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  1. AU=Doshi Paresh
  2. AU="Cecilia Hognon"
  3. AU="Mason, Jeremy K."
  4. AU=Hasumi Hisashi
  5. AU="Swati Sethi"
  6. AU="Martin G. Myers, Jr."
  7. AU="Marcus-Sekura, Carol"
  8. AU="Petagine, Lucy"
  9. AU="Jessa R. Alexander"
  10. AU=Rauner Martina
  11. AU="Richlen, Mindy L"
  12. AU="Merghani, Nada M"
  13. AU=Splitt M P
  14. AU="Zlatanović, Gordana"

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  1. Artikel: Radiofrequency Lesioning for Movement and Psychiatric Disorders-Experience of 107 Cases.

    Doshi, Paresh K

    Frontiers in human neuroscience

    2021  Band 15, Seite(n) 673848

    Abstract: Background: Radiofrequency lesioning (RFL) though used since the 1950s, had been replaced by DBS in the 1990s. The availability of magnetic resonance-guided focused ultrasound for lesioning has renewed the interest in RFL.: Objective: This paper ... ...

    Abstract Background: Radiofrequency lesioning (RFL) though used since the 1950s, had been replaced by DBS in the 1990s. The availability of magnetic resonance-guided focused ultrasound for lesioning has renewed the interest in RFL.
    Objective: This paper analysis RFL in contemporary Functional Neurosurgery for various indications and its outcome. Complication rates of RFL are compared with the same author's experience of DBS.
    Methods: One hundred and seven patients underwent RFL between 1998 and 2019. Indications included Parkinson's Disease (PD), tremors, dystonia, and obsessive-compulsive disorders (OCD). The surgeries performed include thalamotomy (29), pallidotomy (49), subthalamotomy (23), and anterior capsulotomy/nucleus accumbens lesioning (6). Appropriate rating scales were used for preoperative and postoperative evaluations.
    Results: There was a 25% recurrence rate of tremors for PD after thalamotomy. Writer's cramp rating scale improved from a mean of 10.54-1.6 in task specific dystonia (TSD) patients, after thalamotomy. In PD patients, after pallidotomy, contralateral motor Unified Parkinson's Disease Rating Scale (UPDRS) and dyskinesia scores, improved by 41 and 57%, respectively, at 1-year. Burke-Fahn-Marsden Dystonia Rating Scale in hemidystonia patients improved from 18.04 to 6.91, at 1-year. There was 32 and 31% improvement in total and motor UPDRS, respectively, in the subthalamotomy patients, at 2-year. All patients of OCD were in remission. There were three deaths in the pallidotomy group. Postoperative, dysarthria, confusion, hemiparesis, dyskinesia, and paraesthesia occurred in 12 patients, of which, 7 were transient.
    Conclusion: RFL is a useful option in a select group of patients with tremors and dystonia. It is our preferred treatment option for TSD and OCD.
    Sprache Englisch
    Erscheinungsdatum 2021-06-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2021.673848
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Parkinsonism- Hyperpyrexia Syndrome (PHS) Crisis following Deep Brain Stimulator Battery Depletion.

    Rai, Neha / Baldia, Manish / Doshi, Paresh K

    Annals of Indian Academy of Neurology

    2023  Band 26, Heft 5, Seite(n) 799–801

    Sprache Englisch
    Erscheinungsdatum 2023-10-09
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.aian_517_23
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  3. Artikel ; Online: Letter: Functional Neurosurgery-A Neglected Aspect of Global Neurosurgery: Call to Action.

    Slavin, Konstantin V / Régis, Jean M / Hodaie, Mojgan / Doshi, Paresh K / Blomstedt, Patric / Chang, Jin Woo

    Neurosurgery

    2024  Band 94, Heft 4, Seite(n) e55–e56

    Mesh-Begriff(e) Humans ; Neurosurgery/education ; Neurosurgical Procedures ; Internship and Residency
    Sprache Englisch
    Erscheinungsdatum 2024-01-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002850
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Practice Trends of Neuromodulation Therapies for Pain and Spasticity in India.

    Doshi, Preeti P / Russo, Marc / Doshi, Paresh K

    Neuromodulation : journal of the International Neuromodulation Society

    2022  Band 26, Heft 8, Seite(n) 1876–1882

    Abstract: Background: Neuromodulation has been successfully used globally to address severe refractory chronic pain for over five decades. Compared to the wide acceptance that it enjoys in United States and Europe, it is fairly underutilized in Asia, including ... ...

