkinderen, Malvyne / Neunlist, Michel / Venara, Aurélien

    The Journal of surgical research

    2024  Volume 296, Page(s) 165–173

    Abstract: Introduction: Intestinal manipulation (IM)-induced inflammation could contribute to postoperative ileus (POI) pathophysiology via the modulation of prostanoid pathways. To identify the prostanoids involved, we aimed to characterize the profile of ... ...

    Abstract Introduction: Intestinal manipulation (IM)-induced inflammation could contribute to postoperative ileus (POI) pathophysiology via the modulation of prostanoid pathways. To identify the prostanoids involved, we aimed to characterize the profile of prostanoids and their synthesis enzyme expression in a murine model of POI and to determine whether the altered prostanoids could contribute to POI.
    Methods: Four or 14 h after IM in mice, gastrointestinal (GI) motility and intestinal epithelial barrier (IEB) permeability were assessed in vivo and ex vivo in Ussing chambers. Using high sensitivity liquid chromatography-tandem mass spectrometry, we characterized the tissue profile of polyunsaturated fatty acid metabolites in our experimental model. Finally, we evaluated in vivo the effects of the prostanoids studied upon IM-induced gut dysfunctions.
    Results: We first showed that 14 h after IM was significantly faster than jejunal transit at 4 h post-IM, although it remained significantly increased compared to the control. In contrast, we showed that IM-induced inflammation increase in jejunum permeability was similar after four and 14 h. We next showed that expression of prostacyclin synthase and hemopoietic prostaglandin-D synthase mRNA and their products were significantly reduced 14 h after IM as compared to controls. Furthermore, 15-deoxy-delta 12,14-Prostaglandin J2 reduced the IM-induced inflammation increase in IEB permeability but had no effect on GI motility. In contrast, PGI
    Conclusions: Arachidonic acid derivative contributes differentially to GI dysfunction in POI. The decrease of 15-deoxy-delta 12,14-Prostaglandin J2 levels induced by IM could contribute to impaired GI dysfunctions in POI and could be considered as putative therapeutic targets to restore barrier dysfunctions associated with POI.
    MeSH term(s) Mice ; Animals ; Prostaglandins/pharmacology ; Ileus/etiology ; Gastrointestinal Motility ; Jejunum ; Postoperative Complications ; Inflammation/metabolism
    Chemical Substances Prostaglandins
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.12.018
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  2. Article ; Online: Hydroxychloroquine inhibits proteolytic processing of endogenous TLR7 protein in human primary plasmacytoid dendritic cells.

    Cenac, Claire / Ducatez, Mariette F / Guéry, Jean-Charles

    European journal of immunology

    2021  Volume 52, Issue 1, Page(s) 54–61

    Abstract: Toll-like receptor 7 (TLR7) triggers antiviral immune responses through its capacity to recognize ssRNA. Proteolytic cleavage of TLR7 protein is required for its functional maturation in the endosomal compartment. Structural studies demonstrated that the ...

    Abstract Toll-like receptor 7 (TLR7) triggers antiviral immune responses through its capacity to recognize ssRNA. Proteolytic cleavage of TLR7 protein is required for its functional maturation in the endosomal compartment. Structural studies demonstrated that the N- and C-terminal domains of TLR7 are connected and involved in ligand binding after cleavage. Hydroxychloroquine (HCQ), an antimalarial drug, has been studied for its antiviral effects. HCQ increases pH in acidic organelles and has been reported to potently inhibit endosomal TLR activation. Whether HCQ can prevent endogenous TLR7 cleavage in primary immune cells, such as plasmacytoid DCs (pDCs), had never been examined. Here, using a validated anti-TLR7 antibody suitable for biochemical detection of native TLR7 protein, we show that HCQ treatment of fresh PBMCs, CAL-1 leukemic, and primary human pDCs inhibits TLR7 cleavage and results in accumulation of full-length protein. As a consequence, we observe an inhibition of pDC activation in response to TLR7 stimulation with synthetic ligands and viruses including inactivated SARS-CoV2, which we show herein activates pDCs through TLR7-signaling. Together, our finding suggests that the major pathway by which HCQ inhibits ssRNA sensing by pDCs may rely on its capacity to inhibit endosomal acidification and the functional maturation of TLR7 protein.
    MeSH term(s) COVID-19/drug therapy ; COVID-19/immunology ; Cell Line ; Dendritic Cells/immunology ; Endosomes/immunology ; Humans ; Hydroxychloroquine/pharmacology ; Proteolysis/drug effects ; SARS-CoV-2/immunology ; Toll-Like Receptor 7/immunology
    Chemical Substances TLR7 protein, human ; Toll-Like Receptor 7 ; Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-10-21
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149361
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  3. Article ; Online: Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis.

