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  1. Article: Reidentification of cellulolytic enzyme-producing Trichoderma strains W-10 and G-39.

    Lee, Ching-Fu / Liu, Daniel Yuen Teh / Lai, Ming Tsong / Hseu, Tzong-Hsiung

    Canadian journal of microbiology

    2006  Volume 52, Issue 6, Page(s) 570–574

    Abstract: Strain W-10, originally identified as Trichoderma koningii, and its supposed mutant G-39, published ... All the molecular characteristics showed that strains G-39 and W-10 were identical to T. reesei and T ... longibrachiatum, respectively. The results strongly supported that T. koningii G-39 and W-10 should be reassigned ...

    Abstract Strain W-10, originally identified as Trichoderma koningii, and its supposed mutant G-39, published for production and gene expression of cellulase and xylanase, demonstrated morphological characteristics distinct from those of T. koningii, respectively. To clarify the identification derived from morphological characteristics, several methods were used, including electrophoretic karyotyping, internal transcribed spacer (ITS) analysis of rDNA, and polymerase chain reaction (PCR) fingerprinting using the universal primer L45. All the molecular characteristics showed that strains G-39 and W-10 were identical to T. reesei and T. longibrachiatum, respectively. The results strongly supported that T. koningii G-39 and W-10 should be reassigned as T. reesei and T. longibrachiatum, respectively. Strain G-39 should be considered a mutant from T. reesei QM9414 whose spores were contaminated with those of strain W-10 during a laboratory operation. According to this, we declare that T. koningii G-39 and W-10 must be renamed as T. reesei and T. longibrachiatum, respectively.
    MeSH term(s) Cellulase/biosynthesis ; Cellulase/metabolism ; DNA, Fungal/genetics ; DNA, Ribosomal/genetics ; DNA, Ribosomal Spacer/genetics ; Electrophoresis/methods ; Mycological Typing Techniques ; Phylogeny ; Polymerase Chain Reaction/methods ; Species Specificity ; Trichoderma/classification ; Trichoderma/enzymology ; Trichoderma/genetics ; Xylosidases/metabolism
    Chemical Substances DNA, Fungal ; DNA, Ribosomal ; DNA, Ribosomal Spacer ; Xylosidases (EC 3.2.1.-) ; Cellulase (EC 3.2.1.4)
    Language English
    Publishing date 2006-06
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 280534-0
    ISSN 1480-3275 ; 0008-4166
    ISSN (online) 1480-3275
    ISSN 0008-4166
    DOI 10.1139/w06-006
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  2. Article ; Online: Associations between gendered racism, racial identity, and nicotine use among Asian American men.

    Le, Thomas P / Iwamoto, Derek K / Ching, Terence H W

    Journal of clinical psychology

    2024  

    Abstract: ... should continue to examine other culturally relevant and/or potentially protective constructs (e.g., on the basis ...

    Abstract Objectives: The present study utilized an intersectional framework to examine if two forms of gendered racism, psychological emasculation and messages about Asian American men being undesirable partners, were associated with Asian American men's nicotine use. We also examined the potential mediating roles of two racial identity statuses, racial conformity and racial immersion.
    Methods: A sample of 356 Asian American men living in the United States of America (USA) completed a cross-sectional survey via Qualtrics containing measures assessing the aforementioned constructs of interest. The primary analysis examined separate parallel mediation models, situating psychological emasculation and undesirable partner as separate independent variables, racial conformity and racial immersion as parallel mediators, nicotine use as the outcome, and age and employment as covariates.
    Results: In separate parallel mediation models, the links between psychological emasculation and undesirable partner on one hand, and nicotine use on the other, were completely mediated only by racial conformity, and not significantly mediated by racial immersion. Specifically, greater endorsement of gendered racism was associated with greater conformity with (and internalization of) these gendered racist beliefs, which in turn were associated with greater nicotine use.
    Conclusion: Researchers and practitioners may consider racial conformity as an interventional target to ameliorate Asian American men's nicotine use. Future studies should continue to examine other culturally relevant and/or potentially protective constructs (e.g., on the basis of gender, race, and its intersection) that may mitigate Asian American men's nicotine use.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219160-x
    ISSN 1097-4679 ; 0021-9762
    ISSN (online) 1097-4679
    ISSN 0021-9762
    DOI 10.1002/jclp.23681
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  3. Article ; Online: Evaluation of present-day extreme precipitation over the United States

    Akinsanola A A / Kooperman G J / Hannah W M / Reed K A / Pendergrass A G / Hsu Wei-Ching

    Environmental Research: Climate, Vol 3, Iss 1, p

    an inter-comparison of convection and dynamic permitting configurations of E3SMv1

    2023  Volume 011002

    Abstract: Accurate simulation of the present-day characteristics of mean and extreme precipitation at regional scales remains a challenge for Earth system models, which is due in part to deficiencies in model physics such as convective parameterization (CP), and ... ...

