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Article: Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensin.

L'homme, Rafaëlla / Brouwers, Elke / Al-Maharik, Nawaf / Lapcík, O / Hampl, R / Mikola, Heikki / Wähälä, K / Adlercreutz, Herman

The Journal of steroid biochemistry and molecular biology

2002 Volume 81, Issue 4-5, Page(s) 353–361

Abstract: We present a method for the determination of the phytoestrogen metabolite O-desmethylangolensin (O ... DMA) in plasma (serum) and in urine. O-DMA is a metabolite of daidzein, which occurs in soybeans ... using a europium chelate as a label. After the synthesis of 4"-O-carboxymethyl-O-DMA, this compound is ...

Abstract	We present a method for the determination of the phytoestrogen metabolite O-desmethylangolensin (O-DMA) in plasma (serum) and in urine. O-DMA is a metabolite of daidzein, which occurs in soybeans. It has been suggested that isoflavones may afford protection against breast and prostate cancer and therefore, also the metabolites are of interest. The method is based on time-resolved fluoroimmunoassay (TR-FIA) using a europium chelate as a label. After the synthesis of 4"-O-carboxymethyl-O-DMA, this compound is coupled to bovine serum albumin, and then used as antigen in immunization of rabbits. The tracers with the europium chelate are synthesized using the same 4"-O-derivative of the alpha-methyldeoxybenzoin. After enzymatic hydrolysis and ether extraction the immunoassay is carried out by time resolved fluoroimmunoassay (TR-FIA). Cross-reactivity was tested with angolensin, dihydrogenistein, dihydrodaidzein, equol, 6'-OH-angolensin, trans-4-OH-equol, 6'-OH-O-DMA, cis-4-OH-equol and 5-OH-equol. The antiserum cross-reacted only with angolensin. This cross-reactivity seems not to influence the results, which were highly specific. Plasma samples are hydrolyzed and extracted. Urine samples are analyzed directly after hydrolysis without extraction. The correlation coefficient between the plasma TR-FIA results and the GC-MS results was high; r value was 0.985. The correlation coefficient between the urine TR-FIA results and the GC-MS results was high over the entire range of concentrations (0-1500 nmol/l); r value was 0.976, but lower in the low concentration range (0-100 nmol/l), i.e. value was 0.631. The intra-assay coefficients of variation (CVs) for plasma O-DMA concentrations and for urine O-DMA concentrations at three different concentrations varied 2.8-7.7 and 3.0-6.0%, respectively and the inter-assay CVs varied 3.8-8.9 and 4.4-6.6%, respectively. The working range of the plasma and urine O-DMA assays was 0.5-512 nmol/l.
MeSH term(s)	Animals ; Antibody Formation ; Cross Reactions ; Evaluation Studies as Topic ; Fluoroimmunoassay/methods ; Gas Chromatography-Mass Spectrometry ; Humans ; Immune Sera ; Isoflavones/blood ; Isoflavones/immunology ; Isoflavones/urine ; Rabbits ; Sensitivity and Specificity ; Serum Albumin, Bovine ; Glycine max
Chemical Substances	Immune Sera ; Isoflavones ; Serum Albumin, Bovine (27432CM55Q) ; O-desmethylangolensin (SCY1S10OK4)
Language	English
Publishing date	2002-07-02
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/s0960-0760(02)00073-0
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Book ; Online: Random packing fraction of binary similar particles

Brouwers, H. J. H.

Onsager's model revisited

2022

Abstract: ... polydispersity equals 2f(1 - f)X1(1 - X1)(u - 1)^2 + O((u - 1)^3), where f is the monosized packing fraction, X1 ...