    Mas-Orea, Xavier / Basso, Lilian / Blanpied, Catherine / Gaveriaux-Ruff, Claire / Cenac, Nicolas / Dietrich, Gilles

    Journal of neuroinflammation

    2022  Volume 19, Issue 1, Page(s) 7

    Abstract: Background: Inflammatory visceral pain is endogenously controlled by enkephalins locally released by mucosal CD4: Methods: The peripheral analgesia associated with the accumulation of CD4: Results: Endogenous analgesia is lost in conditional ... ...

    Abstract Background: Inflammatory visceral pain is endogenously controlled by enkephalins locally released by mucosal CD4
    Methods: The peripheral analgesia associated with the accumulation of CD4
    Results: Endogenous analgesia is lost in conditional knockout mice for DOR, but not MOR at the later phase of the DSS-induced colitis. The absence of either of the opioid receptors on sensory nerves had no impact on both the colitis severity and the rate of T lymphocytes infiltrating the inflamed colonic mucosa.
    Conclusion: The key role of DOR on primary afferents in relieving intestinal inflammatory pain opens new therapeutic opportunities for peripherally restricted DOR analgesics to avoid most of the side effects associated with MOR-targeting drugs used in intestinal disorders.
    MeSH term(s) Analgesia ; Animals ; Colitis/genetics ; Colitis/metabolism ; Disease Models, Animal ; Inflammation/genetics ; Inflammation/metabolism ; Intestinal Mucosa/metabolism ; Mice ; Mice, Knockout ; Nociceptors/metabolism ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, delta/metabolism ; Visceral Pain/genetics ; Visceral Pain/metabolism
    Chemical Substances Receptors, Opioid, delta
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-021-02352-3
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  4. Article ; Online: HIV-1 infection enhances innate function and <i>TLR7</i> expression in female plasmacytoid dendritic cells.

    Abbas, Flora / Cenac, Claire / Youness, Ali / Azar, Pascal / Delobel, Pierre / Guéry, Jean-Charles

    Life science alliance

    2022  Volume 5, Issue 10

    Abstract: Plasmacytoid dendritic cells (pDCs) express TLR7, a ssRNA-sensor encoded on the X chromosome, which escapes X chromosome inactivation (XCI) in females. pDCs are specialized in the production of type 1 interferons (IFN-I) through TLR7 activation which ... ...

    Abstract Plasmacytoid dendritic cells (pDCs) express TLR7, a ssRNA-sensor encoded on the X chromosome, which escapes X chromosome inactivation (XCI) in females. pDCs are specialized in the production of type 1 interferons (IFN-I) through TLR7 activation which mediates both immune cell activation and also reactivation of latent HIV-1. The effect of HIV-1 infection in women under antiretroviral therapy (ART) on pDC functional responses remains poorly understood. Here, we show that pDCs from HIV/ART women exhibit exacerbated production of IFN-α and TNF-α compared with uninfected controls (UC) upon TLR7 activation. Because TLR7 can escape XCI in female pDCs, we measured the contribution of TLR7 allelic expression using SNP haplotypic markers to rigorously tag the allele of origin of TLR7 gene at single-cell resolution. Herein, we provide evidence that the enhanced functional response of pDCs in HIV/ART women is associated with higher transcriptional activity of the TLR7 locus from both X chromosomes, rather than differences in the frequency of TLR7 biallelic cells. These data reinforce the interest in targeting the HIV-1 reservoir using TLR7 agonists in women.
    MeSH term(s) Female ; Humans ; HIV-1/metabolism ; Toll-Like Receptor 7 ; HIV Infections ; Tumor Necrosis Factor-alpha/metabolism ; Virus Latency ; Dendritic Cells ; Interferon-alpha
    Chemical Substances Toll-Like Receptor 7 ; Tumor Necrosis Factor-alpha ; Interferon-alpha ; TLR7 protein, human
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202201452
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  5. Article ; Online: TLR8 escapes X chromosome inactivation in human monocytes and CD4

    Youness, Ali / Cenac, Claire / Faz-López, Berenice / Grunenwald, Solange / Barrat, Franck J / Chaumeil, Julie / Mejía, José Enrique / Guéry, Jean-Charles

    Biology of sex differences

    2023  Volume 14, Issue 1, Page(s) 60

    Abstract: Background: Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are, respectively, encoded by adjacent X-linked genes. We ... ...

