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Article ; Online: The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.

2021 Volume 12, Issue 1, Page(s) 1859

Abstract: Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins initiates co-transcriptionally ...

Abstract	Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins initiates co-transcriptionally and requires the action of the assembly machinery including the Hsp90/R2TP complex, the Rsa1p:Hit1p heterodimer and the Bcd1 protein. We present genetic interactions between the Rsa1p-encoding gene and genes involved in chromatin organization including RTT106 that codes for the H3-H4 histone chaperone Rtt106p controlling H3K56ac deposition. We show that Bcd1p binds Rtt106p and controls its transcription-dependent recruitment by reducing its association with RNA polymerase II, modulating H3K56ac levels at gene body. We reveal the 3D structures of the free and Rtt106p-bound forms of Bcd1p using nuclear magnetic resonance and X-ray crystallography. The interaction is also studied by a combination of biophysical and proteomic techniques. Bcd1p interacts with a region that is distinct from the interaction interface between the histone chaperone and histone H3. Our results are evidence for a protein interaction interface for Rtt106p that controls its transcription-associated activity.
MeSH term(s)	Cell Proliferation/physiology ; Chromatin/genetics ; Chromatin Assembly and Disassembly/genetics ; Crystallography, X-Ray ; Histones/metabolism ; Molecular Chaperones/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; RNA Polymerase II/metabolism ; RNA-Binding Proteins/metabolism ; Ribonucleoproteins, Small Nucleolar/genetics ; Ribonucleoproteins, Small Nucleolar/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosomes/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription, Genetic/genetics ; Transcriptional Activation/physiology
Chemical Substances	Bcd1 protein, S cerevisiae ; Chromatin ; Histones ; Molecular Chaperones ; RNA-Binding Proteins ; RSA1 protein, S cerevisiae ; Ribonucleoproteins, Small Nucleolar ; Ribosomal Proteins ; Rtt106 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2021-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-22077-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.

Paul, Arnaud / Tiotiu, Decebal / Bragantini, Benoît / Marty, Hélène / Charpentier, Bruno / Massenet, Séverine / Labialle, Stéphane

RNA (New York, N.Y.)

2019 Volume 25, Issue 4, Page(s) 496–506

Abstract: Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins (C/D snoRNPs) is guided ...

Abstract	Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins (C/D snoRNPs) is guided by conserved
MeSH term(s)	Binding Sites ; Chromatin/chemistry ; Chromatin/metabolism ; Humans ; Kruppel-Like Factor 6/genetics ; Kruppel-Like Factor 6/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphorylation ; Protein Binding ; Protein Biosynthesis ; RNA, Small Nucleolar/genetics ; RNA, Small Nucleolar/metabolism ; Ribonucleoproteins, Small Nuclear/genetics ; Ribonucleoproteins, Small Nuclear/metabolism ; Ribonucleoproteins, Small Nucleolar/genetics ; Ribonucleoproteins, Small Nucleolar/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription, Genetic
Chemical Substances	Chromatin ; KLF6 protein, human ; Kruppel-Like Factor 6 ; NOP56 protein, human ; NOP58 protein, human ; Nuclear Proteins ; RNA, Small Nucleolar ; Ribonucleoproteins, Small Nuclear ; Ribonucleoproteins, Small Nucleolar ; Saccharomyces cerevisiae Proteins ; Snu13 protein, human
Language	English
Publishing date	2019-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1241540-6
ISSN	1469-9001 ; 1355-8382
ISSN (online)	1469-9001
ISSN	1355-8382
DOI	10.1261/rna.067967.118
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Article ; Online: The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 17

Abstract: Biogenesis of small nucleolar RNAs ribonucleoproteins (snoRNPs) requires dedicated assembly machinery. Here, the authors show that a subset of snoRNP assembly factors interacts, genetically or directly, with factors modulating chromatin architecture, ... ...