Abstract	In this paper, the binary random packing fraction of similar particles with size ratios ranging from unity to well over 2 is studied. The classic excluded volume model for spherocylinders and cylinders proposed by Onsager [1] is revisited to derive an asymptotically correct expression for these binary packings. From a Taylor series expansion, it follows that the packing fraction increase by binary polydispersity equals 2f(1 - f)X1(1 - X1)(u - 1)^2 + O((u - 1)^3), where f is the monosized packing fraction, X1 is the number fraction of a component, and u is the size ratio of the two particles. This equation is in excellent agreement with the semi-empirical expression provided by Mangelsdorf and Washington [2] for random close packing (RCP) of spheres. Combining both approaches, a generic explicit equation for the bidisperse packing fraction is proposed, which is applicable to size ratios well above 2. This expression is extensively compared with computer simulations of the random close packing of binary spherocylinder packings, spheres included, and random loose sphere packings (1 < u < 2). The derived generic closed-form equation appears to be in excellent agreement with the collection of computer-generated packing data using four different computer algorithms and RCP and random loose packing (RLP) compaction states. Furthermore, the present analysis yields a monodisperse packing fraction map of a wide collection of particle shapes at different compaction states. The explicit boundaries of this map appear to be in good agreement with a broad collection of random close and random loose packing data. The Appendix presents an overview of published monodisperse packing fractions of (sphero)cylinders for aspect ratios from zero to infinity, and at RLP and RCP packing configurations, and they are related to Onsager's theory. Comment: 48 pages, 10 figures, 13 tables
Keywords	Condensed Matter - Other Condensed Matter
Subject code	612
Publishing date	2022-09-20
Publishing country	us
Document type	Book ; Online
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Article ; Online: 24 Hours Ex-vivo Hypothermic Acellular Perfusion of Porcine Forelimb: A 7-day Follow-up Study.

Brouwers, Kaj / Kruit, Anne Sophie / van Midden, Dominique / Zegers, Her J H / Doorduin, Jonne / Koers, Erik / Hummelink, Stefan / Ulrich, Dietmar J O

Plastic and reconstructive surgery

2024

Abstract: Background: One of the limiting factors for vascularized composite allograft (VCA) storage is the short viable ischemic time (4-6 hours). Hypothermic machine perfusion (MP) enables near-physiological preservation, avoiding the deleterious effects of ... ...

Abstract	Background: One of the limiting factors for vascularized composite allograft (VCA) storage is the short viable ischemic time (4-6 hours). Hypothermic machine perfusion (MP) enables near-physiological preservation, avoiding the deleterious effects of hypoxia and static cooling. This study aims to compare muscle injury after 24-hour acellular perfusion with static cold storage (SCS) in a porcine limb replantation model, examining outcomes for up to 7 days after reperfusion. Methods: Sixteen procured porcine forelimbs were perfused hypothermic for 24 hours with Histidine-Tryptophan-Ketoglutarate (HTK, n=8) or preserved on ice for 4 hours (SCS, n=8) before orthotopic replantation. Muscle injury was assessed using biochemical markers and muscle biopsies were analyzed using the Histologic Injury Severity Score (HISS). Results: During preservation, limb weight decreased by 2% in the SCS group and increased by 44% in the perfusion group (p<0.001). Twelve limbs (HTK, n=6; SCS, n=6) survived for 7 days. Three days after replantation, increased creatinine kinase levels were observed in the perfusion group (33781 mmol/liter versus 2163 mmol/liter; p<0.001). Mean endpoint HISS was 3.8 (SD 0.7) in the perfusion group and 1.8 (SD 0.7) in the SCS group (p=0.008), mostly due to increased edema (p=0.004). Conclusion: 24 hours of hypothermic MP and 4 hours of SCS of VCA demonstrated both minimal degenerated muscle tissue seven days after replantation.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000011469
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Article ; Online: Management of free flap salvage using thrombolytic drugs: A systematic review.

Brouwers, Kaj / Kruit, Anne Sophie / Hummelink, Stefan / Ulrich, Dietmar J O

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2020 Volume 73, Issue 10, Page(s) 1806–1814

Abstract: Background: Microvascular free tissue transfer is a reliable method for reconstructive surgery. However, pedicle thrombosis remains a serious complication following free tissue transfer as no consensus has been reached on the optimal management of ... ...

Abstract	Background: Microvascular free tissue transfer is a reliable method for reconstructive surgery. However, pedicle thrombosis remains a serious complication following free tissue transfer as no consensus has been reached on the optimal management of failing flaps. The purpose of this systematic review is to examine the current evidence on the use of thrombolytic drugs and their effects on microvascular flap salvage rates. Methods: A systematic literature search was performed using Medline, Embase, and, PubMed databases to identify scientific literature published between January 1987 and January 2019. This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles of English language studies reporting on free flap salvage procedures or protocols using thrombolytic drugs were included and reviewed by one author. Results: Of 105 articles screened, 27 studies and case reports were included and qualified for data extraction. Overall, the level of evidence of the current literature is low. Thirteen retrospective studies tried to demonstrate a systemic approach for thrombolysis in flap salvage. The other 14 case reports presented clinical use of thrombolytic drugs to salvage free flaps. None of the thrombolytic agents presented had superior salvage outcomes. Conclusion: A review on the current literature did not provide satisfactory and consistent evidence for the optimal management of patients with microvascular thrombosis, since no consensus has been reached on the optimal management of failing flaps. Prospective randomized studies are needed regarding their indications, dosages, and methods of administration, efficacy, and safety.
MeSH term(s)	Fibrinolytic Agents/therapeutic use ; Free Tissue Flaps/blood supply ; Humans ; Postoperative Complications/drug therapy ; Thrombosis/drug therapy
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2020-05-25
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2020.05.057
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Article ; Online: Association between de novo lipogenesis susceptibility genes and coronary artery disease.

