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  1. Article: [Regulation of kidney on potassium balance and its clinical significance].

    Xie, Qiong-Hong / Hao, Chuan-Ming

    Sheng li xue bao : [Acta physiologica Sinica

    2023  Volume 75, Issue 2, Page(s) 216–230

    Abstract: Virtually all of the dietary potassium intake is absorbed in the intestine, over 90% of which is excreted by the kidneys regarded as the most important organ of potassium excretion in the body. The renal excretion of potassium results primarily from the ... ...

    Abstract Virtually all of the dietary potassium intake is absorbed in the intestine, over 90% of which is excreted by the kidneys regarded as the most important organ of potassium excretion in the body. The renal excretion of potassium results primarily from the secretion of potassium by the principal cells in the aldosterone-sensitive distal nephron (ASDN), which is coupled to the reabsorption of Na
    MeSH term(s) Humans ; Bartter Syndrome/genetics ; Bartter Syndrome/metabolism ; Pseudohypoaldosteronism/genetics ; Pseudohypoaldosteronism/metabolism ; Potassium/metabolism ; Aldosterone/metabolism ; Hypokalemia/metabolism ; Gitelman Syndrome/metabolism ; Hyperkalemia/metabolism ; Clinical Relevance ; Epithelial Sodium Channels/genetics ; Epithelial Sodium Channels/metabolism ; Kidney Tubules, Distal/metabolism ; Sodium/metabolism ; Hypertension ; Alkalosis/metabolism ; Water/metabolism ; Kidney/metabolism
    Chemical Substances Potassium (RWP5GA015D) ; Aldosterone (4964P6T9RB) ; Epithelial Sodium Channels ; Sodium (9NEZ333N27) ; Water (059QF0KO0R)
    Language Chinese
    Publishing date 2023-04-24
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Updates on Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in the Treatment of Renal Anemia

    Jing Li / Volker H. Haase / Chuan-Ming Hao

    Kidney Diseases (2022)

    2022  

    Abstract: Background: Anemia is a common complication of chronic kidney disease. The hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) is a new class of oral drugs for the treatment of renal anemia. Summary: Clinical trials have consistently shown ... ...

    Abstract Background: Anemia is a common complication of chronic kidney disease. The hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) is a new class of oral drugs for the treatment of renal anemia. Summary: Clinical trials have consistently shown that HIF-PHIs can effectively increase hemoglobin in both the dialysis population and the nondialysis population. The effects of HIF-PHIs in treating renal anemia include promoting endogenous erythropoietin production and facilitating iron mobilization. Several studies suggest that the erythropoiesis effect of roxadustat is less affected by inflammation. Careful monitoring of thromboembolic events and tumor before and during HIF-PHI treatment is necessary. Key Messages: HIF-PHIs are effective in correcting renal anemia. The long-term safety of HIF-PHIs needs to be further studied.
    Keywords hypoxia-inducible factor ; chronic kidney disease ; anemia ; iron ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Karger Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Rituximab as Initial Therapy in Adult Patients With Minimal Change Disease.

    Guan, Nan / Zhang, Min / Chen, Ruiying / Xie, Qionghong / Hao, Chuan-Ming

    Kidney international reports

    2023  Volume 8, Issue 5, Page(s) 1102–1104

    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.02.1070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Updates on Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in the Treatment of Renal Anemia.

    Li, Jing / Haase, Volker H / Hao, Chuan-Ming

    Kidney diseases (Basel, Switzerland)

    2022  Volume 9, Issue 1, Page(s) 1–11

    Abstract: Background: Anemia is a common complication of chronic kidney disease. The hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) is a new class of oral drugs for the treatment of renal anemia.: Summary: Clinical trials have consistently ... ...

    Abstract Background: Anemia is a common complication of chronic kidney disease. The hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) is a new class of oral drugs for the treatment of renal anemia.
    Summary: Clinical trials have consistently shown that HIF-PHIs can effectively increase hemoglobin in both the dialysis population and the nondialysis population. The effects of HIF-PHIs in treating renal anemia include promoting endogenous erythropoietin production and facilitating iron mobilization. Several studies suggest that the erythropoiesis effect of roxadustat is less affected by inflammation. Careful monitoring of thromboembolic events and tumor before and during HIF-PHI treatment is necessary.
    Key messages: HIF-PHIs are effective in correcting renal anemia. The long-term safety of HIF-PHIs needs to be further studied.
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2817963-8
    ISSN 2296-9357 ; 2296-9381
    ISSN (online) 2296-9357
    ISSN 2296-9381
    DOI 10.1159/000527835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanisms of Scarring in Focal Segmental Glomerulosclerosis

    Ke Sun / Qionghong Xie / Chuan-Ming Hao

    Kidney Diseases, Vol 7, Iss 5, Pp 350-

    2021  Volume 358

    Abstract: Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern characterized by focal glomerular scarring, which often progresses to systemic and diffuse glomerulosclerosis. Previous studies have emphasized that the initiation of classic ... ...

