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Article ; Online: Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase

Martins, Dorival / McKay, Geoffrey / Sampathkumar, Gowthami / Khakimova, Malika / English, Ann M / Nguyen, Dao

Proceedings of the National Academy of Sciences of the United States of America

2018 Volume 115, Issue 39, Page(s) 9797–9802

Abstract: ... requires (p)ppGpp signaling, which mediates the stress and starvation stringent response (SR ...

Abstract	Metabolically quiescent bacteria represent a large proportion of those in natural and host environments, and they are often refractory to antibiotic treatment. Such drug tolerance is also observed in the laboratory during stationary phase, when bacteria face stress and starvation-induced growth arrest. Tolerance requires (p)ppGpp signaling, which mediates the stress and starvation stringent response (SR), but the downstream effectors that confer tolerance are unclear. We previously demonstrated that the SR is linked to increased antioxidant defenses in
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Dose-Response Relationship, Drug ; Drug Resistance, Multiple, Bacterial ; Gentamicins/pharmacology ; Ligases/metabolism ; Microbial Sensitivity Tests ; Ofloxacin/pharmacology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/enzymology ; Signal Transduction ; Superoxide Dismutase/metabolism ; Superoxide Dismutase/physiology ; Thienamycins/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Gentamicins ; Thienamycins ; Ofloxacin (A4P49JAZ9H) ; Superoxide Dismutase (EC 1.15.1.1) ; Ligases (EC 6.-) ; guanosine 3',5'-polyphosphate synthetases (EC 6.-) ; meropenem (FV9J3JU8B1)
Language	English
Publishing date	2018-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1804525115
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Article: The presenilin 1 p.Gly206Ala mutation is a frequent cause of early-onset Alzheimer's disease in Hispanics in Florida.

Ravenscroft, Thomas A / Pottier, Cyril / Murray, Melissa E / Baker, Matt / Christopher, Elizabeth / Levitch, Denise / Brown, Patricia H / Barker, Warren / Duara, Ranjan / Greig-Custo, Maria / Betancourt, Ana / English, Mara / Sun, Xiaoyan / Ertekin-Taner, Nilüfer / Graff-Radford, Neill R / Dickson, Dennis W / Rademakers, Rosa

American journal of neurodegenerative disease

2016 Volume 5, Issue 1, Page(s) 94–101

Abstract: ... including a p.Gly206Ala founder mutation in the Hispanic population. Here we report mutation analysis ... ascertained in Florida. The PSEN1 p.Gly206Ala mutation was identified in 13 out of 27 patients (48.1 ... other patient carried the known PSEN1 p.Gly378Val mutation. Genotyping of the PSEN1 p.Gly206Ala and p.Gly378Val ...

Abstract	Mutations in the gene encoding the presenilin-1 protein (PSEN1) were first discovered to cause Alzheimer's disease (AD) 20 years ago. Since then more than 200 different pathogenic mutations have been reported, including a p.Gly206Ala founder mutation in the Hispanic population. Here we report mutation analysis of known AD genes in a cohort of 27 early-onset (age of onset ≤65, age of death ≤70) Hispanic patients ascertained in Florida. The PSEN1 p.Gly206Ala mutation was identified in 13 out of 27 patients (48.1%), emphasizing the importance of this specific mutation in the etiology of early-onset AD in this population. One other patient carried the known PSEN1 p.Gly378Val mutation. Genotyping of the PSEN1 p.Gly206Ala and p.Gly378Val mutations in 63 late-onset Hispanic AD patients did not identify additional mutation carriers. All p.Gly206Ala mutation carriers shared rare alleles at two microsatellite markers flanking PSEN1 supporting a common founder. This study confirms the p.Gly206Ala variant as a frequent cause of early onset AD in the Hispanic population and for the first time reports the high frequency of this mutation in Hispanics in Florida.
Language	English
Publishing date	2016-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2695563-5
ISSN	2165-591X
ISSN	2165-591X
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Article: Elastic Characterization of S- and P-Wave Velocities in Marinelike Silica: The Role of Nonequilibrium Molecular Dynamics

Melgar, Dolores / Gareth S. O’Brien / Marco Lauricella / Niall J. English

Journal of physical chemistry. 2018 Feb. 08, v. 122, no. 5

2018

Abstract: ... in so doing, determine S- and P-wave velocities in a manner redolent of concept to seismic-based ... we find excellent quantitative agreement with experimental S- and P-wave velocities, in many cases. ...

