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Article ; Online: Lin

Xu, Haoyu / Tan, Shaojing / Zhao, Yu / Zhang, Lin / Cao, Weiyun / Li, Xing / Tian, Jiayi / Wang, Xiaojing / Li, Xiaoyan / Wang, Fengchao / Cao, Jiani / Zhao, Tongbiao

Cell proliferation

2023 Volume 56, Issue 11, Page(s) e13490

Abstract: ... myeloid repopulating activity are specifically enriched in a Lin ...

Abstract	Despite extensive characterization of the state and function of haematopoietic stem cells (HSCs), the use of transcription factors to define the HSC population is still limited. We show here that the HSC population in mouse bone marrow can be defined by the distinct expression levels of Spi1 and Gata1. By using a double fluorescence knock-in mouse model, PGdKI, in which the expression levels of PU.1 and GATA-1 are indicated by the expression of GFP and mCherry, respectively, we uncover that the HSCs with lymphoid and myeloid repopulating activity are specifically enriched in a Lin
MeSH term(s)	Mice ; Animals ; Cell Lineage ; Hematopoietic Stem Cells/metabolism ; Receptor Protein-Tyrosine Kinases ; Proto-Oncogene Proteins c-kit/metabolism ; Bone Marrow Cells/metabolism ; Mice, Inbred C57BL
Chemical Substances	Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.13490
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Article ; Online: Structural evolution of LiN

Ge, Zhongxue / Ding, Kewei / Li, Yisu / Xu, Hongguang / Chen, Zhaoqiang / Ma, Yiding / Li, Taoqi / Zhu, Weiliang / Zheng, Weijun

RSC advances

2019 Volume 9, Issue 12, Page(s) 6762–6769

Abstract: Mixed nitrogen-lithium cluster cations LiN ...

Abstract	Mixed nitrogen-lithium cluster cations LiN
Language	English
Publishing date	2019-02-26
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra00439d
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Article: [Optimization of isolation and culture of Lin

Li, Duan-Duan / Shi, Shan-Hui / Zhou, Mi / Ma, Xiu-Xia / Gao, Jian-Zhong / Zhang, Ya-Qiong / Yang, Li-Wen / Zuo, Lin

Sheng li xue bao : [Acta physiologica Sinica

2017 Volume 69, Issue 4, Page(s) 477–484

Abstract: ... on the isolation of Lin ...

Abstract	Cardiac stem cells (CSCs) transplantation has been recognized to be effective on the treatment of myocardial infarction (MI), but some techniques still need to be developed in the isolation and culture of CSCs, which is the key problem restricting the clinical application of CSCs. This study was focused on the isolation of Lin
MeSH term(s)	Animals ; Animals, Newborn ; Flow Cytometry ; Mice ; Mice, Inbred C57BL ; Myocardium/cytology ; Primary Cell Culture ; Stem Cells/cytology
Language	Chinese
Publishing date	2017-08-17
Publishing country	China
Document type	Journal Article
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
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Article ; Online: Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe

Gu, Yuanyun / Zhang, Zhen / Wang, Yan-En / Dai, Ziteng / Yuan, Yaqi / Xiong, Dan / Li, Jie / Walsh, Patrick J / Mao, Jianyou

The Journal of organic chemistry

2021 Volume 87, Issue 1, Page(s) 406–418

Abstract: Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C( ... ...

Abstract	Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02446
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Article ; Online: Modeling Landslide Susceptibility in Forest-Covered Areas in Lin’an, China, Using Logistical Regression, a Decision Tree, and Random Forests

Chongzhi Chen / Zhangquan Shen / Yuhui Weng / Shixue You / Jingya Lin / Sinan Li / Ke Wang

Remote Sensing, Vol 15, Iss 4378, p

2023 Volume 4378

Abstract: ... areas in Lin’an, southeastern China using logistic regression (LR), decision tree (DT), and random ...