    Abstract Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern characterized by focal glomerular scarring, which often progresses to systemic and diffuse glomerulosclerosis. Previous studies have emphasized that the initiation of classic FSGS occurs in podocytes. The dysfunction and loss of podocytes have been associated with the development of proteinuria and the progression of various diseases. In addition, primary, secondary, and genetic FSGS are caused by different mechanisms of podocyte injury. Summary: The potential sources and mechanism of podocyte supplementation are the focus of our current research. Increasing attention has been paid to the role played by parietal epithelial cells (PECs) during the progression of FSGS. PECs are not only the primary influencing factors in glomerulosclerosis lesions but also have repair abilities, which remain a focus of debate. Notably, other resident glomerular cells also play significant roles in the progression of this disease. Key Message: In this review, we focus on the mechanism of scarring in FSGS and discuss current and potential therapeutic strategies.
    Keywords focal segmental glomerulosclerosis ; podocytes ; parietal epithelial cells ; therapeutic strategies ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Karger Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Mechanisms of Scarring in Focal Segmental Glomerulosclerosis.

    Sun, Ke / Xie, Qionghong / Hao, Chuan-Ming

    Kidney diseases (Basel, Switzerland)

    2021  Volume 7, Issue 5, Page(s) 350–358

    Abstract: Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern characterized by focal glomerular scarring, which often progresses to systemic and diffuse glomerulosclerosis. Previous studies have emphasized that the initiation of classic ... ...

    Abstract Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern characterized by focal glomerular scarring, which often progresses to systemic and diffuse glomerulosclerosis. Previous studies have emphasized that the initiation of classic FSGS occurs in podocytes. The dysfunction and loss of podocytes have been associated with the development of proteinuria and the progression of various diseases. In addition, primary, secondary, and genetic FSGS are caused by different mechanisms of podocyte injury.
    Summary: The potential sources and mechanism of podocyte supplementation are the focus of our current research. Increasing attention has been paid to the role played by parietal epithelial cells (PECs) during the progression of FSGS. PECs are not only the primary influencing factors in glomerulosclerosis lesions but also have repair abilities, which remain a focus of debate. Notably, other resident glomerular cells also play significant roles in the progression of this disease.
    Key message: In this review, we focus on the mechanism of scarring in FSGS and discuss current and potential therapeutic strategies.
    Language English
    Publishing date 2021-07-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2817963-8
    ISSN 2296-9357 ; 2296-9381
    ISSN (online) 2296-9357
    ISSN 2296-9381
    DOI 10.1159/000517108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cyclooxygenase-2 contributes to diabetic nephropathy through glomerular EP4 receptor.

    Guan, Yi / Davis, Linda / Breyer, Matthew D / Hao, Chuan-Ming

    Prostaglandins & other lipid mediators

    2022  Volume 159, Page(s) 106621

    Abstract: Diabetic nephropathy (DN) is a major microvascular complication of diabetes and the leading cause of mortality in diabetic patients. Cyclooxygenase (COX) and COX-derived prostanoids are documented to participate in the pathogenesis of diabetic ... ...

    Abstract Diabetic nephropathy (DN) is a major microvascular complication of diabetes and the leading cause of mortality in diabetic patients. Cyclooxygenase (COX) and COX-derived prostanoids are documented to participate in the pathogenesis of diabetic nephropathy. Herein, we found an increased COX2 expression level in diabetic kidneys of STZ-induced DBA mice. The COX2 inhibitor significantly attenuated albuminuria and histological lesions, accompanied by up-regulation of the renal angiopoietin-1/tie-2 system. This finding is consistent with the presence of an angiogenic signature in endothelial cells during the development of DN. Prostaglandin E2 (PGE2) is the most abundant prostanoid in the kidney, and its receptor EP4 is expressed in the glomerulus, as determined by in situ hybridization. To test the hypothesis that diabetes-associated COX2 overexpression induces renal PGE2 production and endothelial dysfunction by activating glomerular EP4 receptors, the effect of an EP4 antagonist on Akita/DBA mice was investigated. Our results showed that blockade of EP4 receptor significantly reduced albuminuria in diabetic mice. Owing to the established adverse effect of COX2 inhibitors, our study provided new insight into meaningful renal benefits for diabetic nephropathy by targeting the EP4 receptor.
    MeSH term(s) Albuminuria ; Animals ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Diabetes Mellitus, Experimental/complications ; Diabetic Nephropathies ; Dinoprostone ; Endothelial Cells ; Female ; Humans ; Male ; Mice ; Mice, Inbred DBA ; Prostaglandins ; Receptors, Prostaglandin E, EP4 Subtype
    Chemical Substances Cyclooxygenase 2 Inhibitors ; Prostaglandins ; Receptors, Prostaglandin E, EP4 Subtype ; Cyclooxygenase 2 (EC 1.14.99.1) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1426962-4
    ISSN 2212-196X ; 1098-8823 ; 0090-6980
    ISSN (online) 2212-196X
    ISSN 1098-8823 ; 0090-6980
    DOI 10.1016/j.prostaglandins.2022.106621
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    Zs.A 815: Show issues Location:
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  8. Article: Successful Three-Dimensional Mapping-Guided Sinus Node Modification for Drug-Refractory Inappropriate Sinus Tachycardia after Circumferential Pulmonary Vein Isolation.

