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  1. Article ; Online: Association between insulin dysregulation and adrenocorticotropic hormone in aged horses and ponies with no clinical signs of pituitary pars intermedia dysfunction.

    Li, Fang I / Spence, Robert J / de Laat, Melody A / Harris, Patricia A / Sonntag, Johanna / Menzies-Gow, Nicola J / Durham, Andy E / Bailey, Simon R / Sillence, Martin N

    Equine veterinary journal

    2023  Volume 55, Issue 6, Page(s) 1003–1011

    Abstract: Background: High concentrations of adrenocorticotropic hormone (ACTH) are used as an indicator of pituitary pars intermedia dysfunction (PPID), but other factors that may influence ACTH need to be understood, if diagnostic reference ranges for ACTH are ... ...

    Abstract Background: High concentrations of adrenocorticotropic hormone (ACTH) are used as an indicator of pituitary pars intermedia dysfunction (PPID), but other factors that may influence ACTH need to be understood, if diagnostic reference ranges for ACTH are to be used with confidence. Insulin dysregulation (ID) could be one such factor, as insulin affects pituitary hormones in other species.
    Objectives: To test the hypothesis that a relationship exists between high insulin and high ACTH in aged (>15-year-old) animals with no clinical signs of PPID.
    Study design: A cohort study.
    Methods: Thirteen horses and eleven ponies (17-25 years-old; mares and geldings) were clinically examined for signs of PPID in the spring (November 2020) and autumn (April 2021). On the same day, blood samples were taken before and 2 h after an oral glucose test (OGT). Concentrations of insulin, glucose, ACTH and cortisol were measured.
    Results: There was no association between ACTH and cortisol. However, there was a positive linear correlation between ACTH and post-OGT (insulin in the autumn (r = 0.427, p = 0.04). Two horses and six ponies had ACTH above the cut-off value for PPID diagnosis, and of these eight animals, six also had insulin concentrations above the cut-off value for ID.
    Main limitations: The cohort was small and thyrotropin-releasing hormone (TRH) stimulation tests were not performed.
    Conclusions: In autumn, high ACTH was associated with ID, when no clinical signs of PPID were present. Because ACTH is used in PPID diagnosis, further work is required to understand this interaction.
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 41606-x
    ISSN 2042-3306 ; 0425-1644
    ISSN (online) 2042-3306
    ISSN 0425-1644
    DOI 10.1111/evj.13925
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3105: Show issues Location:
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  2. Article ; Online: Barriers and facilitators of immunisation in refugees and migrants in Australia: an east-African case study.

    Abdi, Ikram / Menzies, Robert / Seale, Holly

    Vaccine

    2019  Volume 37, Issue 44, Page(s) 6724–6729

    Abstract: Background: Immunisation programs available in low and middle-income countries include fewer vaccines in comparison to Australia's National Immunisation Program. As a result, refugees and migrants may have a heightened risk of being inadequately ... ...

    Abstract Background: Immunisation programs available in low and middle-income countries include fewer vaccines in comparison to Australia's National Immunisation Program. As a result, refugees and migrants may have a heightened risk of being inadequately immunised upon arrival to Australia. Several studies have suggested that East African immigrants have low vaccination coverage. As such, the aim of this study was to explore the underlying attitudes, barriers and facilitators to immunisation in east African communities in two states of Australia: New South Wales and Victoria.
    Methods: A qualitative study involving 17 semi-structured, in-depth interviews were undertaken with East African refugees and migrants living in two states of Australia: New South Wales and Victoria. These refugees and migrants were from four key East African countries: Kenya, Somalia, Ethiopia and South Sudan. Thematic analysis was undertaken to analyse and interpret the results.
    Results: Language barriers, low risk perception and a lack of education were the key barriers identified by participants. Facilitators mentioned included the development of resources in participants' languages and the implementation of reminder systems consistently across all GP practices. There was also a unanimous agreement amongst participants that community organisations need to play a greater role in the dissemination of information about immunisation.
    Conclusions: Further research needs to be undertaken with regards to how education about immunisation is delivered and disseminated to refugee and migrant communities. Current findings also support the need to improve the health literacy of refugees and migrants by providing culturally and linguistically appropriate resources in participants' respective languages.
    MeSH term(s) Adolescent ; Adult ; Australia/epidemiology ; Communication ; Female ; Health Services Accessibility ; Humans ; Immunization ; Immunization Programs ; Male ; Middle Aged ; Motivation ; Refugees ; Socioeconomic Factors ; Transients and Migrants ; Vaccines ; Young Adult
    Chemical Substances Vaccines
    Language English
    Publishing date 2019-09-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2019.09.025
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    Zs.MO 458: Show issues

