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  1. AU=Kurd Ramzi
  2. AU=Szefel Jaros?aw
  3. AU="Vaisse, Christian"
  4. AU="Jean-Baptiste Poline"
  5. AU="Halekoh, Ulrich"
  6. AU="H. Fayaz"
  7. AU="Saddam Hussain"
  8. AU="Leary, Steven"
  9. AU="Schuit, Ewoud"
  10. AU=Sun Bingbing
  11. AU=d'Arminio Monforte Antonella
  12. AU="Sylvain Latour"
  13. AU="Velhal, S"
  14. AU="Lutz, Richard A"
  15. AU="Raveesh Kumar"
  16. AU="Andreas von Deimling"
  17. AU="Erik MeersauthorLaboratory of Analytical and Applied Ecochemistry, Faculty of Bioscience Engineering, University of Ghent, Coupure Links 653, 9000 Ghent, Belgium"
  18. AU="Thakkar, Nitya"
  19. AU="Hongtao Tie"
  20. AU="Bhati, Saurabh Kumar"
  21. AU="Choi, Hyunho"
  22. AU="Jayaprakash, Balamuralikrishna"
  23. AU="Lee, Brian H"
  24. AU="May, Susann"
  25. AU="Remondes-Costa, Sónia"
  26. AU="Lauren Sauer"
  27. AU="G Saiz, Paula"
  28. AU="Stoica, George"
  29. AU=Odorizzi Pamela M.
  30. AU=Pollaers Katherine
  31. AU="Stefanova, Veselina"
  32. AU="Geraldine M. O’Connor"
  33. AU="Jim E. Banta"
  34. AU="Marti-Bonmati, Luis"
  35. AU="Doris Kampner"
  36. AU="Luca Soraci"

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  1. Artikel: Optic Nerve Inflammation Associated with Severe Acute Respiratory Syndrome Coronavirus 2.

    Feldman, Itamar / Kurd, Ramzi / Nesher, Gideon / Zaghal, Mohamed / Breuer, Gabriel S

    The Israel Medical Association journal : IMAJ

    2023  Band 25, Heft 3, Seite(n) 169–170

    Mesh-Begriff(e) Humans ; SARS-CoV-2 ; COVID-19/complications ; Inflammation ; Optic Nerve
    Sprache Englisch
    Erscheinungsdatum 2023-03-21
    Erscheinungsland Israel
    Dokumenttyp Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Don't forget arterial thrombosis in patients with COVID-19: A case series.

    Gold, Daniel D / Kurd, Ramzi / Einav, Sharon

    Thrombosis update

    2021  Band 5, Seite(n) 100065

    Abstract: Introduction: The acute disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS COV-2) is accompanied by a hypercoagulable state. Multiple publications have described the venous thromboembolic events associated with coronavirus ... ...

    Abstract Introduction: The acute disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS COV-2) is accompanied by a hypercoagulable state. Multiple publications have described the venous thromboembolic events associated with coronavirus disease 2019 (COVID-19) but arterial thromboembolic events have yet to be described.
    Cases description: We describe five COVID-19 patients that developed severe morbidity as a result of occlusive arterial thromboembolic events occurring despite treatment with low molecular weight heparin. All cases presented with an acute confusional state and were accompanied by rapid elevations of lactate and D-dimers and leukocytes. The end organs involved were the kidneys, spleen, liver, lungs, central nervous system, intestines and limbs. Only one of the five patients survived.
    Conclusion: COVID-19 is associated with not only venous but also arterial thromboembolic events. Further research is required to clarify the incidence, causes and possible modes of prevention of this potentially lethal disease complication.
    Sprache Englisch
    Erscheinungsdatum 2021-08-04
    Erscheinungsland England
    Dokumenttyp Case Reports
    ISSN 2666-5727
    ISSN (online) 2666-5727
    DOI 10.1016/j.tru.2021.100065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Hydroxychloroquine-related Rash in COVID-19 Infected Patient.