    Abstract Accurate simulation of the present-day characteristics of mean and extreme precipitation at regional scales remains a challenge for Earth system models, which is due in part to deficiencies in model physics such as convective parameterization (CP), and coarse resolution. High horizontal resolution (HR, ∼25 km) and multiscale modeling framework (MMF, i.e. replacing conventional CP with embedded km-scale cloud-resolving models) are two promising directions that could help improve the interaction between subgrid-scale physical processes and large-scale climate. Here, we evaluate simulated extreme precipitation over the United States (US) across three configurations (i.e. low-resolution [LR], HR, and MMF) of the Energy Exascale Earth System Model (E3SMv1) and intercompare them against two gridded observation datasets (climate prediction center daily US precipitation and integrated multi-satellite retrievals for global precipitation measurement). We assess the model’s ability to simulate very heavy seasonal precipitation (illustrated by the difference between the 99th and 90th percentile values) as well as the spatial distributions of several extreme precipitation indices defined by the expert team on climate change detection and indices. Our results show that both the dry (i.e. consecutive dry days (CDD)) and wet (i.e. consecutive wet days, maximum 5 day precipitation, and very wet days) extremes evaluated herein show some improvement as well as degradation with MMF and HR relative to LR. These results vary across seasons and US subregions. For instance, only the very heavy precipitation of winter is improved with MMF and HR. Both configurations alleviate the well-known drizzling bias evident in LR across both winter and summer in many parts of the US, largely due to the overall improvement in intensity and frequency of precipitation. Additionally, our results suggest that while E3SMv1-MMF has higher intensity rates when it does rain, it has too many CDD during the summer, contributing to a low mean precipitation ...
    Keywords Earth system model ; ETCCDI ; extreme events ; model evaluation ; precipitation extremes ; E3SM ; Meteorology. Climatology ; QC851-999 ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher IOP Publishing
    Document type Article ; Online
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  4. Article ; Online: Impact of Adherence to Operative Standards and Stage-Specific Guideline-Recommended Therapy in Nonmetastatic Pancreatic Adenocarcinoma.

    Spitzer, Holly V / Kemp Bohan, Phillip M / Carpenter, Elizabeth L / Adams, Alexandra M / Chang, Shu-Ching / Grunkemeier, Gary / Vreeland, Timothy J / Tzeng, Ching-Wei D / Katz, Matthew H G / Nelson, Daniel W

    Annals of surgical oncology

    2023  Volume 30, Issue 11, Page(s) 6662–6670

    Abstract: Background: Achieving optimal surgical outcomes in pancreatic adenocarcinoma requires a combination of both curative-intent resection to oncologic standards and stage-specific neoadjuvant or adjuvant therapy. This investigation sought to examine factors ...

    Abstract Background: Achieving optimal surgical outcomes in pancreatic adenocarcinoma requires a combination of both curative-intent resection to oncologic standards and stage-specific neoadjuvant or adjuvant therapy. This investigation sought to examine factors associated with receipt of standard-adherent surgery (SAS) and guideline-recommended therapy (GRT) and determine the impact of compliance on patient survival.
    Patients and methods: From the 2006-2016 National Cancer Database, 21,304 patients underwent resection for nonmetastatic pancreatic adenocarcinoma. SAS was defined as pancreatic resection with negative margins and ≥ 15 lymph nodes examined. Stage-specific GRT was defined by current National Comprehensive Cancer Network guidelines. Multivariable models were used to determine predictors of adherence to SAS and GRT and prognostic impact on overall survival.
    Results: Overall, SAS was achieved in 39% and GRT in 65% of patients, but only 30% received both SAS and GRT. Increasing age, minority race, uninsured status, and greater comorbidities were associated with a decreased odds of receiving both SAS and GRT (all p < 0.05). SAS (HR 0.79; CI 0.76-0.81; p < 0.001) and GRT (HR 0.67; CI 0.65-0.69; p < 0.001) were each independently associated with a survival advantage. Receipt of both SAS and GRT was associated with significant improvement in median OS compared with receiving neither (2.2 years vs 1.1 years; p < 0.001) which was independently associated with a 78% increased risk of death (HR 1.78; CI 1.70-1.86; p < 0.001).
    Conclusions: Despite survival benefits associated with adherence to operative standards and receipt of guideline-recommended therapy, compliance remains poor. Future efforts must be directed toward improved education and implementation efforts around both operative standards and therapy guidelines.
    MeSH term(s) Humans ; Adenocarcinoma/surgery ; Adenocarcinoma/drug therapy ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/drug therapy ; Combined Modality Therapy ; Prognosis ; Retrospective Studies ; Chemotherapy, Adjuvant ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13758-z
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  5. Article ; Online: Trends Over Time in Recurrence Patterns and Survival Outcomes after Neoadjuvant Therapy and Surgery for Pancreatic Cancer.