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  3. Article ; Online: P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats.

    Nespoux, Josselin / Monaghan, Marie-Louise T / Jones, Natalie K / Stewart, Kevin / Denby, Laura / Czopek, Alicja / Mullins, John J / Menzies, Robert I / Baker, Andrew H / Bailey, Matthew A

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9573

    Abstract: P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expression is ... ...

    Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expression is increased in kidney disease and blockade/knockout is renoprotective. We generated a P2X7 knockout rat on F344 background, hypothesising enhanced renal blood flow and protection from angiotensin-II-induced renal injury. CRISPR/Cas9 introduced an early stop codon into exon 2 of P2rx7, abolishing P2X7 protein in kidney and reducing P2rx7 mRNA abundance by ~ 60% in bone-marrow derived macrophages. The M1 polarisation response to lipopolysaccharide was unaffected but P2X7 receptor knockout suppressed ATP-induced IL-1β release. In male knockout rats, acetylcholine-induced dilation of the renal artery ex vivo was diminished but not the response to nitroprusside. Renal function in male and female knockout rats was not different from wild-type. Finally, in male rats infused with angiotensin-II for 6 weeks, P2X7 knockout did not reduce albuminuria, tubular injury, renal macrophage accrual, and renal perivascular fibrosis. Contrary to our hypothesis, global P2X7 knockout had no impact on in vivo renal hemodynamics. Our study does not indicate a major role for P2X7 receptor activation in renal vascular injury.
    MeSH term(s) Animals ; Receptors, Purinergic P2X7/metabolism ; Receptors, Purinergic P2X7/genetics ; Angiotensin II ; Male ; Rats ; Kidney/metabolism ; Kidney/pathology ; Rats, Inbred F344 ; Female ; Gene Knockout Techniques ; Macrophages/metabolism ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/genetics ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/pathology
    Chemical Substances Receptors, Purinergic P2X7 ; Angiotensin II (11128-99-7) ; P2rx7 protein, rat
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59635-x
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  4. Article ; Online: Vaccine coverage in children born to migrant mothers in Australia: A population-based cohort study.

    Abdi, Ikram / Gidding, Heather / Leong, Robert Neil / Moore, Hannah C / Seale, Holly / Menzies, Robert

    Vaccine

    2021  Volume 39, Issue 6, Page(s) 984–993

    Abstract: Background: Overall, infant immunisation coverage is currently >90% in Australia, but there are pockets of under-immunised children including children from migrant backgrounds. This study aimed to examine whether on-time vaccination coverage of ... ...