    Kurd, Ramzi / Zuckerman, Michael / Ben-Chetrit, Eli

    The Israel Medical Association journal : IMAJ

    2020  Band 22, Heft 8, Seite(n) 525

    Mesh-Begriff(e) Aged ; COVID-19/drug therapy ; Drug Eruptions/etiology ; Humans ; Hydroxychloroquine/adverse effects ; Male ; SARS-CoV-2
    Chemische Substanzen Hydroxychloroquine (4QWG6N8QKH)
    Sprache Englisch
    Erscheinungsdatum 2020-11-25
    Erscheinungsland Israel
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Experimental and Compassionate Drug Use During the First Wave of the COVID-19 Pandemic: A Retrospective Single-Center Study.

    Assouline, Or / Ben-Chetrit, Eli / Helviz, Yigal / Kurd, Ramzi / Leone, Marc / Einav, Sharon

    Advances in therapy

    2021  Band 38, Heft 10, Seite(n) 5165–5177

    Abstract: Introduction: Concomitant experimental/compassionate drug administration has been all-pervasive in the treatment of COVID-19 patients. The objective of this study was to study the relationship between patient severity, the number of experimental/ ... ...

    Abstract Introduction: Concomitant experimental/compassionate drug administration has been all-pervasive in the treatment of COVID-19 patients. The objective of this study was to study the relationship between patient severity, the number of experimental/compassionate medications received (main outcome measure), and patient outcomes [survival to hospital discharge and length of hospital stay (LOS)].
    Methods: Retrospective analysis of data collected in real time during the first pandemic wave in a tertiary care hospital. Data included patient demographics, comorbidities, admission vital signs, laboratory values, most extreme respiratory intervention during hospitalization, and data regarding treatment with compassionate/experimental drugs during their stay.
    Results: Overall, 292 PCR-confirmed patients with symptoms of COVID-19 were studied (March/April, 2020). Increasing respiratory support correlated with both LOS and mortality. Patients were more likely to receive more than 1 experimental/compassionate drugs as respiratory support escalated, ranging from 3% (n = 4/136) among patients on room air to 77.3% (n = 17/22) of mechanically ventilated/ECMO patients (P < 0.001, linear by linear association). The mean number of experimental/compassionate drugs received also increased with escalating respiratory support (P < 0.001, one-way ANOVA). After adjustment for severity of patient condition, administration of more experimental/compassionate drugs was unrelated to survival (P = 0.24), but was related to increased LOS (P < 0.001).
    Conclusion: Patients that were hospitalized in worse condition were more likely to receive more experimental/compassionate drugs. Treatment was unrelated to survival but may have been related to LOS. This finding raises questions regarding the results of studies on medication effects that adjusted for multiple drug administration.
    Mesh-Begriff(e) COVID-19 ; Humans ; Pandemics ; Pharmaceutical Preparations ; Retrospective Studies ; SARS-CoV-2
    Chemische Substanzen Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2021-08-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-021-01890-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A Peculiar Case of Purpura.

    Szterenlicht, Yael M / Jarjoui, Amir / Kurd, Ramzi / Levy, Ludmila / Munter, Gabriel

    The American journal of medicine

    2019  Band 132, Heft 8, Seite(n) 934–935

    Mesh-Begriff(e) Adult ; Anemia, Iron-Deficiency/diagnosis ; Anemia, Iron-Deficiency/etiology ; Anemia, Iron-Deficiency/psychology ; Diet Fads/adverse effects ; Diet Fads/psychology ; Edema/etiology ; Humans ; Male ; Purpura/etiology ; Scurvy/diet therapy ; Scurvy/etiology ; Scurvy/psychology
    Sprache Englisch
    Erscheinungsdatum 2019-03-20
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2019.02.047
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Homeopathic Treatment for COVID-19-Related Symptoms: A Case Series.

    Kurd, Ramzi / Freed, Yakov / Jarjoui, Amir / Izbicki, Gabriel / Levin, Philip / Helvitz, Yigal / Sherr, Jeremy / Oberbaum, Menachem

    Complementary medicine research

    2021  Band 29, Heft 1, Seite(n) 83–88

    Abstract: Background: Severe acute respiratory syndrome due to coronavirus 2 (SARS CoV-2) is a novel infectious disease, which has quickly developed into a pandemic. The spectrum of COVID-19 symptoms is broad, ranging from a mild, self-limiting respiratory tract ... ...

