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  1. Article ; Online: Thrombopoietin-receptor agonists for immune thrombocytopenia.

    Jansen, A J Gerard / Swart, Reinout M / te Boekhorst, Peter A W

    The New England journal of medicine

    2011  Volume 365, Issue 23, Page(s) 2240–2241

    MeSH term(s) Autoimmune Diseases/drug therapy ; Benzoates/therapeutic use ; Female ; Humans ; Hydrazines/therapeutic use ; Pyrazoles/therapeutic use ; Receptors, Fc/therapeutic use ; Receptors, Thrombopoietin/agonists ; Recombinant Fusion Proteins/therapeutic use ; Thrombocytopenia/drug therapy ; Thrombopoietin/therapeutic use
    Chemical Substances Benzoates ; Hydrazines ; Pyrazoles ; Receptors, Fc ; Receptors, Thrombopoietin ; Recombinant Fusion Proteins ; Thrombopoietin (9014-42-0)
    Language English
    Publishing date 2011-12-08
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1112230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation.

    Swart, Reinout M / Hoorn, Ewout J / Betjes, Michiel G / Zietse, Robert

    Nephron. Physiology

    2011  Volume 118, Issue 2, Page(s) 45–51

    Abstract: Although hyponatremia is a recognized complication of several inflammatory diseases, its pathophysiology in this setting has remained elusive until recently. A growing body of evidence now points to an important role for interleukin-6 in the non-osmotic ... ...

    Abstract Although hyponatremia is a recognized complication of several inflammatory diseases, its pathophysiology in this setting has remained elusive until recently. A growing body of evidence now points to an important role for interleukin-6 in the non-osmotic release of vasopressin. Here, we review this evidence by exploring the immuno-neuroendocrine pathways connecting interleukin-6 with vasopressin. The importance of these connections extends to several clinical scenarios of hyponatremia and inflammation, including hospital-acquired hyponatremia, postoperative hyponatremia, exercise-associated hyponatremia, and hyponatremia in the elderly. Besides insights in pathophysiology, the recognition of the propensity for antidiuresis during inflammation is also important with regard to monitoring patients and selecting the appropriate intravenous fluid regimen, for which recommendations are provided.
    MeSH term(s) Cytokines/physiology ; Humans ; Hyponatremia/physiopathology ; Inflammation/physiopathology ; Interleukin-6/physiology ; Signal Transduction/physiology ; Vasopressins/physiology ; Water-Electrolyte Balance/physiology
    Chemical Substances Cytokines ; Interleukin-6 ; Vasopressins (11000-17-2)
    Language English
    Publishing date 2011
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 1660-2137 ; 1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
    ISSN (online) 1660-2137 ; 1423-0186 ; 2235-3186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000322238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 169: Show issues Location:
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  3. Article: Hyponatremia and Inflammation: The Emerging Role of Interleukin-6 in Osmoregulation

    Swart, Reinout M. / Hoorn, Ewout J. / Betjes, Michiel G. / Zietse, Robert

    Nephron Physiology

    2010  Volume 118, Issue 2, Page(s) p45–p51

    Abstract: Although hyponatremia is a recognized complication of several inflammatory diseases, its pathophysiology in this setting has remained elusive until recently. A growing body of evidence now points to an important role for interleukin-6 in the non-osmotic ... ...

    Institution Department of Internal Medicine – Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
    Abstract Although hyponatremia is a recognized complication of several inflammatory diseases, its pathophysiology in this setting has remained elusive until recently. A growing body of evidence now points to an important role for interleukin-6 in the non-osmotic release of vasopressin. Here, we review this evidence by exploring the immuno-neuroendocrine pathways connecting interleukin-6 with vasopressin. The importance of these connections extends to several clinical scenarios of hyponatremia and inflammation, including hospital-acquired hyponatremia, postoperative hyponatremia, exercise-associated hyponatremia, and hyponatremia in the elderly. Besides insights in pathophysiology, the recognition of the propensity for antidiuresis during inflammation is also important with regard to monitoring patients and selecting the appropriate intravenous fluid regimen, for which recommendations are provided.
    Keywords Acute phase response ; Infectious disease ; Immuno-neuroendocrinology ; Lipopolysaccharides ; Vasopressin
    Language English
    Publishing date 2010-12-22
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Minireview
    ZDB-ID 207121-6
    ISSN 1660-2137 ; 1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
    ISSN (online) 1660-2137 ; 1423-0186 ; 2235-3186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000322238
    Database Karger publisher's database

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  4. Article ; Online: Hyponatremia due to reset osmostat in dementia with lewy bodies.

