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  1. AU=Oberman Lindsay M.
  2. AU="de Oliveira, Guilherme Xavier Lyra Malcher" AU="de Oliveira, Guilherme Xavier Lyra Malcher"
  3. AU="Afaneh, Hasheemah"
  4. AU="Galicia-Hernández, Victoria"
  5. AU="Daniel A. Haber"
  6. AU=Bu Fangfang
  7. AU="Fox, Kevin J"
  8. AU="Nawazish Naqvi"
  9. AU="Marquardt, Viktoria"
  10. AU="Watts, Robyn"
  11. AU="Caballero, Susana J"
  12. AU="van Dijk, J Hessel M"
  13. AU=Della Guardia Lucio
  14. AU="Zhilich V.N."
  15. AU="George, Darren"
  16. AU=Lin Xiukun
  17. AU="Kanwal Gujral"
  18. AU="Christian Young"
  19. AU=Takeuchi Kaoru
  20. AU="Wiślicki, W."
  21. AU="Veiga, Susana"
  22. AU="Reynolds, Matthew W."
  23. AU="Oates, Stephen B"
  24. AU=Okubo K
  25. AU="Behnood, Sanaz"

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  1. Buch ; Online ; E-Book: Neurotechnology and brain stimulation in pediatric psychiatric and neurodevelopmental disorders

    Oberman, Lindsay M. / Enticott, Peter G.

    2019  

    Verfasserangabe edited by Lindsay M. Oberman, Peter G. Enticott
    Schlagwörter Neurosciences ; Brain stimulation ; Child psychiatry ; Neuropsychiatry ; Developmental disabilities/Diagnosis ; Kind ; Psychische Störung ; Entwicklungsstörung ; Hirnstimulation
    Schlagwörter Tiefe Hirnstimulation ; THS ; Tiefenhirnstimulation ; Hirnschrittmacher ; Entwicklungsanomalie ; Seelische Störung ; Mental disorder ; Psychische Krankheit ; Seelische Krankheit ; Psychiatrische Krankheit ; Psychische Erkrankung ; Psychische Störungen ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Thema/Rubrik (Code) 616.8
    Sprache Englisch
    Umfang 1 Online-Ressource (xi, 356 Seiten)
    Verlag Elsevier AP
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019932915
    ISBN 978-0-12-812778-0 ; 9780128127773 ; 0-12-812778-3 ; 0128127775
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online: The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders

    Oberman, Lindsay M. / Enticott, Peter G.

    2015  

    Abstract: Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be applied in single pulses to ... ...

    Abstract Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be applied in single pulses to depolarize a small population of neurons in a targeted brain region. This protocol can be used, for example, to map cortical motor outputs, study central motor conduction time, or evaluate the cortical silent period (a measure of intracortical inhibition) all of which are relevant to neurodevelopment. TMS can also be applied in pairs of pulses (paired pulse stimulation, ppTMS) where two pulses are presented in rapid succession to study intracortical inhibition and facilitation. Trains of repeated TMS (rTMS) pulses can be applied at various stimulation frequencies and patterns to modulate local cortical excitability beyond the duration of the stimulation itself.-

    Depending on the parameters of stimulation the excitability can be either facilitated or suppressed. TCS (including Transcranial Direct Current Stimulation (tDCS), alternating current (tACS), and random noise current stimulation (tRNS) also have the potential to modulate cortical excitability and have also been used to study and modulate cortical activity in healthy and patient populations. The after-effects of rTMS and TCS are thought to be related to changes in efficacy (in either the positive or negative direction) of synaptic connections of the neurons being stimulated, thus these techniques have been used to study and modulate cortical plasticity mechanisms in a number of populations. Recently, researchers have begun to apply these techniques to the study of neurodevelopmental mechanisms as well as the pathophysiology and development of novel treatments for neurodevelopmental disorders.-

    Though there is much promise, caution is warranted given the vulnerability of pediatric and clinical populations and the potential that these techniques have to modify circuit development in a cortex that is in a very dynamic state. This Research Topic hopes to provide an opportunity to share ideas across areas (human and animal researchers, clinicians and basic scientists). We are particularly interested in papers that address issues of choosing a protocol (intensity, frequency, location, coil geometry etc.), populations where noninvasive brain stimulation may have direct impact on diagnostics and treatment, as well as the safety and ethics of applying these techniques in pediatric populations. As many may not be aware of the potential and limitations of noninvasive brain stimulation and its use for research and treatment in this area, this Research Topic promises to have broad appeal. Submissions for all Frontiers article types are encouraged
    Schlagwörter Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General)
    Umfang 1 electronic resource (68 p.)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT020091131
    ISBN 9782889196999 ; 2889196992
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: Transcranial Magnetic Stimulation Across the Lifespan: Impact of Developmental and Degenerative Processes.

