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  1. Article ; Online: Early High-Dose Gluten Intake to Prevent Celiac Disease: Data Do Not Allow Conclusions-Reply.

    Lack, Gideon / Logan, Kirsty

    JAMA pediatrics

    2021  Volume 175, Issue 5, Page(s) 535–536

    MeSH term(s) Celiac Disease ; Glutens ; Humans ; Surveys and Questionnaires
    Chemical Substances Glutens (8002-80-0)
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.6519
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  2. Article: Novel Coronavirus Disease 2019 and Subarachnoid Hemorrhage: A Case Report.

    Craen, Alexandra / Logan, Gideon / Ganti, Latha

    Cureus

    2020  Volume 12, Issue 4, Page(s) e7846

    Abstract: The novel coronavirus disease 2019 (COVID-19) has had a profound impact on healthcare systems around the world. The emergency department (ED) in particular has become the frontline for the identification and care of these patients. While its effects on ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) has had a profound impact on healthcare systems around the world. The emergency department (ED) in particular has become the frontline for the identification and care of these patients. While its effects on respiratory symptoms are well recognized, neurologic manifestations have been rarer. We report the case of a patient who presented in cardiac arrest with the return of spontaneous circulation (ROSC). The patient was found to have subarachnoid hemorrhage and later tested positive for COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.7846
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  3. Article ; Online: Racial disparities in patients hospitalized for COVID-19.

    Mirajkar, Amber / Oswald, Adam / Rivera, Mark / Logan, Gideon / Macintosh, Tracy / Walker, Ayanna / Lebowitz, David / Ganti, Latha

    Journal of the National Medical Association

    2023  Volume 115, Issue 4, Page(s) 436–440

    Abstract: Background: The COVID-19 pandemic has demonstrated the significance of health disparities across populations with older adults and minoritized groups being disproportionately affected. Data during the COVID-19 pandemic demonstrated higher infection ... ...

    Abstract Background: The COVID-19 pandemic has demonstrated the significance of health disparities across populations with older adults and minoritized groups being disproportionately affected. Data during the COVID-19 pandemic demonstrated higher infection rates, hospitalization rates, morbidity, and potentially greater mortality in Black, Hispanic, and Native Americans compared to Whites.
    Methods: This is a retrospective cohort study of de-identified patient data from 178 hospitals across the United States. Outcome variables were the length of stay, in-hospital mortality, disease severity, and discharge disposition. Outcomes were stratified by sex and racial groups.
    Results: Of 45,360 patients, 22% were Black, 35% were Hispanic, 37% were White, and 6% were Other. The overall mortality rate was 15% across all groups but was 17% for White patients, 10% for Black patients, 14% for Hispanic patients, and 15% for patients categorized as Other. However, White patients have higher median age on admission (71 years) compared to Blacks (60 years), Hispanics (57 years), and Other (61 years). Race remained statistically significant in a multivariable model that included age, sex, and race. 6484 patients required ICU admission, intubation, and hemodynamic support. This burden was disproportionate across racial groups, with 15.6% of Blacks and 13.9% of non-Blacks having such critical disease (p < 0.0001, z-test for proportions).
    Conclusions: In this national study of admitted patients with COVID-19, White patients admitted were older on average compared to other racial/ethnic groups and had a higher mortality rate compared to non-Whites hospitalized for COVID-19. Black patients were significantly more likely to require admission to the ICU, mechanical ventilation, and hemodynamic support. These COVID-19 health disparities highlight the importance of addressing social and structural determinants of health.
    MeSH term(s) Humans ; United States/epidemiology ; Aged ; COVID-19/epidemiology ; COVID-19/therapy ; Retrospective Studies ; Pandemics ; Hospitalization ; Racial Groups ; Healthcare Disparities
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419737-9
    ISSN 1943-4693 ; 0027-9684
    ISSN (online) 1943-4693
    ISSN 0027-9684
    DOI 10.1016/j.jnma.2023.06.006
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  4. Article ; Online: Apnea and Diffuse Alveolar Hemorrhage Caused by Cocaine and Heroin Use: A Case Report.

    Logan, Gideon / Robalino, Ernesto / MacIntosh, Tracy / Ganti, Latha

    Clinical practice and cases in emergency medicine

    2020  Volume 4, Issue 4, Page(s) 537–539

    Abstract: Introduction: Drug overdose represents a growing reason for emergency department visits and hospitalizations in the United States. Co-ingestion of multiple substances is also on the rise, and toxidromes can be seen from any of multiple drugs in a single ...