    Liu, Hao-Tien / Wen, Ming-Shien / Chou, Chung-Chuan

    Acta Cardiologica Sinica

    2024  Volume 40, Issue 1, Page(s) 128–132

    Language English
    Publishing date 2024-01-18
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 1051394-2
    ISSN 1011-6842
    ISSN 1011-6842
    DOI 10.6515/ACS.202401_40(1).20231026A
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3059: Show issues Location:
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  9. Article: [The mechanisms and clinical potential: sodium-glucose cotransporter 2 (SGLT-2) inhibitors treating diabetic kidney disease].

    Wang, Yu-Jia / Hao, Chuan-Ming

    Sheng li xue bao : [Acta physiologica Sinica

    2018  Volume 70, Issue 6, Page(s) 663–669

    Abstract: The employment of sodium-glucose cotransporter 2 (SGLT-2) inhibitors in the treatment of diabetes mellitus and diabetic kidney disease (DKD) becomes a hot topic in recent years. Compared with traditional glucose-lowering drugs, SGLT-2 inhibitors present ... ...

    Abstract The employment of sodium-glucose cotransporter 2 (SGLT-2) inhibitors in the treatment of diabetes mellitus and diabetic kidney disease (DKD) becomes a hot topic in recent years. Compared with traditional glucose-lowering drugs, SGLT-2 inhibitors present distinctive advantages in renal and cardiovascular protection. The mechanisms for renal protection include attenuating glomerular hyperfiltration, lowering serum uric acid, alleviating tubular lesions and regulating intrarenal renin-angiotensin-aldosterone system (RAAS) dysfunction. In addition, the lowering blood pressure, blunting blood glucose fluctuation, increasing insulin sensitivity, optimizing energy metabolism and body fat distribution account for the cardiovascular protective effects of SGLT-2 inhibitors. However, their potential adverse reactions and safety concerns should be carefully addressed in clinical usage.
    MeSH term(s) Diabetes Mellitus, Type 2 ; Diabetic Nephropathies/drug therapy ; Humans ; Hypoglycemic Agents/pharmacology ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Uric Acid
    Chemical Substances Hypoglycemic Agents ; SLC5A2 protein, human ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Uric Acid (268B43MJ25)
    Language Chinese
    Publishing date 2018-12-18
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mesangial cell-derived tenascin-C contributes to mesangial cell proliferation and matrix protein production in IgA nephropathy.

    Yan, Minhua / Liu, Shaojun / Zhang, Min / Lai, Lingyun / Xie, Qionghong / Hao, Chuan-Ming

    Nephrology (Carlton, Vic.)

    2022  Volume 27, Issue 5, Page(s) 458–466

    Abstract: Aim: Tenascin-C (TNC), a non-structural extracellular matrix glycoprotein, is transiently expressed during development or after injury, playing an important role in injury and repair process. The potential role of TNC in the pathogenesis of IgA ... ...

    Abstract Aim: Tenascin-C (TNC), a non-structural extracellular matrix glycoprotein, is transiently expressed during development or after injury, playing an important role in injury and repair process. The potential role of TNC in the pathogenesis of IgA nephropathy (IgAN) remains to be clarified.
    Methods: Immunohistochemistry staining for TNC was conducted on paraffin-embedded slices from renal biopsies of 107 IgAN patients, and correlation analysis was made between mesangial TNC expression and clinic-pathological parameters. In situ hybridization for TNC mRNA was further performed to figure out the cells that express TNC within glomeruli. In vitro experiments were also carried out on mouse mesangial cells (SV40 MES13) to elucidate the effect of TNC on mesangial cells.
    Results: TNC was expressed in the mesangial area of IgAN, as well as in fibrotic regions. Correlation analysis showed that higher mesangial TNC was associated with higher level of proteinuria, lower estimated glomerular filtration rate and more serious pathological lesions (MEST score). In situ hybridization revealed that abundant TNC mRNA expression was observed in the affected glomeruli of IgAN, but not in minimal change disease. Moreover, TNC mRNA co-localized with PDGFRβ mRNA, but not with PODXL mRNA, suggesting that TNC mRNA was expressed in the mesangial cells within glomeruli in IgAN. In vitro experiments showed that exogenous TNC promoted matrix protein production and mesangial cell proliferation, which was attenuated by an epidermal growth factor receptor inhibitor.
    Conclusion: Taken together, these results suggest that mesangial cell-derived TNC contributes to mesangial matrix expansion and mesangial cell proliferation, which is a potential therapeutic target in IgAN.
    MeSH term(s) Animals ; Cell Proliferation ; Extracellular Matrix/metabolism ; Glomerulonephritis, IGA/pathology ; Humans ; Mesangial Cells/pathology ; Mice ; Tenascin/genetics ; Tenascin/pharmacology
    Chemical Substances Tenascin
    Language English
    Publishing date 2022-03-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14031
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