Simons, Pomme I H G / Valkenburg, Olivier / Stehouwer, Coen D A / Brouwers, Martijn C G J

Nutrition, metabolism, and cardiovascular diseases : NMCD

2022 Volume 32, Issue 12, Page(s) 2883–2889

Abstract: Background and aims: Coronary artery disease (CAD) is the principal cause of death in individuals with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to use genetic epidemiology to study the association between de novo lipogenesis ( ...

Abstract	Background and aims: Coronary artery disease (CAD) is the principal cause of death in individuals with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to use genetic epidemiology to study the association between de novo lipogenesis (DNL), one of the major pathways leading to NAFLD, and CAD risk. Methods and results: DNL susceptibility genes were used as instruments and selected using three approaches: 1) genes that are associated with both high serum triglycerides and low sex hormone-binding globulin, both downstream consequences of DNL (unbiased approach), 2) genes that have a known role in DNL (biased approach), and 3) genes that have been associated with serum fatty acids, used as a proxy of DNL. Gene-CAD effect estimates were retrieved from the meta-analysis of CARDIoGRAM and the UK Biobank (∼76014 cases and ∼264785 controls). Effect estimates were clustered using a fixed-effects meta-analysis. Twenty-two DNL susceptibility genes were identified by the unbiased approach, nine genes by the biased approach and seven genes were associated with plasma fatty acids. Clustering of genes selected in the unbiased and biased approach showed a statistically significant association with CAD (OR:1.016, 95%CI:1.012; 1.020 and OR:1.013, 95%CI:1.007; 1.020, respectively), while clustering of fatty acid genes did not (OR:1.004, 95%CI:0.996-1.011). Subsequent exclusion of potential influential outliers did reveal a statistically significant association (OR:1.009, 95%CI:1.000; 1.018). Conclusions: DNL susceptibility genes are associated with an increased risk of CAD. These findings suggest that DNL may be involved in the pathogenesis of CAD and favor further development of strategies that target NAFLD through DNL.
MeSH term(s)	Humans ; Lipogenesis/genetics ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/genetics ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics ; Liver/metabolism ; Fatty Acids/metabolism
Chemical Substances	Fatty Acids
Language	English
Publishing date	2022-09-15
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2022.09.003
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Article ; Online: Tetraspanin-8 sequesters syntaxin-2 to control biphasic release propensity of mucin granules.

Wojnacki, José / Lujan, Agustin Leonardo / Brouwers, Nathalie / Aranda-Vallejo, Carla / Bigliani, Gonzalo / Rodriguez, Maria Pena / Foresti, Ombretta / Malhotra, Vivek

Nature communications

2023 Volume 14, Issue 1, Page(s) 3710

Abstract: Agonist-mediated stimulated pathway of mucin and insulin release are biphasic in which rapid fusion of pre-docked granules is followed by slow docking and fusion of granules from the reserve pool. Here, based on a cell-culture system, we show that plasma ...

Abstract	Agonist-mediated stimulated pathway of mucin and insulin release are biphasic in which rapid fusion of pre-docked granules is followed by slow docking and fusion of granules from the reserve pool. Here, based on a cell-culture system, we show that plasma membrane-located tetraspanin-8 sequesters syntaxin-2 to control mucin release. Tetraspanin-8 affects fusion of granules during the second phase of stimulated mucin release. The tetraspanin-8/syntaxin-2 complex does not contain VAMP-8, which functions with syntaxin-2 to mediate granule fusion. We suggest that by sequestering syntaxin-2, tetraspanin-8 prevents docking of granules from the reserve pool. In the absence of tetraspanin-8, more syntaxin-2 is available for docking and fusion of granules and thus doubles the quantities of mucins secreted. This principle also applies to insulin release and we suggest a cell type specific Tetraspanin/Syntaxin combination is a general mechanism regulating the fusion of dense core granules.
MeSH term(s)	Syntaxin 1/metabolism ; Islets of Langerhans/metabolism ; Insulin Secretion ; Exocytosis/physiology ; Insulin/metabolism ; Mucins/metabolism ; Cytoplasmic Granules/metabolism
Chemical Substances	Syntaxin 1 ; Insulin ; Mucins
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39277-9
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Article ; Online: Ex Vivo Thrombolysis to Salvage Free Flaps Using Machine Perfusion: A Pilot Study in a Porcine Model.

