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Article ; Online: Editorial: Acute pancreatitis infection: Epidemiology, prevention, clinical characteristics, treatment, and prediction.

Hong, Wandong / Pan, Jingye / Goyal, Hemant / Zippi, Maddalena

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1175195

MeSH term(s)	Humans ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/prevention & control ; Acute Disease ; Pancreas ; Infections
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1175195
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A comparison of interpretable XGBoost and artificial neural network model for the prediction of severe acute pancreatitis.

Lu, Yajing / Qiu, Minhao / Pan, Shuang / Basharat, Zarrin / Zippi, Maddalena / Fiorino, Sirio / Hong, Wandong

Polish archives of internal medicine

2024

Abstract: Introduction: Acute pancreatitis (AP) that progresses to persistent organ failure is defined as severe acute pancreatitis (SAP) which has a relatively high mortality. Early establishment of a prediction model is crucial for the improvement of disease ... ...

Abstract	Introduction: Acute pancreatitis (AP) that progresses to persistent organ failure is defined as severe acute pancreatitis (SAP) which has a relatively high mortality. Early establishment of a prediction model is crucial for the improvement of disease prognosis. Objectives: The aim of this study was to evaluate the accuracy of Extreme Gradient Boosting (XGBoost) and artificial neural network model (ANN) for predicting SAP. Patients and methods: A total of 648 patients with AP were enrolled. XGBoost and ANN models were developed and valuated in the training set (519 patients) and test set (129 patients), respectively. The accuracy and results of XGBoost and ANN models were evaluated both by area under the receiver operating characteristic curves (AUC) and the area under precision recall curve. Results: 15 variables were selected for model construction through univariable analysis. The AUCs of XGBoost model and ANN model in five-fold cross-validation of the training set were 0.92 (95%CI, 0.87-0.97) and 0.86 (95%CI, 0.78-0.92), respectively. AUCs of XGBoost model and ANN model for the test set were 0.93 (95%CI, 0.85-1.00) and 0.87 (95%CI, 0.79-0.96). XGBoost outperformed ANN in terms of both diagnostic accuracy and the area under the precision recall curve. Individualized prediction by XGBoost model was explained by local interpretable model-agnostic explanations (LIME) plot. Conclusions: An interpretable XGBoost model showed higher discriminatory efficiency in predicting SAP compared to ANN.
Language	English
Publishing date	2024-03-15
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16700
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Article: An Unexpected Gastric Subepithelial Mass.

Zippi, Maddalena / Fiorino, Sirio / Bertoldi, Innocenzo / Hong, Wandong / Occhigrossi, Giuseppe

Oman medical journal

2021 Volume 36, Issue 2, Page(s) e252

Language	English
Publishing date	2021-03-31
Publishing country	Oman
Document type	Journal Article
ZDB-ID	2571431-4
ISSN	2070-5204 ; 1999-768X
ISSN (online)	2070-5204
ISSN	1999-768X
DOI	10.5001/omj.2021.36
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Article: Candida Albicans Lung Abscess in an Illicit Drugs User With Hepatitis C Virus Chronic Infection.

Zippi, Maddalena / Toma, Antonella / Maccioni, Francesca / Pica, Roberta

Cureus

2021 Volume 13, Issue 2, Page(s) e13117

Abstract: Illicit substances are widely used all over the world. Among them, crack cocaine results to be the most used drug for the fact that it can be taken in different ways, such as inhaled or intravenous. Pulmonary complications are well known in people ... ...

Abstract	Illicit substances are widely used all over the world. Among them, crack cocaine results to be the most used drug for the fact that it can be taken in different ways, such as inhaled or intravenous. Pulmonary complications are well known in people snorting it, mostly due to contamination with other substances contained in the objects able to infuse the drug. Herein, we present a case of lung candida abscess related to nasal insufflation of cocaine in an abuser patient suffering from hepatitis C virus (HCV) and not immunocompromised.
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.13117
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Article ; Online: Comprehensive review on the pathogenesis of hypertriglyceridaemia-associated acute pancreatitis.

