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  1. Article ; Online: All Patients with ADPKD Should Undergo Screening for Intracranial Aneurysms: COMMENTARY.

    Chapman, Arlene B

    Kidney360

    2023  Volume 5, Issue 4, Page(s) 499–500

    MeSH term(s) Humans ; Intracranial Aneurysm/diagnosis ; Intracranial Aneurysm/epidemiology ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Polycystic Kidney, Autosomal Dominant/epidemiology ; Mass Screening/methods
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Magnetic resonance imaging preprocessing and radiomic features for classification of autosomal dominant polycystic kidney disease genotype.

    Kremer, Linnea E / Chapman, Arlene B / Armato, Samuel G

    Journal of medical imaging (Bellingham, Wash.)

    2023  Volume 10, Issue 6, Page(s) 64503

    Abstract: Purpose: Our study aims to investigate the impact of preprocessing on magnetic resonance imaging (MRI) radiomic features extracted from the noncystic kidney parenchyma of patients with autosomal dominant polycystic kidney disease (ADPKD) in the task of ... ...

    Abstract Purpose: Our study aims to investigate the impact of preprocessing on magnetic resonance imaging (MRI) radiomic features extracted from the noncystic kidney parenchyma of patients with autosomal dominant polycystic kidney disease (ADPKD) in the task of classifying PKD1 versus PKD2 genotypes, which differ with regard to cyst burden and disease outcome.
    Approach: The effect of preprocessing on radiomic features was investigated using a single T2-weighted fat saturated (T2W-FS) MRI scan from PKD1 and PKD2 subjects (29 kidneys in total) from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease study. Radiomic feature reproducibility using the intraclass correlation coefficient (ICC) was computed across MRI normalizations (
    Results: Radiomic features extracted from the noncystic kidney parenchyma were sensitive to preprocessing parameters, with varying reproducibility depending on the parameter. The percentage of features with good-to-excellent ICC scores ranged from 14% to 58%. AUC values ranged between 0.47 to 0.68 and 0.56 to 0.73 for the noncystic kidney parenchyma and entire kidney, respectively.
    Conclusions: Reproducibility of radiomic features extracted from the noncystic kidney parenchyma was dependent on the preprocessing parameters used, and the effect on genotype classification was sensitive to preprocessing parameters. The results suggest that texture features may be indicative of genotype expression in ADPKD.
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4302
    ISSN 2329-4302
    DOI 10.1117/1.JMI.10.6.064503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Polycystic Kidney Disease in the Real World.

    Chapman, Arlene B / McGill, Rita

    Kidney360

    2021  Volume 2, Issue 12, Page(s) 1882–1883

    MeSH term(s) Female ; Humans ; Male ; Polycystic Kidney Diseases/diagnosis ; Polycystic Kidney, Autosomal Dominant
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0007062021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Polycystins, ADPKD, and Cardiovascular Disease.

    Kuo, Ivana Y / Chapman, Arlene B

    Kidney international reports

    2019  Volume 5, Issue 4, Page(s) 396–406

    Abstract: Cardiovascular disorders are the most common cause of mortality in autosomal dominant polycystic kidney disease (ADPKD). This review considers recent clinical and basic science studies that address the contributing factors of cardiovascular dysfunction ... ...

    Abstract Cardiovascular disorders are the most common cause of mortality in autosomal dominant polycystic kidney disease (ADPKD). This review considers recent clinical and basic science studies that address the contributing factors of cardiovascular dysfunction in ADPKD. In particular, attention is placed on how dysfunction of the polycystin proteins located in the cardiovascular system contributes to extrarenal manifestations of ADPKD.
    Language English
    Publishing date 2019-12-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2019.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The future of pharmacogenetics in the treatment of hypertension.

    Cunningham, Patrick N / Chapman, Arlene B

    Pharmacogenomics

    2019  Volume 20, Issue 3, Page(s) 129–132

    MeSH term(s) Adrenergic beta-Antagonists/adverse effects ; Adrenergic beta-Antagonists/therapeutic use ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Blood Pressure/genetics ; Calcium Channel Blockers/adverse effects ; Calcium Channel Blockers/therapeutic use ; Humans ; Hypertension/drug therapy ; Hypertension/genetics ; Pharmacogenetics/trends ; Polymorphism, Single Nucleotide/genetics
    Chemical Substances Adrenergic beta-Antagonists ; Antihypertensive Agents ; Calcium Channel Blockers
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Editorial
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2018-0191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Does dopamine connect the dots in ADPKD?

    Chapman, Arlene B

    Kidney international

    2015  Volume 87, Issue 2, Page(s) 279–280

    Abstract: Healthy autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function demonstrate reduced endothelial-dependent vasodilation that improves with increasing local dopamine levels. Dopamine regulates renal sodium excretion, and ... ...

    Abstract Healthy autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function demonstrate reduced endothelial-dependent vasodilation that improves with increasing local dopamine levels. Dopamine regulates renal sodium excretion, and dopamine receptors are located on primary cilia in both vascular and renal tubular epithelial cells. The study by Lorthioir and colleagues links endothelial function and dopamine availability in ADPKD patients.
    MeSH term(s) Female ; Hemodynamics/physiology ; Humans ; Male ; Polycystic Kidney, Autosomal Dominant/physiopathology ; TRPP Cation Channels/deficiency
    Chemical Substances TRPP Cation Channels
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2014.391
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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Agreement of Food Records and 24-Hour Urine Studies in Clinical Practice.