    Titelübersetzung Homöopathische Behandlung bei Symptomen im Zusammenhang mit COVID-19: eine Fallserie.
    Abstract Background: Severe acute respiratory syndrome due to coronavirus 2 (SARS CoV-2) is a novel infectious disease, which has quickly developed into a pandemic. The spectrum of COVID-19 symptoms is broad, ranging from a mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure and possible death. Despite much effort and multiple clinical trials, there are, to date, no specific therapeutic agents to treat or cure the coronavirus infection.
    Case reports: The present paper presents 5 cases of patients with moderate to severe COVID-19 infections, 2 of them hospitalized in the intensive care unit, who were successfully treated with homeopathy.
    Results: All 5 patients responded to homeopathic treatment in an unexpectedly short time span, improving both physically and mentally.
    Conclusion: The present case series emphasizes the rapidity of response among moderate to severely ill patients to homeopathic treatment, when conventional medical options have been unable to relieve or shorten the disease. The observations described should encourage use of homeopathy in treating patients with COVID-19 during the acute phase of the disease.
    Mesh-Begriff(e) COVID-19 ; Homeopathy ; Humans ; Intensive Care Units ; Pandemics ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-09-14
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2885931-5
    ISSN 2504-2106 ; 2504-2092
    ISSN (online) 2504-2106
    ISSN 2504-2092
    DOI 10.1159/000517924
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Compassionate Use of Opaganib For Patients with Severe COVID-19

    Kurd, Ramzi / Ben-Chetrit, Eli / Karameh, Hani / Bar-Meir, Maskit

    medRxiv

    Abstract: Background. Opaganib is a selective sphingosine-kinase (SK)-2 inhibitor with anti-inflammatory and anti-viral properties. Methods. We provided opaganib on a compassionate-use basis to patients with severe COVID-19. Patients who required oxygen support ... ...

    Abstract Background. Opaganib is a selective sphingosine-kinase (SK)-2 inhibitor with anti-inflammatory and anti-viral properties. Methods. We provided opaganib on a compassionate-use basis to patients with severe COVID-19. Patients who required oxygen support via high-flow nasal cannula (HFNC) were offered the treatment. For comparison, we used a control group with same-sex, same-severity patients. Results. Seven patients received at least one dose of opaganib since April 2, 2020. One patient, who received both hydroxychloroquine and azithromycin, developed diarrhea and all his medications were stopped. This was the only adverse effect possibly related to opaganib. A second patient was weaned of oxygen and discharged after receiving two doses of opaganib. Therefore, five patients were included in this analysis. Baseline characteristics were not significantly different between cases and controls. Patients treated with opaganib had significantly faster increase in lymphocyte count. All other clinical outcomes had a non-statistically significant trend in favor of the treatment group: median time to weaning from HFNC was 10 and 15 days in cases vs. controls (HR= 0.3, 95% CI: 0.07-1.7, p=0.2) ,time to ambient air was 13 vs.14.5 days (HR=0.4, 95% CI: 0.15-1.5), none of the cases required mechanical ventilation compared with 33% of controls. Conclusion. In this small cohort of severe COVID-19 patients, opaganib was safe and well tolerated with improvement in both clinical and laboratory parameters in all treated patients. The efficacy of opaganib for COVID-19 infection should be further tested in randomized placebo-controlled trials.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-23
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.06.20.20099010
    Datenquelle COVID19

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  8. Artikel ; Online: Bilateral Adrenal Hemorrhage in Coronavirus Disease 2019 Patient: A Case Report.

    Frankel, Meir / Feldman, Itamar / Levine, Michal / Frank, Yigal / Bogot, Naama R / Benjaminov, Ofer / Kurd, Ramzi / Breuer, Gabriel S / Munter, Gabriel

    The Journal of clinical endocrinology and metabolism

    2020  Band 105, Heft 12

    Abstract: Context: Bilateral adrenal hemorrhage is a rare condition with potentially life-threatening consequences such as acute adrenal insufficiency. Early adrenal axis testing, as well as directed imaging, is crucial for immediate diagnosis and treatment. ... ...