Abstract	The α-quartz polymorph of SiO2 forms the basis of mineral sands stable down to 100 km depths below the surface, making it of central geoscientific relevance. The characterization of the nanoscale properties of these materials is of importance, especially for elastic properties governing phonon and sound propagation, and is of very high industrial relevance for oil exploration. Here, for the first time, we apply non-equilibrium molecular dynamics simulation to analyze the propagation of an artificial velocity perturbation in silica systems and, in so doing, determine S- and P-wave velocities in a manner redolent of concept to seismic-based oil-exploration approaches. This propagation has been analyzed systematically by means of different metrics in terms of spatiotemporal system response; these produce consistent results, by and large. In particular, we find excellent quantitative agreement with experimental S- and P-wave velocities, in many cases.
Keywords	molecular dynamics ; oils ; silica
Language	English
Dates of publication	2018-0208
Size	p. 3006-3013.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021/acs.jpcc.7b10552
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Derivation of an oral reference dose (RfD) for the plasticizer, di-(2-propylheptyl)phthalate (Palatinol® 10-P).

Bhat, Virunya S / Durham, Jennifer L / English, J Caroline

Regulatory toxicology and pharmacology : RTP

2014 Volume 70, Issue 1, Page(s) 65–74

Abstract: Di-(2-propylheptyl) phthalate (DPHP) is a high molecular weight polyvinyl chloride plasticizer. Since increasing production volume and broad utility may result in human exposure, an oral reference dose (RfD) was derived from laboratory animal data due to ...

Abstract	Di-(2-propylheptyl) phthalate (DPHP) is a high molecular weight polyvinyl chloride plasticizer. Since increasing production volume and broad utility may result in human exposure, an oral reference dose (RfD) was derived from laboratory animal data due to the lack of human data. In addition to liver and kidney, target organs were the thyroid, pituitary and adrenal glands in rats, recognizing that reproductive performance was not altered in two successive generations of DPHP-exposed rats. DPHP caused a reduction in pup and maternal body weights but not developmental or testicular effects typical of "phthalate syndrome." DPHP was not genotoxic. Due to the lack of carcinogenicity data, there is inadequate information to assess carcinogenic potential. The RfD of 0.1mg/kg-day was derived from the human equivalent BMDL10 of 10mg/kg-day for thyroid hypertrophy/hyperplasia in male F1 adults from the two-generation study. While in utero exposure did not alter sensitivity to thyroid lesions compared to subchronic exposures beginning at 6weeks of age, F1 adult males were the longest-term exposed population. The total uncertainty factor of 100x was comprised of intraspecies (10x), study duration (3x), and database (3x) factors but not an interspecies factor since rodents are more sensitive than humans to thyroid gland effects.
MeSH term(s)	Administration, Oral ; Adult ; Animals ; Female ; Humans ; Male ; Phthalic Acids/administration & dosage ; Phthalic Acids/toxicity ; Plasticizers/administration & dosage ; Plasticizers/toxicity ; Rats ; Risk Assessment ; Species Specificity ; Toxicity Tests/methods
Chemical Substances	Phthalic Acids ; Plasticizers ; bis(2-propylheptyl)phthalate
Language	English
Publishing date	2014-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	604672-1
ISSN	1096-0295 ; 0273-2300
ISSN (online)	1096-0295
ISSN	0273-2300
DOI	10.1016/j.yrtph.2014.06.002
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Zs.A 1711: Show issues

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Article ; Online: New insights into the band-gap narrowing of (N, P)-codoped TiO2 from hybrid density functional theory calculations.

Long, Run / English, Niall J

Chemphyschem : a European journal of chemical physics and physical chemistry

2011 Volume 12, Issue 14, Page(s) 2604–2608

Abstract: The electronic properties of anatase-TiO(2) codoped by N and P at different concentrations have ... concentrations, we find that the high photocatalytic activity of (N, P)-codoped anatase TiO(2) vis-à-vis the N ... 2011, 106, 066801] via the formation of an effective N-P bond. On the other hand, Ti(3+) and Ti(4+ ...

