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  1. Article ; Online: Hypercoagulable state, pathophysiology, classification and epidemiology.

    Alfirević, Zrinka / Alfirević, Igor

    Clinical chemistry and laboratory medicine

    2010  Volume 48 Suppl 1, Page(s) S15–26

    Abstract: Hypercoagulable state is not a uniform disease. It is a complex condition with an abnormal propensity for thrombosis that may or may not lead to thrombosis, depending on complex gene-gene and gene-environment interactions. The prevalence of the ... ...

    Abstract Hypercoagulable state is not a uniform disease. It is a complex condition with an abnormal propensity for thrombosis that may or may not lead to thrombosis, depending on complex gene-gene and gene-environment interactions. The prevalence of the hypercoagulable state depends on the ethnicity and clinical history of the population being studied. The consequences of a hypercoagulable state due to thrombosis of veins and arteries are the most important cause of sickness and death in developed countries at present. Primary hypercoagulable state is an inherited condition caused by the reduced level of natural anticoagulants due to a qualitative defect or quantitative deficiency of an antithrombotic protein, or increased concentrations or function of coagulation factors. Most of the inherited abnormalities recognized to date have little or no effect on arterial thrombosis and are associated primarily with venous thromboembolism. Arterial thrombosis usually develops as a complication of atherosclerosis and patients usually have more than one traditional risk factor. Secondary hypercoagulable states generally occur as a result of a large number of transient or permanent acquired conditions that increase the tendency for formation of blood clots. New epidemiological data and clinical trials suggest that many acquired risk factors in the pathophysiology of arterial and venous thrombosis overlap and coexist for both disorders.
    MeSH term(s) Blood Coagulation Disorders/classification ; Blood Coagulation Disorders/epidemiology ; Blood Coagulation Disorders/physiopathology ; Blood Coagulation Factors/physiology ; Hemostasis ; Humans ; Thrombosis/physiopathology
    Chemical Substances Blood Coagulation Factors
    Language English
    Publishing date 2010-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/CCLM.2010.371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inferior vena cava agenesia and a massive bilateral iliofemoral venous thrombosis.

    Vucicevic, Zeljko / Degoricija, Vesna / Alfirevic, Zrinka / Sharma, Mirella

    Angiology

    2008  Volume 59, Issue 4, Page(s) 510–513

    Abstract: The absence of the inferior vena cava is a rare congenital anomaly and represents a modest risk for deep-venous thrombosis. When associated with genetic polymorphism or other hypercoagulable states, the risk can increase several times. A case of young ... ...

    Abstract The absence of the inferior vena cava is a rare congenital anomaly and represents a modest risk for deep-venous thrombosis. When associated with genetic polymorphism or other hypercoagulable states, the risk can increase several times. A case of young man with the inferior vena cava agenesia and deep-venous thrombosis of both legs triggered by the physical effort is reported. The view that the congenital inferior vena cava malformation represents a predisposition to deep-venous thrombosis in spite of well-developed collateral circulation is supported. In these circumstances, various external triggers (physical effort, hormonal contraception etc) may precipitate thrombosis. Because the patient had no other convincing and permanent risk factors for thrombosis, the lifelong anticoagulant therapy was not recommended.
    MeSH term(s) Adult ; Anticoagulants/therapeutic use ; Exercise ; Femoral Vein/pathology ; Humans ; Iliac Vein/pathology ; Magnetic Resonance Angiography ; Male ; Risk Factors ; Stockings, Compression ; Treatment Outcome ; Vascular Malformations/complications ; Vascular Malformations/pathology ; Vena Cava, Inferior/abnormalities ; Venous Thrombosis/etiology ; Venous Thrombosis/pathology ; Venous Thrombosis/therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2008-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/0003319707305350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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