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  1. Article ; Online: Tuberculous placenta: a rare bird but not extinct.

    Miranda, Laura / Kugasia, Irfanali / Han, Liying / Chandy, Dipak / Epelbaum, Oleg

    Postgraduate medical journal

    2023  Volume 98, Issue e1, Page(s) e27–e28

    MeSH term(s) Pregnancy ; Female ; Humans ; Mycobacterium tuberculosis ; Placenta
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2021-139902
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.340: Show issues Location:
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  2. Article ; Online: Impact of jet lag on free throw shooting in the National Basketball Association.

    Glinski, John / Chandy, Dipak

    Chronobiology international

    2022  Volume 39, Issue 7, Page(s) 1001–1005

    Abstract: Jet lag can impair a variety of physical and mental functions. The impact of jet lag on athletic performance has been assumed but difficult to prove methodologically. The challenges have involved eliminating the impact of the quality of the opponent and ... ...

    Abstract Jet lag can impair a variety of physical and mental functions. The impact of jet lag on athletic performance has been assumed but difficult to prove methodologically. The challenges have involved eliminating the impact of the quality of the opponent and the difficulties determining when an athlete actually traveled across time zones. Analyzing free throw (FT) shooting in the National Basketball Association allowed these challenges to be overcome. 48,309 games across 19 consecutive seasons were examined of which 675 games involved a team that met our definition of jet lag. In these games, players on the jet lagged teams made 12,154 of 16,286 (74.6%) FTs that were attempted while in the remaining games of that season, the same players on these teams made 993,962 of 1,318,188 (75.4%) FTs attempted,
    MeSH term(s) Athletes ; Athletic Performance ; Basketball ; Circadian Rhythm ; Humans ; Jet Lag Syndrome
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.1080/07420528.2022.2057321
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2068: Show issues Location:
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  3. Article ; Online: The impact of fever as a testing indication on the detection rate of deep vein thrombosis in neurocritically ill patients.

    Henson, Theresa / Velasquez, Ricardo / Martin, Alvaro / Kozlova, Natalya / Chandy, Dipak / Epelbaum, Oleg

    Acute medicine & surgery

    2023  Volume 10, Issue 1, Page(s) e889

    Abstract: Aim: Deep vein thrombosis (DVT) is considered a possible source of non-infectious, non-central fever in the intensive care unit (ICU). In the neurocritically ill, it is unknown whether lower extremity venous Doppler ultrasonography (LEVDUS) for DVT in ... ...

    Abstract Aim: Deep vein thrombosis (DVT) is considered a possible source of non-infectious, non-central fever in the intensive care unit (ICU). In the neurocritically ill, it is unknown whether lower extremity venous Doppler ultrasonography (LEVDUS) for DVT in the setting of fever leads to a higher detection rate than the baseline detection rate of DVT in this population. The aim of this study was to compare the DVT detection rate of LEVDUS performed for the indication of fever to LEVDUS performed for other indications in a neurosciences ICU.
    Methods: Requisition forms for all LEVDUS performed in a referral neurosciences ICU were reviewed and separated into those with "fever" as the stated reason for request and those with other stated reasons. The DVT detection rate was compared between these two categories of indications.
    Results: Five hundred eleven LEVDUS were analyzed, of which 422 had been ordered for indications other than fever. Sixteen of these tests were positive, a detection rate of 3.8%. The remaining 89 LEVDUS had "fever" as the ordering indication. Six of these tests were positive for DVT, a detection rate of 6.7%. The likelihood of positivity of a test obtained as part of fever evaluation relative to one obtained for non-fever indications was not significantly different (OR, 1.83; 95% CI, 0.570-5.11;
    Conclusion: LEVDUS triggered by fever detected DVT at a numerically, but not statistically significantly higher rate than did LEVDUS performed for other indications in a neurocritically ill population. More rigorous investigation of this question is needed.
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.889
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  4. Article ; Online: Pneumothorax and pneumomediastinum in patients hospitalized with coronavirus disease 2019 (COVID-19).

    Greenberg, Daniel J / Nabors, Christopher / Chandy, Dipak / Dhand, Abhay

    Heart & lung : the journal of critical care

    2021  Volume 50, Issue 3, Page(s) 386–387

    MeSH term(s) COVID-19 ; Humans ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Pneumonia ; Pneumothorax/diagnosis ; Pneumothorax/etiology ; SARS-CoV-2
    Language English
    Publishing date 2021-02-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2021.02.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1035: Show issues Location:
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  5. Article: Clinical and Laboratory Profile of COVID-19 Pneumonia Patients With a Complicated Post-Intensive Care Unit Hospital Course.