    Abstract Context: Bilateral adrenal hemorrhage is a rare condition with potentially life-threatening consequences such as acute adrenal insufficiency. Early adrenal axis testing, as well as directed imaging, is crucial for immediate diagnosis and treatment. Coronavirus disease 2019 (COVID-19) has been associated with coagulopathy and thromboembolic events.
    Case description: A 66-year-old woman presented with acute COVID-19 infection and primary adrenal insufficiency due to bilateral adrenal hemorrhage (BAH). She also had a renal vein thrombosis. Her past medical history revealed primary antiphospholipid syndrome (APLS). Four weeks after discharge she had no signs of COVID-19 infection and her polymerase chain reaction test for COVID-19 was negative, but she still needed glucocorticoid and mineralocorticoid replacement therapy. The combination of APLS and COVID-19 was probably responsible of the adrenal event as a "two-hit" mechanism.
    Conclusions: COVID-19 infection is associated with coagulopathy and thromboembolic events, including BAH. Adrenal insufficiency is life threatening; therefore, we suggest that early adrenal axis testing for COVID-19 patients with clinical suspicion of adrenal insufficiency should be carried out.
    Mesh-Begriff(e) Adrenal Gland Diseases/etiology ; Adrenal Gland Diseases/pathology ; Aged ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; Female ; Hemorrhage/etiology ; Hemorrhage/pathology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; Prognosis ; SARS-CoV-2 ; Thrombosis/etiology ; Thrombosis/pathology
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-01
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa487
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: QTc prolongation among hydroxychloroquine sulphate-treated COVID-19 patients: An observational study.

    Fteiha, Bashar / Karameh, Hani / Kurd, Ramzi / Ziff-Werman, Batsheva / Feldman, Itamar / Bnaya, Alon / Einav, Sharon / Orlev, Amir / Ben-Chetrit, Eli

    International journal of clinical practice

    2020  Band 75, Heft 3, Seite(n) e13767

    Abstract: Background: The liberal administration of hydroxychloroquine-sulphate (HCQ) to COVID-19 patients has raised concern regarding the risk of QTc prolongation and cardiac arrhythmias, particularly when prescribed with azithromycin. We evaluated the ... ...

    Abstract Background: The liberal administration of hydroxychloroquine-sulphate (HCQ) to COVID-19 patients has raised concern regarding the risk of QTc prolongation and cardiac arrhythmias, particularly when prescribed with azithromycin. We evaluated the incidence of QTc prolongation among moderately and severely ill COVID-19 patients treated with HCQ and of the existence of concomitant alternative causes.
    Methods: All COVID-19 patients treated with HCQ (between Mar 1 and Apr 14, 2020) in a tertiary medical centre were included. Clinical characteristics and relevant risk factors were collected from the electronic medical records. Individual patient QTc intervals were determined before and after treatment with HCQ. The primary outcome measure sought was a composite end point comprised of either an increase ≥60 milliseconds (ms) in the QTc interval compared with pre-treatment QTc, and/or a maximal QTc interval >500 ms RESULTS: Ninety patients were included. Median age was 65 years (IQR 55-75) and 57 (63%) were male. Thirty-nine patients (43%) were severely or critically ill. Hypertension and obesity were common (n = 23 each, 26%). QTc prolongation evolved in 14 patients (16%). Age >65 years, congestive heart failure, severity of disease, C-reactive protein level, hypokalaemia and furosemide treatment, were all associated with QTc prolongation. Adjusted analysis showed that QTc prolongation was five times more likely with hypokalaemia [OR 5, (95% CI, 1.3-20)], and three times more likely with furosemide treatment [OR 3 (95% CI, 1.01-13.7)].
    Conclusion: In patients treated with HCQ, QTc prolongation was associated with the presence of traditional risk factors such as hypokalaemia and furosemide treatment.
    Mesh-Begriff(e) Aged ; Azithromycin ; COVID-19/drug therapy ; Drug Therapy, Combination ; Electrocardiography ; Female ; Humans ; Hydroxychloroquine/adverse effects ; Long QT Syndrome/chemically induced ; Long QT Syndrome/drug therapy ; Male ; SARS-CoV-2
    Chemische Substanzen Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-12-18
    Erscheinungsland India
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.13767
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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