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  1. Article ; Online: Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels.

    Ji, Yuekai / Temprano-Sagrera, Gerard / Holle, Lori A / Bebo, Allison / Brody, Jennifer A / Le, Ngoc-Quynh / Kangro, Kadri / Brown, Michael R / Martinez-Perez, Angel / Sitlani, Colleen M / Suchon, Pierre / Kleber, Marcus E / Emmert, David B / Bilge Ozel, Ayse / Dobson, Dre'Von A / Tang, Weihong / Llobet, Dolors / Tracy, Russell P / Deleuze, Jean-François /
    Delgado, Graciela E / Gögele, Martin / Wiggins, Kerri L / Souto, Juan Carlos / Pankow, James S / Taylor, Kent D / Trégouët, David-Alexandre / Moissl, Angela P / Fuchsberger, Christian / Rosendaal, Frits R / Morrison, Alanna C / Soria, Jose Manuel / Cushman, Mary / Morange, Pierre-Emmanuel / März, Winfried / Hicks, Andrew A / Desch, Karl C / Johnson, Andrew D / de Vries, Paul S / Wolberg, Alisa S / Smith, Nicholas L / Sabater-Lleal, Maria

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 43, Issue 7, Page(s) e254–e269

    Abstract: Background: Antithrombin, PC (protein C), and PS (protein S) are circulating natural anticoagulant ...

    Abstract Background: Antithrombin, PC (protein C), and PS (protein S) are circulating natural anticoagulant proteins that regulate hemostasis and of which partial deficiencies are causes of venous thromboembolism. Previous genetic association studies involving antithrombin, PC, and PS were limited by modest sample sizes or by being restricted to candidate genes. In the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, we meta-analyzed across ancestries the results from 10 genome-wide association studies of plasma levels of antithrombin, PC, PS free, and PS total.
    Methods: Study participants were of European and African ancestries, and genotype data were imputed to TOPMed, a dense multiancestry reference panel. Each of the 10 studies conducted a genome-wide association studies for each phenotype and summary results were meta-analyzed, stratified by ancestry. Analysis of antithrombin included 25 243 European ancestry and 2688 African ancestry participants, PC analysis included 16 597 European ancestry and 2688 African ancestry participants, PSF and PST analysis included 4113 and 6409 European ancestry participants. We also conducted transcriptome-wide association analyses and multiphenotype analysis to discover additional associations. Novel genome-wide association studies and transcriptome-wide association analyses findings were validated by in vitro functional experiments. Mendelian randomization was performed to assess the causal relationship between these proteins and cardiovascular outcomes.
    Results: Genome-wide association studies meta-analyses identified 4 newly associated loci: 3 with antithrombin levels (
    Conclusions: The use of larger sample sizes, diverse populations, and a denser imputation reference panel allowed the detection of 7 novel genomic loci associated with plasma antithrombin, PC, and PS levels.
    MeSH term(s) Protein C/genetics ; Protein S/genetics ; Genome-Wide Association Study ; Antithrombins ; Transcriptome ; Anticoagulants ; Antithrombin III/genetics ; Polymorphism, Single Nucleotide
    Chemical Substances Protein C ; Protein S ; Antithrombins ; Anticoagulants ; Antithrombin III (9000-94-6)
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.318213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Observation of the B_{c}^{+} Meson in Pb-Pb and pp Collisions at sqrt[s_{NN}]=5.02  TeV and Measurement of its Nuclear Modification Factor.

    Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Dragicevic, M / Del Valle, A Escalante / Frühwirth, R / Jeitler, M / Krammer, N / Lechner, L / Liko, D / Mikulec, I / Paulitsch, P / Pitters, F M / Schieck, J / Schöfbeck, R / Schwarz, D / Templ, S /
    Waltenberger, W / Wulz, C-E / Chekhovsky, V / Litomin, A / Makarenko, V / Darwish, M R / De Wolf, E A / Janssen, T / Kello, T / Lelek, A / Sfar, H Rejeb / Van Mechelen, P / Van Putte, S / Van Remortel, N / Blekman, F / Bols, E S / D'Hondt, J / Delcourt, M / Faham, H El / Lowette, S / Moortgat, S / Morton, A / Müller, D / Sahasransu, A R / Tavernier, S / Van Doninck, W / Van Mulders, P / Beghin, D / Bilin, B / Clerbaux, B / De Lentdecker, G / Favart, L / Grebenyuk, A / Kalsi, A K / Lee, K / Mahdavikhorrami, M / Makarenko, I / Moureaux, L / Pétré, L / Popov, A / Postiau, N / Starling, E / Thomas, L / Vanden Bemden, M / Vander Velde, C / Vanlaer, P / Wezenbeek, L / Cornelis, T / Dobur, D / Knolle, J / Lambrecht, L / Mestdach, G / Niedziela, M / Roskas, C / Samalan, A / Skovpen, K / Tytgat, M / Vermassen, B / Vit, M / Benecke, A / Bethani, A / Bruno, G / Bury, F / Caputo, C / David, P / Delaere, C / Donertas, I S / Giammanco, A / Jaffel, K / Jain, Sa / Lemaitre, V / Mondal, K / Prisciandaro, J / Taliercio, A / Teklishyn, M / Tran, T T / Vischia, P / Wertz, S / Alves, G A / Hensel, C / Moraes, A / Júnior, W L Aldá / Pereira, M Alves Gallo / Filho, M Barroso Ferreira / Malbouisson, H Brandao / Carvalho, W / Chinellato, J / Da Costa, E M / Da Silveira, G G / Damiao, D De Jesus / De Souza, S Fonseca / Figueiredo, D Matos / Herrera, C Mora / Amarilo, K Mota / Mundim, L / Nogima, H / Teles, P Rebello / Santoro, A / Amaral, S M Silva Do / Sznajder, A / Thiel, M / De Araujo, F Torres Da Silva / Pereira, A Vilela / Bernardes, C A / Calligaris, L / Tomei, T R Fernandez Perez / Gregores, E M / Lemos, D S / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Antchev, G / Hadjiiska, R / Iaydjiev, P / Misheva, M / Rodozov, M / Shopova, M / Sultanov, G / Dimitrov, A / Ivanov, T / Litov, L / Pavlov, B / Petkov, P / Petrov, A / Cheng, T / Javaid, T / Mittal, M / Yuan, L / Ahmad, M / Bauer, G / Dozen, C / Hu, Z / Martins, J / Wang, Y / Yi, K / Chapon, E / Chen, G M / Chen, H S / Chen, M / Iemmi, F / Kapoor, A / Leggat, D / Liao, H / Liu, Z-A / Milosevic, V / Monti, F / Sharma, R / Tao, J / Thomas-Wilsker, J / Wang, J / Zhang, H / Zhao, J / Agapitos, A / An, Y / Ban, Y / Chen, C / Levin, A / Li, Q / Lyu, X / Mao, Y / Qian, S J / Wang, D / Wang, Q / Xiao, J / Lu, M / You, Z / Gao, X / Okawa, H / Lin, Z / Xiao, M / Avila, C / Cabrera, A / Florez, C / Fraga, J / Guisao, J Mejia / Ramirez, F / Alvarez, J D Ruiz / González, C A Salazar / Giljanovic, D / Godinovic, N / Lelas, D / Puljak, I / Antunovic, Z / Kovac, M / Sculac, T / Brigljevic, V / Ferencek, D / Majumder, D / Roguljic, M / Starodumov, A / Susa, T / Attikis, A / Christoforou, K / Erodotou, E / Ioannou, A / Kole, G / Kolosova, M / Konstantinou, S / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Saka, H / Finger, M / Kveton, A / Ayala, E / Jarrin, E Carrera / Elgammal, S / Kamel, A Ellithi / Mahmoud, M A / Mohammed, Y / Bhowmik, S / Dewanjee, R K / Ehataht, K / Kadastik, M / Nandan, S / Nielsen, C / Pata, J / Raidal, M / Tani, L / Veelken, C / Eerola, P / Forthomme, L / Kirschenmann, H / Osterberg, K / Voutilainen, M / Bharthuar, S / Brücken, E / Garcia, F / Havukainen, J / Kim, M S / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Lotti, M / Martikainen, L / Myllymäki, M / Ott, J / Siikonen, H / Tuominen, E / Tuominiemi, J / Luukka, P / Petrow, H / Tuuva, T / Amendola, C / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Faure, J L / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / de Monchenault, G Hamel / Jarry, P / Lenzi, B / Locci, E / Malcles, J / Rander, J / Rosowsky, A / Sahin, M Ö / Savoy-Navarro, A / Titov, M / Yu, G B / Ahuja, S / Arleo, F / Beaudette, F / Bonanomi, M / Perraguin, A Buchot / Busson, P / Cappati, A / Charlot, C / Davignon, O / Diab, B / Falmagne, G / Ghosh, S / de Cassagnac, R Granier / Hakimi, A / Kucher, I / Motta, J / Nguyen, M / Ochando, C / Paganini, P / Rembser, J / Salerno, R / Sarkar, U / Sauvan, J B / Sirois, Y / Tarabini, A / Zabi, A / Zghiche, A / Agram, J-L / Andrea, J / Apparu, D / Bloch, D / Bourgatte, G / Brom, J-M / Chabert, E C / Collard, C / Darej, D / Fontaine, J-C / Goerlach, U / Grimault, C / Le Bihan, A-C / Nibigira, E / Van Hove, P / Asilar, E / Beauceron, S / Bernet, C / Boudoul, G / Camen, C / Carle, A / Chanon, N / Contardo, D / Depasse, P / Mamouni, H El / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Laktineh, I B / Lattaud, H / Lesauvage, A / Lethuillier, M / Mirabito, L / Perries, S / Shchablo, K / Sordini, V / Torterotot, L / Touquet, G / Vander Donckt, M / Viret, S / Lomidze, I / Toriashvili, T / Tsamalaidze, Z / Botta, V / Feld, L / Klein, K / Lipinski, M / Meuser, D / Pauls, A / Röwert, N / Schulz, J / Teroerde, M / Dodonova, A / Eliseev, D / Erdmann, M / Fackeldey, P / Fischer, B / Hebbeker, T / Hoepfner, K / Ivone, F / Mastrolorenzo, L / Merschmeyer, M / Meyer, A / Mocellin, G / Mondal, S / Mukherjee, S / Noll, D / Novak, A / Pook, T / Pozdnyakov, A / Rath, Y / Reithler, H / Roemer, J / Schmidt, A / Schuler, S C / Sharma, A / Vigilante, L / Wiedenbeck, S / Zaleski, S / Dziwok, C / Flügge, G / Ahmad, W Haj / Hlushchenko, O / Kress, T / Nowack, A / Pistone, C / Pooth, O / Roy, D / Sert, H / Stahl, A / Ziemons, T / Zotz, A / Petersen, H Aarup / Martin, M Aldaya / Asmuss, P / Baxter, S / Bayatmakou, M / Behnke, O / Martínez, A Bermúdez / Bhattacharya, S / Anuar, A A Bin / Borras, K / Brunner, D / Campbell, A / Cardini, A / Cheng, C / Colombina, F / Rodríguez, S Consuegra / Silva, G Correia / Danilov, V / De Silva, M / Didukh, L / Eckerlin, G / Eckstein, D / Banos, L I Estevez / Filatov, O / Gallo, E / Geiser, A / Giraldi, A / Grohsjean, A / Guthoff, M / Jafari, A / Jomhari, N Z / Jung, H / Kasem, A / Kasemann, M / Kaveh, H / Kleinwort, C / Krücker, D / Lange, W / Lidrych, J / Lipka, K / Lohmann, W / Mankel, R / Melzer-Pellmann, I-A / Morentin, M Mendizabal / Metwally, J / Meyer, A B / Meyer, M / Mnich, J / Mussgiller, A / Otarid, Y / Adán, D Pérez / Pitzl, D / Raspereza, A / Lopes, B Ribeiro / Rübenach, J / Saggio, A / Saibel, A / Savitskyi, M / Scham, M / Scheurer, V / Schütze, P / Schwanenberger, C / Singh, A / Ricardo, R E Sosa / Stafford, D / Tonon, N / Van De Klundert, M / Walsh, R / Walter, D / Wen, Y / Wichmann, K / Wiens, L / Wissing, C / Wuchterl, S / Aggleton, R / Albrecht, S / Bein, S / Benato, L / Connor, P / De Leo, K / Eich, M / Feindt, F / Fröhlich, A / Garbers, C / Garutti, E / Gunnellini, P / Hajheidari, M / Haller, J / Hinzmann, A / Kasieczka, G / Klanner, R / Kogler, R / Kramer, T / Kutzner, V / Lange, J / Lange, T / Lobanov, A / Malara, A / Nigamova, A / Rodriguez, K J Pena / Rieger, O / Schleper, P / Schröder, M / Schwandt, J / Sonneveld, J / Stadie, H / Steinbrück, G / Tews, A / Zoi, I / Bechtel, J / Brommer, S / Butz, E / Caspart, R / Chwalek, T / De Boer, W / Dierlamm, A / Droll, A / Morabit, K El / Faltermann, N / Giffels, M / Gosewisch, J O / Gottmann, A / Hartmann, F / Heidecker, C / Husemann, U / Keicher, P / Koppenhöfer, R / Maier, S / Metzler, M / Mitra, S / Müller, Th / Neukum, M / Nürnberg, A / Quast, G / Rabbertz, K / Rauser, J / Savoiu, D / Schnepf, M / Seith, D / Shvetsov, I / Simonis, H J / Ulrich, R / Van Der Linden, J / Von Cube, R F / Wassmer, M / Weber, M / Wieland, S / Wolf, R / Wozniewski, S / Wunsch, S / Anagnostou, G / Daskalakis, G / Geralis, T / Kyriakis, A / Loukas, D / Stakia, A / Diamantopoulou, M / Karasavvas, D / Karathanasis, G / Kontaxakis, P / Koraka, C K / Manousakis-Katsikakis, A / Panagiotou, A / Papavergou, I / Saoulidou, N / Theofilatos, K / Tziaferi, E / Vellidis, K / Vourliotis, E / Bakas, G / Kousouris, K / Papakrivopoulos, I / Tsipolitis, G / Zacharopoulou, A / Adamidis, K / Bestintzanos, I / Evangelou, I / Foudas, C / Gianneios, P / Katsoulis, P / Kokkas, P / Manthos, N / Papadopoulos, I / Strologas, J / Csanad, M / Farkas, K / Gadallah, M M A / Lökös, S / Major, P / Mandal, K / Mehta, A / Pasztor, G / Rádl, A J / Surányi, O / Veres, G I / Bartók, M / Bencze, G / Hajdu, C / Horvath, D / Sikler, F / Veszpremi, V / Czellar, S / Karancsi, J / Molnar, J / Szillasi, Z / Teyssier, D / Raics, P / Trocsanyi, Z L / Ujvari, B / Csorgo, T / Nemes, F / Novak, T / Komaragiri, J R / Kumar, D / Panwar, L / Tiwari, P C / Bahinipati, S / Kar, C / Mal, P / Mishra, T / Bindhu, V K Muraleedharan Nair / Nayak, A / Saha, P / Sur, N / Swain, S K / Vats, D / Bansal, S / Beri, S B / Bhatnagar, V / Chaudhary, G / Chauhan, S / Dhingra, N / Gupta, R / Kaur, A / Kaur, M / Kaur, S / Kumari, P / Meena, M / Sandeep, K / Singh, J B / Virdi, A K / Ahmed, A / Bhardwaj, A / Choudhary, B C / Gola, M / Keshri, S / Kumar, A / Naimuddin, M / Priyanka, P / Ranjan, K / Shah, A / Bharti, M / Bhattacharya, R / Bhowmik, D / Dutta, S / Gomber, B / Maity, M / Palit, P / Rout, P K / Saha, G / Sahu, B / Sarkar, S / Sharan, M / Singh, B / Thakur, S / Behera, P K / Behera, S C / Kalbhor, P / Muhammad, A / Pradhan, R / Pujahari, P R / Sikdar, A K / Dutta, D / Jha, V / Kumar, V / Mishra, D K / Naskar, K / Netrakanti, P K / Pant, L M / Shukla, P / Aziz, T / Dugad, S / Kumar, M / Banerjee, S / Chudasama, R / Guchait, M / Karmakar, S / Kumar, S / Majumder, G / Mazumdar, K / Alpana, K / Dube, S / Kansal, B / Laha, A / Pandey, S / Rane, A / Rastogi, A / Sharma, S / Bakhshiansohi, H / Khazaie, E / Zeinali, M / Chenarani, S / Etesami, S M / Khakzad, M / Najafabadi, M Mohammadi / Grunewald, M / Abbrescia, M / Aly, R / Aruta, C / Colaleo, A / Creanza, D / De Filippis, N / De Palma, M / Di Florio, A / Di Pilato, A / Elmetenawee, W / Fiore, L / Gelmi, A / Gul, M / Iaselli, G / Ince, M / Lezki, S / Maggi, G / Maggi, M / Margjeka, I / Mastrapasqua, V / Merlin, J A / My, S / Nuzzo, S / Pellecchia, A / Pompili, A / Pugliese, G / Ramos, D / Ranieri, A / Selvaggi, G / Silvestris, L / Simone, F M / Venditti, R / Verwilligen, P / Abbiendi, G / Battilana, C / Bonacorsi, D / Borgonovi, L / Brigliadori, L / Campanini, R / Capiluppi, P / Castro, A / Cavallo, F R / Cuffiani, M / Dallavalle, G M / Diotalevi, T / Fabbri, F / Fanfani, A / Giacomelli, P / Giommi, L / Grandi, C / Guiducci, L / Meo, S Lo / Lunerti, L / Marcellini, S / Masetti, G / Navarria, F L / Perrotta, A / Primavera, F / Rossi, A M / Rovelli, T / Siroli, G P / Albergo, S / Costa, S / Di Mattia, A / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Cassese, A / Ceccarelli, R / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Latino, G / Lenzi, P / Lizzo, M / Meschini, M / Paoletti, S / Seidita, R / Sguazzoni, G / Viliani, L / Benussi, L / Bianco, S / Piccolo, D / Bozzo, M / Ferro, F / Mulargia, R / Robutti, E / Tosi, S / Benaglia, A / Boldrini, G / Brivio, F / Cetorelli, F / De Guio, F / Dinardo, M E / Dini, P / Gennai, S / Ghezzi, A / Govoni, P / Guzzi, L / Lucchini, M T / Malberti, M / Malvezzi, S / Massironi, A / Menasce, D / Moroni, L / Paganoni, M / Pedrini, D / Pinolini, B S / Ragazzi, S / Redaelli, N / de Fatis, T Tabarelli / Valsecchi, D / Zuolo, D / Buontempo, S / Carnevali, F / Cavallo, N / De Iorio, A / Fabozzi, F / Iorio, A O M / Lista, L / Meola, S / Paolucci, P / Rossi, B / Sciacca, C / Azzi, P / Bacchetta, N / Bisello, D / Bortignon, P / Bragagnolo, A / Carlin, R / Checchia, P / Dorigo, T / Dosselli, U / Gasparini, F / Gasparini, U / Grosso, G / Hoh, S Y / Layer, L / Lusiani, E / Margoni, M / Meneguzzo, A T / Pazzini, J / Presilla, M / Ronchese, P / Rossin, R / Simonetto, F / Strong, G / Tosi, M / Yarar, H / Zanetti, M / Zotto, P / Zucchetta, A / Zumerle, G / Aime, C / Braghieri, A / Calzaferri, S / Fiorina, D / Montagna, P / Ratti, S P / Re, V / Riccardi, C / Salvini, P / Vai, I / Vitulo, P / Asenov, P / Bilei, G M / Ciangottini, D / Fanò, L / Lariccia, P / Magherini, M / Mantovani, G / Mariani, V / Menichelli, M / Moscatelli, F / Piccinelli, A / Rossi, A / Santocchia, A / Spiga, D / Tedeschi, T / Azzurri, P / Bagliesi, G / Bertacchi, V / Bianchini, L / Boccali, T / Bossini, E / Castaldi, R / Ciocci, M A / D'Amante, V / Dell'Orso, R / Di Domenico, M R / Donato, S / Giassi, A / Ligabue, F / Manca, E / Mandorli, G / Messineo, A / Palla, F / Parolia, S / Ramirez-Sanchez, G / Rizzi, A / Rolandi, G / Chowdhury, S Roy / Scribano, A / Shafiei, N / Spagnolo, P / Tenchini, R / Tonelli, G / Turini, N / Venturi, A / Verdini, P G / Barria, P / Campana, M / Cavallari, F / Del Re, D / Di Marco, E / Diemoz, M / Longo, E / Meridiani, P / Organtini, G / Pandolfi, F / Paramatti, R / Quaranta, C / Rahatlou, S / Rovelli, C / Santanastasio, F / Soffi, L / Tramontano, R / Amapane, N / Arcidiacono, R / Argiro, S / Arneodo, M / Bartosik, N / Bellan, R / Bellora, A / Antequera, J Berenguer / Biino, C / Cartiglia, N / Cometti, S / Costa, M / Covarelli, R / Demaria, N / Kiani, B / Legger, F / Mariotti, C / Maselli, S / Migliore, E / Monteil, E / Monteno, M / Obertino, M M / Ortona, G / Pacher, L / Pastrone, N / Pelliccioni, M / Angioni, G L Pinna / Ruspa, M / Shchelina, K / Siviero, F / Sola, V / Solano, A / 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    Physical review letters

