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  1. Article ; Online: Monte Carlo simulation study to explore optimum conditions for Astatine-211 SPECT.

    Takahashi, Akihiko / Kajiya, Ryosuke / Baba, Shingo / Sasaki, Masayuki

    Radiological physics and technology

    2023  Volume 16, Issue 1, Page(s) 102–108

    Abstract: ... ...

    Abstract 211
    MeSH term(s) Monte Carlo Method ; Tomography, Emission-Computed, Single-Photon/methods ; Computer Simulation ; Astatine ; Phantoms, Imaging ; Image Processing, Computer-Assisted/methods
    Chemical Substances Astatine-211 ; Astatine (XI595HAL7H)
    Language English
    Publishing date 2023-01-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2433581-2
    ISSN 1865-0341 ; 1865-0333
    ISSN (online) 1865-0341
    ISSN 1865-0333
    DOI 10.1007/s12194-023-00702-9
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  2. Article: Omega-conotoxin MVIIA reduces neuropathic pain after spinal cord injury by inhibiting N-type voltage-dependent calcium channels on spinal dorsal horn.

    Ohashi, Nobuko / Uta, Daisuke / Ohashi, Masayuki / Hoshino, Rintaro / Baba, Hiroshi

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1366829

    Abstract: Spinal cord injury (SCI) leads to the development of neuropathic pain. Although a multitude of pathological processes contribute to SCI-induced pain, excessive intracellular calcium accumulation and voltage-gated calcium-channel upregulation play ... ...

    Abstract Spinal cord injury (SCI) leads to the development of neuropathic pain. Although a multitude of pathological processes contribute to SCI-induced pain, excessive intracellular calcium accumulation and voltage-gated calcium-channel upregulation play critical roles in SCI-induced pain. However, the role of calcium-channel blockers in SCI-induced pain is unknown. Omega-conotoxin MVIIA (MVIIA) is a calcium-channel blocker that selectively inhibits N-type voltage-dependent calcium channels and demonstrates neuroprotective effects. Therefore, we investigated spinal analgesic actions and cellular mechanisms underlying the analgesic effects of MVIIA in SCI. We used SCI-induced pain model rats and conducted behavioral tests, immunohistochemical analyses, and electrophysiological experiments (
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1366829
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  3. Article: Atrio-Hisian block during catheter ablation targeting premature ventricular complexes originating from the left ventricle.

    Hattori, Masayuki / Yoshida, Kentaro / Baba, Masako / Nogami, Akihiko / Ieda, Masaki

    HeartRhythm case reports

    2023  Volume 9, Issue 8, Page(s) 534–538

    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2023.05.005
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  4. Article ; Online: Simultaneous detection of force and tunneling current in electrolyte solution by using qPlus sensor.

    Kobayashi, Naritaka / Hojo, Masayuki / Baba, Kengo / Sakuta, Ken

    The Review of scientific instruments

    2023  Volume 94, Issue 7

    Abstract: We have developed a sensor for simultaneous measurement of atomic force microscopy (AFM) and scanning tunneling microscopy (STM) under liquid environments. The sensor, which is based on the qPlus sensor, is equipped with an insulated conductive tip. ... ...

    Abstract We have developed a sensor for simultaneous measurement of atomic force microscopy (AFM) and scanning tunneling microscopy (STM) under liquid environments. The sensor, which is based on the qPlus sensor, is equipped with an insulated conductive tip. Owing to its electrical insulation except for the tip apex, the developed sensor enabled simultaneous detection of tip-sample interaction force and tunneling current, suppressing the Faradaic leakage current. As a fundamental demonstration, we performed simultaneous AFM/STM imaging in an electrolyte solution by using the developed sensor.
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0152398
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  5. Article ; Online: Prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy in Japanese patients with type 2 diabetes: The Japan Diabetes Complication and its Prevention Prospective study (JDCP study 10).

    Kamiya, Hideki / Himeno, Tatsuhito / Watarai, Atsuko / Baba, Masayuki / Nishimura, Rimei / Tajima, Naoko / Nakamura, Jiro

    Journal of diabetes investigation

    2024  Volume 15, Issue 2, Page(s) 247–253

    Abstract: This study aimed to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in patients with type 2 diabetes registered in the Japan Diabetes Complication and its Prevention Prospective study. In the study, ...

    Abstract This study aimed to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in patients with type 2 diabetes registered in the Japan Diabetes Complication and its Prevention Prospective study. In the study, 6,338 patients with diabetes who had been treated by diabetes specialists were registered in 2007-2009. Of these, patients with type 2 diabetes who could be evaluated for DSPN were analyzed using the t-test, χ
    MeSH term(s) Humans ; Middle Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Prospective Studies ; Japan/epidemiology ; Prevalence ; Diabetic Neuropathies/epidemiology ; Diabetic Neuropathies/etiology ; Diabetic Neuropathies/diagnosis ; Polyneuropathies/epidemiology ; Polyneuropathies/etiology
    Language English
    Publishing date 2024-01-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14105
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    Zs.A 6920: Show issues Location:
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  6. Article: Prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention Prospective study (JDCP study 10).

