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  1. Article ; Online: Hyperactive Delirium Requires More Aggressive Management in Patients With COVID-19: Temporarily Rethinking "Low and Slow".

    Sanders, Barton J / Bakar, Melissa / Mehta, Sonal / Reid, M Carrington / Siegler, Eugenia L / Abrams, Robert C / Adelman, Ronald D / Lachs, Mark S

    Journal of pain and symptom management

    2020  Volume 60, Issue 2, Page(s) e31–e32

    MeSH term(s) Antipsychotic Agents/administration & dosage ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Delirium/complications ; Delirium/therapy ; Disease Management ; Hospice Care ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Psychomotor Agitation/complications ; Psychomotor Agitation/therapy ; Safety
    Chemical Substances Antipsychotic Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Letter
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2020.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2252: Show issues Location:
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  2. Article: Hyperactive Delirium Requires More Aggressive Management in Patients With COVID-19: Temporarily Rethinking "Low and Slow"

    Sanders, Barton J / Bakar, Melissa / Mehta, Sonal / Reid, M Carrington / Siegler, Eugenia L / Abrams, Robert C / Adelman, Ronald D / Lachs, Mark S

    J Pain Symptom Manage

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #347827
    Database COVID19

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  3. Article ; Online: Hyperactive Delirium Requires More Aggressive Management in Patients With COVID-19

    Sanders, Barton J. / Bakar, Melissa / Mehta, Sonal / Reid, M. Carrington / Siegler, Eugenia L. / Abrams, Robert C. / Adelman, Ronald D. / Lachs, Mark S.

    Journal of Pain and Symptom Management

    Temporarily Rethinking “Low and Slow”

    2020  Volume 60, Issue 2, Page(s) e31–e32

    Keywords Anesthesiology and Pain Medicine ; General Nursing ; Clinical Neurology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639142-4
    ISSN 0885-3924
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2020.05.013
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 2252: Show issues Location:
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  4. Article ; Online: Does oxidative DNA damage trigger histotoxic hypoxia via PARP1/AMP-driven mitochondrial ADP depletion-induced ATP synthase inhibition in Alzheimer's disease?

    Davis Sanders, Owen / Rajagopal, Lekshmy / Chase Barton, Chandler / Archa Rajagopal, Jayalekshmi / Lopez, Olga / Lopez, Kalei / Malik, Fayeza

    Mitochondrion

    2022  Volume 67, Page(s) 59–64

    Abstract: The low cerebral metabolic rate of oxygen despite the relatively preserved perfusion in Alzheimer's disease (AD) patients' medial temporal lobes suggest histotoxic hypoxia due to mitochondrial dysfunction that is independent of, but could precede, ... ...

    Abstract The low cerebral metabolic rate of oxygen despite the relatively preserved perfusion in Alzheimer's disease (AD) patients' medial temporal lobes suggest histotoxic hypoxia due to mitochondrial dysfunction that is independent of, but could precede, insulin resistance. Neuropathological, metabolomic, and preclinical evidence are consistent with the notion that this mitochondrial dysfunction may be contributed to by oxidative stress and DNA damage, leading to poly-(ADP-ribose)-polymerase-1 (PARP1) activation and consequent AMP accumulation, clogging of mitochondrial adenine nucleotide transporters (ANTs), matrix ADP deprivation, and ATP synthase inhibition. Complementary mechanisms may include mitochondrial-protein poly-ADP-ribosylation and mitochondrial-biogenesis suppression via PARPs outcompeting Sirtuin-1 (SIRT1) for nicotinamide-adenine-dinucleotide (NAD
    MeSH term(s) Humans ; Poly(ADP-ribose) Polymerases/metabolism ; Alzheimer Disease ; Mitochondrial Proton-Translocating ATPases/metabolism ; Oxidative Stress ; NAD/metabolism ; DNA Damage ; Hypoxia ; Adenosine Triphosphate/metabolism ; Adenosine Monophosphate ; Adenosine Diphosphate/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism
    Chemical Substances Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-) ; NAD (0U46U6E8UK) ; Adenosine Triphosphate (8L70Q75FXE) ; Adenosine Monophosphate (415SHH325A) ; Adenosine Diphosphate (61D2G4IYVH) ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
    Language English
    Publishing date 2022-10-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2022.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Invited commentary on "Optimizing response in surgical systems during and after COVID-19 pandemic: Lessons from China and the UK - Perspective. Int J Surg, 2020, May 4, Epub ahead of print" Hyperactive Delirium Requires More Aggressive Management in Patie

    Huda, Farhanul / Basu, Somprakas / Sanders, Barton J. / Bakar, Melissa / Mehta, Sonal / Reid, M. Carrington / Siegler, Eugenia L. / Abrams, Robert C. / Adelman, Ronald D. / Lachs, Mark S.

    Int J Surg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #607501
    Database COVID19

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  6. Article ; Online: Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions.