    Abstract Background: Overall, infant immunisation coverage is currently >90% in Australia, but there are pockets of under-immunised children including children from migrant backgrounds. This study aimed to examine whether on-time vaccination coverage of diphtheria-tetanus-pertussis dose 3 (DTP3) for children born in Australia differed by mother's region of birth and if so, what factors were associated with these differences.
    Methods: We conducted a population-based cohort study using linked data on perinatal, immunisation and birth records for 2 million children born in Western Australia and New South Wales between 1996 and 2012. We assessed on-time coverage of DTP3 (vaccination from 2 weeks prior to, and up until 30 days after, the due date) in children with mothers born overseas. Logistic regression models were developed to determine factors associated with on-time coverage for each maternal region of birth and all regions combined, adjusting for a range of demographic factors. Adjusted estimates of coverage were calculated for the different regions of birth.
    Results: On-time DTP3 coverage was 76.2% in children of Australian born mothers, lower in children of mothers from Oceania (66.7%) and North America (68%), and higher in children born to mothers from South-East Asia (79.9%) and Southern Asia (79.3%). While most variables were consistently associated with lower coverage in all regions of birth, higher socioeconomic status and jurisdiction of birth showed varied results. Adjusted estimates of DTP3 coverage increased in children born to mothers from Australia (78.3%), Oceania (70.5%), Northern Africa (81.5%) and the Middle East (79.6%). DTP3 coverage decreased in children born to mothers from Europe and former USSR (74.6%), North-east Asia (75.2%), Southern Asia (76.7%), North America (65.5) and South/Central America and the Caribbean (73.2%).
    Conclusions: On-time vaccination rates differed by mother's region of birth. More research is needed to determine the main reasons for these remaining differences to improve vaccine uptake and also help guide policy and practice.
    MeSH term(s) Africa, Northern ; Asia ; Australia ; Caribbean Region ; Child ; Cohort Studies ; Diphtheria-Tetanus-Pertussis Vaccine ; Europe ; Far East ; Female ; Humans ; Infant ; Middle East ; Mothers ; New South Wales ; North America ; Pregnancy ; South America ; Transients and Migrants ; Vaccination ; Western Australia
    Chemical Substances Diphtheria-Tetanus-Pertussis Vaccine
    Language English
    Publishing date 2021-01-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.12.058
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
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    Zs.MO 458: Show issues

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  5. Article ; Online: Modelling the influenza disease burden in people aged 50-64 and ≥65 years in Australia.

    Moa, Aye M / Menzies, Robert I / Yin, J Kevin / MacIntyre, C Raina

    Influenza and other respiratory viruses

    2021  Volume 16, Issue 1, Page(s) 132–141

    Abstract: Background: Estimation of influenza disease burden is necessary to monitor the impact of intervention programmes. This study aims to estimate the attributable fraction of respiratory and circulatory disease due to influenza among Australian adults 50-64 ...

    Abstract Background: Estimation of influenza disease burden is necessary to monitor the impact of intervention programmes. This study aims to estimate the attributable fraction of respiratory and circulatory disease due to influenza among Australian adults 50-64 and ≥65 years of age.
    Methods: A semi-parametric generalised-additive model was used to estimate annual and average rate of influenza-attributable hospitalisation and death per 100,000 population under the principal diagnosis of influenza/pneumonia, respiratory, circulatory and myocardial infarction (MI) from 2001 through 2017.
    Results: Over the study period, seasonal influenza accounted for an estimated annual average respiratory hospitalisation rate of 78.9 (95%CI: 76.3, 81.4) and 287.5 (95%CI: 279.8, 295.3) per 100,000 population in adults aged 50-64 and ≥65 years, respectively. The corresponding respiratory mortality rates were 0.9 (95%CI: 0.7, 1.2) and 18.2 (95%CI: 16.9, 19.4) per 100,000 population. The 2017 season had the highest influenza-attributable respiratory hospitalisations in both age groups, and respiratory complications were estimated approximately 2.5 times higher than the average annual estimate in adults aged ≥65 years in 2017. For mortality, on average, influenza attributed 1,080 circulatory and 361 MI deaths in adults aged ≥65 years per year. Influenza accounted for 1% and 2.8% of total MI deaths in adults aged 50-64 and ≥65 years, respectively.
    Conclusion: Rates of cardiorespiratory morbidity and mortality were high in older adults, whilst the younger age group contributed a lower disease burden. Extension of influenza vaccination programme beyond the targeted population could be an alternative strategy to reduce the burden of influenza.
    MeSH term(s) Aged ; Australia/epidemiology ; Cost of Illness ; Hospitalization ; Humans ; Influenza, Human ; Seasons
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.12902
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    Zs.A 6568: Show issues Location:
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  6. Article ; Online: Association between insulin dysregulation and adrenocorticotropic hormone in aged horses and ponies with no clinical signs of pituitary pars intermedia dysfunction