Abstract	The electronic properties of anatase-TiO(2) codoped by N and P at different concentrations have been investigated via generalized Kohn-Sham theory with the Heyd-Scuseria-Ernzerhof (HSE06) hybrid functional for exchange-correlation in the context of density functional theory. At high doping concentrations, we find that the high photocatalytic activity of (N, P)-codoped anatase TiO(2) vis-à-vis the N-monodoped case can be rationalized by a double-hole-mediated coupling mechanism [Yin et al., Phys. Rev. Lett. 2011, 106, 066801] via the formation of an effective N-P bond. On the other hand, Ti(3+) and Ti(4+) ions' spin double-exchange results in more substantial gap narrowing for larger separations between N and P atoms. At low doping concentrations, double-hole-coupling is dominant, regardless of the N-P distance.
Language	English
Publishing date	2011-10-04
Publishing country	Germany
Document type	Journal Article
ISSN	1439-7641
ISSN (online)	1439-7641
DOI	10.1002/cphc.201100313
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Article: The four "P"s of marketing are dead.

English, J

Marketing health services

2000 Volume 20, Issue 2, Page(s) 20–23

Abstract: For several decades marketing planning in the United States has relied upon the "four Ps" model. Product, price, place, and promotion were considered the foundation of the marketing mix. This model, however, has never been a comfortable fit for health ... ...

Abstract	For several decades marketing planning in the United States has relied upon the "four Ps" model. Product, price, place, and promotion were considered the foundation of the marketing mix. This model, however, has never been a comfortable fit for health care and, as the new century dawns, we find that a new marketing model--emphasizing the "four Rs"--is emerging. The foundations of the new model are relevance, response, relationships, and results.
MeSH term(s)	Evaluation Studies as Topic ; Health Services Research ; Hospital Administration/standards ; Hospital Costs ; Hospital-Patient Relations ; Marketing of Health Services/methods ; Marketing of Health Services/trends ; Models, Organizational ; Product Line Management ; United States
Language	English
Publishing date	2000
Publishing country	United States
Document type	Journal Article
ZDB-ID	1383438-1
ISSN	1094-1304 ; 0737-3252
ISSN	1094-1304 ; 0737-3252
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Zs.B 3140: Show issues

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Article: Substance P axons and sensory threshold increase in burn-graft human skin.

Ward, R Scott / Tuckett, Robert P / English, Kathleen B / Johansson, Olle / Saffle, Jeffrey R

The Journal of surgical research

2004 Volume 118, Issue 2, Page(s) 154–160

Abstract: ... all axons and anti-substance P to label substance P axons (which are predominantly unmyelinated), as well ... threshold measures of pinprick (P < 0.001), warming (P < 0.001), touch (P < 0.001), and vibration (P < 0.01 ... epidermis revealed a significant reduction in burn-graft relative to control skin (54% decrease, P < 0.0001 ...

Abstract	Background: Our knowledge of afferent nerve fiber reinnervation of grafted skin following third-degree burn is limited by a lack of quantitative histological and psychophysical assessment from the same cutaneous area. The current study compares fiber profile and functional recovery measurements in injured and control skin from the same subject. Materials and methods: Nerve regeneration and modality-specific sensory thresholds were compared using immunocytochemical labeling with protein gene product 9.5 antibody to stain all axons and anti-substance P to label substance P axons (which are predominantly unmyelinated), as well as computerized instrumentation to obtain psychophysical estimates. Results: Compared to control skin, threshold measures of pinprick (P < 0.001), warming (P < 0.001), touch (P < 0.001), and vibration (P < 0.01) were significantly elevated in burn-graft skin and correlated with histological analysis of skin biopsies obtained from the same site. Immunohistochemical staining of all axons innervating the dermis and epidermis revealed a significant reduction in burn-graft relative to control skin (54% decrease, P < 0.0001). In contrast, the incidence of substance P nerve fibers was significantly elevated in burn-graft (177% increase, P < 0.05) and appeared to correlate with patient reports of pruritus and pain. Conclusions: Observations support the hypothesis that sensory regeneration is fiber-size-dependent in burn-graft skin. The findings that substance P fiber growth increased while total fiber count decreased and that thermal threshold showed the greatest degree of functional recovery suggest that unmyelinated neurons have the greater ability to transverse scar tissue and reinnervate grafted skin following third-degree burn injury.
MeSH term(s)	Adult ; Axons/physiology ; Burns/physiopathology ; Dermatologic Surgical Procedures ; Humans ; Middle Aged ; Nerve Regeneration ; Nociceptors/physiology ; Pain/physiopathology ; Pruritus/physiopathology ; Recovery of Function ; Sensory Thresholds ; Skin/innervation ; Skin Transplantation ; Substance P/physiology ; Touch ; Vibration
Chemical Substances	Substance P (33507-63-0)
Language	English
Publishing date	2004-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/S0022-4804(03)00350-0
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Zs.A 178: Show issues

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Article: Critical A-P spread.