    Cass, Samuel H / Tzeng, Ching-Wei D / Prakash, Laura R / Maxwell, Jessica / Snyder, Rebecca A / Kim, Michael P / Huey, Ryan W / Smaglo, Brandon G / Pant, Shubham / Koay, Eugene J / Wolff, Robert A / Lee, Jeffery E / Katz, Matthew H G / Ikoma, Naruhiko

    Annals of surgery

    2024  

    Abstract: Objective: We aimed to determine if advances in neoadjuvant therapy affected recurrence patterns and survival outcomes after pancreatectomy for pancreatic ductal adenocarcinoma (PDAC).: Background: Data are limited on how modern multimodality therapy ...

    Abstract Objective: We aimed to determine if advances in neoadjuvant therapy affected recurrence patterns and survival outcomes after pancreatectomy for pancreatic ductal adenocarcinoma (PDAC).
    Background: Data are limited on how modern multimodality therapy affects PDAC recurrence and post-recurrence survival.
    Methods: Patients who received neoadjuvant therapy followed by curative-intent pancreatectomy for PDAC during 1998-2018 were identified. Treatments, recurrence sites and timing, and survival were compared between patients who completed neoadjuvant therapy and pancreatectomy in 1998-2004, 2005-2011, and 2012-2018.
    Results: The study included 727 patients (203, 251, and 273 in the 1998-2004, 2005-2011, and 2012-2018 cohorts, respectively). Use of neoadjuvant induction chemotherapy increased over time, and regimens changed over time, with >80% of patients treated in 2012-2018 receiving FOLFIRINOX or gemcitabine with nab-paclitaxel. Overall, recurrence sites and incidence (67.5%, 66.1%, and 65.9%) remained stable, and 85% of recurrences occurred within 2 years of surgery. However, compared to earlier cohorts, the 2012-2018 cohort had lower conditional risk of recurrence in postoperative year 1 and higher risk in postoperative year 2. Overall survival increased over time (median, 30.6, 33.6, and 48.7 mo, P < 0.005), driven by improved post-recurrence overall survival (median, 7.8, 12.5, and 12.6 mo; 3-year rate, 7%, 10%, and 20%; P < 0.005).
    Conclusions: We observed changes in neoadjuvant therapy regimens over time and an associated shift in the conditional risk of recurrence from postoperative year 1 to postoperative year 2, although recurrence remained common. Overall survival and post-recurrence survival remarkably improved over time, reflecting improved multimodality regimens for recurrent disease.
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006269
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  6. Article ; Online: Control-theoretic integration of stimulation and electrophysiology for cognitive enhancement.

    Singh, Matthew F / Cole, Michael W / Braver, Todd S / Ching, ShiNung

    Frontiers in neuroimaging

    2022  Volume 1, Page(s) 982288

    Abstract: ... shaping how the brain reacts to potential "inputs" (e.g., task contexts) rather than enforcing a fixed ...

