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  1. Article ; Online: Modeling faults among mountainous highway fatal crash-involved drivers with different route familiarity levels.

    Xue, Gang / Zhu, Zian / Liu, Qiandong / Wen, Huiying

    Traffic injury prevention

    2023  Volume 24, Issue 2, Page(s) 140–146

    Abstract: Objective: With the constrained topography and road geometry, adverse weather conditions and restricted roadway facilities, mountainous highway crash rates and fatality rates are much higher. Considering the potential influence of driver's route ... ...

    Abstract Objective: With the constrained topography and road geometry, adverse weather conditions and restricted roadway facilities, mountainous highway crash rates and fatality rates are much higher. Considering the potential influence of driver's route familiarity level on driving behavior and fault assignment, this research investigates high- and low- route familiarity level drivers (HRF and LRF drivers) fault assignment in mountainous highway fatal crashes in Yunnan Province of China by examining factors of driver, crash/environment and pre-crash behaviors.
    Methods: Yunnan Province is famous for its tourism, and tourism can also bring in many drivers with low-route familiarity levels. Spatial distance away from residence-based method is used for identifying route familiarity levels of the drivers in this study. We employed two separate binary logistic regression models to investigate the effects of the explanatory variables on the likelihoods that the HRF or LRF drivers were at fault in the mountainous highway fatal crashes.
    Results: The results show that driver under alcohol influence, sharp turn, dawn/dusk and left turning are 4 common factors that significantly influence both HRF and LRF drivers' fault assignments. Factors including driver age, driver seatbelt use, weather condition, road type, section type, lighting condition and pre-crash behaviors have different or opposite influences on HRF and LRF drivers' fault assignments. HRF drivers are much easier to be distracted under the conditions that are without the need of extra attention. LRF drivers have much more difficulties in figuring out, responding to and making timely driving behavior adjustment to ensure their driving safety on the high-risk sections like tunnels, continuous long downhills and sharp turns. Street parking/backing and left turning of the LRF drivers are very serious problems on the mountainous highways in China.
    Conclusions: There is a large difference of significant factors contributing to the fault assignment of HRF and LRF drivers in mountainous highway fatal crashes. Some more effective and targeted countermeasures are put forward for HRF and LRF drivers and transportation managers to improve mountainous highway traffic safety.
    MeSH term(s) Humans ; Accidents, Traffic ; China/epidemiology ; Automobile Driving ; Weather ; Seat Belts ; Logistic Models
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2089818-6
    ISSN 1538-957X ; 1538-9588
    ISSN (online) 1538-957X
    ISSN 1538-9588
    DOI 10.1080/15389588.2023.2167200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Robotic assisted minimally invasive esophagectomy versus minimally invasive esophagectomy.

    Xue, Mengchao / Liu, Junjie / Lu, Ming / Zhang, Huiying / Liu, Wen / Tian, Hui

    Frontiers in oncology

    2024  Volume 13, Page(s) 1293645

    Abstract: Background: Esophagectomy is the gold standard treatment for resectable esophageal cancer; however, there is insufficient evidence to indicate potential advantages over standard minimally invasive esophagectomy (MIE) in treating thoracic esophageal ... ...

    Abstract Background: Esophagectomy is the gold standard treatment for resectable esophageal cancer; however, there is insufficient evidence to indicate potential advantages over standard minimally invasive esophagectomy (MIE) in treating thoracic esophageal cancer. Robot-assisted minimally invasive esophagectomy (RAMIE) bridges the gap between open and minimally invasive surgery. In this single-center retrospective review, we compare the clinical outcomes of EC patients treated with MIE and RAMIE.
    Method: We retrospectively reviewed the clinical data of patients with esophageal cancer who underwent surgery at Qilu Hospital between August 2020 and August 2022, including 159 patients who underwent MIE and 35 patients who received RAMIE. The intraoperative, postoperative, and preoperative patient characteristics in both groups were evaluated.
    Results: Except for height, the MIE and RAMIE groups showed no significant differences in preoperative features (P>0.05). Further, there were no significant differences in intraoperative indices, including TNM stage of the resected tumor, tumor tissue type, or ASA score, between the two groups. However, statistically significant differences were found in some factors; the RAMIE group had a shorter operative time, less intraoperative bleeding, and more lymph nodes removed compared to the MIE group. Patients in the RAMIE group reported less discomfort and greater chest drainage on the first postoperative day than patients in the MIE group; however, there were no differences in other features between the two datasets.
    Conclusion: By comparing the clinical characteristics and outcomes of RAMIE with MIE, this study verified the feasibility and safety of RAMIE for esophageal cancer. Overall, RAMIE resulted in more complete lymph node clearance, shorter operating time, reduced surgical hemorrhage, reduced postoperative discomfort, and chest drainage alleviation in patients. To investigate the function of RAMIE in esophageal cancer, we propose undertaking a future clinical trial with long-term follow-up to analyze tumor clearance, recurrence, and survival after RAMIE.
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1293645
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  3. Article ; Online: Relationship of sperm motility with clinical outcome of percutaneous epididymal sperm aspiration-intracytoplasmic sperm injection in infertile males with congenital domestic absence of vas deferens: a retrospective study.