Qiu, Minhao / Zhou, Xiaoying / Zippi, Maddalena / Goyal, Hemant / Basharat, Zarrin / Jagielski, Mateusz / Hong, Wandong

Annals of medicine

2023 Volume 55, Issue 2, Page(s) 2265939

Abstract: It is well known, that the inflammatory process that characterizes acute pancreatitis (AP) can lead to both pancreatic damage and systemic inflammatory response syndrome (SIRS). During the last 20 years, there has been a growing incidence of episodes of ... ...

Abstract	It is well known, that the inflammatory process that characterizes acute pancreatitis (AP) can lead to both pancreatic damage and systemic inflammatory response syndrome (SIRS). During the last 20 years, there has been a growing incidence of episodes of acute pancreatitis associated with hypertriglyceridaemia (HTAP). This review provides an overview of triglyceride metabolism and the potential mechanisms that may contribute to developing or exacerbating HTAP. The article comprehensively discusses the various pathological roles of free fatty acid, inflammatory response mechanisms, the involvement of microcirculation, serum calcium overload, oxidative stress and the endoplasmic reticulum, genetic polymorphism, and gut microbiota, which are known to trigger or escalate this condition. Future perspectives on HTAP appear promising, with ongoing research focused on developing more specific and effective treatment strategies.
MeSH term(s)	Humans ; Pancreatitis/complications ; Acute Disease ; Pancreas/pathology ; Hypertriglyceridemia/complications ; Endoplasmic Reticulum/metabolism ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2023.2265939
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Article ; Online: Long COVID-19 gastrointestinal related disorders and traditional Chinese medicine: A network target-based approach.

Mattioli, Laura Beatrice / Frosini, Maria / Corazza, Ivan / Fiorino, Sirio / Zippi, Maddalena / Micucci, Matteo / Budriesi, Roberta

Phytotherapy research : PTR

2024

Abstract: The significant number of individuals impacted by the pandemic makes prolonged symptoms after COVID-19 a matter of considerable concern. These are numerous and affect multiple organ systems. According to the World Health Organization (WHO), prolonged ... ...

Abstract	The significant number of individuals impacted by the pandemic makes prolonged symptoms after COVID-19 a matter of considerable concern. These are numerous and affect multiple organ systems. According to the World Health Organization (WHO), prolonged gastrointestinal issues are a crucial part of post-COVID-19 syndrome. The resulting disruption of homeostasis underscores the need for a therapeutic approach based on compounds that can simultaneously affect more than one target/node. The present review aimed to check for nutraceuticals possessing multiple molecular mechanisms helpful in relieving Long COVID-19-specific gastrointestinal symptoms. Specific plants used in Keywords Chinese Medicine (TCM) expected to be included in the WHO Global Medical Compendium were selected based on the following criteria: (1) they are widely used in the Western world as natural remedies and complementary medicine adjuvants; (2) their import and trade are regulated by specific laws that ensure quality and safety (3) have the potential to be beneficial in alleviating intestinal issues associated with Long COVID-19. Searches were performed in PubMed, Elsevier, Google Scholar, Scopus, Science Direct, and ResearchGate up to 2023. Cinnamomum cassia, Glycyrrhiza uralensis, Magnolia officinalis, Poria cocos, Salvia miltiorrhiza, Scutellaria baicalensis, and Zingiber officinalis were identified as the most promising for their potential impact on inflammation and oxidative stress. Based on the molecular mechanisms of the phytocomplexes and isolated compounds of the considered plants, their clinical use may lead to benefits in gastrointestinal diseases associated with Long COVID-19, thanks to a multiorgan and multitarget approach.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.8163
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Article ; Online: Simultaneous laparoscopic removal of a Todani type II choledochal cyst and a microlithiasic cholecystitis.

Grottesi, Alfonso / Iacovitti, Simonetta / Ciano, Paolo / Borrini, Francesco / Zippi, Maddalena

Annals of hepato-biliary-pancreatic surgery

2022 Volume 26, Issue 3, Page(s) 281–284

Abstract: Diverticula of the choledochus, better known as Todani type II cysts, are very rare and represent a predominantly pediatric pathology. Their identification by radiological methods, even if occasional, requires clinical doctors to request a surgical ... ...

