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  1. Book ; Online: Diabetes and Heart Failure: Pathogenesis and Novel Therapeutic Approaches

    Sardu, Celestino / de Lucia, Claudio / Metzinger, Laurent / Zuurbier, Coert J.

    2019  

    Keywords Science: general issues ; Physiology ; diabetes ; Heart Failure ; diastolic dysfunction ; arrhythmia ; SGLT2 (sodium-glucose cotransporter 2) inhibitor ; GLP-1 - glucagon-like peptide-1
    Size 1 electronic resource (122 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229849
    ISBN 9782889458516 ; 2889458512
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: COVID-19 and Its Cardiovascular Effects: Risk Factors, Prevention and Management.

    Sardu, Celestino / Marfella, Raffele

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by a positive-stranded, single-stranded RNA virus, which is a member of the Sarbecovirus subgenus (beta-CoV lineage B) [ ... ]. ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by a positive-stranded, single-stranded RNA virus, which is a member of the Sarbecovirus subgenus (beta-CoV lineage B) [...].
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and Its Cardiovascular Effects

    Celestino Sardu / Raffele Marfella

    Journal of Clinical Medicine, Vol 12, Iss 4457, p

    Risk Factors, Prevention and Management

    2023  Volume 4457

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by a positive-stranded, single-stranded RNA virus, which is a member of the Sarbecovirus subgenus (beta-CoV lineage B) [.] ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by a positive-stranded, single-stranded RNA virus, which is a member of the Sarbecovirus subgenus (beta-CoV lineage B) [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article: Editorial: Influence of lifestyle factors in the management of diabetes mellitus.

    Sardu, Celestino / Santulli, Gaetano / D' Onofrio, Nunzia

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1258766

    MeSH term(s) Humans ; Diabetes Mellitus/therapy ; Life Style
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1258766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Continuous flow left ventricular assist devices and cardiac resynchronization: Friends or foe?

    Sardu, Celestino / Amarelli, Cristiano

    International journal of cardiology

    2021  Volume 344, Page(s) 138–139

    MeSH term(s) Cardiac Resynchronization Therapy ; Echocardiography ; Heart Failure/diagnosis ; Heart Failure/therapy ; Heart-Assist Devices/adverse effects ; Humans ; Treatment Outcome ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2021-10-04
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2021.09.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
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  6. Article ; Online: Impact of Sex Differences in Incident and Recurrent Coronary Events and All-Cause Mortality.

    Sardu, Celestino / Paolisso, Giuseppe / Marfella, Raffaele

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 6, Page(s) 829–830

    MeSH term(s) Cause of Death ; Female ; Humans ; Male ; Myocardial Infarction ; Sex Characteristics
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.10.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  7. Article ; Online: Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease.

    Martino, Elisa / D'Onofrio, Nunzia / Balestrieri, Anna / Colloca, Antonino / Anastasio, Camilla / Sardu, Celestino / Marfella, Raffaele / Campanile, Giuseppe / Balestrieri, Maria Luisa

    Nutrients

    2024  Volume 16, Issue 1

    Abstract: In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into the circulatory system and organs of recipients, especially humans, and potentially contribute to modulating health and diseases. Evidence suggests that ... ...

    Abstract In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into the circulatory system and organs of recipients, especially humans, and potentially contribute to modulating health and diseases. Evidence suggests that food uptake, by carrying exogenous miRNAs (xenomiRNAs), regulates the individual miRNA profile, modifying the redox homeostasis and inflammatory conditions underlying pathological processes, such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, and cancer. The capacity of diet to control miRNA levels and the comprehension of the unique characteristics of dietary miRNAs in terms of gene expression regulation show important perspectives as a strategy to control disease susceptibility via epigenetic modifications and refine the clinical outcomes. However, the absorption, stability, availability, and epigenetic roles of dietary miRNAs are intriguing and currently the subject of intense debate; additionally, there is restricted knowledge of their physiological and potential side effects. Within this framework, we provided up-to-date and comprehensive knowledge on dietary miRNAs' potential, discussing the latest advances and controversial issues related to the role of miRNAs in human health and disease as modulators of chronic syndromes.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/genetics ; Nutritional Status ; Diet ; Epigenesis, Genetic ; MicroRNAs/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16010160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19.

