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Article ; Online: Completion of adjuvant S-1 chemotherapy after surgical resection for biliary tract cancer: A single center experience.

Iwaki, Kentaro / Yoh, Tomoaki / Nishino, Hiroto / Nishio, Takahiro / Koyama, Yukinori / Ogiso, Satoshi / Ishii, Takamichi / Kanai, Masashi / Hatano, Etsuro

Asian journal of surgery

2023 Volume 47, Issue 3, Page(s) 1383–1388

Abstract: ... of adjuvant S-1 chemotherapy (ASC) for biliary tract cancer (BTC) after surgical resection ...

Abstract	Backgrounds: A recent randomized control trial (JCOG1202; ASCOT trial) demonstrated the efficacy of adjuvant S-1 chemotherapy (ASC) for biliary tract cancer (BTC) after surgical resection; however, the significance of the completion of ASC in the real-world setting remains unknown. Methods: Data of consecutive patients who underwent surgical resection for biliary tract cancer (BTC) from 2011 to 2021 were retrospectively reviewed. Of these, patients who underwent ASC were enrolled in this study. Patients were divided into two groups according to whether ASC was completed: the completion group and the non-completion group. Clinicopathological features and survival outcomes were assessed. Results: Of the 223 patients with BTC who underwent surgical resection, 75 patients who underwent ASC were included for analysis. Among them, 48 (64.0 %) completed the intended ASC course, while 27 cases (36.0 %) discontinued the treatment. The most common reason for the discontinuation was adverse event (n = 16, 59.3 %), followed by disease recurrence (n = 9, 33.3 %). Patients in the completion group showed significantly better overall survival (OS) (p < 0.001) and recurrence-free survival (RFS) (p < 0.001) compared to the non-completion group. Further, after excluding the patients in the non-completion group who discontinued ASC due to disease recurrence, the significance of ASC completion was retained for both OS and RFS. Conclusion: The completion of ASC was associated with improved prognosis in patients with BTC after surgical resection. The achievement of ASC should be the goal after surgical resection, while further study may be warranted regarding the resistance of ASC.
MeSH term(s)	Humans ; Retrospective Studies ; Neoplasm Recurrence, Local ; Chemotherapy, Adjuvant ; Biliary Tract Neoplasms/drug therapy ; Biliary Tract Neoplasms/surgery ; Prognosis
Language	English
Publishing date	2023-12-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.12.119
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Article ; Online: A latitudinal gradient in Darwin’s naturalization conundrum at the global scale for flowering plants

Shu-ya Fan / Qiang Yang / Shao-peng Li / Trevor S. Fristoe / Marc W. Cadotte / Franz Essl / Holger Kreft / Jan Pergl / Petr Pyšek / Patrick Weigelt / John Kartesz / Misako Nishino / Jan J. Wieringa / Mark van Kleunen

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract Darwin’s naturalization conundrum describes two seemingly contradictory hypotheses ... gradient in Darwin’s naturalization conundrum. Naturalized alien plant species are more closely related ... that joint consideration of climatic and anthropogenic conditions is critical to reconciling Darwin’s ...

Abstract	Abstract Darwin’s naturalization conundrum describes two seemingly contradictory hypotheses regarding whether alien species closely or distantly related to native species should be more likely to naturalize in regional floras. Both expectations have accumulated empirical support, and whether such apparent inconsistency can be reconciled at the global scale is unclear. Here, using 219,520 native and 9,531 naturalized alien plant species across 487 globally distributed regions, we found a latitudinal gradient in Darwin’s naturalization conundrum. Naturalized alien plant species are more closely related to native species at higher latitudes than they are at lower latitudes, indicating a greater influence of preadaptation in harsher climates. Human landscape modification resulted in even steeper latitudinal clines by selecting aliens distantly related to natives in warmer and drier regions. Our results demonstrate that joint consideration of climatic and anthropogenic conditions is critical to reconciling Darwin’s naturalization conundrum.
Keywords	Science ; Q
Subject code	580
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article: Complete Response of Locally Advanced Gastric Cancer with Pancreatic Invasion and Gastric Outlet Obstruction after Neoadjuvant Chemotherapy with S-1 and Oxaliplatin.