Abstract	Biogenesis of small nucleolar RNAs ribonucleoproteins (snoRNPs) requires dedicated assembly machinery. Here, the authors show that a subset of snoRNP assembly factors interacts, genetically or directly, with factors modulating chromatin architecture, suggesting a link between ribosome formation and chromatin functions.
Keywords	Science ; Q
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Observation of a Charmed Baryon Decaying to D;{0}p at a Mass Near 2.94 GeV/c;{2}.

Aubert, B / Barate, R / Bona, M / Boutigny, D / Couderc, F / Karyotakis, Y / Lees, J P / Poireau, V / Tisserand, V / Zghiche, A / Grauges, E / Palano, A / Pappagallo, M / Chen, J C / Qi, N D / Rong, G / Wang, P / Zhu, Y S / Eigen, G /

Ofte, I / Stugu, B / Abrams, G S / Battaglia, M / Brown, D N / Button-Schafer, J / Cahn, R N / Charles, E / Day, C T / Gill, M S / Groysman, Y / Jacobsen, R G / Kadyk, J A / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Lynch, G / Mir, L M / Oddone, P J / Orimoto, T J / Pripstein, M / Roe, N A / Ronan, M T / Wenzel, W A / Barrett, M / Ford, K E / Harrison, T J / Hart, A J / Hawkes, C M / Morgan, S E / Watson, A T / Goetzen, K / Held, T / Koch, H / Lewandowski, B / Pelizaeus, M / Peters, K / Schroeder, T / Steinke, M / Boyd, J T / Burke, J P / Cottingham, W N / Walker, D / Cuhadar-Donszelmann, T / Fulsom, B G / Hearty, C / Knecht, N S / Mattison, T S / McKenna, J A / Khan, A / Kyberd, P / Saleem, M / Teodorescu, L / Blinov, V E / Bukin, A D / Druzhinin, V P / Golubev, V B / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Yu Todyshev, K / Best, D S / Bondioli, M / Bruinsma, M / Chao, M / Curry, S / Eschrich, I / Kirkby, D / Lankford, A J / Lund, P / Mandelkern, M / Mommsen, R K / Roethel, W / Stoker, D P / Abachi, S / Buchanan, C / Foulkes, S D / Gary, J W / Long, O / Shen, B C / Wang, K / Zhang, L / Hadavand, H K / Hill, E J / Paar, H P / Rahatlou, S / Sharma, V / Berryhill, J W / Campagnari, C / Cunha, A / Dahmes, B / Hong, T M / Kovalskyi, D / Richman, J D / Beck, T W / Eisner, A M / Flacco, C J / Heusch, C A / Kroseberg, J / Lockman, W S / Nesom, G / Schalk, T / Schumm, B A / Seiden, A / Spradlin, P / Williams, D C / Wilson, M G / Albert, J / Chen, E / Dvoretskii, A / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Ryd, A / Samuel, A / Andreassen, R / Mancinelli, G / Meadows, B T / Sokoloff, M D / Blanc, F / Bloom, P C / Chen, S / Ford, W T / Hirschauer, J F / Kreisel, A / Nauenberg, U / Olivas, A / Ruddick, W O / Smith, J G / Ulmer, K A / Wagner, S R / Zhang, J / Chen, A / Eckhart, E A / Soffer, A / Toki, W H / Wilson, R J / Winklmeier, F / Zeng, Q / Altenburg, D D / Feltresi, E / Hauke, A / Jasper, H / Spaan, B / Brandt, T / Klose, V / Lacker, H M / Mader, W F / Nogowski, R / Petzold, A / Schubert, J / Schubert, K R / Schwierz, R / Sundermann, J E / Volk, A / Bernard, D / Bonneaud, G R / Grenier, P / Latour, E / Thiebaux, Ch / Verderi, M / Bard, D J / Clark, P J / Gradl, W / Muheim, F / Playfer, S / Robertson, A I / Xie, Y / Andreotti, M / Bettoni, D / Bozzi, C / Calabrese, R / Cibinetto, G / Luppi, E / Negrini, M / Petrella, A / Piemontese, L / Prencipe, E / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Pacetti, S / Patteri, P / Peruzzi, I M / Piccolo, M / Rama, M / Zallo, A / Buzzo, A / Capra, R / Contri, R / Lo Vetere, M / Macri, M M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Brandenburg, G / Chaisanguanthum, K S / Morii, M / Wu, J / Dubitzky, R S / Marks, J / Schenk, S / Uwer, U / Bhimji, W / Bowerman, D A / Dauncey, P D / Egede, U / Flack, R L / Gaillard, J R / Nash, J A / Nikolich, M B / Panduro Vazquez, W / Chai, X / Charles, M J / Mallik, U / Meyer, N T / Ziegler, V / Cochran, J / Crawley, H B / Dong, L / Eyges, V / Meyer, W T / Prell, S / Rosenberg, E I / Rubin, A E / Gristan, A V / Fritsch, M / Schott, G / Arnaud, N / Davier, M / Grosdidier, G / Höcker, A / Le Diberder, F / Lepeltier, V / Lutz, A M / Oyanguren, A / Pruvot, S / Rodier, S / Roudeau, P / Schune, M H / Stocchi, A / Wang, W F / Wormser, G / Cheng, C H / Lange, D J / Wright, D M / Chavez, C A / Forster, I J / Fry, J R / Gabathuler, E / Gamet, R / George, K A / Hutchcroft, D E / Payne, D J / Schofield, K C / Touramanis, C / Bevan, A J / Di Lodovico, F / Menges, W / Sacco, R / Brown, C L / Cowan, G / Flaecher, H U / Hopkins, D A / Jackson, P S / McMahon, T R / Ricciardi, S / Salvatore, F / Davis, C L / Allison, J / Barlow, N R / Barlow, R J / Chia, Y M / Edgar, C L / Kelly, M P / Lafferty, G D / Naisbit, M T / Williams, J C / Yi, J I / Chen, C / Hulsbergen, W D / Jawahery, A / Lae, C K / Roberts, D A / Simi, G / Blaylock, G / Dallapiccola, C / Hertzbach, S S / Li, X / Moore, T B / Saremi, S / Staengle, H / Willocq, S Y / Cowan, R / Koeneke, K / Sciolla, G / Sekula, S J / Spitznagel, M / Taylor, F / Yamamoto, R K / Kim, H / Patel, P M / Potter, C T / Robertson, S H / Lazzaro, A / Lombardo, V / Palombo, F / Bauer, J M / Cremaldi, L / Eschenburg, V / Godang, R / Kroeger, R / Reidy, J / Sanders, D A / Summers, D J / Zhao, H W / Brunet, S / Côté, D / Simard, M / Taras, P / Viaud, F B / Nicholson, H / Cavallo, N / De Nardo, G / Del Re, D / Fabozzi, F / Gatto, C / Lista, L / Monorchio, D / Paolucci, P / Piccolo, D / Sciacca, C / Baak, M / Bulten, H / Raven, G / Snoek, H L / Jessop, C P / Losecco, J M / Allmendinger, T / Benelli, G / Gan, K K / Honscheid, K / Hufnagel, D / Jackson, P D / Kagan, H / Kass, R / Pulliam, T / Rahimi, A M / Ter-Antonyan, R / Wong, Q K / Blout, N L / Brau, J / Frey, R / Igonkina, O / Lu, M / Rahmat, R / Sinev, N B / Strom, D / Strube, J / Torrence, E / Galeazzi, F / Gaz, A / Margoni, M / Morandin, M / Pompili, A / Posocco, M / Rotondo, M / Simonetto, F / Stroili, R / Voci, C / Benayoun, M / Chauveau, J / David, P / Del Buono, L / de la