    Matarese, Alessandro / Gambardella, Jessica / Sardu, Celestino / Santulli, Gaetano

    Biomedicines

    2020  Volume 8, Issue 11

    Abstract: The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Here, we focused on the study of microRNAs ... ...

    Abstract The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Here, we focused on the study of microRNAs that specifically target TMPRSS2. Through a bioinformatic approach, we identified miR-98-5p as a suitable candidate. Since we and others have shown that endothelial cells play a pivotal role in the pathogenesis of the coronavirus disease 2019 (COVID-19), we mechanistically validated miR-98-5p as a regulator of TMPRSS2 transcription in two different human endothelial cell types, derived from the lung and from the umbilical vein. Taken together, our findings indicate that TMPRSS2 represents a valid target in COVID-19 treatment, which may be achieved by specific non-coding-RNA approaches.
    Keywords covid19
    Language English
    Publishing date 2020-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines8110462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evidence for human diabetic cardiomyopathy.

    Marfella, Raffaele / Sardu, Celestino / Mansueto, Gelsomina / Napoli, Claudio / Paolisso, Giuseppe

    Acta diabetologica

    2021  Volume 58, Issue 8, Page(s) 983–988

    Abstract: Growing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate ... ...

    Abstract Growing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate the detrimental effects both of hyperglycemia and insulin resistance, a lot of preclinical models were developed. However, the evidence of pathogenic and histological alterations of the so-called diabetic cardiomyopathy (DCM) is still poorly understood in humans. Here, we provide a stringent literature analysis to investigate unique data regarding human DCM. This approach established that lipotoxic-related events might play a central role in the initiation and progression of human DCM. The major limitation in the acquisition of human data is due to the fact of heart specimen availability. Postmortem analysis revealed the end stage of the disease; thus, we need to gain knowledge on the pathogenic events from the early stages until cardiac fibrosis underlying the end-stage HF.
    MeSH term(s) Diabetes Mellitus ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/pathology ; Diabetic Cardiomyopathies/physiopathology ; Disease Progression ; Heart/physiopathology ; Heart Failure/epidemiology ; Humans ; Hyperglycemia/complications ; Insulin Resistance/physiology ; Myocardium/pathology
    Language English
    Publishing date 2021-03-31
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-021-01705-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 611: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Inflammatory Related Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Targets.

    Sardu, Celestino / Paolisso, Giuseppe / Marfella, Raffaele

    Current pharmaceutical design

    2020  Volume 26, Issue 22, Page(s) 2565–2573

    Abstract: Inflammation is a pathogenic response to multiple factors, that causes over-activation of different molecules and pro-inflammatory cellular lines. Different behavioral factors and risk factors might enhance the inflammatory stress, and this might cause ... ...

    Abstract Inflammation is a pathogenic response to multiple factors, that causes over-activation of different molecules and pro-inflammatory cellular lines. Different behavioral factors and risk factors might enhance the inflammatory stress, and this might cause cardiovascular disease (CVD). CVD is the world's leading cause of morbidity and mortality, and it is represented by hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease and cardiomyopathies. In this context, inflammation is both a cause and an aggravating factor in CVD, as well as a mediator of its worst prognostic. The mechanisms that link inflammation to CVD are multiple, complex and multi-factorial. To date, the role of inflammation in the genesis and progression of CVD has been extensively analyzed in recent studies. However, in the last decades, new biomarkers are joining the already known inflammatory biomarkers, such as Creactive protein, interleukins, tumor necrosis factor alpha and nitrotyrosine. Among these new biomarkers, we have to report sirtuins, microRNAs, ST2 protein, apolipoprotein E protein, adiponectin, and others. These biomarkers are preferentially expressed locally in the target tissue of inflammation, but also released in peripheral blood and then used as diagnostic and prognostic biomarkers. Indeed, these biomarkers might also predict future adverse cardiovascular events and worse prognosis in patients with CVD. Furthermore, these new inflammatory biomarkers can also be analyzed to evaluate therapeutic efficacy in patients with CVD. Furthermore, this might open up new fields and interesting research concerning the link between inflammation and CVD.
    MeSH term(s) Biomarkers ; Cardiovascular Diseases/drug therapy ; Humans ; Inflammation ; MicroRNAs ; Risk Factors
    Chemical Substances Biomarkers ; MicroRNAs
    Language English
    Publishing date 2020-02-13
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612826666200213123029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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