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  1. Article ; Online: Response to 'blast identification in cerebrospinal fluid specimens from patients with acute myeloid leukemia: laboratory perspectives'.

    Sastow, Dahniel / Tatarian, Joshua / Salib, Christian / Lin, Tara L / Tremblay, Douglas

    Leukemia & lymphoma

    2024  Volume 65, Issue 1, Page(s) 141

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/diagnosis ; Blast Crisis
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2274658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
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  2. Article ; Online: A case of hairy cell leukemia with markedly hypocellular marrow mimicking aplastic anemia.

    Salib, Christian / Hussein, Shafinaz

    Blood

    2021  Volume 137, Issue 1, Page(s) 142

    MeSH term(s) Anemia, Aplastic/diagnosis ; Anemia, Aplastic/pathology ; Biomarkers, Tumor/analysis ; Bone Marrow/pathology ; Diagnosis, Differential ; Humans ; Leukemia, Hairy Cell/diagnosis ; Leukemia, Hairy Cell/pathology ; Male ; Middle Aged
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020008906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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  3. Article ; Online: Hypersegmented granulocytes and COVID-19 infection.

    Salib, Christian / Teruya-Feldstein, Julie

    Blood

    2020  Volume 135, Issue 24, Page(s) 2196

    MeSH term(s) Aged ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronary Artery Disease/complications ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Diabetes Mellitus, Type 2/complications ; Granulocytes/pathology ; Granulocytes/virology ; Humans ; Hypoxia/complications ; Kidney Failure, Chronic/complications ; Leukocyte Count ; Leukocytosis/blood ; Leukocytosis/complications ; Leukocytosis/pathology ; Male ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020006483
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  5. Article ; Online: Lymphoma Mimicking Chronic Active Epstein-Barr Virus: A Case Report.

    Bahethi, Rohini / Gray, Mingyang / Salib, Christian / Likhterov, Ilya

    Head and neck pathology

    2020  Volume 14, Issue 4, Page(s) 1028–1031

    Abstract: Epstein-Barr virus (EBV) is the main cause of infectious mononucleosis (IM), a self-limiting infection among immunocompetent patients. EBV is also implicated in the development of several malignancies. We describe a case of a previously healthy 34-year- ... ...

    Abstract Epstein-Barr virus (EBV) is the main cause of infectious mononucleosis (IM), a self-limiting infection among immunocompetent patients. EBV is also implicated in the development of several malignancies. We describe a case of a previously healthy 34-year-old man who presented with non-tender, enlarging, right cervical lymphadenopathy for over a year that was associated with significant weight loss, fevers, and night sweats. Two fine needle core biopsies showed inconclusive then reactive tissue, respectively. A third excisional biopsy demonstrated a reactive lymph node with EBV-positive IM. There was no evidence of lymphoma by histologic examination or flow cytometry. A diagnosis of chronic active EBV (CAEBV) was rendered. Subsequent lymph node debulking six months later showed classic Hodgkin lymphoma (CHL) positive for EBV. The patient underwent chemotherapy with full treatment response. This is an unusual presentation of EBV infection that led to either a delayed onset or delayed diagnosis of CHL.
    MeSH term(s) Adult ; Biopsy, Fine-Needle ; Diagnostic Errors ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/pathology ; Hodgkin Disease/diagnosis ; Hodgkin Disease/pathology ; Hodgkin Disease/virology ; Humans ; Infectious Mononucleosis/diagnosis ; Infectious Mononucleosis/pathology ; Lymph Nodes/pathology ; Male
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-020-01154-y
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  6. Article ; Online: Discontinuation Syndrome With JAK2 Selective Agents: Case Presentation and Mechanistic Insights.

    Handa, Shivani / Farina, Kyle A / Becker, Michelle / Kelly, Brianna / Yu, Ashley / Feld, Jonathan / Tremblay, Douglas / Marcellino, Bridget K / Salib, Christian / Mascarenhas, John / Shih, Alan H

    JCO precision oncology

    2024  Volume 8, Page(s) e2300234

    Abstract: We report the first case of pacritinib-withdrawal syndrome with in vitro elucidation of underlying mechanisms. ...