    Hoorn, Ewout J / Swart, Reinout M / Westerink, Margriet / van den Dorpel, Marinus A / Berghout, Arie / Bakker, Jet J

    Journal of the American Geriatrics Society

    2008  Volume 56, Issue 3, Page(s) 567–569

    MeSH term(s) Aged ; Female ; Humans ; Inappropriate ADH Syndrome/diagnosis ; Inappropriate ADH Syndrome/etiology ; Lewy Body Disease/complications
    Language English
    Publishing date 2008-03
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/j.1532-5415.2008.01579.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nontuberculous Mycobacterium Infection and Tumor Necrosis Factor-α Antagonists

    Reinout M. Swart / Jakko van Ingen / Dick van Soolingen / Rob Slingerland / Willem D.H. Hendriks / Jan G. den Hollander

    Emerging Infectious Diseases, Vol 15, Iss 10, Pp 1700-

    2009  Volume 1701

    Keywords Tuberculosis and other mycobacteria ; nontuberculous mycobacteria ; pneumonia ; rheumatoid arthritis ; tumor necrosis factor-α antagonists ; adalimumab ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2009-10-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Nontuberculous mycobacteria infection and tumor necrosis factor-alpha antagonists.

    Swart, Reinout M / van Ingen, Jakko / van Soolingen, Dick / Slingerland, Rob / Hendriks, Willem D H / den Hollander, Jan G

    Emerging infectious diseases

    2009  Volume 15, Issue 10, Page(s) 1700–1701

    MeSH term(s) Adalimumab ; Aged ; Anti-Bacterial Agents/therapeutic use ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Female ; Humans ; Methotrexate/therapeutic use ; Mycobacterium Infections/microbiology ; Mycobacterium haemophilum/isolation & purification ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
    Chemical Substances Anti-Bacterial Agents ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; Tumor Necrosis Factor-alpha ; Adalimumab (FYS6T7F842) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2009-10-28
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid1510.090110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4778: Show issues Location:
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  7. Article ; Online: Acute kidney injury during therapy with an antisense oligonucleotide directed against PCSK9.

    van Poelgeest, Eveline P / Swart, Reinout M / Betjes, Michiel G H / Moerland, Matthijs / Weening, Jan J / Tessier, Yann / Hodges, Michael R / Levin, Arthur A / Burggraaf, Jacobus

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2013  Volume 62, Issue 4, Page(s) 796–800

    Abstract: ... dL at baseline (corresponding to an estimated glomerular filtration rate [eGFR] of 78 mL/min/1.73 m(2 ... to 2.67 mg/dL (eGFR, 20 mL/min/1.73 m(2)), and this increase coincided with the presence ... peaked at 3.81 mg/dL (eGFR, 13 mL/min/1.73 m(2)) 1 week after the last oligonucleotide dose. Kidney ...

    Abstract Antisense oligonucleotides have been explored widely in clinical trials and generally are considered to be nontoxic for the kidney, even at high concentrations. We report a case of toxic acute tubular injury in a healthy 56-year-old female volunteer after a pharmacologically active dose of a locked nucleic acid antisense oligonucleotide was administered. The patient received 3 weekly subcutaneous doses of experimental drug SPC5001, an antisense oligonucleotide directed against PCSK9 (proprotein convertase subtilisin/kexin type 9) that is under investigation as an agent to reduce low-density lipoprotein cholesterol levels. Five days after the last dose, the patient's serum creatinine level increased from 0.81 mg/dL at baseline (corresponding to an estimated glomerular filtration rate [eGFR] of 78 mL/min/1.73 m(2)) to 2.67 mg/dL (eGFR, 20 mL/min/1.73 m(2)), and this increase coincided with the presence of white blood cells, granular casts, and minimal hematuria on urine microscopy. The patient's serum creatinine level peaked at 3.81 mg/dL (eGFR, 13 mL/min/1.73 m(2)) 1 week after the last oligonucleotide dose. Kidney biopsy showed multifocal tubular necrosis and signs of oligonucleotide accumulation. Upon conservative treatment, the patient's serum creatinine level gradually decreased and reached her baseline level 44 days after the last oligonucleotide was administered. The patient recovered fully and kidney function was normal at every follow-up visit.
    MeSH term(s) Acute Kidney Injury/chemically induced ; Female ; Humans ; Middle Aged ; Oligonucleotides, Antisense/adverse effects ; Oligonucleotides, Antisense/therapeutic use ; Proprotein Convertase 9 ; Proprotein Convertases/adverse effects ; Proprotein Convertases/therapeutic use ; Serine Endopeptidases/adverse effects ; Serine Endopeptidases/therapeutic use
    Chemical Substances Oligonucleotides, Antisense ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Proprotein Convertases (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2013.02.359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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