    Li, Fang I. / Spence, Robert J. / de Laat, Melody A. / Harris, Patricia A. / Sonntag, Johanna / Menzies‐Gow, Nicola J. / Durham, Andy E. / Bailey, Simon R. / Sillence, Martin N.

    Equine Veterinary Journal. 2023 Nov., v. 55, no. 6 p.1003-1011

    2023  

    Abstract: BACKGROUND: High concentrations of adrenocorticotropic hormone (ACTH) are used as an indicator of pituitary pars intermedia dysfunction (PPID), but other factors that may influence ACTH need to be understood, if diagnostic reference ranges for ACTH are ... ...

    Abstract BACKGROUND: High concentrations of adrenocorticotropic hormone (ACTH) are used as an indicator of pituitary pars intermedia dysfunction (PPID), but other factors that may influence ACTH need to be understood, if diagnostic reference ranges for ACTH are to be used with confidence. Insulin dysregulation (ID) could be one such factor, as insulin affects pituitary hormones in other species. OBJECTIVES: To test the hypothesis that a relationship exists between high insulin and high ACTH in aged (>15‐year‐old) animals with no clinical signs of PPID. STUDY DESIGN: A cohort study. METHODS: Thirteen horses and eleven ponies (17–25 years‐old; mares and geldings) were clinically examined for signs of PPID in the spring (November 2020) and autumn (April 2021). On the same day, blood samples were taken before and 2 h after an oral glucose test (OGT). Concentrations of insulin, glucose, ACTH and cortisol were measured. RESULTS: There was no association between ACTH and cortisol. However, there was a positive linear correlation between ACTH and post‐OGT (insulin in the autumn (r = 0.427, p = 0.04). Two horses and six ponies had ACTH above the cut‐off value for PPID diagnosis, and of these eight animals, six also had insulin concentrations above the cut‐off value for ID. MAIN LIMITATIONS: The cohort was small and thyrotropin‐releasing hormone (TRH) stimulation tests were not performed. CONCLUSIONS: In autumn, high ACTH was associated with ID, when no clinical signs of PPID were present. Because ACTH is used in PPID diagnosis, further work is required to understand this interaction.
    Keywords autumn ; blood ; cohort studies ; corticotropin ; cortisol ; glucose ; horses ; insulin ; spring ; thyrotropin-releasing hormone
    Language English
    Dates of publication 2023-11
    Size p. 1003-1011.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 41606-x
    ISSN 0425-1644
    ISSN 0425-1644
    DOI 10.1111/evj.13925
    Database NAL-Catalogue (AGRICOLA)

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    Z 3563: Show issues

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  7. Article ; Online: Vaccine myopia: adult vaccination also needs attention.

    Menzies, Robert I / Royle, Jenny / MacIntyre, C Raina

    The Medical journal of Australia

    2018  Volume 207, Issue 9, Page(s) 407

    MeSH term(s) Adult ; Attention ; Humans ; Myopia ; Travel ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2018-01-11
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja17.00677
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    Ua VI Zs.398: Show issues Location:
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  8. Article ; Online: Estimated health and economic impact of using high-dose influenza vaccine on respiratory and circulatory plus respiratory hospitalizations of older adults in Australia.