Vaissière, Ch / Hamon, O / Hartfiel, B L / John, M J J / Leruste, Ph / Malclès, J / Ocariz, J / Roos, L / Therin, G / Behera, P K / Gladney, L / Panetta, J / Biasini, M / Covarelli, R / Pioppi, M / Angelini, C / Batignani, G / Bettarini, S / Bucci, F / Calderini, G / Carpinelli, M / Cenci, R / Forti, F / Giorgi, M A / Lusiani, A / Marchiori, G / Mazur, M A / Morganti, M / Neri, N / Paoloni, E / Rizzo, G / Walsh, J / Haire, M / Judd, D / Wagoner, D E / Biesiada, J / Danielson, N / Elmer, P / Lau, Y P / Lu, C / Olsen, J / Smith, A J S / Telnov, A V / Bellini, F / Cavoto, G / D'Orazio, A / Di Marco, E / Faccini, R / Ferrarotto, F / Ferroni, F / Gaspero, M / Li Gioi, L / Mazzoni, M A / Morganti, S / Piredda, G / Polci, F / Safai Tehrani, F / Voena, C / Ebert, M / Schröder, H / Waldi, R / Adye, T / De Groot, N / Franek, B / Olaiya, E O / Wilson, F F / Emery, S / Gaidot, A / Ganzhur, S F / Hamel de Monchenault, G / Kozanecki, W / Legendre, M / Mayer, B / Vasseur, G / Yèche, Ch / Zito, M / Park, W / Purohit, M V / Weidemann, A W / Wilson, J R / Allen, M T / Aston, D / Bartoldus, R / Bechtle, P / Berger, N / Boyarski, A M / Claus, R / Coleman, J P / Convery, M R / Cristinziani, M / Dingfelder, J C / Dong, D / Dorfan, J / Dubois-Felsmann, G P / Dujmic, D / Dunwoodie, W / Field, R C / Glanzman, T / Gowdy, S J / Graham, M T / Halyo, V / Hast, C / Hyrn'ova, T / Innes, W R / Kelsey, M H / Kim, P / Kocian, M L / Leith, D W G S / Li, S / Libby, J / Luitz, S / Luth, V / Lynch, H L / Macfarlane, D B / Marsiske, H / Messner, R / Muller, D R / O'grady, C P / Ozcan, V E / Perazzo, A / Perl, M / Ratcliff, B N / Roodman, A / Salnikov, A A / Schindler, R H / Schwiening, J / Snyder, A / Stelzer, J / Su, D / Sullivan, M K / Suzuki, K / Swain, S K / Thompson, J M / Va'vra, J / van Bakel, N / Weaver, M / Weinstein, A J R / Wisniewski, W J / Wittgen, M / Wright, D H / Yarritu, A K / Yi, K / Young, C C / Burchat, P R / Edwards, A J / Majewski, S A / Petersen, B A / Roat, C / Wilden, L / Ahmed, S / Alam, M S / Bula, R / Ernst, J A / Jain, V / Pan, B / Saeed, M A / Wappler, F R / Zain, S B / Bugg, W / Krishnamurthy, M / Spanier, S M / Eckmann, R / Ritchie, J L / Satpathy, A / Schilling, C J / Schwitters, R F / Izen, J M / Kitayama, I / Lou, X C / Ye, S / Bianchi, F / Gallo, F / Gamba, D / Bomben, M / Bosisio, L / Cartaro, C / Cossutti, F / Della Ricca, G / Dittongo, S / Grancagnolo, S / Lanceri, L / Vitale, L / Azzolini, V / Martinez-Vidal, F / Banerjee, Sw / Bhuyan, B / Brown, C M / Fortin, D / Hamano, K / Kowalewski, R / Nugent, I M / Roney, J M / Sobie, R J / Back, J J / Harrison, P F / Latham, T E / Mohanty, G B / Band, H R / Chen, X / Cheng, B / Dasu, S / Datta, M / Eichenbaum, A M / Flood, K T / Hollar, J J / Johnson, J R / Kutter, P E / Li, H / Liu, R / Mellado, B / Mihalyi, A / Mohapatra, A K / Pan, Y / Pierini, M / Prepost, R / Tan, P / Wu, S L / Yu, Z / Neal, H