    Jixiang, Zhong / Lianmei, Zhang / Yanghua, Zuo / Huiying, Xue

    Zygote (Cambridge, England)

    2021  Volume 30, Issue 2, Page(s) 234–238

    Abstract: Congenital domestic absence of vas deferens (CBAVD) is a common factor in male infertility, and percutaneous epididymal sperm aspiration (PESA) combined with intracytoplasmic sperm injection (ICSI) is a primary clinical treatment, but the effect of the ... ...

    Abstract Congenital domestic absence of vas deferens (CBAVD) is a common factor in male infertility, and percutaneous epididymal sperm aspiration (PESA) combined with intracytoplasmic sperm injection (ICSI) is a primary clinical treatment, but the effect of the sperm obtained on pregnancy outcome remains to be explored. This study aimed to investigate the relationship between sperm motility with clinical outcome of PESA-ICSI in infertile males with CBAVD. A cohort of 110 couples was enrolled. In total, 76 infertile males were included in the high motility group, while the remaining 34 males were placed in the low motility group. Clinical pregnancy, embryo implantation rate and live birth rate were included as the primary outcome. After all follow-ups, we found that the high motility group achieved higher normal fertilization rates, cleavage rates, transplantable embryo rates and high-quality embryo rates than those in low motility group (normal fertilization rate, 78.2 ± 11.7% vs. 70.5 ± 10.2%, P = 0.003; cleavage rate, 97.1 ± 2.9% vs. 92.3 ± 3.0%, P = 0.000; transplantable embryo rate, 66.8 ± 14.9% vs. 58.6 ± 12.6%, P = 0.009 and high-quality embryo rate, 49.9 ± 10.5% vs. 40.5 ± 11.2%, P = 0.000). Additionally, compared with the low motility group, the clinical pregnancy rates, embryo implantation rates, and live birth rates in the high motility group were significantly increased (pregnancy rate, 61.8% vs. 26.5%, P = 0.009; embryo implantation rate, 36.5% vs. 18.0%, P = 0.044; live birth rate, 55.3% vs. 17.6%, P = 0.000). We concluded that the motility of sperm obtained by PESA affected the clinical outcome of ICSI in infertile males with CBAVD.
    MeSH term(s) Epididymis ; Female ; Humans ; Infertility, Male/therapy ; Male ; Male Urogenital Diseases ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Sperm Injections, Intracytoplasmic ; Sperm Motility ; Sperm Retrieval ; Spermatozoa ; Vas Deferens/abnormalities
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1166294-3
    ISSN 1469-8730 ; 0967-1994
    ISSN (online) 1469-8730
    ISSN 0967-1994
    DOI 10.1017/S0967199421000587
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  4. Article ; Online: The role of adenocarcinoma subtypes and immunohistochemistry in predicting lymph node metastasis in early invasive lung adenocarcinoma.

    Xue, Mengchao / Liu, Junjie / Li, Zhenyi / Lu, Ming / Zhang, Huiying / Liu, Wen / Tian, Hui

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 139

    Abstract: Background: Identifying lymph node metastasis areas during surgery for early invasive lung adenocarcinoma remains challenging. The aim of this study was to develop a nomogram mathematical model before the end of surgery for predicting lymph node ... ...