Abstract	Diverticula of the choledochus, better known as Todani type II cysts, are very rare and represent a predominantly pediatric pathology. Their identification by radiological methods, even if occasional, requires clinical doctors to request a surgical consultation, even for asymptomatic subjects, to proceed with their removal, given the risk of associated neoplasms. The laparoscopic approach for surgical treatment of these cysts has been recently introduced with excellent results. Due to the poor clinical records, currently there are neither shared protocols about their management nor long-term follow-up of operated patients. We report a case of an adult female suffering for years from biliary colic due to the presence of a duodenal diverticulum associated with microlithiasis' cholecystitis, who was laparoscopically treated, with excellent results in terms of symptomatic regression, reduced hospitalization, and no surgery-related complications.
Language	English
Publishing date	2022-06-07
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	3012179-6
ISSN	2508-5859 ; 2508-5778
ISSN (online)	2508-5859
ISSN	2508-5778
DOI	10.14701/ahbps.22-011
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Article: An Ulcerated Large Colic Lipoma Causing Rectorrhagia Treated With Endoscopic Loop-Assisted Resection.

Zippi, Maddalena / Toma, Antonella / Paoluzi, Nada / Maccioni, Francesca / Pica, Roberta

Cureus

2021 Volume 13, Issue 4, Page(s) e14321

Abstract: Colonic lipomatous polyps are often an incidental finding during colonoscopy. Generally, these types of polyps can cause gastrointestinal bleeding when they are larger than 4 cm in size. Some case reports have documented the occurrence of overlying ... ...

Abstract	Colonic lipomatous polyps are often an incidental finding during colonoscopy. Generally, these types of polyps can cause gastrointestinal bleeding when they are larger than 4 cm in size. Some case reports have documented the occurrence of overlying adenomatous formations in the apical portion, as well as ulcerated mucosa. There is currently no standardized endoscopic removal technique for their treatment. In this report, we present a case of a large and ulcerated lipoma causing rectorrhagia, which was successfully treated with endoscopic en-bloc resection and endoloop placement.
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.14321
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Article: Hypertransaminasemia in the course of infection with SARS-CoV-2: Incidence and pathogenetic hypothesis.

Zippi, Maddalena / Fiorino, Sirio / Occhigrossi, Giuseppe / Hong, Wandong

World journal of clinical cases

2020 Volume 8, Issue 8, Page(s) 1385–1390

Abstract: In patients infected with severe acute respiratory syndrome coronavirus 2, the respiratory symptoms, such as fever, cough and dyspnea, are the most frequent clinical manifestations. These patients may also present with less well-defined symptoms like ... ...

Abstract	In patients infected with severe acute respiratory syndrome coronavirus 2, the respiratory symptoms, such as fever, cough and dyspnea, are the most frequent clinical manifestations. These patients may also present with less well-defined symptoms like diarrhea, nausea, vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical course. In a few cases, these symptoms may also present before the appearance of respiratory symptoms. To penetrate the body, Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors, which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver cholangiocytes. In several cases, viral RNA is detectable in the stool of patients with coronavirus disease 2019 (COVID-19). The liver damage seems to show a multifactorial origin. About 2%-11% of patients with COVID-19 have known underlying hepatic pathologies. In 14%-53% of COVID-19 cases, there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19, especially during hospitalization.
Keywords	covid19
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v8.i8.1385
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Article ; Online: An Unexpected Gastric Subepithelial Mass

Maddalena Zippi / Sirio Fiorino / Innocenzo Bertoldi / Wandong Hong / Giuseppe Occhigrossi

Oman Medical Journal, Vol 36, Iss 2, Pp e252-e

2021 Volume 252

Abstract: A 63-year-old man came to our observation complaining of symptoms referable to gastroesophageal reflux disease. No epigastric pain, postprandial fullness, or vomiting were present during clinical examination. His history did not show noteworthy ... ...

Abstract	A 63-year-old man came to our observation complaining of symptoms referable to gastroesophageal reflux disease. No epigastric pain, postprandial fullness, or vomiting were present during clinical examination. His history did not show noteworthy pathologies. The patient did not follow any pharmacological therapy, and there was no family history for neoplasia of the digestive system.
Keywords	cysts ; subepithelial lesions ; Medicine ; R
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Oman Medical Specialty Board
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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