    2022  Volume 128, Issue 25, Page(s) 252301

    Abstract: ... collisions at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=5.02  TeV, via the B_{c}^{+}→(J/ψ→μ^ ... The B_{c}^{+} meson is observed for the first time in heavy ion collisions. Data from the CMS ... detector are used to study the production of the B_{c}^{+} meson in lead-lead (Pb-Pb) and proton-proton (pp ...

    Abstract The B_{c}^{+} meson is observed for the first time in heavy ion collisions. Data from the CMS detector are used to study the production of the B_{c}^{+} meson in lead-lead (Pb-Pb) and proton-proton (pp) collisions at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=5.02  TeV, via the B_{c}^{+}→(J/ψ→μ^{+}μ^{-})μ^{+}ν_{μ} decay. The B_{c}^{+} nuclear modification factor, derived from the Pb-Pb-to-pp ratio of production cross sections, is measured in two bins of the trimuon transverse momentum and of the Pb-Pb collision centrality. The B_{c}^{+} meson is shown to be less suppressed than quarkonia and most of the open heavy-flavor mesons, suggesting that effects of the hot and dense nuclear matter created in heavy ion collisions contribute to its production. This measurement sets forth a promising new probe of the interplay of suppression and enhancement mechanisms in the production of heavy-flavor mesons in the quark-gluon plasma.
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.252301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Generation of Thiyl Radicals from Air-Stable, Odorless Thiophenol Surrogates: Application to Visible-Light-Promoted CS Cross-Coupling

    Swan, Charlie / Maggi, Lorenzo / Park, Mahri / Taylor, Sophie / Shepherd, William / Ball, Liam T.

    Synthesis

    2022  Volume 54, Issue 15, Page(s) 3399–3408

    Abstract: ... demonstrated that S -aryl isothiouronium salts can be used as precursors to thiyl radicals, extending ... by the synthesis of non-symmetrical diaryl thioethers via light-promoted S -arylation. ...

    Abstract The synthetic versatility of thiophenols is offset by their air-sensitivity and foul odor. It is demonstrated that S -aryl isothiouronium salts can be used as precursors to thiyl radicals, extending the practical benefits of these air-stable, odorless salts from ionic to single electron manifolds. The isothiouronium salts are accessed via Ni-catalyzed cross-coupling of (hetero)aryl iodides and thiourea and are isolated as free-flowing solids following anion exchange. Judicious choice of a redox-innocent counteranion enables use of these convenient thiophenol surrogates in radical processes, as is exemplified by the synthesis of non-symmetrical diaryl thioethers via light-promoted S -arylation.
    Keywords thiophenols ; nickel catalysis ; C–S cross-coupling ; photochemistry ; electron donor–acceptor complexes ; thiyl radicals ; diaryl sulfides
    Language English
    Publishing date 2022-02-10
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/s-0041-1737816
    Database Thieme publisher's database

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  4. Article ; Online: Observation of Two Excited B_{c}^{+} States and Measurement of the B_{c}^{+}(2S) Mass in pp Collisions at sqrt[s]=13  TeV.