    Raina MacIntyre, C / Kevin Yin, J / Felter, Christian / Menzies, Robert I / Thommes, Edward / Largeron, Nathalie / Moa, Aye M / Trent, Mallory / Costantino, Valentina / Choi, Seulki / Alvarez, Fabián P

    Vaccine: X

    2023  Volume 15, Page(s) 100365

    Abstract: Background: Standard dose influenza vaccine provides moderate protection from infection, but with lower effectiveness among the elderly. High dose and adjuvanted vaccines (HD-TIV and aTIV) were developed to address this. This study aims to estimate the ... ...

    Abstract Background: Standard dose influenza vaccine provides moderate protection from infection, but with lower effectiveness among the elderly. High dose and adjuvanted vaccines (HD-TIV and aTIV) were developed to address this. This study aims to estimate the incremental health and economic impact of using HD-TIV (high dose trivalent vaccine) instead of aTIV (adjuvanted trivalent vaccine) on respiratory and circulatory plus respiratory hospitalizations of older people (≥65 years) in Australia.
    Methods: This is a modelling study comparing predicted hospitalization outcomes in people receiving HD-TIV or aTIV during an average influenza season in Australia. Hospitalization records of Australian adults ≥65 years of age from 01 April to 30 November during 15 influenza seasons (2002-2017 excluding 2009, which was a pandemic) were extracted from the Australian Institute of Health and Welfare [AIHW] and used to calculate hospitalisation rates during an average season. Relative vaccine effectiveness data for aTIV and HD-TIV were used to estimate morbidity burden related to influenza.
    Results: Between 2002 and 2017, the average respiratory hospitalization rate among older people during influenza season (April-November) was 3,445/100,000 population-seasons, with an average cost of AU$ 7,175 per admission. The average circulatory plus respiratory hospitalization rate among older Australian people during that time was 10,393/100,000 population-seasons, with an average cost of AU$ 7829 per admission. For older Australians, HD-TIV may avert an additional 6,315-9,410 respiratory admissions each year, with an incremental healthcare cost saving of AU$ 15.9-38.2 million per year compared to aTIV. Similar results were also noted for circulatory plus respiratory hospitalizations.
    Conclusions: From the modelled estimations, HD-TIV was associated with less economic burden and fewer respiratory, and circulatory plus respiratory hospitalizations than aTIV for older Australians.
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article
    ISSN 2590-1362
    ISSN (online) 2590-1362
    DOI 10.1016/j.jvacx.2023.100365
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  9. Article ; Online: The sodium glucose co-transporter 2 inhibitor dapagliflozin ameliorates the fluid-retaining effect of the endothelin A receptor antagonist zibotentan.

    Veenit, Vandana / Heerspink, Hiddo J L / Ahlström, Christine / Greasley, Peter J / Skritic, Stanko / van Zuydam, Natalie / Kohan, Donald E / Hansen, Pernille B L / Menzies, Robert I

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue 10, Page(s) 2289–2297

    Abstract: Background: Endothelin A receptor antagonists (ETARA) slow chronic kidney disease (CKD) progression but their use is limited due to fluid retention and associated clinical risks. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) cause osmotic diuresis ...

