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  1. Article ; Online: Hypoalbuminaemia in COVID-19 infection: A predictor of severity or a potential therapeutic target?

    Herlekar, Rahul / Sur Roy, Akangsha / Matson, Montgomery

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 83–84

    MeSH term(s) COVID-19 ; Comorbidity ; Humans ; Hypoalbuminemia/epidemiology ; Morbidity ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Response to 'Vitamin D concentrations and COVID-19 infection in UK Biobank'.

    Roy, Akangsha Sur / Matson, Montgomery / Herlekar, Rahul

    Diabetes & metabolic syndrome

    2020  Volume 14, Issue 5, Page(s) 777

    MeSH term(s) Betacoronavirus ; Biological Specimen Banks ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; United Kingdom ; Vitamin D
    Chemical Substances Vitamin D (1406-16-2)
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2020.05.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hypoalbuminaemia in COVID‐19 infection

    Herlekar, Rahul / Sur Roy, Akangsha / Matson, Montgomery

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    A predictor of severity or a potential therapeutic target?

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26151
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Response to ‘Vitamin D concentrations and COVID-19 infection in UK Biobank’

    Roy, Akangsha Sur / Matson, Montgomery / Herlekar, Rahul

    Diabetes & Metabolic Syndrome: Clinical Research & Reviews

    2020  Volume 14, Issue 5, Page(s) 777

    Keywords Internal Medicine ; Endocrinology, Diabetes and Metabolism ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2020.05.049
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: The contribution of competing mechanisms in stroke despite anticoagulation in patients with atrial fibrillation.

    Herlekar, Rahul / Sur Roy, Akangsha / Hajiev, Saur / Induruwa, Isuru / Agarwal, Smriti / Evans, Nicholas R / Khadjooi, Kayvan / Markus, Hugh / O'Brien, Eoin / Warburton, Elizabeth / Zachariah, George / McCabe, John J

    European stroke journal

    2023  Volume 8, Issue 2, Page(s) 541–548

    Abstract: Background: For reasons poorly understood, strokes frequently occur in patients with atrial fibrillation (AF) despite oral anticoagulation. Better data are needed to inform randomised trials (RCTs) of new strategies to prevent recurrence in these ... ...

    Abstract Background: For reasons poorly understood, strokes frequently occur in patients with atrial fibrillation (AF) despite oral anticoagulation. Better data are needed to inform randomised trials (RCTs) of new strategies to prevent recurrence in these patients. We investigate the relative contribution of competing stroke mechanisms in patients with AF who have stroke despite anticoagulation (OAC+) compared with those who are anticoagulant naïve (OAC-) at the time of their event.
    Patients and methods: We performed a cross-sectional study leveraging data from a prospective stroke registry (2015-2022). Eligible patients had ischemic stroke and AF. Stroke classification was performed by a single stroke-specialist blinded to OAC status using TOAST criteria. The presence of atherosclerotic plaque was determined using duplex ultrasonography, computerised tomography (CT) or magnetic resonance (MR) angiography. Imaging was reviewed by a single reader. Logistic regression was used to identify independent predictors of stroke despite anticoagulation.
    Results: Of 596 patients included, 198 (33.2%) were in the OAC+ group. A competing cause for stroke was more frequent in patients with OAC+ versus OAC- (69/198 (34.8%)) versus 77/398 (19.3%),
    Discussion and conclusion: Patients with AF-associated stroke despite OAC are much more likely than patients who are OAC-naïve to have competing stroke mechanisms. Rigorous investigation for alternative stroke causes in stroke despite OAC has a high diagnostic yield. These data should be used to guide patient selection for future RCTs in this population.
    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Cross-Sectional Studies ; Stroke/epidemiology ; Anticoagulants/therapeutic use ; Blood Coagulation
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2851287-X
    ISSN 2396-9881 ; 2396-9873
    ISSN (online) 2396-9881
    ISSN 2396-9873
    DOI 10.1177/23969873231168367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review.

    Whitehouse, Daniel P / Vile, Alexander R / Adatia, Krishma / Herlekar, Rahul / Roy, Akangsha Sur / Mondello, Stefania / Czeiter, Endre / Amrein, Krisztina / Büki, András / Maas, Andrew I R / Menon, David K / Newcombe, Virginia F J

    Neurosurgery

    2021  Volume 90, Issue 2, Page(s) 170–179

    Abstract: Background: Blood biomarkers are of increasing importance in the diagnosis and assessment of traumatic brain injury (TBI). However, the relationship between them and lesions seen on imaging remains unclear.: Objective: To perform a systematic review ... ...