    Caniels, Tom G / Medina-Ramírez, Max / Zhang, Jinsong / Sarkar, Anita / Kumar, Sonu / LaBranche, Alex / Derking, Ronald / Allen, Joel D / Snitselaar, Jonne L / Capella-Pujol, Joan / Sánchez, Iván Del Moral / Yasmeen, Anila / Diaz, Marilyn / Aldon, Yoann / Bijl, Tom P L / Venkatayogi, Sravani / Martin Beem, Joshua S / Newman, Amanda / Jiang, Chuancang /
    Lee, Wen-Hsin / Pater, Maarten / Burger, Judith A / van Breemen, Mariëlle J / de Taeye, Steven W / Rantalainen, Kimmo / LaBranche, Celia / Saunders, Kevin O / Montefiori, David / Ozorowski, Gabriel / Ward, Andrew B / Crispin, Max / Moore, John P / Klasse, Per Johan / Haynes, Barton F / Wilson, Ian A / Wiehe, Kevin / Verkoczy, Laurent / Sanders, Rogier W

    Cell reports. Medicine

    2023  Volume 4, Issue 4, Page(s) 101003

    Abstract: Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is attractive because of its distinct genetic signature. However, VRC01-class bNAbs often ...

    Abstract Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is attractive because of its distinct genetic signature. However, VRC01-class bNAbs often require extensive somatic hypermutation, including rare insertions and deletions. We describe a BG505 SOSIP trimer, termed GT1.2, to optimize binding to gl-CH31, the unmutated common precursor of the CH30-34 bNAb lineage that acquired a large CDRH1 insertion. The GT1.2 trimer activates gl-CH31 naive B cells in knock-in mice, and B cell responses could be matured by selected boosting immunogens to generate cross-reactive Ab responses. Next-generation B cell sequencing reveals selection for VRC01-class mutations, including insertions in CDRH1 and FWR3 at positions identical to VRC01-class bNAbs, as well as CDRL1 deletions and/or glycine substitutions to accommodate the N276 glycan. These results provide proof of concept for vaccine-induced affinity maturation of B cell lineages that require rare insertions and deletions.
    MeSH term(s) Mice ; Animals ; Broadly Neutralizing Antibodies ; Antibodies, Neutralizing ; HIV-1/genetics ; HIV Antibodies ; HIV Seropositivity ; Vaccination
    Chemical Substances Broadly Neutralizing Antibodies ; Antibodies, Neutralizing ; HIV Antibodies
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101003
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  7. Article ; Online: Long-term dynamics of the distribution of the invasive Argentine ant, Linepithema humile, and native ant taxa in northern California.

    Sanders, Nathan J / Barton, Kasey E / Gordon, Deborah M

    Oecologia

    2001  Volume 127, Issue 1, Page(s) 123–130

    Abstract: Invasive species, where successful, can devastate native communities. We studied the dynamics of the invasive Argentine ant, Linepithema humile, for 7 years in Jasper Ridge, a biological preserve in northern California. We monitored the distributions at ... ...

    Abstract Invasive species, where successful, can devastate native communities. We studied the dynamics of the invasive Argentine ant, Linepithema humile, for 7 years in Jasper Ridge, a biological preserve in northern California. We monitored the distributions at the hectare scale of native ant taxa and L. humile in the spring and fall from 1993 to 1999. We also studied the invasion dynamics at a finer resolution by searching for ants in 1-m
    Language English
    Publishing date 2001-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123369-5
    ISSN 1432-1939 ; 0029-8549
    ISSN (online) 1432-1939
    ISSN 0029-8549
    DOI 10.1007/s004420000572
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    In stock of ZB MED Bonn / Germany

    Z 70/109: Show issues

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  8. Article ; Online: Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition.

    Speakman, Christopher M / Domke, Tanja C E / Wongpaiboonwattana, Wikrom / Sanders, Kelly / Mudaliar, Manikhandan / van Aalten, Daan M F / Barton, Geoffrey J / Stavridis, Marios P

    Stem cells (Dayton, Ohio)

    2014  Volume 32, Issue 10, Page(s) 2605–2615

    Abstract: The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways, typically mediated by post-translational protein modifications. The addition of O-linked N-acetylglucosamine (O-GlcNAc) to serine ... ...