Physical review letters

2007 Volume 98, Issue 1, Page(s) 12001

Abstract: A search for charmed baryons decaying to D(0)p reveals two states: the Lambdac(2880)+ baryon and ...

Abstract	A search for charmed baryons decaying to D(0)p reveals two states: the Lambdac(2880)+ baryon and a previously unobserved state at a mass of [2939.8+/-1.3(stat)+/-1.0(syst)] MeV/c2 and with an intrinsic width of [17.5+/-5.2(stat)+/-5.9(syst)] MeV. Consistent and significant signals are observed for the K(-)pi(+) and K(-)pi(+)pi(-)pi(+) decay modes of the D0 in 287 fb(-1) annihilation data recorded by the BABAR detector at a center-of-mass energy of 10.58 GeV. There is no evidence in the D+p spectrum of doubly charged partners. The mass and intrinsic width of the Lambdac(2880)+ baryon and relative yield of the two baryons are also measured.
Language	English
Publishing date	2007-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.98.012001
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Book: Pharmacology of the endocrine system and related drugs: Parathyroid hormone, thyrocalcitonin and related drugs / 1 / contrib.: C. D. Arnaud ...

Arnaud, Claude D. / Rasmussen, Howard

(International encyclopedia of pharmacology and therapeutics ; 51,1)

1970

Author's details	sect. ed.: H. Rasmussen
Series title	International encyclopedia of pharmacology and therapeutics ; 51,1 Pharmacology of the endocrine system and related drugs ; Parathyroid hormone, thyrocalcitonin and related drugs
Collection	Pharmacology of the endocrine system and related drugs ; Parathyroid hormone, thyrocalcitonin and related drugs
Language	English
Size	364 S.
Publisher	Pergamon Pr
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT004866218
Database	Catalogue ZB MED Medicine, Health

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1967 A 476 -51,1-	order for loan	Magazin

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Article: Exclusion of pulmonary embolism using C-reactive protein and D-dimer. A prospective comparison.

Aujesky, Drahomir / Hayoz, Daniel / Yersin, Bertrand / Perrier, Arnaud / Barghouth, Ghassan / Schnyder, Pierre / Bischof-Delaloye, Angelika / Cornuz, Jacques

Thrombosis and haemostasis

2003 Volume 90, Issue 6, Page(s) 1198–1203

Abstract: Our goal was to evaluate the diagnostic utility of C-reactive protein (CRP) alone or combined ... its performance to a D-dimer assay. We conducted a prospective study in which we performed a common immuno ... turbidimetric CRP test and a rapid enzyme-linked immunosorbent assay (ELISA) D-dimer test in 259 consecutive ...

Abstract	Our goal was to evaluate the diagnostic utility of C-reactive protein (CRP) alone or combined with clinical probability assessment in patients with suspected pulmonary embolism (PE), and to compare its performance to a D-dimer assay. We conducted a prospective study in which we performed a common immuno-turbidimetric CRP test and a rapid enzyme-linked immunosorbent assay (ELISA) D-dimer test in 259 consecutive outpatients with suspected PE at the emergency department of a teaching hospital. We assessed clinical probability of PE by a validated prediction rule overridden by clinical judgment. Patients with D-dimer levels > or = 500 microg/l underwent a work-up consisting of lower-limb venous ultrasound, spiral computerized tomography, ventilation-perfusion scan, or pulmonary angiography. Patients were followed up for three months. Seventy-seven (30%) of the patients had PE. The CRP alone had a sensitivity of 84% (95% confidence interval [CI).: 74 to 92%) and a negative predictive value (NPV) of 87% (95% CI: 78 to 93%) at a cutpoint of 5 mg/l. Overall, 61 (24%) patients with a low clinical probability of PE had a CRP < 5 mg/l. Due to the low prevalence of PE (9%) in this subgroup, the NPV increased to 97% (95% CI: 89 to 100%). The D-dimer (cutpoint 500 micro g/l) showed a sensitivity of 100% (95% CI: 95 to 100%) and a NPV of 100% (95% CI: 94 to 100%) irrespective of clinical probability and accurately rule out PE in 56 (22%) patients. Standard CRP tests alone or combined with clinical probability assessment cannot safely exclude PE.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Algorithms ; Angiography ; C-Reactive Protein/analysis ; Diagnosis, Differential ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Immunoassay ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Embolism/diagnosis ; Sensitivity and Specificity ; Tomography, Spiral Computed ; Ultrasonography ; Ventilation-Perfusion Ratio
Chemical Substances	Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2003-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	518294-3
ISSN	0340-6245
ISSN	0340-6245
DOI	10.1160/TH03-03-0175
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Article: Exclusion of pulmonary embolism using C-reactive protein and D-dimer