    Abstract Introduction: Drug overdose represents a growing reason for emergency department visits and hospitalizations in the United States. Co-ingestion of multiple substances is also on the rise, and toxidromes can be seen from any of multiple drugs in a single patient.
    Case report: We present a case of diffuse alveolar hemorrhage secondary to cocaine abuse in a patient who was apneic and unresponsive after heroin overdose. The patient responded to supportive care and was discharged with complete return to physical and mental baseline.
    Conclusion: Clinicians must be vigilant for any number of concomitant toxidromes when a patient is brought in with complications following drug overdose.
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article
    ISSN 2474-252X
    ISSN (online) 2474-252X
    DOI 10.5811/cpcem.2020.7.48438
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  5. Article: Novel Coronavirus Disease 2019 and Subarachnoid Hemorrhage: A Case Report

    Craen, Alexandra / Logan, Gideon / Ganti, Latha

    Cureus

    Abstract: The novel coronavirus disease 2019 (COVID-19) has had a profound impact on healthcare systems around the world The emergency department (ED) in particular has become the frontline for the identification and care of these patients While its effects on ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) has had a profound impact on healthcare systems around the world The emergency department (ED) in particular has become the frontline for the identification and care of these patients While its effects on respiratory symptoms are well recognized, neurologic manifestations have been rarer We report the case of a patient who presented in cardiac arrest with the return of spontaneous circulation (ROSC) The patient was found to have subarachnoid hemorrhage and later tested positive for COVID-19
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #482060
    Database COVID19

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  6. Article: Hypercoagulable State in COVID-19: A Case Series of Three Patients.

    Logan, Gideon / Dub, Larissa / Drone, Emily / Ganti, Latha / Webb, Amanda L

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8872

    Abstract: The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that originated in China in late 2019, has caused significant morbidity and mortality worldwide. Although fever, cough, and ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that originated in China in late 2019, has caused significant morbidity and mortality worldwide. Although fever, cough, and shortness of breath have been recognized as hallmark symptoms, other lesser known complications continue to be described. We report a series of three patients who presented to the emergency department, who tested positive for COVID-19, and were found to have or subsequently developed thromboembolic complications.
    Keywords covid19
    Language English
    Publishing date 2020-06-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8872
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  7. Article ; Online: Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance.

    Logan, Kirsty / Du Toit, George / Giovannini, Mattia / Turcanu, Victor / Lack, Gideon

    Annual review of cell and developmental biology

    2020  Volume 36, Page(s) 511–528

    Abstract: Pediatric allergic disease is a significant health concern worldwide, and the prevalence of childhood eczema, asthma, allergic rhinitis, and food allergy continues to increase. Evidence to support specific interventions for the prevention of eczema, ... ...

    Abstract Pediatric allergic disease is a significant health concern worldwide, and the prevalence of childhood eczema, asthma, allergic rhinitis, and food allergy continues to increase. Evidence to support specific interventions for the prevention of eczema, asthma, and allergic rhinitis is limited, and no consensus on prevention strategies has been reached. Randomized controlled trials investigating the prevention of food allergy via oral tolerance induction and the early introduction of allergenic foods have been successful in reducing peanut and egg allergy prevalence. Infant weaning guidelines in the United Sates were recently amended to actively encourage the introduction of peanut for prevention of peanut allergy.
    MeSH term(s) Animals ; Child ; Food Hypersensitivity/immunology ; Humans ; Immune Tolerance ; Immunotherapy ; Models, Biological ; Peanut Hypersensitivity/immunology ; Practice Guidelines as Topic
    Language English
    Publishing date 2020-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1293750-2
    ISSN 1530-8995 ; 1081-0706
    ISSN (online) 1530-8995
    ISSN 1081-0706
    DOI 10.1146/annurev-cellbio-100818-125346
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  8. Article ; Online: Efficacy of the insect repellent IR3535 on the sand fly Phlebotomus papatasi in human volunteers.

    Weeks, Emma N I / Wasserberg, Gideon / Logan, James L / Agneessens, Joost / Stewart, Sophie A / Dewhirst, Sarah

    Journal of vector ecology : journal of the Society for Vector Ecology

    2019  Volume 44, Issue 2, Page(s) 290–292

    MeSH term(s) Animals ; Female ; Healthy Volunteers ; Humans ; Insect Repellents/pharmacology ; Insect Vectors/drug effects ; Male ; Phlebotomus/drug effects ; Propionates/pharmacology
    Chemical Substances Insect Repellents ; Propionates ; ethyl-3-(N-n-butyl-N-acetyl)aminopropionate (65GQA237EH)
    Language English
    Publishing date 2019-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2212806-2
    ISSN 1948-7134 ; 1081-1710
    ISSN (online) 1948-7134
    ISSN 1081-1710
    DOI 10.1111/jvec.12362
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  9. Article ; Online: Successful Proof-of-Concept for Topical Delivery of Novel Peptide ALM201 with Potential Usefulness for Treating Neovascular Eye Disorders.