Kondo, Masato / Nishino, Shogo / Yamashita, Daisuke / Kaihara, Satoshi

Case reports in oncology

2020 Volume 13, Issue 2, Page(s) 716–720

Abstract: ... chemotherapy with S-1 and oxaliplatin (SOX). A 74-year-old man presented to our hospital with abdominal pain ...

Abstract	The prognosis of locally advanced gastric cancer is poor even if radical gastrectomy with D2 lymphadenectomy is followed by adjuvant chemotherapy. Hence, neoadjuvant chemotherapy is performed to try to improve the prognosis, as it can significantly downstage the tumor and safely improve the R0 resection rate of patients. Herein, we report a case of locally advanced gastric cancer with pancreatic invasion and gastric outlet obstruction that showed a pathological complete response after neoadjuvant chemotherapy with S-1 and oxaliplatin (SOX). A 74-year-old man presented to our hospital with abdominal pain and pyloric stenosis. CT images revealed a cStage IVb, cT4b tumor in the pancreas, cN1, cM0. Therefore, we performed laparoscopic gastrojejunostomy, and the patient's oral intake improved after surgery; we then administered neoadjuvant chemotherapy with SOX on postoperative day 18, without any surgical complications. After 3 courses of neoadjuvant chemotherapy, the patient underwent radical distal gastrectomy, thereby avoiding pancreatoduodenectomy. Histopathological examination of the resected sample revealed no residual cancer cells, indicating a pathological complete response. No recurrence has occurred for 1 year after surgery. Thus, neoadjuvant chemotherapy with SOX can help in tumor downstaging and may be a multipotent option for the treatment of locally advanced gastric cancer, such as cases with the invasion of other organs; this treatment can result in improved curability and avoid overinvasive surgery.
Language	English
Publishing date	2020-06-24
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000507983
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Article: Hybrid Molecular Junctions Using Au–S and Au−π Bindings

Fujii, Shintaro / Iwane, Madoka / Furukawa, Shunsuke / Tada, Tomofumi / Nishino, Tomoaki / Saito, Masaichi / Kiguchi, Manabu

Journal of physical chemistry. 2020 Apr. 03, v. 124, no. 17

2020

Abstract: ... molecular junction that consists of Au–S and Au−π bindings using a sumanene derivative with three phosphine ... anchoring groups and the sumanene backbone in the junction form the Au–S chemical bonds and Au−π direct ... bonds, respectively. The Au–S chemical binding immobilized the molecule on the Au electrode and provided ...

Abstract	Electrically conductive molecular junctions are highly desirable components for applications in future molecular-scale electronic circuits. Here, we demonstrate an electrically conductive hybrid molecular junction that consists of Au–S and Au−π bindings using a sumanene derivative with three phosphine–sulfide anchoring groups at the periphery of the sumanene backbone. The molecular junction was prepared between the Au electrodes by the scanning tunneling microscopy-based break junction method. The three anchoring groups and the sumanene backbone in the junction form the Au–S chemical bonds and Au−π direct bonds, respectively. The Au–S chemical binding immobilized the molecule on the Au electrode and provided the high mechanical stability of the junction, while the direct Au−π binding led to the large metal–molecule electric coupling and high electronic conductance of the molecular junction. This study analyzes the molecular design of the electrically conductive molecular junctions based on the hybrid binding groups.
Keywords	chemical bonding ; electrodes ; electronic circuits ; gold
Language	English
Dates of publication	2020-0403
Size	p. 9261-9268.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021/acs.jpcc.9b11725
Database	NAL-Catalogue (AGRICOLA)

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Article: [A Case of Recurrent Gastric Cancer Successfully Treated by S-1 Chemotherapy].

Kawada, Junji / Nishino, Masaya / Hata, Motoki / Tanizaki, Keiko / Ogino, Takayuki / Hoshino, Hiromitsu / Okano, Miho / Nagai, Kenichi / Kim, Yongkook / Okuyama, Masaki / Tsujinaka, Toshimasa / Imamoto, Haruhiko

Gan to kagaku ryoho. Cancer & chemotherapy

2019 Volume 46, Issue 2, Page(s) 357–359

Abstract: We report a case of recurrent gastric cancer that was successfully treated by S-1 chemotherapy ... in the liver.She was diagnosed with liver metastasis and started receiving S-1 chemotherapy.The liver ... metastasis achieved complete response, so S-1 chemotherapy was discontinued 12 months after recurrence ...