English, C E

The Implant Society : [periodical

1990 Volume 1, Issue 1, Page(s) 2–3

MeSH term(s)	Dental Implants ; Dental Stress Analysis ; Denture Design ; Humans
Chemical Substances	Dental Implants
Language	English
Publishing date	1990-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137618-1
ISSN	1059-3489
ISSN	1059-3489
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Article ; Online: The IRA and the Partition of Ireland

Richard English

Review of Irish Studies in Europe, Vol 6, Iss 2, Pp 23-

2023 Volume 35

Abstract: The Irish Republican Army (IRA) has been the most aggressively hostile opponent of the border that was established in Ireland during the 1920s. This article focuses on the fact that the IRA’s own violence emerged from a substantial, evolving and complex ... ...

Abstract	The Irish Republican Army (IRA) has been the most aggressively hostile opponent of the border that was established in Ireland during the 1920s. This article focuses on the fact that the IRA’s own violence emerged from a substantial, evolving and complex politics. It suggests that close consideration of that politics, of associated IRA violence and of the long-term implications of both, represents a necessary part of understanding the Irish border and its associated and important histories. Three case studies are considered: Ernie O’Malley (1897–1957); Peadar O’Donnell (1893–1986); the Provisional IRA (1969–2005). The article argues that the paradoxical outcomes of these three significant IRA case studies point towards the need for greater honesty about the actual effects of non-state political violence; it also argues for an empathetic approach to understanding those with whom one instinctively disagrees, if the political history of the Irish border and its legacies is to be properly understood.
Keywords	ira ; ernie o'malley ; peadar o'donnell ; provisional ira ; political violence ; irish revolution ; thomas hobbes ; partition ; northern ireland troubles ; good friday agreement ; conflict resolution ; Language and Literature ; P ; History (General) and history of Europe ; D
Subject code	941
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	European Federation of Associations and Centres of Irish Studies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia.

Maitland, K / Levin, M / English, M / Mithwani, S / Peshu, N / Marsh, K / Newton, C R J C

QJM : monthly journal of the Association of Physicians

2003 Volume 96, Issue 6, Page(s) 427–434

Abstract: ... in 160, of who only 7 (4.4%) died (chi(2) = 14.9; p = 0.001).: Discussion: Impaired tissue perfusion ...

Abstract	Background: The role of volume resuscitation in severe Plasmodium falciparum malaria is controversial. Aim: To examine the role of hypovolaemia in severe childhood malaria. Study design: Retrospective review. Methods: We studied 515 children admitted with severe malaria to a high-dependency unit (HDU) in Kilifi, Kenya. On admission to the HDU, children underwent a further assessment of vital signs and a standard clinical examination. Results: Factors associated with a fatal outcome included deep breathing or acidosis (base excess below -8), hypotension (systolic blood pressure <80 mmHg), raised plasma creatinine (>80 micro mol/l), low oxygen saturation (<90%), dehydration and hypoglycaemia (<2.5 mmol/l). Shock was present in 212/372 (57%) children, of whom 37 (17.5%) died, and was absent in 160, of who only 7 (4.4%) died (chi(2) = 14.9; p = 0.001). Discussion: Impaired tissue perfusion may play a role in the mortality of severe malaria. Moreover, volume resuscitation, an important life-saving intervention in children with hypovolaemia, should be considered in severe malaria with evidence of impaired tissue perfusion.
MeSH term(s)	Acidosis/drug therapy ; Acidosis/etiology ; Blood Transfusion/methods ; Child ; Child, Preschool ; Female ; Fluid Therapy/methods ; Humans ; Hypovolemia/complications ; Hypovolemia/drug therapy ; Infant ; Infant, Newborn ; Kenya/epidemiology ; Malaria, Falciparum/complications ; Malaria, Falciparum/mortality ; Male ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2003-05-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1199985-8
ISSN	1460-2393 ; 1460-2725 ; 0033-5622
ISSN (online)	1460-2393
ISSN	1460-2725 ; 0033-5622
DOI	10.1093/qjmed/hcg077
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