    Kamiya, Hideki / Himeno, Tatsuhito / Watarai, Atsuko / Baba, Masayuki / Nishimura, Rimei / Tajima, Naoko / Nakamura, Jiro

    Diabetology international

    2024  Volume 15, Issue 1, Page(s) 19–27

    Abstract: Aim/introduction: This study aims to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in patients with type 2 diabetes registered in the Japan Diabetes Complication and its Prevention Prospective ( ... ...

    Abstract Aim/introduction: This study aims to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in patients with type 2 diabetes registered in the Japan Diabetes Complication and its Prevention Prospective (JDCP) study.
    Materials and methods: In the study, 6338 patients with diabetes who had been treated by diabetes specialists were registered in 2007-2009. Of these, patients with type 2 diabetes who could be evaluated for DSPN were analyzed using
    Results: Of the total participants, 5451 patients (mean age 61.4 years old and duration of diabetes 10.8 years) were analyzed. Based on the criteria, 35.8% of patients were diagnosed with DSPN. The prevalence of sensory symptoms was 25.8%. The following factors increased risk for DSPN: age [odds ratio (OR) 1.57, 95% confidence intervals (CI) 1.42-1.73], duration of diabetes (OR 1.32, 95% CI 1.21-1.43), body mass index (OR 1.19, 95% CI 1.09-1.30), systolic blood pressure (OR 1.06, 95% CI 1.01-1.10), hemoglobin A1c (OR 1.15, 95% CI 1.09-1.22), biguanides (OR 1.22, 95% CI 1.06-1.39), and insulin therapy (OR 1.59, 95% CI 1.36-1.84). The following factors decreased risk for DSPN: total cholesterol (OR 0.98, 95% CI 0.96-1.00) and exercise therapy (OR 0.85, 95% CI 0.73-0.98).
    Conclusions: The baseline survey clarified the prevalence and characteristics of DSPN in Japanese patients with type 2 diabetes. The survey also revealed the risk factors of DSPN.
    Language English
    Publishing date 2024-01-12
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2574501-3
    ISSN 2190-1686 ; 2190-1678
    ISSN (online) 2190-1686
    ISSN 2190-1678
    DOI 10.1007/s13340-023-00678-2
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  7. Article ; Online: Inter-atrial epicardial muscular fibers as a possible source of atrial tachyarrhythmias.

    Hattori, Masayuki / Baba, Masako / Hasebe, Hideyuki / Yoshida, Kentaro

    Journal of cardiology cases

    2022  Volume 27, Issue 4, Page(s) 143–147

    Abstract: A 22-year-old woman without structural heart disease underwent catheter ablation of frequent premature atrial contractions (PACs). Radiofrequency applications from both the right and left atrium were effective in suppressing or eliminating these PACs. ... ...

    Abstract A 22-year-old woman without structural heart disease underwent catheter ablation of frequent premature atrial contractions (PACs). Radiofrequency applications from both the right and left atrium were effective in suppressing or eliminating these PACs. The distance between the right atrial ablation site and the successful ablation site at the right-sided pulmonary venous carina measured 18 mm on the CARTO map, and no cardiac structure, i.e. the inter-atrial septum, was present between those sites. Taken together, the epicardial muscular fibers in the inter-atrial groove were considered to play a role as an arrhythmogenic source of this atrial tachyarrhythmia.
    Learning objective: Epicardial muscular fibers connecting the right atrium and right-sided pulmonary venous carina are known to preclude isolation of the veins. This epicardial connection in the interatrial groove can be an arrhythmogenic source or part of a reentrant circuit of atrial tachyarrhythmias.
    Language English
    Publishing date 2022-12-22
    Publishing country Japan
    Document type Case Reports
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2022.12.003
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  8. Article ; Online: Norepinephrine Restores Inhibitory Tone of Spinal Lamina X Circuitry, thus Contributing to Analgesia Against Inflammatory Pain.

    Ohashi, Nobuko / Uta, Daisuke / Ohashi, Masayuki / Baba, Hiroshi

    Neuroscience

    2022  Volume 490, Page(s) 224–235

    Abstract: Norepinephrine (NE) acts directly on the inhibitory interneurons of spinal lamina X and may act on spinal lamina X neurons for inhibiting nociceptive synaptic transmission against pain. We investigated this mechanism within inflammatory pain model rats. ... ...