Brouwers, Kaj / Kruit, Anne Sophie / Koers, Erik J / Zegers, Her J H / Hummelink, Stefan / Ulrich, Dietmar J O

Journal of reconstructive microsurgery

2022 Volume 38, Issue 9, Page(s) 757–766

Abstract: Background: Mechanical evacuation of capillary thrombi in free flaps is difficult, and often requires thrombolytic therapy. Utilizing machine perfusion systems, the possibility rises to salvage free flaps ex vivo by administering high doses of ... ...

Abstract	Background: Mechanical evacuation of capillary thrombi in free flaps is difficult, and often requires thrombolytic therapy. Utilizing machine perfusion systems, the possibility rises to salvage free flaps ex vivo by administering high doses of thrombolytic agents. The primary aim of this pilot study in a porcine model is to investigate the feasibility of ex vivo thrombolysis using an extracorporeal perfusion machine. Methods: A model of stasis-induced thrombosis was used in 12 free rectus abdominis flaps harvested from six Dutch Landrace pigs. Compromised flaps were ex vivo perfused with University of Wisconsin preservation solution and treated according to the following study groups: (1) 1 mg of tissue plasminogen activator (t-PA) as additive, (2) 3 mg of t-PA as an additive, and (3) no thrombolytic additive. Microcirculation was assessed using near-infrared fluorescence angiography. Results: Pedicled abdominal flaps were created and thrombus formation was successfully induced. Eleven abdominal flaps were perfused using the modified heart-lung machine setup. Near-infrared fluorescence angiography showed delayed or no filling was noted in the control group. In comparison, the flaps which were perfused with 1 mg t-PA or 3 mg t-PA as additive showed increased fluorescence intensity curves. Conclusion: This pilot study in a porcine model presents a reliable and reproductive stasis-induced thrombosis model in free flaps. By adding t-PA to a custom-made extracorporeal perfusion system, the indocyanine green fluorescence intensity curves increased of all flaps that were perfused with different dosages of t-PA as additives, indicating restoration of capillary pressure and microcirculatory inflow.
MeSH term(s)	Swine ; Animals ; Free Tissue Flaps/blood supply ; Tissue Plasminogen Activator ; Pilot Projects ; Microcirculation ; Perfusion ; Thrombolytic Therapy ; Thrombosis/drug therapy
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	605983-1
ISSN	1098-8947 ; 0743-684X ; 0743-684X
ISSN (online)	1098-8947 ; 0743-684X
ISSN	0743-684X
DOI	10.1055/s-0042-1749341
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Article ; Online: Optimisation of scan duration and image quality in oncological

van Sluis, Joyce / Boellaard, Ronald / Dierckx, Rudi A J O / van Esch, Evelien L M / Croes, Demi A / de Ruijter, Laura Kist / van de Donk, Pim P / de Vries, Elisabeth G E / Noordzij, Walter / Brouwers, Adrienne H

European journal of nuclear medicine and molecular imaging

2023 Volume 50, Issue 8, Page(s) 2258–2270

Abstract: Purpose: Monoclonal antibody (mAb)-based PET (immunoPET) imaging can characterise tumour lesions non-invasively. It may be a valuable tool to determine which patients may benefit from treatment with a specific monoclonal antibody (mAb) and evaluate ... ...

Abstract	Purpose: Monoclonal antibody (mAb)-based PET (immunoPET) imaging can characterise tumour lesions non-invasively. It may be a valuable tool to determine which patients may benefit from treatment with a specific monoclonal antibody (mAb) and evaluate treatment response. For Methods: Data were acquired on day 4 post 37 MBq Results: When images were reconstructed using 100% acquisition time on both systems following EARL standard 1 compliant reconstruction protocols, results regarding semiquantification were comparable. For Vision data, reconstructed images that conform to EARL1 standards still resulted in comparable semiquantification at shorter scan durations (75% and 50%) regarding 100% acquisition time. Conclusion: Scan duration of
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography/methods ; Neoplasms/diagnostic imaging ; Reference Standards ; Antibodies, Monoclonal ; Positron-Emission Tomography/methods ; Image Processing, Computer-Assisted
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2023-03-22
Publishing country	Germany
Document type	Journal Article ; Comment
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-023-06194-4
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Article ; Online: Ultra-low dose CT scanning for PET/CT.