Abstract	We report a case of recurrent gastric cancer that was successfully treated by S-1 chemotherapy.An 81-year-old woman with advanced gastric cancer[L Less, Type 2, cT4a(SE), cN0H0P0M0, cStageⅡB]underwent distal gastrectomy.Abdominal CT performed 6 months after surgery revealed a low-density area in the liver.She was diagnosed with liver metastasis and started receiving S-1 chemotherapy.The liver metastasis achieved complete response, so S-1 chemotherapy was discontinued 12 months after recurrence.Abdominal CT performed 9 months after the discontinuation of S-1 chemotherapy revealed multiple low-density areas in the liver.She started receiving S-1 chemotherapy again, but S-1 chemotherapy was discontinued because of side effects after 2 courses.The patient died 24 months after receiving S-1 chemotherapy.
MeSH term(s)	Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Drug Combinations ; Female ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Neoplasm Recurrence, Local ; Oxonic Acid/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Tegafur/therapeutic use
Chemical Substances	Drug Combinations ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG)
Language	Japanese
Publishing date	2019-03-11
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Assessment of the underlying causes of adult deaths using a short version of verbal autopsy in Xaiyabouli Province, Lao People’s Democratic Republic

Bounbouly Thanavanh / Nobuyuki Hamajima / Kaiyason Sida / Kene Duangdy / Lasavong Latsamy / Khounsavath Senaphane / Viengsakhone Louangpradith / Souphaphone Sadettan / Souphalak Inthaphatha / Kimihiro Nishino / Eiko Yamamoto

BMC Public Health, Vol 23, Iss 1, Pp 1-

2023 Volume 13

Abstract: ... in Lao People’s Democratic Republic (Lao PDR). Methods A short version of VA for deaths outside health facilities was developed ...

Abstract	Abstract Background In developing countries, it is difficult to collect the data of the underlying cause of death (UCOD), especially when a death does not occur in a health facility. This study aimed to develop a short version of verbal autopsy (VA) and identify the UCOD of adults in Lao People’s Democratic Republic (Lao PDR). Methods A short version of VA for deaths outside health facilities was developed. This study included all deaths of people aged 15 years old or older in Xaiyabouli Province in 2020. Socio-demographic factors, place of death, and UCOD of the deceased were collected from health facilities or from family members using a questionnaire including the short VA form. UCOD was compared between home deaths and hospital deaths, between the age group of 15–59 years old and the age group ≥ 60 years old, and between males and females. Results Of all the 1,235 deaths included in this study, 1,012 deaths (81.9%) occured at home and 223 deaths (18.1%) at hospitals. The most common UCOD was senility (13.3%), followed by heart/renal failure (10.5%), pneumonia (9.6%) and traffic accident (7.1%). Compared to hospital deaths, home deaths had more people who were females, 75 years old or older, and Lao-Tai. Home deaths had more deaths than hospital deaths due to accident/injury (16.0% vs. 8.1%), tumor (4.7% vs. 1.8%), and senility (16.2% vs. 0%); fewer deaths due to heart/renal disease (15.1% vs. 32.3%), respiratory disease (12.2% vs. 18.8%), liver/gastro-intestine disease (5.3% vs. 9.0%), and infection (3.1% vs. 14.3%). The age group of 15–59 years had more deaths in the categories of accident/injury (28.1% vs. 4.4%), liver/gastro-intestine disease (8.1% vs. 4.4%), infection (7.2% vs. 3.5%), and tumor (6.0% vs. 2.8%). Males had more deaths due to tumor (5.2% vs. 3.0%) and fewer natural deaths (11.2% vs. 15.9%) than females. Conclusions The major UCOD category was heart/renal disease in the adult generation in Xaiyabouli Province. Cost-effective interventions based on the multisectoral noncommunicable disease ...
Keywords	Lao PDR ; Underlying cause of death ; Verbal autopsy ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Asymmetric deformation of the Earth’s magnetosphere under low Alfvén Mach number solar wind

Masaki N. Nishino / Hiroshi Hasegawa / Yoshifumi Saito / Benoit Lavraud / Yukinaga Miyashita / Motoharu Nowada / Satoshi Kasahara / Tsugunobu Nagai

Earth, Planets and Space, Vol 74, Iss 1, Pp 1-

Observations and MHD simulation

2022 Volume 16

Abstract: Abstract The density of the solar wind plasma near the Earth’s magnetosphere sometimes decreases ... expansion of the Earth’s magnetosphere by the low dynamic pressure was assumed in previous studies, a global ...