Aujesky, Drahomir / Hayoz, Daniel / Yersin, Bertrand / Perrier, Arnaud / Barghouth, Ghassan / Schnyder, Pierre / Bischof-Delaloye, Angelika / Cornuz, Jacques

Thrombosis and Haemostasis

2003 Volume 89, Issue 06, Page(s) 1198–1203

Abstract	Our goal was to evaluate the diagnostic utility of C-reactive protein (CRP) alone or combined with clinical probability assessment in patients with suspected pulmonary embolism (PE), and to compare its performance to a D-dimer assay. We conducted a prospective study in which we performed a common immuno-turbidimetric CRP test and a rapid enzyme-linked immunosorbent assay (ELISA) D-dimer test in 259 consecutive outpatients with suspected PE at the emergency department of a teaching hospital. We assessed clinical probability of PE by a validated prediction rule overridden by clinical judgment. Patients with D-dimer levels ≥ 500 µg/l underwent a work-up consisting of lower-limb venous ultrasound, spiral computer-ized tomography, ventilation-perfusion scan, or pulmonary angiography. Patients were followed up for three months. Seventy-seven (30%) of the patients had PE.The CRP alone had a sensitivity of 84% (95% confidence interval [CI).: 74 to 92%) and a negative predictive value (NPV) of 87% (95% CI: 78 to 93%) at a cutpoint of 5 mg/l. Overall, 61 (24%) patients with a low clinical probability of PE had a CRP < 5 mg/l. Due to the low prevalence of PE (9%) in this subgroup, the NPV increased to 97% (95% CI: 89 to 100%). The D-dimer (cutpoint 500 µg/l) showed a sensitivity of 100% (95% CI: 95 to 100%) and a NPV of 100% (95% CI: 94 to 100%) irrespective of clinical probability and accurately rule out PE in 56 (22%) patients. Standard CRP tests alone or combined with clinical probability assessment cannot safely exclude PE.
Keywords	Pulmonary embolism ; C-reactive protein ; D-dimer ; clinical probability assessment
Language	English
Publishing date	2003-01-01
Publisher	Schattauer GmbH
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1160/TH03-03-0175
Database	Thieme publisher's database

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Article: A composite element binding the vitamin D receptor, retinoid X receptor alpha, and a member of the CTF/NF-1 family of transcription factors mediates the vitamin D responsiveness of the c-fos promoter.

Candeliere, G A / Jurutka, P W / Haussler, M R / St-Arnaud, R

Molecular and cellular biology

1996 Volume 16, Issue 2, Page(s) 584–592

Abstract: ... characterized a vitamin D response element (VDRE) in the promoter of c-fos. The 1,25-(OH)2D3-responsive region ... The hormonal form of vitamin D, 1 alpha,25-dihydroxyvitamin D3 [1,25- (OH)2D3], transiently ... stimulates the transcription of the c-fos proto-oncogene in osteoblastic cells. We have identified and ...