    Sirunyan, A M / Tumasyan, A / Adam, W / Ambrogi, F / Bergauer, T / Brandstetter, J / Dragicevic, M / Erö, J / Escalante Del Valle, A / Flechl, M / Frühwirth, R / Jeitler, M / Krammer, N / Krätschmer, I / Liko, D / Madlener, T / Mikulec, I / Rad, N / Schieck, J /
    Schöfbeck, R / Spanring, M / Spitzbart, D / Waltenberger, W / Wittmann, J / Wulz, C-E / Zarucki, M / Drugakov, V / Mossolov, V / Suarez Gonzalez, J / Darwish, M R / De Wolf, E A / Di Croce, D / Janssen, X / Lauwers, J / Lelek, A / Pieters, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Blekman, F / Bols, E S / Chhibra, S S / D'Hondt, J / De Clercq, J / Flouris, G / Lontkovskyi, D / Lowette, S / Marchesini, I / Moortgat, S / Moreels, L / Python, Q / Skovpen, K / Tavernier, S / Van Doninck, W / Van Mulders, P / Van Parijs, I / Beghin, D / Bilin, B / Brun, H / Clerbaux, B / De Lentdecker, G / Delannoy, H / Dorney, B / Favart, L / Grebenyuk, A / Kalsi, A K / Luetic, J / Popov, A / Postiau, N / Starling, E / Thomas, L / Vander Velde, C / Vanlaer, P / Vannerom, D / Wang, Q / Cornelis, T / Dobur, D / Fagot, A / Gul, M / Khvastunov, I / Roskas, C / Trocino, D / Tytgat, M / Verbeke, W / Vermassen, B / Vit, M / Zaganidis, N / Bondu, O / Bruno, G / Caputo, C / David, P / Delaere, C / Delcourt, M / Giammanco, A / Krintiras, G / Lemaitre, V / Magitteri, A / Piotrzkowski, K / Prisciandaro, J / Saggio, A / Vidal Marono, M / Vischia, P / Zobec, J / Alves, F L / Alves, G A / Correia Silva, G / Hensel, C / Moraes, A / Rebello Teles, P / Belchior Batista Das Chagas, E / Carvalho, W / Chinellato, J / Coelho, E / Da Costa, E M / Da Silveira, G G / De Jesus Damiao, D / Fonseca De Souza, S / Huertas Guativa, L M / Malbouisson, H / Matos Figueiredo, D / Medina Jaime, M / Melo De Almeida, M / Mora Herrera, C / Mundim, L / Nogima, H / Sanchez Rosas, L J / Santoro, A / Sznajder, A / Thiel, M / Tonelli Manganote, E J / Torres Da Silva De Araujo, F / Vilela Pereira, A / Ahuja, S / Bernardes, C A / Calligaris, L / De Souza Lemos, D / Tomei, T R Fernandez Perez / Gregores, E M / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Hadjiiska, R / Iaydjiev, P / Marinov, A / Misheva, M / Rodozov, M / Shopova, M / Sultanov, G / Dimitrov, A / Litov, L / Pavlov, B / Petkov, P / Fang, W / Gao, X / Yuan, L / Ahmad, M / Chen, G M / Chen, H S / Chen, M / Jiang, C H / Leggat, D / Liao, H / Liu, Z / Shaheen, S M / Spiezia, A / Tao, J / Yazgan, E / Zhang, H / Zhang, S / Zhao, J / Ban, Y / Chen, G / Li, J / Li, L / Li, Q / Mao, Y / Qian, S J / Wang, D / Wang, Y / Avila, C / Cabrera, A / Chaparro Sierra, L F / Florez, C / González Hernández, C F / Segura Delgado, M A / Mejia Guisao, J / Ruiz Alvarez, J D / Giljanović, D / Godinovic, N / Lelas, D / Puljak, I / Sculac, T / Antunovic, Z / Kovac, M / Brigljevic, V / Ferencek, D / Kadija, K / Mesic, B / Roguljic, M / Starodumov, A / Susa, T / Ather, M W / Attikis, A / Erodotou, E / Ioannou, A / Kolosova, M / Konstantinou, S / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Tsiakkouri, D / Finger, M / Ayala, E / Carrera Jarrin, E / Assran, Y / Elgammal, S / Bhowmik, S / Carvalho Antunes De Oliveira, A / Dewanjee, R K / Ehataht, K / Kadastik, M / Raidal, M / Veelken, C / Eerola, P / Kirschenmann, H / Pekkanen, J / Voutilainen, M / Havukainen, J / Heikkilä, J K / Järvinen, T / Karimäki, V / Kinnunen, R / Lampén, T / Lassila-Perini, K / Laurila, S / Lehti, S / Lindén, T / Luukka, P / Mäenpää, T / Siikonen, H / Tuominen, E / Tuominiemi, J / Tuuva, T / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Leloup, C / Locci, E / Malcles, J / Rander, J / Rosowsky, A / Sahin, M Ö / Savoy-Navarro, A / Titov, M / Amendola, C / Beaudette, F / Busson, P / Charlot, C / Diab, B / Granier de Cassagnac, R / Kucher, I / Lobanov, A / Martin Perez, C / Nguyen, M / Ochando, C / Paganini, P / Rembser, J / Salerno, R / Sauvan, J B / Sirois, Y / Zabi, A / Zghiche, A / Agram, J-L / Andrea, J / Bloch, D / Bourgatte, G / Brom, J-M / Chabert, E C / Collard, C / Conte, E / Fontaine, J-C / Gelé, D / Goerlach, U / Jansová, M / Le Bihan, A-C / Tonon, N / Van Hove, P / Gadrat, S / Beauceron, S / Bernet, C / Boudoul, G / Camen, C / Chanon, N / Chierici, R / Contardo, D / Depasse, P / El Mamouni, H / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Lagarde, F / Laktineh, I B / Lattaud, H / Lethuillier, M / Mirabito, L / Perries, S / Sordini, V / Touquet, G / Vander Donckt, M / Viret, S / Toriashvili, T / Tsamalaidze, Z / Autermann, C / Feld, L / Kiesel, M K / Klein, K / Lipinski, M / Meuser, D / Pauls, A / Preuten, M / Rauch, M P / Schomakers, C / Teroerde, M / Wittmer, B / Albert, A / Erdmann, M / Erdweg, S / Esch, T / Fischer, B / Fischer, R / Ghosh, S / Hebbeker, T / Hoepfner, K / Keller, H / Mastrolorenzo, L / Merschmeyer, M / Meyer, A / Millet, P / Mocellin, G / Mondal, S / Mukherjee, S / Noll, D / Novak, A / Pook, T / Pozdnyakov, A / Quast, T / Radziej, M / Rath, Y / Reithler, H / Rieger, M / Schmidt, A / Schuler, S C / Sharma, A / Thüer, S / Wiedenbeck, S / Flügge, G / Hlushchenko, O / Kress, T / Müller, T / Nehrkorn, A / Nowack, A / Pistone, C / 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/ Shevchenko, R / Singh, A / Tholen, H / Turkot, O / Vagnerini, A / Van De Klundert, M / Van Onsem, G P / Walsh, R / Wen, Y / Wichmann, K / Wissing, C / Zenaiev, O / Zlebcik, R / Aggleton, R / Bein, S / Benato, L / Benecke, A / Blobel, V / Dreyer, T / Ebrahimi, A / Fröhlich, A / Garbers, C / Garutti, E / Gonzalez, D / Gunnellini, P / Haller, J / Hinzmann, A / Karavdina, A / Kasieczka, G / Klanner, R / Kogler, R / Kovalchuk, N / Kurz, S / Kutzner, V / Lange, J / Lange, T / Malara, A / Marconi, D / Multhaup, J / Niedziela, M / Niemeyer, C E N / Nowatschin, D / Perieanu, A / Reimers, A / Rieger, O / Scharf, C / Schleper, P / Schumann, S / Schwandt, J / Sonneveld, J / Stadie, H / Steinbrück, G / Stober, F M / Stöver, M / Vormwald, B / Zoi, I / Akbiyik, M / Barth, C / Baselga, M / Baur, S / Berger, T / Butz, E / Chwalek, T / De Boer, W / Dierlamm, A / El Morabit, K / Giffels, M / Goldenzweig, P / Harrendorf, M A / Hartmann, F / Husemann, U / Kudella, S / Mitra, S / Mozer, M U / Müller, Th / 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    Physical review letters

    2019  Volume 122, Issue 13, Page(s) 132001

    Abstract: Signals consistent with the B_{c}^{+}(2S) and B_{c}^{*+}(2S) states are observed in proton-proton ... collisions at sqrt[s]=13  TeV, in an event sample corresponding to an integrated luminosity of 143  fb^{-1 ... collected by the CMS experiment during the 2015-2018 LHC running periods. These excited b[over ¯]c states ...

    Abstract Signals consistent with the B_{c}^{+}(2S) and B_{c}^{*+}(2S) states are observed in proton-proton collisions at sqrt[s]=13  TeV, in an event sample corresponding to an integrated luminosity of 143  fb^{-1}, collected by the CMS experiment during the 2015-2018 LHC running periods. These excited b[over ¯]c states are observed in the B_{c}^{+}π^{+}π^{-} invariant mass spectrum, with the ground state B_{c}^{+} reconstructed through its decay to J/ψπ^{+}. The two states are reconstructed as two well-resolved peaks, separated in mass by 29.1±1.5(stat)±0.7(syst)  MeV. The observation of two peaks, rather than one, is established with a significance exceeding five standard deviations. The mass of the B_{c}^{+}(2S) meson is measured to be 6871.0±1.2(stat)±0.8(syst)±0.8(B_{c}^{+})  MeV, where the last term corresponds to the uncertainty in the world-average B_{c}^{+} mass.
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.132001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply from S. C. Gandevia, S. L. Khan and J. L. Taylor.