    Abstract Norepinephrine (NE) acts directly on the inhibitory interneurons of spinal lamina X and may act on spinal lamina X neurons for inhibiting nociceptive synaptic transmission against pain. We investigated this mechanism within inflammatory pain model rats. Using immunohistochemical staining and in vivo extracellular recording, the increased number of phosphorylated extracellular signal-regulated kinase profiles in lamina X (n = 6/group) and increased frequency of spontaneous neuronal firing on putative lamina X (n = 14) under the inflammatory pain were significantly suppressed by the direct application of NE (P < 0.01). Following in vivo observation of enhanced spontaneous neuronal firing, we tested the impact of NE on this discharge using an in vitro spinal slice preparation. Using in vitro patch-clamps recording, the baseline level of miniature inhibitory postsynaptic currents (mIPSCs) frequency on spinal lamina X neurons cord is decreased under inflammatory pain. Direct application of NE to spinal lamina X neurons in inflammatory pain model rats facilitates mIPSCs frequency and induces an outward current (n = 8; P < 0.05), and these responses are inhibited by α1A- and α2-receptor antagonists (n = 8; P > 0.05). Considering these results and those of our previous study (Ohashi et al., 2019), NE might act on inhibitory interneurons of spinal lamina X to facilitate inhibitory transmission and induces neurons located in or around lamina X membrane hyperpolarization. These NE-mediated responses acted through α1A- and α2-receptors. These mechanisms of NE on spinal lamina X might contribute to analgesia against inflammatory pain.
    MeSH term(s) Analgesia ; Animals ; Norepinephrine/pharmacology ; Pain/drug therapy ; Patch-Clamp Techniques ; Rats ; Spinal Cord ; Synaptic Transmission
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2022.03.023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
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  9. Article ; Online: A review of harmonization strategies for quantitative PET.

    Akamatsu, Go / Tsutsui, Yuji / Daisaki, Hiromitsu / Mitsumoto, Katsuhiko / Baba, Shingo / Sasaki, Masayuki

    Annals of nuclear medicine

    2023  Volume 37, Issue 2, Page(s) 71–88

    Abstract: PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are ... ...

    Abstract PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are variable depending on technical, biological, and physical factors. The variability may have a significant impact on a study outcome. Appropriate scanner calibration and quality control, standardization of imaging protocols, and any necessary harmonization strategies are essential to make use of PET as a biomarker with low bias and variability. This review summarizes benefits, limitations, and remaining challenges for harmonization of quantitative PET, including whole-body PET in oncology, brain PET in neurology, PET/MR, and non-
    MeSH term(s) Humans ; Positron-Emission Tomography/methods ; Phantoms, Imaging ; Reference Standards ; Calibration ; Head
    Language English
    Publishing date 2023-01-06
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-022-01820-x
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    Zs.A 3657: Show issues Location:
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  10. Article ; Online: ER membrane protein complex 1 interacts with STIM1 and regulates store-operated Ca2+ entry.

    Kawata, Kazuhiko / Baba, Akemi / Shiota, Masayuki / Wanibuchi, Hideki / Baba, Yoshihiro

    Journal of biochemistry

    2021  Volume 170, Issue 4, Page(s) 483–488

    Abstract: Store-operated calcium entry (SOCE) is the process by which the emptying of endoplasmic reticulum (ER) Ca2+ stores causes an influx of Ca2+ across the plasma membrane (PM). It is the major Ca2+ influx pathway in nonexcitable cells and has a wide array of ...

    Abstract Store-operated calcium entry (SOCE) is the process by which the emptying of endoplasmic reticulum (ER) Ca2+ stores causes an influx of Ca2+ across the plasma membrane (PM). It is the major Ca2+ influx pathway in nonexcitable cells and has a wide array of physiological functions. Upon store depletion, stromal interaction molecule 1 (STIM1), an ER calcium sensor relocates into discrete puncta at the ER-PM junction region, which results in the coupling of Ca2+ channels to initiate SOCE. However, the mechanism regulating STIM1 activity remains poorly understood. Here, we performed affinity purification of STIM1 and uncovered ER membrane protein complex 1 (EMC1) as an STIM1 binding partner. We showed that this interaction occurred in the ER through the intraluminal region of STIM1. After store depletion, EMC1 does not cluster adjacent to the PM, which suggests that it is distributed differently from STIM1. EMC1 knockdown with small interfering RNA resulted in a marked decrease in SOCE. Thus, these findings suggest that EMC1 functions as a positive regulator of SOCE.
    MeSH term(s) Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling ; Cell Membrane/metabolism ; Endoplasmic Reticulum/metabolism ; Gene Knockdown Techniques/methods ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Protein Binding ; RNA, Small Interfering/genetics ; Stromal Interaction Molecule 1/metabolism
    Chemical Substances Calcium Channels ; Membrane Proteins ; RNA, Small Interfering ; Stromal Interaction Molecule 1 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvab063
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