Abstract	Landslides are a common geodynamic phenomenon that cause substantial life and property damage worldwide. In the present study, we developed models to evaluate landslide susceptibility in forest-covered areas in Lin’an, southeastern China using logistic regression (LR), decision tree (DT), and random forest (RF) techniques. In addition to conventional landslide-related natural and human disturbance factors, factors describing forest cover, including forest type (two plantations (hickory and bamboo) and four natural forests (conifer, hardwood, shrub, and moso bamboo) and understory vegetation conditions, were included as predictors. Model performance was evaluated based on true-positive rate, Kappa value, and area under the ROC curve using a 10-fold cross-validation method. All models exhibited good performance with measures of ≥0.70, although the LR model was relatively inferior. The key predictors were forest type, understory vegetation height (UVH), normalized differential vegetation index (NDVI) in summer, distance to road (DTRD), and maximum daily rainfall (MDR). Hickory plantations yielded the highest landslide probability, while conifer and hardwood forests had the lowest values. Bamboo plantations had probability results comparable to those of natural forests. Using the RF model, areas with a shorter UVH (<1.2 m), a lower NDVI (<0.70), a heavier MDR (>115 mm), or a shorter DTRD (<500 m) were predicted to be landslide-prone. Information on forest cover is essential for predicting landslides in areas with rich forest cover, and conversion from natural forests to plantations could increase landslide risk. Across the study areas, the northwestern part was the most landslide-prone. In terms of landslide prevention, the RF model-based map produced the most accurate predictions for the “very high” category of landslide. These results will help us better understand landslide occurrences in forest-covered areas and provide valuable information for governments in designing disaster mitigation.
Keywords	decision tree ; forest type ; landslide susceptibility ; logistic regression ; random forests ; understory vegetation ; Science ; Q
Subject code	333 ; 910
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Thermal runaway of Lithium-ion batteries employing LiN(SO

Hou, Junxian / Lu, Languang / Wang, Li / Ohma, Atsushi / Ren, Dongsheng / Feng, Xuning / Li, Yan / Li, Yalun / Ootani, Issei / Han, Xuebing / Ren, Weining / He, Xiangming / Nitta, Yoshiaki / Ouyang, Minggao

Nature communications

2020 Volume 11, Issue 1, Page(s) 5100

Abstract: ... batteries due to their low flammability. Here, we show that LiN(SO ...

Abstract	Concentrated electrolytes usually demonstrate good electrochemical performance and thermal stability, and are also supposed to be promising when it comes to improving the safety of lithium-ion batteries due to their low flammability. Here, we show that LiN(SO
Language	English
Publishing date	2020-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18868-w
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Article ; Online: Isolation of Swine Bone Marrow Lin-/CD45-/CD133 + Cells and Cardio-protective Effects of its Exosomes.

Li, Hongxiao / Gu, Jianjun / Sun, Xiaolin / Zuo, Qisheng / Li, Bichun / Gu, Xiang

Stem cell reviews and reports

2022 Volume 19, Issue 1, Page(s) 213–229

Abstract: Background: The identification in murine bone marrow (BM) of CD133 + /Lin-/CD45- cells, possessing ... unclear.: Objective: To establish an isolation and amplification method of CD133 + /Lin-/CD45- cells ... Lin-/CD45- cells and probe into their biological characteristics further. Furher more, to extract ...