    Oberman, Lindsay M / Benussi, Alberto

    Biological psychiatry

    2023  Band 95, Heft 6, Seite(n) 581–591

    Abstract: Transcranial magnetic stimulation (TMS) has emerged as a pivotal noninvasive technique for investigating cortical excitability and plasticity across the lifespan, offering valuable insights into neurodevelopmental and neurodegenerative processes. In this ...

    Abstract Transcranial magnetic stimulation (TMS) has emerged as a pivotal noninvasive technique for investigating cortical excitability and plasticity across the lifespan, offering valuable insights into neurodevelopmental and neurodegenerative processes. In this review, we explore the impact of TMS applications on our understanding of normal development, healthy aging, neurodevelopmental disorders, and adult-onset neurodegenerative diseases. By presenting key developmental milestones and age-related changes in TMS measures, we provide a foundation for understanding the maturation of neurotransmitter systems and the trajectory of cognitive functions throughout the lifespan. Building on this foundation, the paper delves into the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette syndrome, and adolescent depression. Highlighting recent findings on altered neurotransmitter circuits and dysfunctional cortical plasticity, we underscore the potential of TMS as a valuable tool for unraveling underlying mechanisms and informing future therapeutic interventions. We also review the emerging role of TMS in investigating and treating the most common adult-onset neurodegenerative disorders and late-onset depression. By outlining the therapeutic applications of noninvasive brain stimulation techniques in these disorders, we discuss the growing body of evidence supporting their use as therapeutic tools for symptom management and potentially slowing disease progression. The insights gained from TMS studies have advanced our understanding of the underlying mechanisms in both healthy and disease states, ultimately informing the development of more targeted diagnostic and therapeutic strategies for a wide range of neuropsychiatric conditions.
    Mesh-Begriff(e) Adolescent ; Humans ; Transcranial Magnetic Stimulation/methods ; Longevity ; Autism Spectrum Disorder/therapy ; Neurodegenerative Diseases/therapy ; Neurotransmitter Agents
    Chemische Substanzen Neurotransmitter Agents
    Sprache Englisch
    Erscheinungsdatum 2023-07-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2023.07.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Current State of the Art of Transcranial Magnetic Stimulation in Psychiatry: Innovations and Challenges for the Future.

    van den Heuvel, Odile A / Oberman, Lindsay M

    Biological psychiatry

    2023  Band 95, Heft 6, Seite(n) 485–487

    Mesh-Begriff(e) Transcranial Magnetic Stimulation ; Psychiatry ; Transcranial Direct Current Stimulation
    Sprache Englisch
    Erscheinungsdatum 2023-11-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2023.11.024
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  5. Artikel ; Online: The use of noninvasive brain stimulation techniques in autism spectrum disorder.

    Oberman, Lindsay M / Francis, Sunday M / Lisanby, Sarah H

    Autism research : official journal of the International Society for Autism Research

    2023  Band 17, Heft 1, Seite(n) 17–26

    Abstract: Noninvasive brain stimulation (NIBS) techniques, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), have recently emerged as alternative, nonpharmacological interventions for a variety of ... ...

    Abstract Noninvasive brain stimulation (NIBS) techniques, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), have recently emerged as alternative, nonpharmacological interventions for a variety of psychiatric, neurological, and neurodevelopmental conditions. NIBS is beginning to be applied in both research and clinical settings for the treatment of core and associated symptoms of autism spectrum disorder (ASD) including social communication deficits, restricted and repetitive behaviors, irritability, hyperactivity, depression and impairments in executive functioning and sensorimotor integration. Though there is much promise for these targeted device-based interventions, in other disorders (including adult major depressive disorder (MDD) and obsessive compulsive disorder (OCD) where rTMS is FDA cleared), data on the safety and efficacy of these interventions in individuals with ASD is limited especially in younger children when neurodevelopmental interventions typically begin. Most studies are open-label, small scale, and/or focused on a restricted subgroup of individuals with ASD. There is a need for larger, randomized controlled trials that incorporate neuroimaging in order to develop predictive biomarkers of treatment response and optimize treatment parameters. We contend that until such studies are conducted, we do not have adequate estimates of the safety and efficacy of NIBS interventions in children across the spectrum. Thus, broad off-label use of these techniques in this population is not supported by currently available evidence. Here we discuss the existing data on the use of NIBS to treat symptoms related to ASD and discuss future directions for the field.
    Mesh-Begriff(e) Child ; Adult ; Humans ; Transcranial Direct Current Stimulation/methods ; Depressive Disorder, Major/therapy ; Autism Spectrum Disorder/therapy ; Transcranial Magnetic Stimulation/methods ; Brain/diagnostic imaging
    Sprache Englisch
    Erscheinungsdatum 2023-10-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.3041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Autism Spectrum Disorder Versus Autism Spectrum Disorders: Terminology, Concepts, and Clinical Practice.