    Abstract Transcranial electrical stimulation (tES) technology and neuroimaging are increasingly coupled in basic and applied science. This synergy has enabled individualized tES therapy and facilitated causal inferences in functional neuroimaging. However, traditional tES paradigms have been stymied by relatively small changes in neural activity and high inter-subject variability in cognitive effects. In this perspective, we propose a tES framework to treat these issues which is grounded in dynamical systems and control theory. The proposed paradigm involves a tight coupling of tES and neuroimaging in which M/EEG is used to parameterize generative brain models as well as control tES delivery in a hybrid closed-loop fashion. We also present a novel quantitative framework for cognitive enhancement driven by a new computational objective: shaping how the brain reacts to potential "inputs" (e.g., task contexts) rather than enforcing a fixed pattern of brain activity.
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3123824-5
    ISSN 2813-1193 ; 2813-1193
    ISSN (online) 2813-1193
    ISSN 2813-1193
    DOI 10.3389/fnimg.2022.982288
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  7. Article ; Online: Does Caudate Resection Improve Outcomes of Patients Undergoing Curative Resection for Perihilar Cholangiocarcinoma? A Systematic Review and Meta-Analysis.

    Gilbert, Richard W D / Lenet, Tori / Cleary, Sean P / Smoot, Rory / Tzeng, Ching-Wei D / Rocha, Flavio G / Martel, Guillaume / Bertens, Kimberly A

    Annals of surgical oncology

    2022  Volume 29, Issue 11, Page(s) 6759–6771

    Abstract: Background: Margin-negative (R0) resection is the strongest positive prognostic factor in perihilar cholangiocarcinoma (PHC). Due to its anatomic location, the caudate lobe is frequently involved in PHC. This review aimed to examine the impact of ... ...

    Abstract Background: Margin-negative (R0) resection is the strongest positive prognostic factor in perihilar cholangiocarcinoma (PHC). Due to its anatomic location, the caudate lobe is frequently involved in PHC. This review aimed to examine the impact of caudate lobe resection (CLR) in addition to hepatectomy and bile duct resection for patients with PHC.
    Methods: The MEDLINE, EMBASE, and Cochrane databases were systematically reviewed from inception to October 2021 to identify studies comparing patients undergoing surgical resection with hepatectomy and bile duct resection with or without CLR for treatment of PHC. Outcomes included the proportion of patients achieving R0 resection, overall survival (OS), and perioperative morbidity.
    Results: Altogether, 949 studies were screened. The review included eight observational studies reporting on 1137 patients. The patients who underwent CLR had a higher likelihood of R0 resection (odds ratio [OR], 5.85; 95% confidence interval [CI], 2.64-12.95) and a better OS (hazard ratio [HR], 0.65; 95% CI, 0.54-0.79) than those who did not. The use of CLR did not increase the risk of perioperative morbidity (OR, 1.03; 95% CI, 0.65-1.63).
    Conclusions: Given the higher likelihood of R0 resection, improved OS, and no apparent increase in perioperative morbidity, this review supports routine caudate lobectomy in the surgical management of PHC. These results should be interpreted with caution given the lack of high-quality prospective data and the high probability of selection bias.
    MeSH term(s) Bile Duct Neoplasms/pathology ; Cholangiocarcinoma/surgery ; Hepatectomy ; Humans ; Klatskin Tumor/pathology ; Margins of Excision ; Prospective Studies ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-11990-7
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  8. Article ; Online: Retraction

    Guan-Wei Lin / Ching Hung

    Applied Sciences, Vol 11, Iss 3, p

    Lin, G.-W., et al. Reconstructing the Dynamic Processes of the Taimali Landslide in Taiwan Using the Waveform Inversion Method. Appl. Sci. 2020, 10 , 5872

    2021  Volume 1192

    Abstract: The authors and journal retract the article, “Reconstructing the Dynamic Processes of the Taimali Landslide in Taiwan Using the Waveform Inversion Method” [.] ...

    Abstract The authors and journal retract the article, “Reconstructing the Dynamic Processes of the Taimali Landslide in Taiwan Using the Waveform Inversion Method” [.]
    Keywords n/a ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Article ; Online: Robotic upper tract surgery in infants 6 months or less: is there enough space?

    Carsel, Alex J / DaJusta, Daniel G / Ching, Christina B / McLeod, Daryl J / Smith, Jennifer / Fuchs, Molly E / Rehfuss, Alexandra W

    Journal of robotic surgery

    2021  Volume 16, Issue 1, Page(s) 193–197

    Abstract: Robot-assisted laparoscopic surgery (RALS) has recently been described in children < 1 year old. However, little data exist on robotic utilization in infants ≤ 6 months old, likely due to concerns for limited intraabdominal space and decreased distance ... ...