Abstract	The hormonal form of vitamin D, 1 alpha,25-dihydroxyvitamin D3 [1,25- (OH)2D3], transiently stimulates the transcription of the c-fos proto-oncogene in osteoblastic cells. We have identified and characterized a vitamin D response element (VDRE) in the promoter of c-fos. The 1,25-(OH)2D3-responsive region was delineated between residues -178 and -144 upstream of the c-fos transcription start site. A mutation that inhibited binding to the sequence concomitantly abolished 1,25-(OH)2D3-induced transcriptional responsiveness; similarly, cloning to the site upstream of a heterologous promoter conferred copy-number-dependent vitamin D responsiveness to a reporter gene, demonstrating that we have identified a functional response element. The structure of the c-fos VDRE was found to be unusual. Mutational analysis revealed that the c-fos VDRE does not conform to the direct repeat configuration in which hexameric core-binding sites are spaced by a few nucleotide residues. In contrast, the entire 36-bp sequence was essential for binding. We identified the vitamin D receptor and the retinoid X receptor alpha as components of the complex that bound the c-fos VDRE. However, our results also show that a putative CCAAT-binding transcription factor/nuclear factor 1 (CTF/NF-1) family member bound the response element in conjunction with the nuclear hormone receptors. The expression of this CTF/NF-1 family member appeared restricted to bone cells. These data hint at new molecular mechanisms of action for vitamin D.
MeSH term(s)	Base Sequence ; Binding Sites ; Bone and Bones/cytology ; Bone and Bones/metabolism ; CCAAT-Enhancer-Binding Proteins ; Calcitriol/metabolism ; Cells, Cultured ; DNA Mutational Analysis ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Molecular Sequence Data ; NFI Transcription Factors ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Promoter Regions, Genetic ; Protein Binding ; Proto-Oncogene Proteins c-fos/genetics ; Receptors, Calcitriol/metabolism ; Receptors, Retinoic Acid/metabolism ; Retinoid X Receptors ; Signal Transduction ; Tissue Distribution ; Transcription Factors/metabolism
Chemical Substances	CCAAT-Enhancer-Binding Proteins ; CTF-1 transcription factor ; DNA-Binding Proteins ; NFI Transcription Factors ; Proto-Oncogene Proteins c-fos ; Receptors, Calcitriol ; Receptors, Retinoic Acid ; Retinoid X Receptors ; Transcription Factors ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	1996-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.16.2.584
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Représentation surfacique d'évènements ponctuels discrets. Comparaison méthodologique à partir de l'exemple des accidents de la route dans la C.U.D.L.

Arnaud Banos / Jérome Bolot

CyberGeo (1999)

1999

Abstract: L’identification visuelle de structures spatiales à partir d’un semis de points est une tache ... délicate, pour peu que le nombre d’individus soit élevé. Cet article présente et compare deux méthodes ... permettant d’améliorer significativement la représentation graphique de données spatiales ponctuelles ...

Abstract	L’identification visuelle de structures spatiales à partir d’un semis de points est une tache délicate, pour peu que le nombre d’individus soit élevé. Cet article présente et compare deux méthodes permettant d’améliorer significativement la représentation graphique de données spatiales ponctuelles. La première est basée sur l’estimation d’une fonction de densité de Kernel au sein de fenêtres mobiles, tandis que la seconde repose sur un carroyage spatial. Ces deux méthodes sont appliquées aux accidents de route dans la Communauté urbaine de Lille.
Keywords	kernel density function ; point pattern analysis ; raster display ; road accident ; Geography (General) ; G1-922
Language	German
Publishing date	1999-06-01T00:00:00Z
Publisher	Unité Mixte de Recherche 8504 Géographie-cités
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Représentation surfacique d'évènements ponctuels discrets. Comparaison méthodologique à partir de l'exemple des accidents de la route dans la C.U.D.L.

Arnaud Banos / Jérome Bolot

Cybergeo (1999)

1999

Abstract: Spatial point pattern analysis of large data sets involves powerful visualization techniques. This paper intends to present two suitable methods : the first one is based on kernel density estimation technique, while the second uses regular grid of ... ...

Abstract	Spatial point pattern analysis of large data sets involves powerful visualization techniques. This paper intends to present two suitable methods : the first one is based on kernel density estimation technique, while the second uses regular grid of quadrats superimposed on the event distribution. Both methods are applied to road accidents analysis in the urban community of Lille (France).
Keywords	Geography (General) ; G1-922
Language	German
Publishing date	1999-06-01T00:00:00Z
Publisher	Unité Mixte de Recherche 8504 Géographie-cités
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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