    Yaqoob, Hamid / Vernik, David / Feustel, Paul J / Chandy, Dipak / Epelbaum, Oleg

    Journal of clinical medicine research

    2021  Volume 13, Issue 10-11, Page(s) 487–496

    Abstract: Background: Characteristics of intensive care unit (ICU) downgrades who experience a complicated post-ICU ward course (ICU return or floor death) and the incidence of this phenomenon have not been examined in ICU survivors of coronavirus disease 2019 ( ... ...

    Abstract Background: Characteristics of intensive care unit (ICU) downgrades who experience a complicated post-ICU ward course (ICU return or floor death) and the incidence of this phenomenon have not been examined in ICU survivors of coronavirus disease 2019 (COVID-19) pneumonia. The aim of the present study was to establish the rate of a complicated post-ICU ward course among survivors of COVID-19 pneumonia and describe the associated patient, ICU management, and serum biomarker characteristics. An additional aim was to compare these parameters between those who experienced a complicated post-ICU course and those who did not.
    Methods: This was a retrospective study of patients who were admitted to the ICU with COVID-19 pneumonia and were downgraded to a hospital floor at the end of their initial ICU stay. Patients were divided based on a complicated or uncomplicated post-ICU course. Groups were compared with respect to relevant clinical variables. Serum biomarker levels were compared on day of ICU exit and were trended in the days preceding the downgrade. Ward stay of patients who had a complicated course was examined for notable floor events surrounding their decompensation.
    Results: Eighteen out of 99 downgraded patients (18%) experienced a complicated post-ICU course, among them there were 14 returns (14%) and four deaths (4%). They had higher Charlson Comorbidity Index, higher Acute Physiology and Chronic Health Evaluation (APACHE) IV score, as well as higher D-dimer and C-reactive protein (CRP) at ICU departure. They were less likely to have received therapeutic anticoagulation and convalescent plasma during their ICU stay. On multivariable analysis, these parameters except D-dimer remained independently associated with a complicated course. Review of biomarker trends preceding ICU exit demonstrated an upward trajectory of D-dimer, CRP, and lactate dehydrogenase (LDH) in the complicated course group not mirrored by the uncomplicated course group. Examination of notable floor events leading up to decompensation revealed that in 50% the ward course was characterized by new cardiac disturbances.
    Conclusions: Our rate of ward death among ICU downgrades was similar to pre-COVID data, but the rate of ICU return was higher. Complicated post-ICU course patients were exhibiting upward biomarker trends at ICU exit, and their ward stay was punctuated by acute cardiac abnormalities.
    Language English
    Publishing date 2021-10-27
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2548987-2
    ISSN 1918-3011 ; 1918-3003
    ISSN (online) 1918-3011
    ISSN 1918-3003
    DOI 10.14740/jocmr4555
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  6. Article: Stroke in critical COVID-19 patients: a cautionary tale from the frontlines.

    Jain, Anant / Jafri, Firas / Manglani, Ravi / Al-Mufti, Fawaz / Aronow, Wilbert S / Chandy, Dipak

    Archives of medical sciences. Atherosclerotic diseases

    2020  Volume 5, Page(s) e263–e270

    Abstract: Introduction: Although Coronavirus Disease 2019 (COVID-19) is primarily a disease of the respiratory system in its transmission and clinical manifestations, physicians have also reported a tropism toward the nervous system.: Methods: Neurological ... ...

    Abstract Introduction: Although Coronavirus Disease 2019 (COVID-19) is primarily a disease of the respiratory system in its transmission and clinical manifestations, physicians have also reported a tropism toward the nervous system.
    Methods: Neurological symptoms can occur as one of many systemic manifestations of a critical form of the disease or in isolation as the predominant presenting complaint.
    Results: We report a series of 6 patients who suffered significant cerebrovascular accidents while being treated for critical COVID-19 in the intensive care units of a quaternary care hospital in New York's Hudson valley.
    Conclusions: This series demonstrates how a relatively rare but catastrophic neurological complication can occur in patients with COVID-19 while they are being managed for their more common problems such as respiratory and renal failure.
    Language English
    Publishing date 2020-12-29
    Publishing country Poland
    Document type Journal Article
    ISSN 2451-0629
    ISSN 2451-0629
    DOI 10.5114/amsad.2020.102423
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  7. Article: Obstructive sleep apnoea and cardiovascular disease: a literature review.

    Assallum, Hussein / Song, Tian Yue / Aronow, Wilbert S / Chandy, Dipak

    Archives of medical science : AMS

    2019  Volume 17, Issue 5, Page(s) 1200–1212

    Abstract: As obesity becomes more common worldwide, the prevalence of obstructive sleep apnoea (OSA) continues to rise. Obstructive sleep apnoea is a well-known disorder that causes chronic intermittent hypoxia (CIH), which is considered a risk factor for ... ...