    Abstract Robot-assisted laparoscopic surgery (RALS) has recently been described in children < 1 year old. However, little data exist on robotic utilization in infants ≤ 6 months old, likely due to concerns for limited intraabdominal space and decreased distance between ports in this cohort. We hypothesized that the robotic approach can be successfully used for infants ≤ 6 months old. A prospectively collected database of patients undergoing urologic robotic surgery at our institution was reviewed. Patients ≤ 6 months and ≥ 4 kg were included. Patient demographics, intraoperative details, hospital length of stay, and complications were reviewed. Descriptive statistics were performed. Twelve patients ≤ 6 months old underwent urologic robotic surgery by three surgeons at our institution (2013-2019): pyeloplasty (6), ureteroureterostomy (4), heminephrectomy (1), and nephrectomy (1). Median age at surgery was 4.75 months (IQR 4, 6). Median weight was 7.09 kg (IQR 6.33, 7.78). Median console time was 105 min (IQR 86, 123). For all procedures, 8-mm robotic arm ports were used. No procedures were converted to open. Median post-operative hospital stay was 24 h (IQR). Febrile UTI was the only complication occurring within 30 days of surgery (n = 4, 33%; 7-20 days, Clavien grade 2). For those undergoing pyeloplasty or ureteroureterostomy (n = 10), postoperative ultrasound showed improved (n = 9) or stable hydronephrosis (n = 1). At a median follow-up of 19.73 months (IQR 4.27, 38.32), no patient required an unplanned secondary intervention. Robotic upper urinary tract surgery is feasible and safe in patients ≤ 6 months of age and can be performed successfully with the same technique as for older children.
    MeSH term(s) Adolescent ; Child ; Humans ; Infant ; Kidney Pelvis/surgery ; Laparoscopy/methods ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Treatment Outcome ; Ureteral Obstruction/surgery ; Urologic Surgical Procedures/methods
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-021-01231-6
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  10. Article ; Online: Case report: Zika surveillance complemented with wastewater and mosquito testing.

    Wong, Judith Chui Ching / Tay, Martin / Hapuarachchi, Hapuarachchige Chanditha / Lee, Benjamin / Yeo, Gladys / Maliki, Dzulkhairul / Lee, Winston / Mohamed Suhaimi, Nur-Afidah / Chio, Kaiyun / Tan, Wilson Cheong Huat / Ng, Lee Ching

    EBioMedicine

    2024  Volume 101, Page(s) 105020

    Abstract: Background: In June 2023, a local cluster of 15 Zika cases was reported in a neighbourhood in Northeastern Singapore. The last significant local transmission of Zika virus (ZIKV) with more than 450 cases was in 2016-2017. To monitor the situation and ... ...

    Abstract Background: In June 2023, a local cluster of 15 Zika cases was reported in a neighbourhood in Northeastern Singapore. The last significant local transmission of Zika virus (ZIKV) with more than 450 cases was in 2016-2017. To monitor the situation and mitigate further transmission, case, entomological and wastewater-based surveillance were carried out.
    Methods: Primary healthcare practitioners and the community were alerted to encourage timely case identification. Surveillance was enhanced through testing of Aedes mosquitoes collected from the National Gravitrap surveillance system, and wastewater samples were collected from a network of autosamplers deployed at manholes across the country.
    Findings: ZIKV RNA was detected in mosquito pools (3/43; 7%) and individual mosquitoes (3/82; 3.7%) captured, and in wastewater samples (13/503) collected from the vicinity of the cluster of cases. Respective samples collected from other sites across the country were negative. The peak detection of ZIKV RNA in mosquitoes and wastewater coincided temporally with the peak in the number of cases in the area (15-25 May 2023).
    Interpretation: The restriction of ZIKV signals from wastewater and mosquitoes within the neighbourhood suggested limited ZIKV transmission. The subsequent waning of signals suggested effectiveness of control measures. We demonstrate the utility of wastewater-based surveillance of ZIKV, which complements existing case- and entomological-based surveillance. The non-intrusive approach is particularly useful to monitor diseases such as Zika, which generally causes silent or mild infections, but may cause severe outcomes such as congenital Zika syndrome.
    Funding: This study was funded by Singapore's Ministry of Finance and the National Environment Agency, Singapore.
    MeSH term(s) Animals ; Humans ; Zika Virus/genetics ; Zika Virus Infection/diagnosis ; Zika Virus Infection/epidemiology ; Wastewater ; Mosquito Vectors ; Aedes ; RNA
    Chemical Substances Wastewater ; RNA (63231-63-0)
    Language English
    Publishing date 2024-02-21
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2024.105020
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