    Gandevia, S C / Khan, S L / Taylor, J L

    The Journal of physiology

    2016  Volume 594, Issue 13, Page(s) 3847–3848

    Language English
    Publishing date 2016-07-01
    Publishing country England
    Document type Letter
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP272663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Second Biggest Infectious Disease Killer in the U.S.: Hepatitis C Virus Infection and Steps Towards its Elimination in Rhode Island and Beyond.

    Taylor, Lynn E

    Rhode Island medical journal (2013)

    2020  Volume 103, Issue 5, Page(s) 19–21

    MeSH term(s) Disease Eradication/methods ; Hepacivirus ; Hepatitis C/epidemiology ; Hepatitis C/prevention & control ; Humans ; Rhode Island/epidemiology ; United States/epidemiology
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419430-5
    ISSN 2327-2228 ; 0363-7913
    ISSN (online) 2327-2228
    ISSN 0363-7913
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  7. Article ; Online: Commentary on: Hahn M, Anslinger K, Eckert M, Fimmers R, Grethe S, Hohoff C, et al. [Joint recommendations of the project group "Biostatistical DNA Calculations" and the Trace Commission on the Biostatistical Evaluation of Forensic DNA Analytical Findings with Fully Continuous Models (FCM)]. Rechtsmedizin (Berl). 2023; 33(1):3-12. doi: 10.1007/s00194-022-00599-5.

    Berger, Charles E H / Kruijver, Maarten / Hicks, Tacha / Champod, Christophe / Taylor, Duncan / Buckleton, John

    Journal of forensic sciences

    2023  Volume 69, Issue 2, Page(s) 730–735

    MeSH term(s) DNA ; Forensic Genetics
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Letter
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/1556-4029.15424
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  8. Article ; Online: Brief report: Prevalence of hepatitis B and C virus infections in U.S. Air Force basic military trainees who donated blood, 2013-2016.

    Taylor, Douglas F / Cho, Ryan S / Okulicz, Jason F / Webber, Bryant J / Gancayco, John G

    MSMR

    2018  Volume 24, Issue 12, Page(s) 20–22

    Abstract: Hepatitis B virus (HBV) and hepatitis C virus (HCV) can cause significant morbidity in military ... service members. Prevalences of HBV and HCV infections among military recruits accessioning into the U.S ... is much lower among U.S. Air Force basic trainees, compared to other active and reserve component ...

    Abstract Hepatitis B virus (HBV) and hepatitis C virus (HCV) can cause significant morbidity in military service members. Prevalences of HBV and HCV infections among military recruits accessioning into the U.S. Air Force have not previously been described. The Joint Base San Antonio-Lackland Blood Donor Center was queried for the results of HBV and HCV screening tests among all basic military trainees who donated blood between 25 November 2013 and 16 April 2016. Other active and reserve component members were excluded. The estimated prevalences of HBV and HCV infections among recruit blood donors were 0.0098% and 0.007%, respectively. This study suggests that the overall estimated prevalence of HBV and HCV infection is much lower among U.S. Air Force basic trainees, compared to other active and reserve component members and U.S. civilian populations. HBV and HCV viral infections can have a negative impact on mission readiness and individual deployment status, and have significant costs for the military. Additional studies are needed to determine cost effectiveness of screening for viral hepatitis among military populations.
    MeSH term(s) Adolescent ; Adult ; Aerospace Medicine ; Blood Donors/statistics & numerical data ; Cross-Sectional Studies ; Female ; Hepatitis B, Chronic/epidemiology ; Hepatitis C, Chronic/epidemiology ; Humans ; Male ; Military Personnel/statistics & numerical data ; Prevalence ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2018-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623409-9
    ISSN 2152-8217 ; 2158-0111
    ISSN (online) 2152-8217
    ISSN 2158-0111
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  9. Article ; Online: Association of Hepatitis C Virus With Alcohol Use Among U.S. Adults: NHANES 2003-2010.

    Taylor, Amber L / Denniston, Maxine M / Klevens, R Monina / McKnight-Eily, Lela R / Jiles, Ruth B

    American journal of preventive medicine

    2016  Volume 51, Issue 2, Page(s) 206–215

    Abstract: Introduction: Excessive alcohol use exacerbates morbidity and mortality among hepatitis C ...