Abstract	Background: The identification in murine bone marrow (BM) of CD133 + /Lin-/CD45- cells, possessing several features of pluripotent stem cells, encouraged us to investigate if similar population of cells could be also isolated from the swine BM. Heart failure is the terminal stage of many cardiovascular diseases, and its key pathological basis is cardiac fibrosis (CF). Research showed that stem cell derived exosomes may play a critical role in cardiac fibrosis. The effect of exosomes (Exos) on CF has remained unclear. Objective: To establish an isolation and amplification method of CD133 + /Lin-/CD45- cells from newbron swine BM in vitro, explore an highly efficient method to enrich swine bone marrow derived CD133 + /Lin-/CD45- cells and probe into their biological characteristics further. Furher more, to extract exosomes from it and explore its effect on CF. Methods: The mononuclear cells isolated from swine bone marrow by red blood cell (RBC) lysing buffer were coated by adding FcR blocking solution and coupled with CD133 antibody immunomagnetic beads, obtaining CD133 + cell group via Magnetic Activated Cell Sorting (MACS). In steps, the CD133 + /Lin-/CD45- cells were collected by fluorescence-activated cell sorting (FACS) labeled with CD133, Lin and CD45 antibodies, which were cultured and amplified in vitro. The biological features of CD133 + /Lin-/CD45- cells were studied in different aspects, including morphological trait observed with inverted microscope, ultrastructural characteristics observed under transmission electron microscope, expression of pluripotent markersidentified by immunofluorescent staining and Alkaline phosphatase staining. The Exos were extracted using a sequential centrifugation approach and its effects on CF were analyzed in Angiotensin II (Ang-II) induced-cardiac fibrosis in vivo. Rats in each group were treated for 4 weeks, and 2D echocardiography was adopted to evaluate the heart function. The degree of cardiac fibrosis was assessed by Hematoxylin-Eosin (HE) and Masson's trichrome staining. Results: The CD133 + /Lin-/CD45- cells accounted for about 0.2%-0.5% of the total mononuclear cells isolated from swine bone marrow. The combination of MACS and FACS to extract CD133 + /Lin-/CD45- cells could improved efficiency and reduced cell apoptosis. The CD133 + /Lin-/CD45- cells featured typical traits of pluripotent stem cells, the nucleus is large, mainly composed of euchromatin, with less cytoplasm and larger nucleoplasmic ratio, which expressed pluripotent markers (SSEA-1, Oct-4, Nanog and Sox-2) and alkaline phosphatase staining was positive.Animal experiment indicated that the cardiac injury related indexes (BNP、cTnI、CK-MB and TNF-α), the expression of key gene Smad3 and the degree of cardiac fibrosis in Exo treatment group were significantly reduced compared with the control group. 4 weeks after the treatment, cardiac ejection fraction (EF) value in the model group showed a remarkable decrease, indicating the induction of HF model. While Exo elevated the EF values, demonstrating cardio-protective effects. Conclusion: The CD133 + /Lin-/CD45- cells derived from swine bone marrow were successfully isolated and amplified, laying a good foundation for further research on this promising therapeutic cell. The Exos may be a promising potential treatment strategy for CF.
MeSH term(s)	Mice ; Rats ; Animals ; Swine ; Cell Differentiation ; Exosomes ; Alkaline Phosphatase ; Bone Marrow ; Fibrosis
Chemical Substances	Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-022-10432-x
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Article ; Online: Two new species of the spider genus Sinamma Lin amp; Li, 2014 (Araneae, Tetrablemmidae) from Guangdong Province, China.

Cheng, Weihua / Ren, Lingshu / Tong, Yanfeng / Bian, Dongju / Li, Shuqiang

Zootaxa

2022 Volume 5091, Issue 3, Page(s) 443–454

Abstract: Two new species of the genus Sinamma Lin Li, 2014, Sinamma quadrata Tong Li, sp. nov. (male, female ... and Sinamma yingae Tong Li, sp. nov. (male, female) are described from Guangdong, China ...

Abstract	Two new species of the genus Sinamma Lin Li, 2014, Sinamma quadrata Tong Li, sp. nov. (male, female) and Sinamma yingae Tong Li, sp. nov. (male, female) are described from Guangdong, China. The geographic distribution of the genus is updated and a key to all known species is provided.
MeSH term(s)	Animals ; China ; Female ; Male ; Spiders
Language	English
Publishing date	2022-01-14
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5091.3.4
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Article ; Online: Urban Inundation under Different Rainstorm Scenarios in Lin’an City, China

Yan Chen / Hao Hou / Yao Li / Luoyang Wang / Jinjin Fan / Ben Wang / Tangao Hu

International Journal of Environmental Research and Public Health, Vol 19, Iss 7210, p

2022 Volume 7210

Abstract: ... to simulate the inundation conditions in the typical urbanized area in the north of Lin’an. Two historical ... rainfall duration. According to the analysis results, the urban inundation in Lin’an is mainly affected ... of Lin’an to design inundation prevention measures. ...