    Abstract Background: Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are, respectively, encoded by adjacent X-linked genes. We previously established that TLR7 evades X chromosome inactivation (XCI) in female immune cells. Whether TLR8 also evades XCI, however, has not yet been explored.
    Method: In the current study, we used RNA fluorescence in situ hybridization (RNA FISH) to directly visualize, on a single-cell basis, primary transcripts of TLR7 and TLR8 relative to X chromosome territories in CD14
    Results: Using RNA FISH, we show that TLR8, like TLR7, evades XCI in immune cells, and that cells harboring simultaneously TLR7 and TLR8 transcript foci are more frequent in women and KS men than in euploid men, resulting in a sevenfold difference in frequency. This transcriptional bias was again observable when comparing the single X of XY males with the active X of cells from females or KS males. Interestingly, TLR8 protein expression was significantly higher in female mononuclear blood cells, including all monocyte subsets, than in male cells.
    Conclusions: TLR8, mirroring TLR7, escapes XCI in human monocytes and CD4
    MeSH term(s) Humans ; Female ; Male ; X Chromosome Inactivation ; Monocytes ; Toll-Like Receptor 8/genetics ; T-Lymphocytes ; In Situ Hybridization, Fluorescence ; Toll-Like Receptor 7/genetics ; CD4-Positive T-Lymphocytes
    Chemical Substances Toll-Like Receptor 8 ; Toll-Like Receptor 7 ; TLR8 protein, human
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2587352-0
    ISSN 2042-6410 ; 2042-6410
    ISSN (online) 2042-6410
    ISSN 2042-6410
    DOI 10.1186/s13293-023-00544-5
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  6. Article ; Online: B cell-intrinsic TLR7 signaling is required for neutralizing antibody responses to SARS-CoV-2 and pathogen-like COVID-19 vaccines.

    Miquel, Charles-Henry / Abbas, Flora / Cenac, Claire / Foret-Lucas, Charlotte / Guo, Chang / Ducatez, Mariette / Joly, Etienne / Hou, Baidong / Guéry, Jean-Charles

    European journal of immunology

    2023  Volume 53, Issue 10, Page(s) e2350437

    Abstract: Toll-like receptor 7 (TLR7) triggers antiviral immune responses through its capacity to recognize single-stranded RNA. TLR7 loss-of-function mutants are associated with life-threatening pneumonia in severe COVID-19 patients. Whereas TLR7-driven innate ... ...

    Abstract Toll-like receptor 7 (TLR7) triggers antiviral immune responses through its capacity to recognize single-stranded RNA. TLR7 loss-of-function mutants are associated with life-threatening pneumonia in severe COVID-19 patients. Whereas TLR7-driven innate induction of type I IFN appears central to control SARS-CoV2 virus spreading during the first days of infection, the impact of TLR7-deficiency on adaptive B-cell immunity is less clear. In the present study, we examined the role of TLR7 in the adaptive B cells response to various pathogen-like antigens (PLAs). We used inactivated SARS-CoV2 and a PLA-based COVID-19 vaccine candidate designed to mimic SARS-CoV2 with encapsulated bacterial ssRNA as TLR7 ligands and conjugated with the RBD of the SARS-CoV2 Spike protein. Upon repeated immunization with inactivated SARS-CoV2 or PLA COVID-19 vaccine, we show that Tlr7-deficiency abolished the germinal center (GC)-dependent production of RBD-specific class-switched IgG2b and IgG2c, and neutralizing antibodies to SARS-CoV2. We also provide evidence for a non-redundant role for B-cell-intrinsic TLR7 in the promotion of RBD-specific IgG2b/IgG2c and memory B cells. Together, these data demonstrate that the GC reaction and class-switch recombination to the Myd88-dependent IgG2b/IgG2c in response to SARS-CoV2 or PLAs is strictly dependent on cell-intrinsic activation of TLR7 in B cells.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 Vaccines ; Antibodies, Neutralizing/metabolism ; COVID-19 ; Toll-Like Receptor 7 ; RNA, Viral ; Immunoglobulin G ; Polyesters ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Neutralizing ; Toll-Like Receptor 7 ; RNA, Viral ; Immunoglobulin G ; Polyesters ; Antibodies, Viral ; TLR7 protein, human
    Language English
    Publishing date 2023-07-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202350437
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  7. Article ; Online: TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells

    Ali Youness / Claire Cenac / Berenice Faz-López / Solange Grunenwald / Franck J. Barrat / Julie Chaumeil / José Enrique Mejía / Jean-Charles Guéry

    Biology of Sex Differences, Vol 14, Iss 1, Pp 1-

    2023  Volume 21

    Abstract: Abstract Background Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are, respectively, encoded by adjacent X-linked genes. ...

    Abstract Abstract Background Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are, respectively, encoded by adjacent X-linked genes. We previously established that TLR7 evades X chromosome inactivation (XCI) in female immune cells. Whether TLR8 also evades XCI, however, has not yet been explored. Method In the current study, we used RNA fluorescence in situ hybridization (RNA FISH) to directly visualize, on a single-cell basis, primary transcripts of TLR7 and TLR8 relative to X chromosome territories in CD14+ monocytes and CD4+ T lymphocytes from women, Klinefelter syndrome (KS) men, and euploid men. To assign X chromosome territories in cells lacking robust expression of a XIST compartment, we designed probes specific for X-linked genes that do not escape XCI and therefore robustly label the active X chromosome. We also assessed whether XCI escape of TLR8 was associated with sexual dimorphism in TLR8 protein expression by western blot and flow cytometry. Results Using RNA FISH, we show that TLR8, like TLR7, evades XCI in immune cells, and that cells harboring simultaneously TLR7 and TLR8 transcript foci are more frequent in women and KS men than in euploid men, resulting in a sevenfold difference in frequency. This transcriptional bias was again observable when comparing the single X of XY males with the active X of cells from females or KS males. Interestingly, TLR8 protein expression was significantly higher in female mononuclear blood cells, including all monocyte subsets, than in male cells. Conclusions TLR8, mirroring TLR7, escapes XCI in human monocytes and CD4+ T cells. Co-dependent transcription from the active X chromosome and escape from XCI could both contribute to higher TLR8 protein abundance in female cells, which may have implications for the response to viruses and bacteria, and the risk of developing inflammatory and autoimmune diseases.
    Keywords X chromosome inactivation escape ; Toll-like receptor 8 ; Toll-like receptor 7 ; Human monocytes and CD4+ T cells ; Klinefelter syndrome ; Medicine ; R ; Physiology ; QP1-981
    Subject code 570
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Monocytes are the main source of STING-mediated IFN-α production.

    Congy-Jolivet, Nicolas / Cenac, Claire / Dellacasagrande, Jérôme / Puissant-Lubrano, Bénédicte / Apoil, Pol André / Guedj, Kevin / Abbas, Flora / Laffont, Sophie / Sourdet, Sandrine / Guyonnet, Sophie / Nourhashemi, Fati / Guéry, Jean-Charles / Blancher, Antoine

    EBioMedicine

    2022  Volume 80, Page(s) 104047

    Abstract: Background: Type I interferon (IFN-I) production by plasmacytoid dendritic cells (pDCs) occurs during viral infection, in response to Toll-like receptor 7 (TLR7) stimulation and is more vigorous in females than in males. Whether this sex bias persists ... ...