Abstract	Abstract The density of the solar wind plasma near the Earth’s magnetosphere sometimes decreases to only several per cent of the usual value, and such density extrema result in a significant reduction of the dynamic pressure and Alfvén Mach number ( $$M_A$$ M A ) of the solar wind flow. While a symmetric expansion of the Earth’s magnetosphere by the low dynamic pressure was assumed in previous studies, a global magnetohydrodynamic (MHD) simulation study predicted a remarkable dawn-dusk asymmetry of the magnetospheric shape under low-density solar wind and Parker-spiral interplanetary magnetic field (IMF) configuration. Here, we present observations consistent with the asymmetric deformation of the magnetosphere under low- $$M_A$$ M A solar wind and Parker-spiral IMF conditions, focusing on the significant expansion of the dawn-flank magnetosphere detected by the Geotail spacecraft. A global MHD simulation reproduced the dawnward expansion of the near-Earth magnetosphere, which was consistent with the observation by Geotail. The solar wind flow had a non-negligible dusk-to-dawn component and partly affected the dawnward expansion of the magnetosphere. Local, roughly Alfvénic sunward acceleration of magnetosheath ions at the dawn flank magnetopause suggests magnetosheath plasma entry into the magnetosphere through open field lines generated by magnetic reconnection at the dayside magnetopause. At the same time, Cluster 1 and 3, located near the southern polar cusp, also detected continuous antisunward ion jets and occasional sunward jets, which are consistent with the occurrence of magnetic reconnection near the southern cusp. These observations suggest that enhanced plasma acceleration at the dayside magnetopause operates under the low- $$M_A$$ M A solar wind and Parker spiral IMF conditions and that plasma influx across the dawnside magnetopause is at work under such a low- $$M_A$$ M A condition. These results can be helpful in understanding interactions between low- $$M_A$$ M A solar/stellar winds and celestial ...
Keywords	Low density solar wind ; Earth’s magnetosphere ; Alfvén Mach number ; Solar wind–magnetosphere interaction ; Geography. Anthropology. Recreation ; G ; Geodesy ; QB275-343 ; Geology ; QE1-996.5
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Glutathione S-transferase π complexes with and stimulates Na⁺,K⁺-ATPase.

Ochiai, Hideo / Eguchi, Hiroshi / Noguchi, Shunsuke / Hayashi, Yutaro / Nishino, Hideaki / Kawamura, Masaru / Wu, Chau H

Journal of molecular recognition : JMR

2013 Volume 26, Issue 1, Page(s) 32–37

Abstract: Glutathione S-transferase (GST) was found to complex with the Na⁺,K⁺-ATPase as shown by binding ...