Abstract	Under the circumstances of global warming and rapid urbanization, damage caused by urban inundation are becoming increasingly severe, attracting the attention of both researchers and governors. The accurate simulation of urban inundation is essential for the prevention of inundation hazards. In this study, a 1D pipe network and a 2D urban inundation coupling model constructed by InfoWorks ICM was used to simulate the inundation conditions in the typical urbanized area in the north of Lin’an. Two historical rainfall events in 2020 were utilized to verify the modeling results. The spatial–temporal variation and the causes of urban inundation under different designed rainfalls were studied. The results were as follows: (1) The constructed model had a good simulation accuracy, the Nash–Sutcliffe efficiency coefficient was higher than 0.82, R 2 was higher than 0.87, and the relative error was ±20%. (2) The simulation results of different designed rainfall scenarios indicated that the maximum inundation depth and inundation extent increased with the increase in the return period, rainfall peak position coefficient, and rainfall duration. According to the analysis results, the urban inundation in Lin’an is mainly affected by topography, drainage network (spatial distribution and pipe diameter), and rainfall patterns. The results are supposed to provide technical support and a decision-making reference for the urban management department of Lin’an to design inundation prevention measures.
Keywords	urban inundation ; InfoWorks ICM ; designed rainfalls ; Lin’an city ; Medicine ; R
Subject code	910
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Epidemiological characteristics of norovirus infection in Lin’an District of Hangzhou City from 2012 to 2020

SHI Shuiliang / LYU Lei / DUAN Tianxiao / ZHAO Ming / YE Yajun / YUAN Busheng / LI Xuan

Shanghai yufang yixue, Vol 34, Iss 7, Pp 650-

2022 Volume 654

Abstract: ObjectiveTo determine the epidemiological characteristics of norovirus infections in Lin ... reported in Lin’an District of Hangzhou from 2012 to 2020， including 8 outbreaks in kindergartens， 15 ones ... epidemic of norovirus infection in Lin’an District， Hangzhou City is characterized by certain population ...

Abstract	ObjectiveTo determine the epidemiological characteristics of norovirus infections in Lin’an District， Hangzhou City from 2012 to 2020， and provide scientific evidence for improving preventive and control measures.MethodsDescriptive epidemiological methods were used to characterize the epidemic and conduct statistical analysis to determine related factors.ResultsA total of 37 clustered outbreaks of norovirus infection were reported in Lin’an District of Hangzhou from 2012 to 2020， including 8 outbreaks in kindergartens， 15 ones in elementary schools， 8 ones in middle and high schools， 2 ones in universities， and 4 other ones. The total number of cases with norovirus infection was 1 194， with the average attack rate of 3.76%. The incidence of norovirus was higher in winter and spring. It was also higher in urban areas， followed by suburban and mountainous areas neighbored to traffic lines. Moreover， attack rates differed significantly by transmission routes， including mixed contact and aerosol transmission， contact transmission， food-borne transmission， and water-borne transmission （χ2=186.91，P<0.001）. There was significant difference in the incidence among kindergartens， schools， and universities （χ2=980.15，P<0.001）. In the 37 outbreaks， norovirus were mainly classified as GⅡ in the 34 ones （accounting for 91.89%）， and GⅠ in the remaining 3 ones.ConclusionThe epidemic of norovirus infection in Lin’an District， Hangzhou City is characterized by certain population， time， space， transmission routes， and strains. It warrants enhanced health education and promotion， preparedness and response plan， syndromic surveillance， early alerting， school closure， and environmental disinfection for further prevention and control of norovirus infection.
Keywords	norovirus ; epidemiology ; characteristics ; hangzhou ; Medicine ; R
Subject code	900
Language	Chinese
Publishing date	2022-07-01T00:00:00Z
Publisher	Shanghai Preventive Medicine Association
Document type	Article ; Online
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