    Abstract We report the first case of pacritinib-withdrawal syndrome with in vitro elucidation of underlying mechanisms.
    MeSH term(s) Humans ; Primary Myelofibrosis ; Bridged-Ring Compounds ; Pyrimidines ; Janus Kinase 2/genetics
    Chemical Substances Bridged-Ring Compounds ; Pyrimidines ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.23.00234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Digital Pathology in the Detection of Infectious Microorganisms: An Evaluation of Its Strengths and Weaknesses Across a Panel of Immunohistochemical and Histochemical Stains Routinely Used in Diagnostic Surgical Pathology.

    Haghighi, Mehrvash / Bryce, Clare / Paulsen, John D / Hussein, Shafinaz / Veremis, Brandon / Salib, Christian / Alialy, Roshanak / Lahori, Mega / Hao, Yansheng / Liang, Yuanxin / Szporn, Arnold / Westra, William

    Archives of pathology & laboratory medicine

    2024  

    Abstract: Context.—: The diagnosis of some infectious diseases requires their identification in tissue specimens. As institutions adopt digital pathology for primary diagnosis, the limits of microorganism detection from digital images must be delineated.: ... ...

    Abstract Context.—: The diagnosis of some infectious diseases requires their identification in tissue specimens. As institutions adopt digital pathology for primary diagnosis, the limits of microorganism detection from digital images must be delineated.
    Objective.—: To assess the reliability of microorganism detection from digitized images of histochemical and immunohistochemical stains commonly used in pathology.
    Design.—: Original glass slides from 620 surgical pathology cases evaluated for the presence of infectious microorganisms were digitized. Immunohistochemical stains included those for herpes simplex virus (n = 100), cytomegalovirus (n = 100), Helicobacter pylori (n = 100), and spirochetes (n = 80). Histochemical stains included mucicarmine for Cryptococcus spp (n = 20), Grocott methenamine silver for fungi (n = 100), Giemsa for H pylori (n = 100), and Ziehl-Neelsen for acid-fast bacilli (n = 20). The original diagnosis based on the glass slides was regarded as the reference standard. Six pathologists reviewed the digital images.
    Results.—: Digital review was generally associated with high (ie, ≥90%) specificity and positive predictive value owing to a low percentage of false positive reads, whereas a high percentage of false negatives contributed to low sensitivity and negative predictive value for many stains. Fleiss κ showed substantial interobserver agreement in the interpretation of Grocott methenamine silver and immunostains for herpes simplex virus, H pylori, and cytomegalovirus; moderate agreement for spirochete, Ziehl-Neelsen, and mucicarmine; and poor agreement for Giemsa.
    Conclusions.—: Digital immunohistochemistry generally outperforms histochemical stains for microorganism detection. Digital interpretation of Ziehl-Neelsen and mucicarmine stains is associated with low scores for interrater reliability, accuracy, sensitivity, and negative predictive value such that it should not substitute for conventional review of glass slides.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2023-0214-OA
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    Ud II Zs.36: Show issues Location:
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  8. Article ; Online: Regression of smoldering myeloma with treatment of Gaucher disease.

    Barley, Kevin / Parekh, Anshuman / Salam, Syed / Mendu, Damodara Rao / Shukla, Ravi Prakash / Vatti, Deepa / Verina, Daniel / Stauffer, Chanan / Salib, Christian / El Jamal, Siraj / Teruya-Feldstein, Julie / Duffield, Amy S / Leshchenko, Violetta V / Jagannath, Sundar / Balwani, Manisha / Parekh, Samir

    Blood advances

    2024  Volume 8, Issue 7, Page(s) 1634–1638

    MeSH term(s) Humans ; Smoldering Multiple Myeloma ; Gaucher Disease/drug therapy ; Multiple Myeloma/diagnosis ; Multiple Myeloma/therapy ; Disease Progression
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023012304
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    Zs.A 7153: Show issues Location:
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  9. Article ; Online: Burkitt lymphoma of the nasopharynx causing life-threatening airway obstruction: A case report.

    Goel, Alexander N / Filimonov, Andrey / Teruya-Feldstein, Julie / Salib, Christian / Rousso, Joseph J / Hackett, Alyssa M / Rothschild, Michael A / Wanna, George B

    American journal of otolaryngology

    2021  Volume 42, Issue 4, Page(s) 102977

    Abstract: Objective: To describe a case of Burkitt lymphoma (BL) in a child manifesting with acute airway obstruction. To review available literature on the clinical features and characteristic presentation of this disease.: Methods: Case report with ... ...