    Abstract Background: Type I interferon (IFN-I) production by plasmacytoid dendritic cells (pDCs) occurs during viral infection, in response to Toll-like receptor 7 (TLR7) stimulation and is more vigorous in females than in males. Whether this sex bias persists in ageing people is currently unknown. In this study, we investigated the effect of sex and aging on IFN-α production induced by PRR agonist ligands.
    Methods: In a large cohort of individuals from 19 to 97 years old, we measured the production of IFN-α and inflammatory cytokines in whole-blood upon stimulation with either R-848, ODN M362 CpG-C, or cGAMP, which activate the TLR7/8, TLR9 or STING pathways, respectively. We further characterized the cellular sources of IFN-α.
    Findings: We observed a female predominance in IFN-α production by pDCs in response to TLR7 or TLR9 ligands. The higher TLR7-driven IFN-α production in females was robustly maintained across ages, including the elderly. The sex-bias in TLR9-driven interferon production was lost after age 60, which correlated with the decline in circulating pDCs. By contrast, STING-driven IFN-α production was similar in both sexes, preserved with aging, and correlated with circulating monocyte numbers. Indeed, monocytes were the primary cellular source of IFN-α in response to cGAMP.
    Interpretation: We show that the sex bias in the TLR7-induced IFN-I production is strongly maintained through ages, and identify monocytes as the main source of IFN-I production via STING pathway.
    Funding: This work was supported by grants from Région Occitanie/Pyrénées-Méditerranée (#12052910, Inspire Program #1901175), University Paul Sabatier, and the European Regional Development Fund (MP0022856).
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Female ; Humans ; Interferon-alpha/biosynthesis ; Interferon-alpha/blood ; Interferon-alpha/immunology ; Ligands ; Male ; Membrane Proteins/blood ; Membrane Proteins/immunology ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Toll-Like Receptor 7 ; Toll-Like Receptor 9/metabolism ; Young Adult
    Chemical Substances Interferon-alpha ; Ligands ; Membrane Proteins ; STING1 protein, human ; Toll-Like Receptor 7 ; Toll-Like Receptor 9
    Language English
    Publishing date 2022-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104047
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  9. Article ; Online: Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells.

    Berger, Mathieu / Guiraud, Laura / Dumas, Alexia / Sagnat, David / Payros, Gaëlle / Rolland, Corinne / Vergnolle, Nathalie / Deraison, Céline / Cenac, Nicolas / Racaud-Sultan, Claire

    American journal of physiology. Gastrointestinal and liver physiology

    2022  Volume 323, Issue 6, Page(s) G609–G626

    Abstract: Prenatal stress is associated with a high risk of developing adult intestinal pathologies, such as irritable bowel syndrome, chronic inflammation, and cancer. Although epithelial stem cells and progenitors have been implicated in intestinal ... ...

    Abstract Prenatal stress is associated with a high risk of developing adult intestinal pathologies, such as irritable bowel syndrome, chronic inflammation, and cancer. Although epithelial stem cells and progenitors have been implicated in intestinal pathophysiology, how prenatal stress could impact their functions is still unknown. We have investigated the proliferative and differentiation capacities of primitive cells using epithelial crypts isolated from colons of adult male and female mice whose mothers have been stressed during late gestation. Our results show that stem cell/progenitor proliferation and differentiation in vitro are negatively impacted by prenatal stress in male progeny. This is promoted by a reinforcement of the negative proliferative/differentiation control by the protease-activated receptor 2 (PAR2) and the muscarinic receptor 3 (M3), two G protein-coupled receptors present in the crypt. Conversely, prenatal stress does not change in vitro proliferation of colon primitive cells in female progeny. Importantly, this maintenance is associated with a functional switch in the M3 negative control of colonoid growth, becoming proliferative after prenatal stress. In addition, the proliferative role of PAR2 specific to females is maintained under prenatal stress, even though PAR2-targeted stress signals Dusp6 and activated GSK3β are increased, reaching the levels of males. An epithelial serine protease could play a critical role in the activation of the survival kinase GSK3β in colonoids from prenatally stressed female progeny. Altogether, our results show that following prenatal stress, colon primitive cells cope with stress through sexually dimorphic mechanisms that could pave the way to dysregulated crypt regeneration and intestinal pathologies.
    MeSH term(s) Male ; Female ; Mice ; Animals ; Pregnancy ; Receptor, PAR-2/genetics ; Glycogen Synthase Kinase 3 beta ; Colon ; Stem Cells ; Receptors, G-Protein-Coupled
    Chemical Substances Receptor, PAR-2 ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00061.2022
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  10. Article ; Online: 2-μm double-pulse single-frequency Tm:fiber laser pumped Ho:YLF laser for a space-borne CO

    Gibert, Fabien / Pellegrino, Jessica / Edouart, Dimitri / Cénac, Claire / Lombard, Laurent / Le Gouët, Julien / Nuns, Thierry / Cosentino, Alberto / Spano, Paolo / Di Nepi, Giorgia

    Applied optics

    2019  Volume 57, Issue 36, Page(s) 10370–10379

    Abstract: In the framework of space-borne ... ...

    Abstract In the framework of space-borne CO
    Language English
    Publishing date 2019-01-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.57.010370
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