    Abstract Background: Endothelin A receptor antagonists (ETARA) slow chronic kidney disease (CKD) progression but their use is limited due to fluid retention and associated clinical risks. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) cause osmotic diuresis and improve clinical outcomes in CKD and heart failure. We hypothesized that co-administration of the SGLT2i dapagliflozin with the ETARA zibotentan would mitigate the fluid retention risk using hematocrit (Hct) and bodyweight as proxies for fluid retention.
    Methods: Experiments were performed in 4% salt fed WKY rats. First, we determined the effect of zibotentan (30, 100 or 300 mg/kg/day) on Hct and bodyweight. Second, we assessed the effect of zibotentan (30 or 100 mg/kg/day) alone or in combination with dapagliflozin (3 mg/kg/day) on Hct and bodyweight.
    Results: Hct at Day 7 was lower in zibotentan versus vehicle groups [zibotentan 30 mg/kg/day, 43% (standard error 1); 100 mg/kg/day, 42% (1); and 300 mg/kg/day, 42% (1); vs vehicle, 46% (1); P < .05], while bodyweight was numerically higher in all zibotentan groups compared with vehicle. Combining zibotentan with dapagliflozin for 7 days prevented the change in Hct [zibotentan 100 mg/kg/day and dapagliflozin, 45% (1); vs vehicle 46% (1); P = .44] and prevented the zibotentan-driven increase in bodyweight (zibotentan 100 mg/kg/day + dapagliflozin 3 mg/kg/day = -3.65 g baseline corrected bodyweight change; P = .15).
    Conclusions: Combining ETARA with SGLT2i prevents ETARA-induced fluid retention, supporting clinical studies to assess the efficacy and safety of combining zibotentan and dapagliflozin in individuals with CKD.
    MeSH term(s) Animals ; Rats ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Endothelin A Receptor Antagonists ; Receptor, Endothelin A ; Rats, Inbred WKY ; Benzhydryl Compounds/pharmacology ; Benzhydryl Compounds/therapeutic use ; Renal Insufficiency, Chronic ; Symporters ; Glucose ; Sodium ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; dapagliflozin (1ULL0QJ8UC) ; ZD4054 ; Endothelin A Receptor Antagonists ; Receptor, Endothelin A ; Benzhydryl Compounds ; Symporters ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad078
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  10. Article ; Online: Why is influenza vaccine uptake so low among Aboriginal adults?

    Menzies, Robert / Aqel, Jalil / Abdi, Ikram / Joseph, Telphia / Seale, Holly / Nathan, Sally

    Australian and New Zealand journal of public health

    2020  Volume 44, Issue 4, Page(s) 279–283

    Abstract: Objectives: Determine major barriers to, and facilitators of, influenza vaccination of Aboriginal adults, in order to improve coverage from the current level of 30%.: Methods: i) A focus group with 13 Aboriginal Immunisation Healthcare Workers; and ... ...

    Abstract Objectives: Determine major barriers to, and facilitators of, influenza vaccination of Aboriginal adults, in order to improve coverage from the current level of 30%.
    Methods: i) A focus group with 13 Aboriginal Immunisation Healthcare Workers; and ii) a cross-sectional survey of Aboriginal people aged ≥18 years at the 2017 New South Wales Koori Knockout (29 September-2 October).
    Results: The focus group nominated poor identification of Aboriginality in general practice. Of 273 survey respondents, a substantial minority (30%) were unaware of their eligibility for free influenza vaccination. More than half (52%) believed the vaccine could cause influenza, 40% reported there were better ways than vaccination for avoiding infection and 30% said they would not have the vaccine if it was offered to them. Regarding health service access, few reported experiencing difficulty (17%), feeling uncomfortable (15%) or being discriminated against (8%), but 53% reported not receiving a reminder from a health professional.
    Conclusions: Misconceptions about influenza disease and vaccine among Aboriginal people and inadequate identification of Aboriginality in general practice appear to be the greatest barriers to vaccination, rather than health service access in general. Implications for public health: More active communication to and targeting of Aboriginal adults is required; this is even more urgent following the arrival of COVID-19.
    MeSH term(s) Adolescent ; Adult ; Cross-Sectional Studies ; Female ; General Practice ; Health Knowledge, Attitudes, Practice ; Health Personnel ; Health Services Accessibility ; Health Services, Indigenous/organization & administration ; Humans ; Immunization Programs ; Influenza Vaccines/administration & dosage ; Influenza, Human/prevention & control ; Male ; Middle Aged ; Oceanic Ancestry Group/psychology ; Oceanic Ancestry Group/statistics & numerical data ; Vaccination/statistics & numerical data ; Vaccination Coverage
    Chemical Substances Influenza Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1323548-5
    ISSN 1753-6405 ; 1326-0200
    ISSN (online) 1753-6405
    ISSN 1326-0200
    DOI 10.1111/1753-6405.13004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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