    Abstract Introduction: Excessive alcohol use exacerbates morbidity and mortality among hepatitis C virus (HCV)-infected people. The purpose of this study was to describe self-reported patterns of alcohol use and examine the association with HCV infection and other sociodemographic and health-related factors.
    Methods: Data from 20,042 participants in the 2003-2010 National Health and Nutrition Examination Survey were analyzed in 2014. Estimates were derived for self-reported demographic characteristics, HCV-RNA (indicative of current HCV infection) status, and alcohol use at four levels: lifetime abstainers, former drinkers, non-excessive current drinkers, and excessive current drinkers.
    Results: Former drinkers and excessive current drinkers had a higher prevalence of HCV infection (2.2% and 1.5%, respectively) than never or non-excessive current drinkers (0.4% and 0.9%, respectively). HCV-infected adults were estimated to ever drink five or more drinks/day almost every day at some time during their lifetime about 3.3 times more often (43.8% vs 13.7%, p<0.001) than those who were never infected with HCV. Controlling for age, sex, race/ethnicity, education, and having a usual source of health care, HCV infection was significantly associated with excessive current drinking (adjusted prevalence ratio, 1.3; 95% CI=1.1, 1.6) and former drinking (adjusted prevalence ratio, 1.3; 95% CI=1.1, 1.6).
    Conclusions: Chronic HCV infection is associated with both former and excessive current drinking. Public health HCV strategies should implement interventions with emphasis on alcohol abuse, which negatively impacts disease progression for HCV-infected individuals.
    MeSH term(s) Adult ; Aged ; Alcohol Drinking/epidemiology ; Alcoholism ; Female ; Hepacivirus/isolation & purification ; Hepatitis C, Chronic/epidemiology ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Prevalence ; United States/epidemiology
    Language English
    Publishing date 2016-05-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 632646-8
    ISSN 1873-2607 ; 0749-3797
    ISSN (online) 1873-2607
    ISSN 0749-3797
    DOI 10.1016/j.amepre.2016.02.033
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  10. Article: Observation of new states decaying into Lambda(c)(+)Kappa(-)pi(+) and Lambda(c)(+)Kappa(0)/(s)pi(-).

    Chistov, R / Abe, K / Adachi, I / Aihara, H / Anipko, D / Aulchenko, V / Aushev, T / Bakich, A M / Balagura, V / Barberio, E / Bay, A / Bedny, I / Belous, K / Bitenc, U / Bizjak, I / Blyth, S / Bondar, A / Bozek, A / Bracko, M /
    Brodzicka, J / Browder, T E / Chang, M-C / Chao, Y / Chen, A / Chen, K-F / Chen, W T / Cheon, B G / Choi, Y / Choi, Y K / Chuvikov, A / Cole, S / Dalseno, J / Danilov, M / Dash, M / Dragic, J / Drutskoy, A / Eidelman, S / Epifanov, D / Gabyshev, N / Garmash, A / Gershon, T / Go, A / Gokhroo, G / Golob, B / Gorisek, A / Ha, H / Haba, J / Hara, T / Hayasaka, K / Hayashii, H / Hazumi, M / Heffernan, D / Hokuue, T / Hoshi, Y / Hou, S / Hou, W-S / Hsiung, Y B / Iijima, T / Imoto, A / Inami, K / Ishikawa, A / Itoh, R / Iwasaki, M / Iwasaki, Y / Kang, J H / Katayama, N / Kawai, H / Kawasaki, T / Khan, H R / Kichimi, H / Kim, H J / Kim, H O / Kinoshita, K / Korpar, S / Krizan, P / Krokovny, P / Kumar, R / Kuo, C C / Kuzmin, A / Kwon, Y-J / Leder, G / Lee, J / Lesiak, T / Lin, S-W / Liventsev, D / Mandl, F / Marlow, D / Matsumoto, T / Matyja, A / McOnie, S / Mitaroff, W / Miyabayashi, K / Miyake, H / Miyata, H / Miyazaki, Y / Mizuk, R / Moloney, G R / Nagamine, T / Nakano, E / Nakao, M / Nishida, S / Nitoh, O / Nozaki, T / Ogawa, S / Ohshima, T / Okabe, T / Okuno, S / Olsen, S L / Onuki, Y / Ozaki, H / Pakhlov, P / Pakhlova, G / Palka, H / Park, H / Park, K S / Pestotnik, R / Piilonen, L E / Sakai, Y / Schietinger, T / Schneider, O / Schwartz, A J / Seidl, R / Sevior, M E / Shapkin, M / Shibuya, H / Shwartz, B / Sidorov, V / Singh, J B / Sokolov, A / Somov, A / Soni, N / Stanic, S / Staric, M / Stoeck, H / Sumiyoshi, T / Suzuki, S / Takasaki, F / Tamura, N / Tanaka, M / Taylor, G N / Teramoto, Y / Tian, X C / Tikhomirov, I / Tsuboyama, T / Tsukamoto, T / Uehara, S / Uglov, T / Ueno, K / Uno, S / Usov, Y / Varner, G / Villa, S / Wang, C C / Wang, C H / Wang, M-Z / Watanabe, Y / Won, E / Wu, C-H / Xie, Q L / Yabsley, B D / Yamaguchi, A / Yamashita, Y / Yamauchi, M / Zhang, L M / Zhang, Z P

    Physical review letters

    2006  Volume 97, Issue 16, Page(s) 162001

    Abstract: ... partner states that decay into Lambda(c)(+)Kappa(0)/(s)pi(-) and observe a significant signal at the mass ... We report the first observation of two charmed strange baryons that decay into Lambda(c)(+)Kappa ... 9+/-0.5 MeV/c;{2} and 6.2+/-1.2+/-0.8 MeV/c2, respectively. We also perform a search for the isospin ...

    Abstract We report the first observation of two charmed strange baryons that decay into Lambda(c)(+)Kappa(-)pi(+). The broader of the two states is measured to have a mass of 2978.5+/-2.1+/-2.0 MeV/c2 and a width of 43.5+/-7.5+/-7.0 MeV/c2. The mass and width of the narrow state are measured to be 3076.7+/-0.9+/-0.5 MeV/c;{2} and 6.2+/-1.2+/-0.8 MeV/c2, respectively. We also perform a search for the isospin partner states that decay into Lambda(c)(+)Kappa(0)/(s)pi(-) and observe a significant signal at the mass of 3082.8+/-1.8+/-1.5 MeV/c2. The data used for this analysis were accumulated at or near the Upsilon(4S) resonance, using the Belle detector at the e+ e- asymmetric-energy collider KEKB. The integrated luminosity of the data sample used is 461.5 fb(-1).
    Language English
    Publishing date 2006-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.97.162001
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