    Abstract Background: Neuromodulation has been successfully used globally to address severe refractory chronic pain for over five decades. Compared to the wide acceptance that it enjoys in United States and Europe, it is fairly underutilized in Asia, including India.
    Objectives: We conducted the first systematic nationwide survey to provide an overview of neuromodulation in the past 20 years to investigate the practice trends for severe refractory chronic pain and barriers for the uptake of neuromodulation therapies for pain in India.
    Design: A 20-point detailed questionnaire survey was sent out for online completion in August 2020 to practitioners in India involved in interventions for pain. The survey was completed by 112 practitioners (10% return rate). The response data collected were analyzed, tabulated, and presented as percentages.
    Results: The average duration of pain practice in India for the majority of respondents was less than a decade. About 70% of practitioners expressed that they manage severe refractory pain without neuromodulation. This survey confirms that neuromodulation is grossly underutilized for pain, comprising only 10% of total neuromodulation implants performed per annum in India. The most common indications were neuropathic pain (45%) and failed back surgery syndrome (42%). The respondents expressed the main barriers to be related to the cost (85%), lack of awareness (68%), and lack of good training (59%). More than 50% of respondents also expressed difficulty of access to neuromodulation therapies for pain and acceptance by patients.
    Conclusion: The younger generation of pain practitioners in India is becoming more aware and convinced about the role of neuromodulation to alleviate severe pain and suffering. An all-round approach combining improved training, awareness at various levels, more flexible options of newer technology and reimbursement approval can positively influence its use. This can be achieved with the collective efforts of physicians, insurers, industry, and focused academic activities of clinical societies.
    Mesh-Begriff(e) Humans ; Chronic Pain/therapy ; Spinal Cord Stimulation ; Neuralgia/therapy ; Pain Management ; Pain, Intractable ; India
    Sprache Englisch
    Erscheinungsdatum 2022-06-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1500372-3
    ISSN 1525-1403 ; 1094-7159
    ISSN (online) 1525-1403
    ISSN 1094-7159
    DOI 10.1111/ner.13393
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  5. Artikel: Neurosurgery for psychiatric disorders.

    Doshi, Paresh K

    Neurology India

    2017  Band 65, Heft 4, Seite(n) 777–778

    Mesh-Begriff(e) Humans ; Mental Disorders/surgery ; Neurosurgery ; Neurosurgical Procedures
    Sprache Englisch
    Erscheinungsdatum 2017-07-05
    Erscheinungsland India
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/neuroindia.NI_521_17
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  6. Artikel: Expanding indications for deep brain stimulation.

    Doshi, Paresh K

    Neurology India

    2018  Band 66, Heft Supplement, Seite(n) S102–S112

    Abstract: It has been three decades since the first application of deep brain stimulation (DBS) for tremors was described by Benabid. Over the years, the indications for the performance of DBS have been expanding. There are now more than 1,50,000 patients around ... ...

    Abstract It has been three decades since the first application of deep brain stimulation (DBS) for tremors was described by Benabid. Over the years, the indications for the performance of DBS have been expanding. There are now more than 1,50,000 patients around the world who have undergone DBS for various disorders. The main appeal of DBS is in its reversibility and titratability. Though the initial interest in DBS was for pain, the main indications for DBS have been movement disorders. Despite its wide appeal and "perceived" advantage, United States Food and Drug Administration, the nodal agency for approving therapies, has been cautious and guarded in providing approvals. Only two indications, i.e., Parkinson's disease and tremors, have been approved; the two other indications, i.e., dystonia and obsessive compulsive disorder (OCD), have been granted exemption under the humanitarian device usage. However, the European community has been more liberal and several of these indications have CE (Conformite Europeene) approval. Most of them will be reviewed in this article. There have been numerous indications for which DBS has been applied, which in turn has helped to change the lives of several patients. Unfortunately, due to the paucity of the number of procedures performed and the inherent difficulty in conducting "surgical" double blind randomized trials, Class 1 or Class 2 evidence for several of these indications is lacking. Hence, it is advisable that one does not embark on using each and any target for each and any indication without having the understanding or the team backup. It is cautionary that most of these therapies should be conducted in an institutional setting with an ethics and scientific committee backup and ably assisted by an experienced team.
    Mesh-Begriff(e) Deep Brain Stimulation/methods ; Dystonia/therapy ; Humans ; Movement Disorders/therapy ; Obsessive-Compulsive Disorder/therapy ; Tremor/therapy
    Sprache Englisch
    Erscheinungsdatum 2018-03-13
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.226450
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  7. Artikel ; Online: Mania Induced by Stimulation following DBS of the Bed Nucleus of Stria Terminalis for Obsessive-Compulsive Disorder.

    Doshi, Paresh K

    Stereotactic and functional neurosurgery

    2016  Band 94, Heft 5, Seite(n) 326

    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 645069-6
    ISSN 1423-0372 ; 1011-6125
    ISSN (online) 1423-0372
    ISSN 1011-6125
    DOI 10.1159/000449066
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  8. Artikel ; Online: Surgical and Hardware Complications of Deep Brain Stimulation-A Single Surgeon Experience of 519 Cases Over 20 Years.

    Doshi, Paresh K / Rai, Neha / Das, Deepak

    Neuromodulation : journal of the International Neuromodulation Society

    2022  Band 25, Heft 6, Seite(n) 895–903

    Abstract: Objective: Deep brain stimulation (DBS) surgery has its own set of risks and complications. This study from a single center and a single surgeon analyzes various risk factors for complications and tries to establish if there is a learning curve effect ... ...