    Abstract Background: Identifying lymph node metastasis areas during surgery for early invasive lung adenocarcinoma remains challenging. The aim of this study was to develop a nomogram mathematical model before the end of surgery for predicting lymph node metastasis in patients with early invasive lung adenocarcinoma.
    Methods: In this study, we included patients with invasive lung adenocarcinoma measuring ≤ 2 cm who underwent pulmonary resection with definite pathology at Qilu Hospital of Shandong University from January 2020 to January 2022. Preoperative biomarker results, clinical features, and computed tomography characteristics were collected. The enrolled patients were randomized into a training cohort and a validation cohort in a 7:3 ratio. The training cohort was used to construct the predictive model, while the validation cohort was used to test the model independently. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors. The prediction model and nomogram were established based on the independent risk factors. Recipient operating characteristic (ROC) curves were used to assess the discrimination ability of the model. Calibration capability was assessed using the Hosmer-Lemeshow test and calibration curves. The clinical utility of the nomogram was assessed using decision curve analysis (DCA).
    Results: The overall incidence of lymph node metastasis was 13.23% (61/461). Six indicators were finally determined to be independently associated with lymph node metastasis. These six indicators were: age (P < 0.001), serum amyloid (SA) (P = 0.008); carcinoma antigen 125 (CA125) (P = 0. 042); mucus composition (P = 0.003); novel aspartic proteinase of the pepsin family A (Napsin A) (P = 0.007); and cytokeratin 5/6 (CK5/6) (P = 0.042). The area under the ROC curve (AUC) was 0.843 (95% CI: 0.779-0.908) in the training cohort and 0.838 (95% CI: 0.748-0.927) in the validation cohort. the P-value of the Hosmer-Lemeshow test was 0.0613 in the training cohort and 0.8628 in the validation cohort. the bias of the training cohort corrected C-index was 0.8444 and the bias-corrected C-index for the validation cohort was 0.8375. demonstrating that the prediction model has good discriminative power and good calibration.
    Conclusions: The column line graphs created showed excellent discrimination and calibration to predict lymph node status in patients with ≤ 2 cm invasive lung adenocarcinoma. In addition, the predictive model has predictive potential before the end of surgery and can inform clinical decision making.
    MeSH term(s) Humans ; Adenocarcinoma/surgery ; Adenocarcinoma of Lung ; Immunohistochemistry ; Lung Neoplasms ; Lymphatic Metastasis ; Nomograms ; Retrospective Studies
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-024-11843-4
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  5. Article ; Online: Precise measurement of single molecule and single cell based on nanopores/nanochannels' charge transfer.

    Huang, Yu / Xue, Huiying / Lou, Xiaoding / Xia, Fan

    Science bulletin

    2021  Volume 66, Issue 16, Page(s) 1599–1600

    MeSH term(s) Nanopores ; Nanotechnology ; Biomimetic Materials
    Language English
    Publishing date 2021-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2021.03.011
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  6. Article ; Online: The Relationship Between Anti-Müllerian Hormone and Body Composition Components in Patients With Polycystic Ovary Syndrome of Reproductive Age.

    Li, Xue / Tang, Qingtao / Feng, Yaru / Zhang, Yanfang / Tian, Wenyan / Zhang, Huiying

    Reproductive sciences (Thousand Oaks, Calif.)

    2024  

    Abstract: To investigate and analyze the relationship between body composition components, including Body Mass Index (BMI), body fat percentage, waist-to-hip ratio, and visceral fat index, and Anti-Müllerian Hormone (AMH) levels in patients diagnosed with ... ...

    Abstract To investigate and analyze the relationship between body composition components, including Body Mass Index (BMI), body fat percentage, waist-to-hip ratio, and visceral fat index, and Anti-Müllerian Hormone (AMH) levels in patients diagnosed with Polycystic Ovary Syndrome (PCOS), The study aims to provide a comprehensive understanding of how various aspects of body composition impact AMH levels. This study enrolled 167 women with PCOS of reproductive age. Serum AMH level and body composition were measured, and the correlation between body composition elements and AMH levels was analyzed. AMH level was negatively correlated with body weight, BMI, fat-free mass, body fat percentage, waist-hip ratio, and visceral fat level (P < 0.01). And negatively correlated with skeletal muscle ratio ( P = 0.003). AMH level remained significantly associated with BMI ( P = 0.028), body fat percentage ( P = 0.040), waist-hip ratio (P = 0.003), and visceral fat level ( P = 0.040) after age was included and a multiple linear regression model was established. After adjusting for age, BMI was still significantly associated with AMH (P = 0.029). At the same time, there was no obvious linear correlation between BSA and AMH. The results showed that AMH levels were significantly different among the three groups (9.53 ± 5.12 vs 6.98 ± 3.35 vs 6.38 ± 3.38, P < 0.001; ng/mL). The level of AMH in the non-central obesity group was higher than that in the central obesity group (9.68 ± 5.22vs7.09 ± 3.83, P < 0.001; ng/mL). In PCOS patients, those who are more obese have lower AMH levels, indicating poorer Ovarian Reserve. BMI may independently affect AMH levels, apart from age, BSA, and other factors. Ovarian function in centrally obese patients is poorer than in those with non-central obesity.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-024-01561-4
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  7. Article ; Online: Quantitative Phosphoproteomic Analysis Provides Insights into the Sodium Bicarbonate Responsiveness of

    Li, Qiang / Li, Minglong / Ma, Huiying / Xue, Man / Chen, Tong / Ding, Xiaodong / Zhang, Shuzhen / Xiao, Jialei

    Biomolecules

    2023  Volume 13, Issue 10

    Abstract: Sodium bicarbonate stress caused by ... ...