Abstract	Glutathione S-transferase (GST) was found to complex with the Na⁺,K⁺-ATPase as shown by binding assay using quartz crystal microbalance. The complexation was obstructed by the addition of antiserum to the α-subunit of the Na⁺,K⁺-ATPase, suggesting the specificity of complexation between GST and the Na⁺,K⁺-ATPase. Co-immunoprecipitation experiments, using the anti-α-subunit antiserum to precipitate the GST-Na⁺,K⁺-ATPase complex and then using antibodies specific to an isoform of GST to identify the co-precipitated proteins, revealed that GSTπ was complexed with the Na⁺,K⁺-ATPase. GST stimulated the Na⁺,K⁺-ATPase activity up to 1.4-fold. The level of stimulation exhibited a saturable dose-response relationship with the amount of GST added, although the level of stimulation varied depending on the content of GSTπ in the lots of GST received from supplier. The stimulation was also obtained when recombinant GSTπ was used, confirming the results. When GST was treated with reduced glutathione, GST activity was greatly stimulated, whereas the level of stimulation of the Na⁺,K⁺-ATPase activity was similar to that when untreated GST was added. When GST was treated with H₂O₂, GST activity was greatly diminished while the stimulation of the Na⁺,K⁺-ATPase activity was preserved. The results suggest that GSTπ complexes with the Na⁺,K⁺-ATPase and stimulates the latter independent of its GST activity.
MeSH term(s)	Animals ; Glutathione/chemistry ; Glutathione S-Transferase pi/chemistry ; Glutathione S-Transferase pi/metabolism ; Hydrogen Peroxide/chemistry ; Immune Sera/chemistry ; Immunoprecipitation/methods ; Sodium-Potassium-Exchanging ATPase/chemistry ; Sodium-Potassium-Exchanging ATPase/metabolism ; Swine
Chemical Substances	Immune Sera ; Hydrogen Peroxide (BBX060AN9V) ; Glutathione S-Transferase pi (EC 2.5.1.18) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2013-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1015084-5
ISSN	1099-1352 ; 0952-3499
ISSN (online)	1099-1352
ISSN	0952-3499
DOI	10.1002/jmr.2238
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Article ; Online: Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

Shingo Tsuji / Takeshi Hase / Ayako Yachie-Kinoshita / Taiko Nishino / Samik Ghosh / Masataka Kikuchi / Kazuro Shimokawa / Hiroyuki Aburatani / Hiroaki Kitano / Hiroshi Tanaka

Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-

2021 Volume 15

Abstract: ... novel putative target genes for Alzheimer’s disease and successfully identified key genes that may serve ...

Abstract	Abstract Background Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets for FDA-approved drugs. As a result, it is inevitable to develop powerful computational tools that can identify potential novel therapeutic targets. Fortunately, the human protein-protein interaction network (PIN) could be a useful resource to achieve this objective. Methods In this study, we developed a deep learning-based computational framework that extracts low-dimensional representations of high-dimensional PIN data. Our computational framework uses latent features and state-of-the-art machine learning techniques to infer potential drug target genes. Results We applied our computational framework to prioritize novel putative target genes for Alzheimer’s disease and successfully identified key genes that may serve as novel therapeutic targets (e.g., DLG4, EGFR, RAC1, SYK, PTK2B, SOCS1). Furthermore, based on these putative targets, we could infer repositionable candidate-compounds for the disease (e.g., tamoxifen, bosutinib, and dasatinib). Conclusions Our deep learning-based computational framework could be a powerful tool to efficiently prioritize new therapeutic targets and enhance the drug repositioning strategy.
Keywords	Network embedding ; Deep learning ; Machine learning ; Systems biology ; Drug discovery ; Protein interaction network ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	006
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article: [A case of advanced gastric cancer responding to S-1/CDDP neoadjuvant chemotherapy, leading to a pathological complete response].

Kitayama, Kishu / Kanehara, Isao / Teraoka, Hitoshi / Nishimura, Junya / Nomura, Shinya / Noda, Eiji / Nishino, Hiroji / Hirakawa, Kosei

Gan to kagaku ryoho. Cancer & chemotherapy

2015 Volume 42, Issue 1, Page(s) 85–87

Abstract: ... with esophageal invasion was treated with S-1/CDDP as neoadjuvant chemotherapy. After 3 courses of chemotherapy ...

Abstract	A 66-year-old man with cStage III B (cT4aN2H0P0M0) advanced gastric cancer in the cardia with esophageal invasion was treated with S-1/CDDP as neoadjuvant chemotherapy. After 3 courses of chemotherapy, a significant reduction in tumor burden was observed. Total gastrectomy and splenectomy with lymph node dissection (D2) were performed. Pathological specimens showed no cancer cells in the stomach and lymph nodes, indicating a pathological complete response.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/administration & dosage ; Drug Combinations ; Humans ; Lymphatic Metastasis ; Male ; Neoadjuvant Therapy ; Neoplasm Staging ; Oxonic Acid/administration & dosage ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Tegafur/administration & dosage
Chemical Substances	Drug Combinations ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG) ; Cisplatin (Q20Q21Q62J)
Language	Japanese
Publishing date	2015-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article ; Review
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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