    Betz, Melanie V / Coe, Fredric L / Chapman, Arlene B

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

    2021  Volume 32, Issue 1, Page(s) 51–57

    Abstract: Objective: The objective of this study was to determine the level of agreement between 3-day food records obtained as part of clinical care with 24-hour urine collections specifically assessing sodium, potassium, phosphorus, calcium, protein, and fluid ... ...

    Abstract Objective: The objective of this study was to determine the level of agreement between 3-day food records obtained as part of clinical care with 24-hour urine collections specifically assessing sodium, potassium, phosphorus, calcium, protein, and fluid intake.
    Design and methods: Data were collected from patients at a nephrology clinic in a metropolitan, academic medical center. Patients who completed both a 3-day food record and a 24-hour urine collection were analyzed. Food record and urine collection measurements were compared using a simple ratio, Pearson's correlation, and general linear models.
    Results: Patients (n = 85) were 47.9 ± 15.2 years of age, 54% were female, with a mean serum creatinine of 1.3 ± 0.7 mg/dL and estimated glomerular filtration rate of 64.2 ± 25.6 mL/min. Patients had autosomal-dominant polycystic kidney disease (48.2%), nephrolithiasis (31.1%), chronic kidney disease (4.7%), or other genetic or cystic conditions impacting the kidney (12.9%). Nutrient intake was measured utilizing a 3-day food record. Food records and urine collections were compared using the values, correlations, and general linear models. Fluid intake demonstrated the highest agreement (ratio 1.01) and calcium demonstrated the least agreement (ratio 6.30). Significant correlations were demonstrated for phosphorus (r = 0.321, P = .003), magnesium (r = 0.256, P = .018), protein (r = 0.555, P < .000), and fluid (r = 0.277, P = .010) intake. Food record intake of potassium (P = .046), protein (P = .004), and fluid (P = .010) were significant predictors of 24-hour urine excretion.
    Conclusion: 3-day food records are useful tools to determine patient dietary patterns, but should be used with caution when assessing specific nutrient intake in clinical settings.
    MeSH term(s) Calcium, Dietary ; Creatinine ; Female ; Humans ; Kidney Calculi/diagnosis ; Potassium ; Sodium
    Chemical Substances Calcium, Dietary ; Sodium (9NEZ333N27) ; Creatinine (AYI8EX34EU) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2021-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1080003-7
    ISSN 1532-8503 ; 1051-2276
    ISSN (online) 1532-8503
    ISSN 1051-2276
    DOI 10.1053/j.jrn.2021.07.005
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    Zs.A 3273: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to Hypertension.

    Elliott, Brandon / Márquez-Nogueras, Karla M / Thuo, Paula / DiNello, Elisabeth / Knutila, Ryne M / Fritzmann, Geena E / Willis, Monte / Chapman, Arlene B / Cao, Quan / Barefield, David Y / Kuo, Ivana Y

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Cardiovascular complications are the most common cause of mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Hypertension is seen in 70% of patients by the age of 30 prior to decline in kidney function. The natriuretic ... ...

    Abstract Cardiovascular complications are the most common cause of mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Hypertension is seen in 70% of patients by the age of 30 prior to decline in kidney function. The natriuretic peptides (NPs), atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), are released by cardiomyocytes in response to membrane stretch, increasing urinary excretion of sodium and water. Mice heterozygous for
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.02.573922
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  9. Article ; Online: The importance of quantifying genetic heterogeneity in ADPKD.

    Chapman, Arlene B

    Kidney international

    2014  Volume 85, Issue 2, Page(s) 236–237

    Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease. New data from Paul et al. suggest that mutations in the PKD1 and PKD2 genes may account for all cases of ADPKD. Further improvements in mutation detection ... ...

    Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease. New data from Paul et al. suggest that mutations in the PKD1 and PKD2 genes may account for all cases of ADPKD. Further improvements in mutation detection methodologies are needed to determine the true relative frequency of PKD1 versus PKD2 as well as to establish the value of mutation type and location to predict disease severity in this disorder.
    MeSH term(s) Female ; Genetic Loci ; Humans ; Male ; Mutation ; Polycystic Kidney, Autosomal Dominant/genetics ; TRPP Cation Channels/genetics
    Chemical Substances TRPP Cation Channels ; polycystic kidney disease 1 protein ; polycystic kidney disease 2 protein
    Language English
    Publishing date 2014-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2013.371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Autosomal dominant polycystic kidney disease.

    Lanktree, Matthew B / Chapman, Arlene B

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2017  Volume 189, Issue 45, Page(s) E1396

    MeSH term(s) Humans ; Hypertension/drug therapy ; Intracranial Aneurysm/complications ; Pain Management ; Polycystic Kidney, Autosomal Dominant/diagnostic imaging ; Polycystic Kidney, Autosomal Dominant/therapy
    Language English
    Publishing date 2017-11-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.170443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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