    Abstract Sodium bicarbonate stress caused by NaHCO
    MeSH term(s) Glycine max/metabolism ; Sodium Bicarbonate/pharmacology ; Sodium Bicarbonate/metabolism ; Plant Proteins/metabolism ; Phosphopeptides/chemistry ; Phosphopeptides/metabolism ; Phosphoproteins/metabolism
    Chemical Substances Sodium Bicarbonate (8MDF5V39QO) ; Plant Proteins ; Phosphopeptides ; Phosphoproteins
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13101520
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  8. Article ; Online: The Value of High-Resolution Ultrasound Combined with Shear-Wave Elastography under Artificial Intelligence Algorithm in Quantitative Evaluation of Skin Thickness in Localized Scleroderma.

    Jia, Kun / Li, Huiying / Wu, Xiaojing / Xu, Caina / Xue, Hongyuan

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 1613783

    Abstract: The aim of this study was to explore the value of high-resolution ultrasound combined with shear-wave elastography (SWE) in measuring skin thickness in patients with localized scleroderma (LS). Fifty patients with LS diagnosed by pathology in the ... ...

    Abstract The aim of this study was to explore the value of high-resolution ultrasound combined with shear-wave elastography (SWE) in measuring skin thickness in patients with localized scleroderma (LS). Fifty patients with LS diagnosed by pathology in the hospital were selected as the research object, with a total of 96 lesions. Healthy people (50 cases) in the same period were selected as the control group. The skin thickness of the abdomen, chest, and left finger of the two groups was compared. The traditional nonlocal means (NLM) algorithm was improved by changing the Euclidean distance and introducing a cosine function, which was applied to the ultrasonic imaging intelligent diagnosis of patients with localized scleroderma. SWE imaging was evaluated, and the results demonstrated that LS lesion edema stage accounted for 7.29%, hardening stage occupied 43.75%, and the proportion of atrophy stage reached 48.96%. When the size of shell was 1 mm, maximum elastic modulus (
    MeSH term(s) Algorithms ; Artificial Intelligence ; Elasticity Imaging Techniques/methods ; Humans ; Scleroderma, Localized/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/1613783
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  9. Article ; Online: Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.

    Li, Huiying / Hardy, Christine D / Reidl, Cory T / Jing, Qing / Xue, Fengtian / Cinelli, Maris / Silverman, Richard B / Poulos, Thomas L

    Biochemistry

    2024  Volume 63, Issue 6, Page(s) 788–796

    Abstract: In our efforts to develop inhibitors selective for neuronal nitric oxide synthase (nNOS) over endothelial nitric oxide synthase (eNOS), we found that nNOS can undergo conformational changes in response to inhibitor binding that does not readily occur in ... ...

    Abstract In our efforts to develop inhibitors selective for neuronal nitric oxide synthase (nNOS) over endothelial nitric oxide synthase (eNOS), we found that nNOS can undergo conformational changes in response to inhibitor binding that does not readily occur in eNOS. One change involves movement of a conserved tyrosine, which hydrogen bonds to one of the heme propionates, but in the presence of an inhibitor, changes conformation, enabling part of the inhibitor to hydrogen bond with the heme propionate. This movement does not occur as readily in eNOS and may account for the reason why these inhibitors bind more tightly to nNOS. A second structural change occurs upon the binding of a second inhibitor molecule to nNOS, displacing the pterin cofactor. Binding of this second site inhibitor requires structural changes at the dimer interface, which also occurs more readily in nNOS than in eNOS. Here, we used a combination of crystallography, mutagenesis, and computational methods to better understand the structural basis for these differences in NOS inhibitor binding. Computational results show that a conserved tyrosine near the primary inhibitor binding site is anchored more tightly in eNOS than in nNOS, allowing for less flexibility of this residue. We also find that the inefficiency of eNOS to bind a second inhibitor molecule is likely due to the tighter dimer interface in eNOS compared with nNOS. This study provides a better understanding of how subtle structural differences in NOS isoforms can result in substantial dynamic differences that can be exploited in the development of isoform-selective inhibitors.
    MeSH term(s) Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/chemistry ; Nitric Oxide Synthase Type I ; Protein Isoforms/chemistry ; Crystallography, X-Ray ; Enzyme Inhibitors/pharmacology ; Heme/chemistry ; Tyrosine ; Nitric Oxide
    Chemical Substances Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Nitric Oxide Synthase Type I (EC 1.14.13.39) ; Protein Isoforms ; Enzyme Inhibitors ; Heme (42VZT0U6YR) ; Tyrosine (42HK56048U) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00601
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  10. Article: Structure and Function Analysis of Cultivated

    Wang, Yan / Ma, Qingyun / Wang, Lingling / Hu, Jingkuo / Xue, Huiying / Han, Dongfei / Xing, Zhen / Ruan, Zhiyong

    Biology

    2023  Volume 12, Issue 2

    Abstract: 1) Background: The structure, function, and community interactions of soil microbial communities of ... ...

    Abstract (1) Background: The structure, function, and community interactions of soil microbial communities of cultivated
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12020160
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