    Abstract Background: Blood biomarkers are of increasing importance in the diagnosis and assessment of traumatic brain injury (TBI). However, the relationship between them and lesions seen on imaging remains unclear.
    Objective: To perform a systematic review of the relationship between blood biomarkers and intracranial lesion types, intracranial lesion injury patterns, volume/number of intracranial lesions, and imaging classification systems.
    Methods: We searched Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, and Cumulative Index to Nursing and Allied Health Literature from inception to May 2021, and the references of included studies were also screened. Heterogeneity in study design, biomarker types, imaging modalities, and analyses inhibited quantitative analysis, with a qualitative synthesis presented.
    Results: Fifty-nine papers were included assessing one or more biomarker to imaging comparisons per paper: 30 assessed imaging classifications or injury patterns, 28 assessed lesion type, and 11 assessed lesion volume or number. Biomarker concentrations were associated with the burden of brain injury, as assessed by increasing intracranial lesion volume, increasing numbers of traumatic intracranial lesions, and positive correlations with imaging classification scores. There were inconsistent findings associating different biomarkers with specific imaging phenotypes including diffuse axonal injury, cerebral edema, and intracranial hemorrhage.
    Conclusion: Blood-based biomarker concentrations after TBI are consistently demonstrated to correlate burden of intracranial disease. The relation with specific injury types is unclear suggesting a lack of diagnostic specificity and/or is the result of the complex and heterogeneous nature of TBI.
    MeSH term(s) Biomarkers ; Brain Injuries ; Brain Injuries, Traumatic/complications ; Diagnostic Imaging ; Humans ; Intracranial Hemorrhages/complications
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

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  9. Article ; Online: Atrial fibrillation cryoablation is an effective day case treatment: the UK PolarX vs. Arctic Front Advance experience.

    Honarbakhsh, Shohreh / Martin, Claire A / Mesquita, Joao / Herlekar, Rahul / Till, Richard / Srinivasan, Neil T / Duncan, Edward / Leong, Fong / Dulai, Rajdip / Veasey, Rick / Panikker, Sandeep / Paisey, John / Ramgopal, Balasubramanian / Das, Moloy / Ahmed, Wissam / Sahu, Jonathan / Earley, Mark J / Finlay, Malcolm C / Schilling, Richard J /
    Hunter, Ross J

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2023  Volume 25, Issue 11

    Abstract: Aims: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation for atrial fibrillation (AF). There are limited data on the PolarX Cryoballoon. The study aimed to establish the safety, efficacy, and feasibility of same day discharge for ... ...

    Abstract Aims: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation for atrial fibrillation (AF). There are limited data on the PolarX Cryoballoon. The study aimed to establish the safety, efficacy, and feasibility of same day discharge for Cryoballoon PVI.
    Methods and results: Multi-centre study across 12 centres. Procedural metrics, safety profile, and procedural efficacy of the PolarX Cryoballoon with the Arctic Front Advance (AFA) Cryoballoon were compared in a cohort large enough to provide definitive comparative data. A total of 1688 patients underwent PVI with cryoablation (50% PolarX and 50% AFA). Successful PVI was achieved with 1677 (99.3%) patients with 97.2% (n = 1641) performed as day case procedures with a complication rate of <1%. Safety, procedural metrics, and efficacy of the PolarX Cryoballoon were comparable with the AFA cohort. The PolarX Cryoballoon demonstrated a nadir temperature of -54.6 ± 7.6°C, temperature at 30 s of -38.6 ± 7.2°C, time to -40°C of 34.1 ± 13.7 s, and time to isolation of 49.8 ± 33.2 s. Independent predictors for achieving PVI included time to reach -40°C [odds ratio (OR) 1.34; P < 0.001] and nadir temperature (OR 1.24; P < 0.001) with an optimal cut-off of ≤34 s [area under the curve (AUC) 0.73; P < 0.001] and nadir temperature of ≤-54.0°C (AUC 0.71; P < 0.001), respectively.
    Conclusions: This large-scale UK multi-centre study has shown that Cryoballoon PVI is a safe, effective day case procedure. PVI using the PolarX Cryoballoon was similarly safe and effective as the AFA Cryoballoon. The cryoablation metrics achieved with the PolarX Cryoballoon were different to that reported with the AFA Cryoballoon. Modified cryoablation targets are required when utilizing the PolarX Cryoballoon.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Cryosurgery/adverse effects ; Cryosurgery/methods ; Treatment Outcome ; Time Factors ; Pulmonary Veins/surgery ; Catheter Ablation/methods ; United Kingdom ; Recurrence
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euad286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5434: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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