    Abstract The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways, typically mediated by post-translational protein modifications. The addition of O-linked N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of nuclear and cytoplasmic proteins is one such modification (O-GlcNAcylation), whose function in ESCs is only now beginning to be elucidated. Here, we demonstrate that the specific inhibition of O-GlcNAc hydrolase (Oga) causes increased levels of protein O-GlcNAcylation and impairs differentiation of mouse ESCs both in serum-free monolayer and in embryoid bodies (EBs). Use of reporter cell lines demonstrates that Oga inhibition leads to a reduction in the number of Sox1-expressing neural progenitors generated following induction of neural differentiation as well as maintained expression of the ESC marker Oct4 (Pou5f1). In EBs, expression of mesodermal and endodermal markers is also delayed. However, the transition of naïve cells to primed pluripotency indicated by Rex1 (Zfp42), Nanog, Esrrb, and Dppa3 downregulation and Fgf5 upregulation remains unchanged. Finally, we demonstrate that increased O-GlcNAcylation results in upregulation of genes normally epigenetically silenced in ESCs, supporting the emerging role for this protein modification in the regulation of histone modifications and DNA methylation.
    MeSH term(s) Acetylglucosamine/metabolism ; Animals ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Dimethyl Sulfoxide/pharmacology ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/drug effects ; Embryonic Stem Cells/metabolism ; Epigenesis, Genetic/drug effects ; Glycosylation/drug effects ; Mice ; N-Acetylglucosaminyltransferases/antagonists & inhibitors ; N-Acetylglucosaminyltransferases/metabolism ; Phosphorylation/drug effects ; Transcription, Genetic/drug effects
    Chemical Substances N-Acetylglucosaminyltransferases (EC 2.4.1.-) ; Acetylglucosamine (V956696549) ; Dimethyl Sulfoxide (YOW8V9698H)
    Language English
    Publishing date 2014-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1002/stem.1761
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    Zs.A 1894: Show issues Location:
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  9. Article ; Online: Extensive projections of myenteric serotonergic neurons suggest they comprise the central processing unit in the colon.

    Okamoto, T / Barton, M J / Hennig, G W / Birch, G C / Grainger, N / Corrigan, R D / Koh, S D / Sanders, K M / Smith, T K

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2014  Volume 26, Issue 4, Page(s) 556–570

    Abstract: Background: 5-Hydroxytryptamine (5-HT, serotonin) is an important regulator of colonic motility and secretion; yet the role of serotonergic neurons in the colon is controversial.: Methods: We used immunohistochemical techniques to examine their ... ...

    Abstract Background: 5-Hydroxytryptamine (5-HT, serotonin) is an important regulator of colonic motility and secretion; yet the role of serotonergic neurons in the colon is controversial.
    Methods: We used immunohistochemical techniques to examine their projections throughout the enteric nervous system and interstitial cells of Cajal (ICC) networks in the murine proximal to mid colon.
    Key results: Serotonergic neurons, which were mainly calbindin positive, occurred only in myenteric ganglia (1 per 3 ganglia). They were larger than nNOS neurons but similar in size to Dogiel Type II (AH) neurons. 5-HT neurons, appeared to make numerous varicose contacts with each other, most nNOS neurons, Dogiel Type II/AH neurons and glial cells. 5-HT, calbindin and nNOS nerve fibers also formed a thin perimuscular nerve plexus that was associated with ganglia, which contained both nNOS positive and negative neurons, which lay directly upon the submucosal pacemaker ICC network. Neurons in perimuscular ganglia were surrounded by 5-HT varicosities. Submucous ganglia contained nNOS positive and negative neurons, and calbindin positive neurons, which also appeared richly supplied by serotonergic nerve varicosities. Serotonergic nerve fibers ran along submucosal arterioles, but not veins. Varicosities of serotonergic nerve fibers were closely associated with pacemaker ICC networks and with intramuscular ICC (ICC-IM). 5-HT2B receptors were found on a subpopulation of non-5-HT containing myenteric neurons and their varicosities, pacemaker ICC-MY and ICC-IM.
    Conclusions & inferences: Myenteric serotonergic neurons, whose axons exhibit considerable divergence, regulate the entire enteric nervous system and are important in coordinating motility with secretion. They are not just interneurons, as regularly assumed, but possibly also motor neurons to ICC and blood vessels, and some may even be sensory neurons.
    MeSH term(s) Animals ; Colon/innervation ; Colon/metabolism ; Interstitial Cells of Cajal/cytology ; Male ; Mice ; Mice, Inbred C57BL ; Myenteric Plexus/cytology ; Receptor, Serotonin, 5-HT2B/metabolism ; Serotonergic Neurons/cytology
    Chemical Substances Receptor, Serotonin, 5-HT2B
    Language English
    Publishing date 2014-01-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.12302
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    Zs.A 2979: Show issues Location:
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  10. Article: Alcohol awareness and unit labelling.

    Webster-Harrison, Phil J / Barton, Andy G / Sanders, Hilary P / Anderson, Susan D / Dobbs, Frank

    Journal of public health medicine

    2003  Volume 24, Issue 4, Page(s) 332–333

    MeSH term(s) Adolescent ; Adult ; Aged ; Alcohol Drinking/psychology ; Awareness ; Female ; Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Product Labeling ; United Kingdom
    Language English
    Publishing date 2003-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1033559-6
    ISSN 0957-4832
    ISSN 0957-4832
    DOI 10.1093/pubmed/24.4.332
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