    Abstract Objective: Deep brain stimulation (DBS) surgery has its own set of risks and complications. This study from a single center and a single surgeon analyzes various risk factors for complications and tries to establish if there is a learning curve effect in minimizing the complications.
    Materials and methods: A retrospective analysis of 519 patients (1024 leads) who underwent DBS surgery and 232 patients who underwent implantable pulse generator replacement (IPG), by a single surgeon, between the years 1999 and 2019 was performed. Perioperative and hardware related complications were evaluated.
    Results: The follow-up period ranged from six months to 20 years. Surgery-related complications occurred in 46 (8.9%) cases which included confusion in 31 (5.98%), intracerebral hemorrhage in 7 (1.3%), vasovagal attack in 3 (0.58%), respiratory distress in 2 (0.38%), postoperative aggressiveness in 1 (0.19%), and blepharospasm in 2 (0.38%) patients. Complications related to the DBS hardware were found in 35 cases, including erosion and infection in 22 (2.95%), inaccurate lead placement or migration in 6 (0.6%) lead fracture/extension wire failure in 2 (0.26%), IPG malfunction in 2 (0.26%), and hardware discomfort in 3 (0.4%) cases. In three patients, one lead was repositioned. In cases of infection, 87% of patients had either partial or complete removal of hardware. There was no mortality. The complications were analyzed for every 100 DBS procedures. There was a significant drop in the percentage of complications in from 23% in the first 100 cases to 7% in the last 100 cases (p < 0.0001).
    Conclusion: Confusion remains the most frequent operative and perioperative complication. Erosion and infection of the surgical site represents the most frequent hardware complication. DBS surgery is safe and the complication rates are acceptably low. The complication rate also decreases with cumulative years of experience, demonstrating a learning curve effect.
    Mesh-Begriff(e) Deep Brain Stimulation/adverse effects ; Deep Brain Stimulation/methods ; Electrodes, Implanted/adverse effects ; Humans ; Retrospective Studies ; Surgeons
    Sprache Englisch
    Erscheinungsdatum 2022-02-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1500372-3
    ISSN 1525-1403 ; 1094-7159
    ISSN (online) 1525-1403
    ISSN 1094-7159
    DOI 10.1111/ner.13360
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  9. Artikel ; Online: Deep Brain Stimulation for Parkinson's Disease: Currents Status and Emerging Concepts.

    Doshi, Paresh K / Das, Deepak

    Neurology India

    2020  Band 68, Heft Supplement, Seite(n) S179–S186

    Abstract: The clinical application of DBS has become manifold and there has been a tremendous growth in DBS technology in the last few decades making it safer and user friendly. The earlier concept of its delayed application in motor fluctuations of Parkinson's ... ...

    Abstract The clinical application of DBS has become manifold and there has been a tremendous growth in DBS technology in the last few decades making it safer and user friendly. The earlier concept of its delayed application in motor fluctuations of Parkinson's disease has been replaced by Class-I evidence of EARLY-STIM trial in 2013, leading to its FDA approval to be used in early-stage despite criticism. Various studies have provided evidence of beneficial effects of bilateral STN-DBS on both motor as well as nonmotor symptoms and different new targets such as the pedunculopontine nucleus, posterior subthalamic area or caudal zona incerta, centromedian-parafascicular complex, and substantia nigra pars reticulata have now become a new area of interest in addition to the subthalamic nucleus and globus pallidus internus for the alleviation of both motor and nonmotor symptoms of Parkinson's disease. New data has confirmed that the DBS is clinically as effective and safe in elderly patients as it is in younger ones. Technological advances like current steering, directional leads, and closed-loop DBS are directed towards reducing the stimulation-induced adverse effects and preservation of the battery life for a longer period. Results of the long-term efficacy of DBS on Parkinson's disease are now available. These have shown that as the motor benefit continues, the clinical progression of Parkinson's disease also continues. We plan to discuss all these in this paper.
    Mesh-Begriff(e) Aged ; Deep Brain Stimulation ; Globus Pallidus ; Humans ; Parkinson Disease/therapy ; Subthalamic Nucleus
    Sprache Englisch
    Erscheinungsdatum 2020-12-13
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.302466
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  10. Artikel ; Online: Globus Pallidus Internal Deep-Brain Stimulation in a Patient with Neuroacanthocytosis with Drug-Induced Parkinsonism.

    Doshi, Paresh / Chamankar, Nikhil

    Stereotactic and functional neurosurgery

    2018  Band 96, Heft 4, Seite(n) 276

    Sprache Englisch
    Erscheinungsdatum 2018-08-28
    Erscheinungsland Switzerland
    Dokumenttyp Letter
    ZDB-ID 645069-6
    ISSN 1423-0372 ; 1011-6125
    ISSN (online) 1423-0372
    ISSN 1011-6125
    DOI 10.1159/000492234
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