    Abstract As obesity becomes more common worldwide, the prevalence of obstructive sleep apnoea (OSA) continues to rise. Obstructive sleep apnoea is a well-known disorder that causes chronic intermittent hypoxia (CIH), which is considered a risk factor for atherosclerosis directly and indirectly. Ischaemic heart disease remains the leading cause of death. Most risk factors for atherosclerosis are well understood. However, other factors such as CIH are less well understood. Several studies have investigated the pathophysiology of CIH, attempting to uncover its link to atherosclerosis and to determine whether OSA treatment can be a therapeutic modality to modify the risk for atherosclerosis. In this article, we will review the pathophysiology of OSA as an independent risk factor for cardiovascular disease and discuss the most common markers that have been studied. We will also examine the potential impact of OSA management as a risk factor modifier on the reversibility of atherosclerosis.
    Language English
    Publishing date 2019-10-08
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2019.88558
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  8. Article: Low Risk Monitoring in Neurocritical Care.

    Becker, Christian D / Bowers, Christian / Chandy, Dipak / Cole, Chad / Schmidt, Meic H / Scurlock, Corey

    Frontiers in neurology

    2018  Volume 9, Page(s) 938

    Abstract: Background/Rationale: ...

    Abstract Background/Rationale:
    Language English
    Publishing date 2018-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2018.00938
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  9. Article: Postobstructive pneumonia in lung cancer.

    Valvani, Aashish / Martin, Alvaro / Devarajan, Anusha / Chandy, Dipak

    Annals of translational medicine

    2017  Volume 7, Issue 15, Page(s) 357

    Abstract: Postobstructive pneumonia can complicate lung cancer, particularly in more advanced stages of the disease, producing significant clinical decline and a poorer prognosis. It can lead to complications such as empyema, lung abscess and fistula formation. ... ...

    Abstract Postobstructive pneumonia can complicate lung cancer, particularly in more advanced stages of the disease, producing significant clinical decline and a poorer prognosis. It can lead to complications such as empyema, lung abscess and fistula formation. Postobstructive pneumonia can also be the first manifestation of an underlying malignancy. There are multiple challenges in the management of these patients. Recognition and treatment of this entity can be complex and includes the use of imaging, administration of broad-spectrum antibiotics to cover the wide variety of microorganisms involved and the use of different interventional modalities to relieve the obstruction. Existing literature on postobstructive pneumonia is scarce. In this article, we review the pathophysiology, different diagnostic methods and the therapeutic options to treat this condition. The utility and efficacy of the various modalities that are currently available in clinical practice to the interventional pulmonologist are described in some detail.
    Language English
    Publishing date 2017-07-26
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.05.26
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  10. Article ; Online: Pulmonary sarcoidosis: an update.

    Ramachandraiah, Vidya / Aronow, Wilbert / Chandy, Dipak

    Postgraduate medicine

    2017  Volume 129, Issue 1, Page(s) 149–158

    Abstract: Sarcoidosis is a multisystem disease characterized by the presence of noncaseating granulomas, the exact etiology of which is yet to be determined. Pulmonary involvement occurs in the majority of patients and its severity ranges from asymptomatic ... ...

    Abstract Sarcoidosis is a multisystem disease characterized by the presence of noncaseating granulomas, the exact etiology of which is yet to be determined. Pulmonary involvement occurs in the majority of patients and its severity ranges from asymptomatic involvement of mediastinal lymph nodes to progressive pulmonary fibrosis and chronic respiratory failure that is insensitive to treatment. Diagnosis of pulmonary sarcoidosis requires a compatible clinical picture supported by radiologic and pathologic data. A recent development in establishing the diagnosis of pulmonary sarcoidosis is endobronchial ultrasound that increases the yield of transbronchial needle aspiration of hilar and/or mediastinal lymph nodes. Fluorodeoxyglucose positron emission tomography (FDG-PET) is highly sensitive in detecting occult sites of disease and is of value in guiding biopsies of these sites. A combined imaging modality using both FDG-PET and CT scan is more sensitive than PET alone and is now the standard of care in patients requiring biopsies of active lesions. Biologic agents like anti-tumor necrosis factor antibodies are being used as second line treatment in those patients dependent on steroids or in cases of refractory sarcoidosis. Lung transplantation is the final option in suitable patients with end-stage pulmonary sarcoidosis.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Lung Transplantation ; Lymph Nodes/diagnostic imaging ; Male ; Middle Aged ; Positron-Emission Tomography ; Sarcoidosis, Pulmonary/diagnosis ; Sarcoidosis, Pulmonary/diagnostic imaging ; Sarcoidosis, Pulmonary/genetics ; Sarcoidosis, Pulmonary/therapy ; Tomography, X-Ray Computed ; Ultrasonography
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2017.1251818
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    Ua VI Zs.407: Show issues Location:
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