    Oberman, Lindsay M / Kaufmann, Walter E

    Frontiers in psychiatry

    2020  Band 11, Seite(n) 484

    Sprache Englisch
    Erscheinungsdatum 2020-05-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00484
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Repetitive Transcranial Magnetic Stimulation for the Treatment of Depression, Post-Traumatic Stress Disorder, and Suicidal Ideation in Military Populations: A Scholarly Review.

    Exley, Shannon L / Oberman, Lindsay M

    Military medicine

    2021  Band 187, Heft 1-2, Seite(n) e65–e69

    Abstract: Introduction: Military mental health conditions, such as depression, PTSD, and suicidal ideation, are currently understudied and undertreated. Repetitive transcranial magnetic stimulation (rTMS) is currently being considered as a treatment for these ... ...

    Abstract Introduction: Military mental health conditions, such as depression, PTSD, and suicidal ideation, are currently understudied and undertreated. Repetitive transcranial magnetic stimulation (rTMS) is currently being considered as a treatment for these conditions; however, there exists a paucity of research in this area. This scholarly review will examine the limitations of the existing literature on the use of rTMS to treat depression, PTSD, and suicidal ideation in service members (SMs) and veterans.
    Materials and methods: Publications that evaluated rTMS for the treatment of depression, PTSD, or suicidal ideation in military samples were identified via a PubMed search. Non-interventional rTMS studies, studies where the sample could not be confirmed to be primarily composed of SMs or veteran participants, studies without psychiatric outcome measures, and studies not published in a peer-reviewed journal were excluded from this review.
    Results: This literature search identified 20 total publications (eight primary analyses of randomized controlled trials (RCTs), one longitudinal analysis of an RCT, five open label trials, and six retrospective analyses of clinical data), inclusive of 879 participants. Eighteen studies utilized a protocol targeting the prefrontal cortex (PFC), and one of these also targeted the supplementary motor area (SMA) with the PFC (one study did not specify the stimulation site). Eight studies applied standard 10 Hz frequency stimulation, and four applied standard 1 Hz frequency stimulation. The remainder of studies applied alternative stimulation protocols including 5 Hz (two studies), 20 Hz (one study), a combination of 1 and 10 Hz (two studies), and theta burst stimulation (TBS) (two studies). Twelve studies reported significant results, including four RCTs, three open label studies, and five retrospective analyses.
    Conclusions: rTMS offers a promising area of research for mental health conditions in military populations. However, the number of studies that focus specifically on this population are few in number and have many notable limitations. Further research is needed to validate the effectiveness of this tool for SMs and veterans.
    Mesh-Begriff(e) Depression/therapy ; Humans ; Prefrontal Cortex ; Stress Disorders, Post-Traumatic/therapy ; Suicidal Ideation ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2021-05-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usab187
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  8. Artikel ; Online: Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.

    Jannati, Ali / Oberman, Lindsay M / Rotenberg, Alexander / Pascual-Leone, Alvaro

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2022  Band 48, Heft 1, Seite(n) 191–208

    Abstract: Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain stimulation based on electromagnetic induction where a fluctuating magnetic field induces a small intracranial electric current in the brain. For more than 35 years, TMS ... ...

    Abstract Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain stimulation based on electromagnetic induction where a fluctuating magnetic field induces a small intracranial electric current in the brain. For more than 35 years, TMS has shown promise in the diagnosis and treatment of neurological and psychiatric disorders in adults. In this review, we provide a brief introduction to the TMS technique with a focus on repetitive TMS (rTMS) protocols, particularly theta-burst stimulation (TBS), and relevant rTMS-derived metrics of brain plasticity. We then discuss the TMS-EEG technique, the use of neuronavigation in TMS, the neural substrate of TBS measures of plasticity, the inter- and intraindividual variability of those measures, effects of age and genetic factors on TBS aftereffects, and then summarize alterations of TMS-TBS measures of plasticity in major neurological and psychiatric disorders including autism spectrum disorder, schizophrenia, depression, traumatic brain injury, Alzheimer's disease, and diabetes. Finally, we discuss the translational studies of TMS-TBS measures of plasticity and their therapeutic implications.
    Mesh-Begriff(e) Adult ; Humans ; Transcranial Magnetic Stimulation/methods ; Autism Spectrum Disorder ; Neuronal Plasticity/physiology ; Brain
    Sprache Englisch
    Erscheinungsdatum 2022-10-05
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-022-01453-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI).

    Kirkovski, Melissa / Donaldson, Peter H / Do, Michael / Speranza, Bridgette E / Albein-Urios, Natalia / Oberman, Lindsay M / Enticott, Peter G

    Brain structure & function

    2023  Band 228, Heft 3-4, Seite(n) 717–749

    Abstract: Theta burst stimulation (TBS) is associated with the modulation of a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and ... ...

    Abstract Theta burst stimulation (TBS) is associated with the modulation of a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging (fMRI) outcomes post-TBS in healthy human adults. Fifty studies that applied either continuous-or intermittent-(c/i) TBS, and adopted a pretest-posttest or sham-controlled design, were included. For resting-state outcomes following stimulation applied to motor, temporal, parietal, occipital, or cerebellar regions, functional connectivity generally decreased in response to cTBS and increased in response to iTBS, though there were some exceptions to this pattern of response. These findings are mostly consistent with the assumed long-term depression (LTD)/long-term potentiation (LTP)-like plasticity effects of cTBS and iTBS, respectively. Task-related outcomes following TBS were more variable. TBS applied to the prefrontal cortex, irrespective of task or state, also produced more variable responses, with no consistent patterns emerging. Individual participant and methodological factors are likely to contribute to the variability in responses to TBS. Future studies assessing the effects of TBS via fMRI must account for factors known to affect the TBS outcomes, both at the level of individual participants and of research methodology.
    Mesh-Begriff(e) Adult ; Humans ; Magnetic Resonance Imaging ; Transcranial Magnetic Stimulation/methods ; Motor Cortex/physiology ; Neuronal Plasticity/physiology ; Long-Term Potentiation ; Theta Rhythm/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-04-19
    Erscheinungsland Germany
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-023-02634-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Rett Syndrome Behaviour Questionnaire in Children and Adults With Rett Syndrome: Psychometric Characterization and Revised Factor Structure.

    Oberman, Lindsay M / Leonard, Helen / Downs, Jenny / Cianfaglione, Rina / Stahlhut, Michelle / Larsen, Jane L / Madden, Katherine V / Kaufmann, Walter E

    American journal on intellectual and developmental disabilities

    2023  Band 128, Heft 3, Seite(n) 237–253

    Abstract: Rett syndrome (RTT) is a severe neurodevelopmental disorder associated with multiple neurobehavioral abnormalities. The Rett Syndrome Behaviour Questionnaire (RSBQ) was developed for pediatric RTT observational studies. Because its application has ... ...

    Abstract Rett syndrome (RTT) is a severe neurodevelopmental disorder associated with multiple neurobehavioral abnormalities. The Rett Syndrome Behaviour Questionnaire (RSBQ) was developed for pediatric RTT observational studies. Because its application has expanded to adult and interventional studies, we evaluated the RSBQ's psychometric properties in six pediatric (n = 323) and five adult (n = 309) datasets. Total and General Mood subscale scores had good reliability. Clinical severity had no influence on RSBQ scores. Exploratory and confirmatory factor analyses yielded 6 pediatric and 7 adult clinically relevant and psychometrically strong factors including the original Breathing Problems and Fear/Anxiety subscales and the novel Emotional and Disruptive Behavior subscale composed of items from the original General Mood and Nighttime Behaviours subscales. The present findings support additional evaluations and improvements of an important RTT behavioral measure.
    Mesh-Begriff(e) Child ; Adult ; Humans ; Rett Syndrome/diagnosis ; Psychometrics ; Reproducibility of Results ; Emotions ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2023-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2477909-X
    ISSN 1944-7558 ; 1944-7515
    ISSN (online) 1944-7558
    ISSN 1944-7515
    DOI 10.1352/1944-7558-128.3.237
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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