    Abstract Objective: To describe a case of Burkitt lymphoma (BL) in a child manifesting with acute airway obstruction. To review available literature on the clinical features and characteristic presentation of this disease.
    Methods: Case report with literature review.
    Results: We present the case of an 8-year-old boy with nasopharyngeal BL manifesting initially as sore throat, nasal congestion, and snoring that progressed to dyspnea and, ultimately, acute airway obstruction requiring emergent tracheostomy. The child was treated with intensive chemotherapy and achieved complete response.
    Conclusion: This case highlights the importance of maintaining high clinical suspicion when evaluating common otolaryngologic symptoms and emphasizes the potential for Burkitt lymphoma to cause rapid patient deterioration.
    MeSH term(s) Acute Disease ; Airway Obstruction/diagnostic imaging ; Airway Obstruction/etiology ; Airway Obstruction/surgery ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Burkitt Lymphoma/complications ; Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/diagnostic imaging ; Burkitt Lymphoma/drug therapy ; Child ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Dyspnea/diagnostic imaging ; Dyspnea/etiology ; Dyspnea/surgery ; Early Detection of Cancer ; Emergencies ; Humans ; Male ; Methotrexate/administration & dosage ; Nasopharyngeal Neoplasms/complications ; Nasopharyngeal Neoplasms/diagnosis ; Nasopharyngeal Neoplasms/diagnostic imaging ; Nasopharyngeal Neoplasms/drug therapy ; Positron-Emission Tomography ; Prednisone/administration & dosage ; Rituximab/administration & dosage ; Tomography, X-Ray Computed ; Tracheostomy/methods ; Treatment Outcome ; Vincristine/administration & dosage
    Chemical Substances R-CHOP protocol ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2021.102977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1637: Show issues Location:
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  10. Article ; Online: USP6 Gene Rearrangement by FISH Analysis in Cranial Fasciitis: A Report of Three Cases.

    Salib, Christian / Edelman, Morris / Lilly, Joshua / Fantasia, John E / Yancoskie, Aaron E

    Head and neck pathology

    2019  Volume 14, Issue 1, Page(s) 257–261

    Abstract: Cranial fasciitis (CF) is an uncommon benign myofibroblastic proliferation involving the soft and hard tissues of the cranium. It typically occurs in the pediatric population with a male predilection (male-to-female ratio 1.5:1). The clinical ... ...

    Abstract Cranial fasciitis (CF) is an uncommon benign myofibroblastic proliferation involving the soft and hard tissues of the cranium. It typically occurs in the pediatric population with a male predilection (male-to-female ratio 1.5:1). The clinical presentation is usually a rapidly expanding, painless nodule. Bone erosion may be appreciated radiographically. Histopathologic sections of CF show plump, fibroblast-like cells with pale, oval shaped nuclei and prominent nucleoli in a fibrous or myxoid background. Growth is self-limited and surgical excision is considered curative. Due to these features, CF is thought to be a variant of nodular fasciitis (NF). As with NF, CF may mimic a sarcomatous process and pose a diagnostic challenge to clinicians and pathologists alike. Erickson-Johnson et al. identified rearrangements of the ubiquitin-specific protease 6 (USP6) gene in 44 of 48 cases of NF. MYH9 was the fusion partner in 12 of these cases. To date, the molecular profile of CF has not been studied. Here we present the molecular findings in three cases of CF identified at our institution. Each case was subjected to fluorescence in-situ hybridization with appropriate negative controls. Two of three cases were positive for the USP6 gene rearrangement. The third case failed to hybridize, likely related to nucleic acid damage secondary to decalcification. Negative controls did not demonstrate the genetic rearrangement. These findings warrant further investigation of the USP6 gene rearrangement in CF, as it may prove helpful as a diagnostic adjunct in challenging cases.
    MeSH term(s) Child ; Child, Preschool ; Fasciitis/genetics ; Fasciitis/pathology ; Gene Rearrangement ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/pathology ; Humans ; Infant ; Male ; Myofibroma/genetics ; Myofibroma/pathology ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Ubiquitin Thiolesterase/genetics
    Chemical Substances USP6 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-019-01018-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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