    Obasanmi, Gideon / Nesbit, M Andrew / Cobice, Diego / Mackay, Logan / McGimpsey, Stuart / Wappett, Mark / Cranston, Aaron N / Moore, Tara C B

    Ophthalmology science

    2022  Volume 2, Issue 2, Page(s) 100150

    Abstract: Purpose: To evaluate the therapeutic benefit of a novel peptide, ALM201, in ocular pathologic vascularization.: Design: Experimental study in mouse, rat, and rabbit animal models.: Participants: Ten-week-old Lister Hooded male rats, 8-week-old ... ...

    Abstract Purpose: To evaluate the therapeutic benefit of a novel peptide, ALM201, in ocular pathologic vascularization.
    Design: Experimental study in mouse, rat, and rabbit animal models.
    Participants: Ten-week-old Lister Hooded male rats, 8-week-old Brown Norway male rats, 9-day-old C57BL/6J mice, and 12-month-old New Zealand male rabbits.
    Methods: Corneal vascularization was scored for vessel density and vessel distance to suture in a rat corneal suture model. Ocular penetration and biodistribution were evaluated by matrix-assisted laser desorption/ionization mass spectrometry imaging after topical ALM201 application to rabbit eyes. A mouse choroidal sprouting assay, with aflibercept as positive control, was used to evaluate choroidal neovascularization (CNV) in the posterior segment tissue. Efficacy of topical ALM201 was assessed using a rat laser CNV model of neovascular age-related macular degeneration.
    Main outcome measures: Clinical scoring and histologic analysis of vascularized corneas, sprouting area, lesion size, and vessel leakiness in posterior segments.
    Results: Assessment of ALM201 treatment in the rat corneal suture model showed a significant decrease in vessel density (
    Conclusions: ALM201 is a promising novel molecule with anti-inflammatory and antivascularization activity and is a strong candidate to meet the clinical need of a new, topically delivered therapeutic agent for treating inflammation and pathologic vascularization in the anterior and posterior segments of the eye.
    Language English
    Publishing date 2022-04-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9145
    ISSN (online) 2666-9145
    DOI 10.1016/j.xops.2022.100150
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  10. Article ; Online: Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses

    Logan, Kirsty / Bahnson, Henry T. / Ylescupidez, Alyssa / Beyer, Kirsten / Bellach, Johanna / Campbell, Dianne E. / Craven, Joanna / Du Toit, George / Clare Mills, E. N. / Perkin, Michael R. / Roberts, Graham / Ree, Ronald van / Lack, Gideon

    Allergy. 2023 May, v. 78, no. 5, p. 1307-1318

    2023  , Page(s) 1307–1318

    Abstract: BACKGROUND: The Learning Early About Peanut allergy (LEAP) study has shown the effectiveness of early peanut introduction in prevention of peanut allergy (PA). In the Enquiring About Tolerance (EAT) study, a statistically significant reduction in PA was ... ...

    Abstract BACKGROUND: The Learning Early About Peanut allergy (LEAP) study has shown the effectiveness of early peanut introduction in prevention of peanut allergy (PA). In the Enquiring About Tolerance (EAT) study, a statistically significant reduction in PA was present only in per‐protocol (PP) analyses, which can be subject to bias. OBJECTIVE: The aim of this study was to combine individual‐level data from the LEAP and EAT trials and provide robust evidence on the bias‐corrected, causal effect of early peanut introduction. METHOD: As part of the European Union‐funded iFAAM project, this pooled analysis of individual pediatric patient data combines and compares effectiveness and efficacy estimates of oral tolerance induction among different risk strata and analysis methods. RESULTS: An intention‐to‐treat (ITT) analysis of pooled data showed a 75% reduction in PA (p < .0001) among children randomized to consume peanut from early infancy. A protective effect was present across all eczema severity groups, irrespective of enrollment sensitization to peanut, and across different ethnicities. Earlier age of introduction was associated with improved effectiveness of the intervention. In the pooled PP analysis, peanut consumption reduced the risk of PA by 98% (p < .0001). A causal inference analysis confirmed the strong PP effect (89% average treatment effect relative risk reduction p < .0001). A multivariable causal inference analysis approach estimated a large (100%) reduction in PA in children without eczema (p = .004). CONCLUSION: We demonstrate a significant reduction in PA with early peanut introduction in a large group of pooled, randomized participants. This significant reduction was demonstrated across all risk subgroups, including children with no eczema. Furthermore, our results point to increased efficacy of the intervention with earlier age of introduction.
    Keywords eczema ; hypersensitivity ; infancy ; patients ; peanuts ; protective effect ; relative risk ; risk reduction
    Language English
    Dates of publication 2023-05
    Size p. 1307-1318
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15597
    Database NAL-Catalogue (AGRICOLA)

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