Mostafapour, Samaneh / Greuter, Marcel / van Snick, Johannes H / Brouwers, Adrienne H / Dierckx, Rudi A J O / van Sluis, Joyce / Lammertsma, Adriaan A / Tsoumpas, Charalampos

Medical physics

2023 Volume 51, Issue 1, Page(s) 139–155

Abstract: Background: The use of computed tomography (CT) for attenuation correction (AC) in whole-body PET/CT can result in a significant contribution to radiation exposure. This can become a limiting factor for reducing considerably the overall radiation ... ...

Abstract	Background: The use of computed tomography (CT) for attenuation correction (AC) in whole-body PET/CT can result in a significant contribution to radiation exposure. This can become a limiting factor for reducing considerably the overall radiation exposure of the patient when using the new long axial field of view (LAFOV) PET scanners. However, recent CT technology have introduced features such as the tin (Sn) filter, which can substantially reduce the CT radiation dose. Purpose: The purpose of this study was to investigate the ultra-low dose CT for attenuation correction using the Sn filter together with other dose reduction options such as tube current (mAs) reduction. We explore the impact of dose reduction in the context of AC-CT and how it affects PET image quality. Methods: The study evaluated a range of ultra-low dose CT protocols using five physical phantoms that represented a broad collection of tissue electron densities. A long axial field of view (LAFOV) PET/CT scanner was used to scan all phantoms, applying various CT dose reduction parameters such as reducing tube current (mAs), increasing the pitch value, and applying the Sn filter. The effective dose resulting from the CT scans was determined using the CTDI Results: By incorporating the Sn filter and adjusting mAs to the lowest available value, the radiation dose in CT images of PBU-60 phantom was significantly reduced; resulting in an effective dose of nearly 2% compared to the routine low dose CT protocols currently in clinical use. The assessment of PET images using VOI and voxel-based comparisons indicated relative differences (RD%) of under 6% for mean activity concentration (AC) in the torso phantom and patient dataset and under 8% for a source point in the CIRS phantom. The maximum RD% value of AC was 14% for the point source in the CIRS phantom. Increasing the tube current from 6 mAs to 30 mAs in patients with high BMI, or with arms down, can suppress the photon starvation artifact, whilst still preserving a dose reduction of 90%. Conclusions: Introducing a Sn filter in CT imaging lowers radiation dose by more than 90%. This reduction has minimal effect on PET image quantification at least for patients without Body Mass Index (BMI) higher than 30. Notably, this study results need validation using a larger clinical PET/CT dataset in the future, including patients with higher BMI.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Radiation Dosage ; Tomography, X-Ray Computed/methods ; Tomography Scanners, X-Ray Computed ; Positron-Emission Tomography/methods ; Phantoms, Imaging
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.16862
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Article ; Online: Sex hormone-binding globulin: biomarker and hepatokine?

Simons, Pomme I H G / Valkenburg, Olivier / Stehouwer, Coen D A / Brouwers, Martijn C G J

Trends in endocrinology and metabolism: TEM

2021 Volume 32, Issue 8, Page(s) 544–553

Abstract: Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study has provided new insights at the ... ...

Abstract	Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study has provided new insights at the population level. Thorough study of genetic variants affecting serum SHBG has identified de novo lipogenesis as one of the mechanistic links between the metabolic syndrome and reduced serum SHBG levels in humans. Furthermore, careful deduction of the Mendelian randomization results suggests a direct, causal role for SHBG in the pathogenesis of type 2 diabetes, as a hepatokine, in women. These findings prompt the development of SHBG-raising therapies as a means to prevent or treat disorders such as type 2 diabetes and polycystic ovary syndrome.
MeSH term(s)	Biomarkers ; Diabetes Mellitus, Type 2/genetics ; Female ; Genome-Wide Association Study ; Humans ; Polycystic Ovary Syndrome/genetics ; Sex Hormone-Binding Globulin/genetics
Chemical Substances	Biomarkers ; Sex Hormone-Binding Globulin
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2021.05.002
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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito