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Article ; Online: Physical exercises with free weights and elastic bands can improve body composition parameters in postmenopausal women: WEB protocol with a randomized controlled trial.

Bittar, Simoni T / Maeda, Sergio S / Marone, Marília M S / Santili, Cláudio

2016 Volume 23, Issue 4, Page(s) 383–389

Abstract: Objective: The aim of this study was to assess the impact of a program of supervised physical exercises (WEB protocol) versus home-based exercises on body composition (lean mass and fat mass) in postmenopausal women.: Methods: The initial sample ... ...

Abstract	Objective: The aim of this study was to assess the impact of a program of supervised physical exercises (WEB protocol) versus home-based exercises on body composition (lean mass and fat mass) in postmenopausal women. Methods: The initial sample comprised 60 women who were randomized into two groups. After exclusion, the final randomized sample included a supervised group (n = 16; mean age, 66.4 ± 6.5 y) and a home group (n = 18; mean age, 68.2 ± 6.0 y). Both groups underwent a 12-month intervention with physical exercises, including muscle impact exercises and strength and stretching consisting of two weekly sessions of 60 minutes. Body composition was determined by densitometry. Results: The supervised group exhibited increased lean mass in the upper limbs (P = 0.003) and lower limbs (P = 0.011), total lean tissue (P = 0.015), and appendicular lean mass index (P = 0.001) compared with baseline. The home group exhibited no differences in the lean mass assessments. Conclusions: Our results suggest that regular supervised physical exercises with free weights and elastic bands can promote greater improvements in lean body mass than unsupervised exercises in postmenopausal women.
MeSH term(s)	Absorptiometry, Photon ; Aged ; Body Composition ; Exercise ; Female ; Humans ; Middle Aged ; Postmenopause ; Prospective Studies ; Resistance Training/methods
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000000542
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Article ; Online: Reference values of 25-hydroxyvitamin D revisited: a position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC).

Moreira, Carolina Aguiar / Ferreira, Carlos Eduardo Dos S / Madeira, Miguel / Silva, Barbara Campolina Carvalho / Maeda, Sergio Setsuo / Batista, Marcelo Cidade / Bandeira, Francisco / Borba, Victória Z Cochenski / Lazaretti-Castro, Marise

Archives of endocrinology and metabolism

2020 Volume 64, Issue 4, Page(s) 462–478

Abstract: Hypovitaminosis D is a common condition with a negative impact on health. This statement, prepared by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society of Clinical Pathology/Laboratory Medicine, includes ... ...

Abstract	Hypovitaminosis D is a common condition with a negative impact on health. This statement, prepared by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society of Clinical Pathology/Laboratory Medicine, includes methodological aspects and limitations of the measurement of 25-hydroxyvitamin D [25(OH)D] for identification of vitamin D status, and identifies individuals at increased risk for deficiency of this vitamin in whom 25(OH)D measurement is recommended. For the general population, 25(OH)D levels between 20 and 60 ng/mL are considered normal, while individuals with levels below 20 ng/mL are considered to be vitamin D deficient. This statement identifies potential benefits of maintaining 25(OH)D levels > 30 ng/mL in specific conditions, including patients aged > 65 years or pregnant, those with recurrent falls, fragility fractures, osteoporosis, secondary hyperparathyroidism, chronic kidney disease, or cancer, and individuals using drugs with the potential to affect the vitamin D metabolism. This statement also calls attention to the risk of vitamin D intoxication, a life-threatening condition that occurs at 25(OH)D levels above 100 ng/mL.
MeSH term(s)	Aged ; Brazil ; Humans ; Pathology, Clinical ; Reference Values ; Vitamin D/analogs & derivatives ; Vitamin D Deficiency
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2020-06-05
Publishing country	Brazil
Document type	Journal Article
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-3997000000258
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Article ; Online: Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors.

Anfray, Clément / Varela, Carmen Fernández / Ummarino, Aldo / Maeda, Akihiro / Sironi, Marina / Gandoy, Sara / Brea, Jose / Loza, María Isabel / León, Sergio / Calvo, Alfonso / Correa, Juan / Fernandez-Megia, Eduardo / Alonso, María José / Allavena, Paola / Crecente-Campo, José / Andón, Fernando Torres

Frontiers in immunology

2024 Volume 14, Page(s) 1334800

Abstract: Background: In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod ( ... ...

Abstract	Background: In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able to reprogram TAMs towards M1-like antitumor effector cells. The objective of our work has been to develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, to improve drug stability and systemic toxicity, and evaluate their targeting and therapeutic activity towards TAMs in the TME of solid tumors. Methods: NCs were developed by the solvent displacement and layer-by-layer methodologies and characterized by dynamic light scattering and nanoparticle tracking analysis. Hyaluronic acid (HA) was chemically functionalized with mannose for the coating of the NCs to target TAMs. NCs loaded with TLR ligands were evaluated Results: We have developed polymeric NCs loaded with poly(I:C)+R848. Among a series of 5 lead prototypes, protamine-NCs were selected based on their physicochemical properties (size, charge, stability) and Conclusion: Mannose-HA-protamine-NCs loaded with poly(I:C)+R848 successfully reprogram TAMs
MeSH term(s)	Humans ; Animals ; Mice ; Tumor-Associated Macrophages ; Nanocapsules ; Mannose ; Lung Neoplasms/drug therapy ; Disease Models, Animal ; Protamines ; Tumor Microenvironment ; Imidazoles
Chemical Substances	resiquimod (V3DMU7PVXF) ; Nanocapsules ; Mannose (PHA4727WTP) ; Protamines ; Imidazoles
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1334800
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Article ; Online: Reference values of 25-hydroxyvitamin D revisited

Carolina Aguiar Moreira / Carlos Eduardo dos S Ferreira / Miguel Madeira / Barbara Campolina Carvalho Silva / Sergio Setsuo Maeda / Marcelo Cidade Batista / Francisco Bandeira / Victória Z. Cochenski Borba / Marise Lazaretti-Castro

Archives of Endocrinology and Metabolism, Vol 64, Iss 4, Pp 462-

a position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC)

2020 Volume 478

Abstract: ABSTRACT Hypovitaminosis D is a common condition with a negative impact on health. This statement, prepared by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society of Clinical Pathology/Laboratory Medicine, ... ...

Abstract	ABSTRACT Hypovitaminosis D is a common condition with a negative impact on health. This statement, prepared by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society of Clinical Pathology/Laboratory Medicine, includes methodological aspects and limitations of the measurement of 25-hydroxyvitamin D [25(OH)D] for identification of vitamin D status, and identifies individuals at increased risk for deficiency of this vitamin in whom 25(OH)D measurement is recommended. For the general population, 25(OH)D levels between 20 and 60 ng/mL are considered normal, while individuals with levels below 20 ng/mL are considered to be vitamin D deficient. This statement identifies potential benefits of maintaining 25(OH)D levels > 30 ng/mL in specific conditions, including patients aged > 65 years or pregnant, those with recurrent falls, fragility fractures, osteoporosis, secondary hyperparathyroidism, chronic kidney disease, or cancer, and individuals using drugs with the potential to affect the vitamin D metabolism. This statement also calls attention to the risk of vitamin D intoxication, a life-threatening condition that occurs at 25(OH)D levels above 100 ng/mL
Keywords	Vitamin D ; 25-hydroxyvitamin D ; reference range ; vitamin D intoxication ; Medicine ; R ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Subject code	610
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Brazilian Society of Endocrinology and Metabolism
Document type	Article ; Online
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Article ; Online: Aggressive nonfunctioning pituitary neuroendocrine tumors.

Portovedo, Sérgio / Neto, Leonardo Vieira / Soares, Paula / Carvalho, Denise Pires de / Takiya, Christina Maeda / Miranda-Alves, Leandro

Brain tumor pathology

2022 Volume 39, Issue 4, Page(s) 183–199

Abstract: Nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) are tumors that are not associated with clinical evidence of hormonal hypersecretion. According to the World Health Organization (WHO), there are some subtypes of PitNETs that exhibit more ... ...

Abstract	Nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) are tumors that are not associated with clinical evidence of hormonal hypersecretion. According to the World Health Organization (WHO), there are some subtypes of PitNETs that exhibit more aggressive behavior than others. Among the types of potentially aggressive PitNETs, three are nonfunctional: silent sparsely granulated somatotropinomas, silent corticotropinomas, and poorly differentiated PIT-1 lineage tumors. Several biological markers have been investigated in NF-PitNETs. However, there is no single biomarker able to independently predict aggressive behavior in NF-PitNETs. Thus, a more complex and multidisciplinary proposal of a comprehensive definition of aggressive NF-PitNETs is necessary. Here, we suggest a combined and more complete criterion for the NF-PitNETs classification. We propose that aggressiveness is due to a multifactorial combination, and we emphasize the need to include new emerging markers that are involved in the aggressiveness of NF-PitNETs and the need to identify.
MeSH term(s)	Humans ; Neuroendocrine Tumors/pathology ; Pituitary Neoplasms/genetics ; Pituitary Neoplasms/pathology ; Transcription Factors ; World Health Organization
Chemical Substances	Transcription Factors
Language	English
Publishing date	2022-06-20
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1193775-0
ISSN	1861-387X ; 1433-7398 ; 0914-8108
ISSN (online)	1861-387X
ISSN	1433-7398 ; 0914-8108
DOI	10.1007/s10014-022-00441-6
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Zs.A 4555: Show issues

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Article: Obesity, Bariatric Surgery, and Vitamin D.

Borges, Joao Lindolfo C / Miranda, Isabella Santiago de M / Sarquis, Marta M S / Borba, Victoria / Maeda, Sergio Setsuo / Lazaretti-Castro, Marise / Blinkey, Neil

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

2017 Volume 21, Issue 2, Page(s) 157–162

Abstract: The high prevalence of obesity is a worldwide problem associated with multiple comorbidities, including cardiovascular diseases. Vitamin D deficiency with secondary hyperparathyroidism is common in obese individuals and can be aggravated after bariatric ... ...

Abstract	The high prevalence of obesity is a worldwide problem associated with multiple comorbidities, including cardiovascular diseases. Vitamin D deficiency with secondary hyperparathyroidism is common in obese individuals and can be aggravated after bariatric surgery. Moreover, there is no consensus on the optimal supplementation dose of vitamin D in postbariatric surgical patients. We present new data on the variability of 25(OH)D response to supplementation in postmenopausal obese women. It is important to recognize and treat vitamin D deficiency before bariatric surgery to avoid postoperative complications, such as metabolic bone disease with associated high fracture risk. The objective of this article is to discuss the bone metabolism consequences of vitamin D deficiency after bariatric surgery.
MeSH term(s)	25-Hydroxyvitamin D 2/blood ; Bariatric Surgery/adverse effects ; Bone Density ; Bone and Bones/metabolism ; Dietary Supplements ; Humans ; Hyperparathyroidism, Secondary/etiology ; Obesity/complications ; Obesity/metabolism ; Obesity/surgery ; Postmenopause/physiology ; Postoperative Complications/prevention & control ; Risk Factors ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/etiology ; Vitamin D Deficiency/metabolism
Chemical Substances	Vitamin D (1406-16-2) ; 25-Hydroxyvitamin D 2 (21343-40-8)
Language	English
Publishing date	2017-04-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2040951-5
ISSN	1094-6950
ISSN	1094-6950
DOI	10.1016/j.jocd.2017.03.001
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Zs.A 5425: Show issues

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Article ; Online: Hydroxyapatite Dome for Bone Neoformation in Rabbit Tibia.

Maeda, Nancy Tiaki / Yoshimoto, Marcelo / Allegrini, Sergio / Bressiani, Ana Helena

The International journal of oral & maxillofacial implants

2016 Volume 31, Issue 3, Page(s) 571–579

Abstract: Purpose: To evaluate supracortical bone neoformation with the use of hydroxyapatite (HA) hollow domes specially manufactured for osteogenesis promotion.: Materials and methods: Nine New Zealand rabbits were selected and 18 domes were placed, divided ... ...

Abstract	Purpose: To evaluate supracortical bone neoformation with the use of hydroxyapatite (HA) hollow domes specially manufactured for osteogenesis promotion. Materials and methods: Nine New Zealand rabbits were selected and 18 domes were placed, divided into three groups according to the filler: control (blood clot), vitamin complex, and particulate β-tricalcium phosphate (β-TCP). The healing period was 8 weeks, hence fluorescent markers were applied. After healing, the samples were embedded in resin to prepare slides for light and fluorescence microscopic evaluation of the amount of neoformed bone tissue. Energy dispersive spectroscopy was also used for chemical analysis of the material inside the domes. Results: The quality of neoformed bone tissue with active bone remodeling areas was observed. As a filler, β-TCP showed higher bone formation (14.1%), better quality of neoformed bone tissue with organized structures, and an area of mineralized tissue in the dome. Bone neoformation inside the dome filled with blood clot confirmed the osteoconductive property of HA, as indicated by the migration of osteogenic cells from the blood clot, without the action of another biomaterial (mean area of bone formation for blood clot filler = 7.5%). Bone neoformation was not favored in samples filled with vitamin complex because of the difficulty of blood penetration through the material. Conclusion: HA domes performed well as a scaffold for bone neoformation over the cortical bone of rabbits, and this is based on maintenance of good stability and good integration with bone tissue. β-TCP presented higher values of neoformed bone area compared with the blood clot. HA domes have osteoconductive properties, especially when filled with blood clot, because of the migration of osteogenic cells without action of any other biomaterial. In domes filled with vitamin complex, no bone formation was noted because of the absence of resorption.
MeSH term(s)	Animals ; Biocompatible Materials ; Bone Regeneration/physiology ; Bone Substitutes/chemistry ; Calcium Phosphates/administration & dosage ; Disease Models, Animal ; Durapatite/chemistry ; Osteogenesis/physiology ; Rabbits ; Tibia/physiology ; Tibia/surgery ; Tissue Scaffolds/chemistry ; Vitamins/administration & dosage ; Wound Healing/physiology
Chemical Substances	Biocompatible Materials ; Bone Substitutes ; Calcium Phosphates ; Vitamins ; beta-tricalcium phosphate ; Durapatite (91D9GV0Z28)
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	632880-5
ISSN	1942-4434 ; 0882-2786
ISSN (online)	1942-4434
ISSN	0882-2786
DOI	10.11607/jomi.4412
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Article ; Online: Increases in summer serum 25-hydroxyvitamin D (25OHD) concentrations in elderly subjects in São Paulo, Brazil vary with age, gender and ethnicity.

Maeda, Sergio S / Kunii, Ilda S / Hayashi, Lilian F / Lazaretti-Castro, Marise

BMC endocrine disorders

2010 Volume 10, Page(s) 12

Abstract: Background: Hypovitaminosis D is a common condition among elderly individuals in temperate-climate countries, with a clear seasonal variation on 25 hydroxyvitamin D levels, increasing after summer and decreasing after winter, but there are few data from ...

Abstract	Background: Hypovitaminosis D is a common condition among elderly individuals in temperate-climate countries, with a clear seasonal variation on 25 hydroxyvitamin D levels, increasing after summer and decreasing after winter, but there are few data from sunny countries such as Brazil. Many factors can interfere on vitamin D cutaneous synthesis. We aimed at studying the 25OHD variations during winter and summer in an outdoor physically active elderly population living in São Paulo city, and analysed their determining factors. Methods: Ninety-nine individuals (52 women and 47 men, from 55 to 83 years old) from different ethnic groups were selected from an outdoor physical activity group. Data are reported as Mean +/- SD, and we used Pearson Linear Correlation, Student's t-test for non-related samples, Chi-square (chi(2)) test and One-way ANOVA for analysis. Results: Mean 25OHD value for the whole group was 78.9 +/- 30.9 nmol/L in the winter and 91.6 +/- 31.7 nmol/L in the summer (p = 0.005). Mean winter serum 25OHD concentrations were not different between men and women (81.2 +/- 30.1 nmol/L vs. 76.7 +/- 31.8 nmol/L, respectively), and 19.2% of the individuals showed values < 50 nmol/L. In the summer, we noticed an increase only for men (107.6 +/- 31.4 nmol/L) compared to women (76.7 +/- 24.0 nmol/L), and 6.5% showed values < 50 nmol/L. A decrease in the mean PTH in the summer compared to the winter was noticed, with PTH levels showing a relationship with 25OHD concentrations only in the winter (r = -0.208, p = 0.041). White individuals showed an increase in mean serum 25OHD in the summer (p = 0.016) which was not noticed for other ethnic groups (Asians, native Brazilians and blacks). An increase in 25OHD values in the summer was observed in the age groups ranging from 51-60 and 61-70 years old (p < 0.05), but not in the age group from 71 years old on. Conclusions: 25OHD values increased during the summer in elderly residents of São Paulo, but to different extents depending on ethnicity, gender and age. This season-dependent increase was noticed only among men, white and who were in the youngest group of individuals.
Language	English
Publishing date	2010-06-14
Publishing country	England
Document type	Journal Article
ISSN	1472-6823
ISSN (online)	1472-6823
DOI	10.1186/1472-6823-10-12
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Article ; Online: Comparison of quality of life evaluated by SF-36 and DLQI in multibacillary and paucibacillary leprosy patients from Sao Paulo, Brazil.

Guimenes Albuquerque, Rachel / Grüdtner Buratto, Gabriel / Hirotsu, Camila / Maeda, Solange M / Floriano, Marcos C / Levy Andersen, Monica / Tufik, Sergio / Tomimori, Jane

International journal of dermatology

2019 Volume 58, Issue 12, Page(s) 1415–1422

Abstract: Background: Dermatological diseases have a negative impact on quality of life (QoL), affecting mental and physical health. Leprosy patients usually present with a worse QoL compared with those affected by other conditions. Reactions, neural damage, and ... ...

Abstract	Background: Dermatological diseases have a negative impact on quality of life (QoL), affecting mental and physical health. Leprosy patients usually present with a worse QoL compared with those affected by other conditions. Reactions, neural damage, and pain are some of the consequences that contribute to the lower QoL. However, due to the wide spectrum of the disease, symptoms vary according to leprosy's subtype. This study aimed to compare the QoL between paucibacillary and multibacillary leprosy patients. Individuals were also compared considering the presence of reactions and a correlation between questionnaires was performed. Methods: A total of 104 patients with leprosy aged 18 years old and over were selected. QoL was assessed by the Brazilian-Portuguese validated versions of the Medical Outcomes Study 36-item short-form health survey (SF-36) and the Dermatology Life Quality Life Index (DLQI). Results: Multibacillary patients showed a more impaired physical function, worse bodily pain, lower score of SF-36, and higher interference of skin on the performance of daily activities when compared to the paucibacillary group. Individuals without reactions presented lower bodily pain and less effect of the skin on clothing choices compared to those with reactions. The SF-36 domains exhibited weak correlations with most DLQI questions, and the linear regression model showed that 32% of changes in QoL were related to the skin aspect. Conclusions: Multibacillary leprosy patients have a worse QoL when compared to paucibacillary patients. Reactions played a small role in the QoL of our cohort of patients.
MeSH term(s)	Adult ; Brazil ; Female ; Health Surveys/statistics & numerical data ; Humans ; Leprosy, Multibacillary/complications ; Leprosy, Multibacillary/diagnosis ; Leprosy, Multibacillary/microbiology ; Leprosy, Multibacillary/psychology ; Leprosy, Paucibacillary/complications ; Leprosy, Paucibacillary/diagnosis ; Leprosy, Paucibacillary/microbiology ; Leprosy, Paucibacillary/psychology ; Male ; Middle Aged ; Mycobacterium leprae/isolation & purification ; Pain/diagnosis ; Pain/etiology ; Pain/psychology ; Pain Measurement ; Quality of Life ; Severity of Illness Index ; Skin/microbiology ; Skin/pathology
Language	English
Publishing date	2019-05-30
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.14489
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Article ; Online: In vivo biomechanical properties of heavy versus light weight monofilament polypropylene meshes. Does the knitting pattern matter?

Bigozzi, Miguel Angel / Provenzano, Sergio / Maeda, Fernando / Palma, Paulo / Riccetto, Cassio

Neurourology and urodynamics

2017 Volume 36, Issue 1, Page(s) 73–79

Abstract: Aims: This work evaluated the post-implant biomechanical properties of light-weight (LW) and heavy-weight (HW) monofilament polypropylene (PP) meshes with different knitting patterns in an animal model in vivo.: Methods: Forty-five adult female ... ...

Abstract	Aims: This work evaluated the post-implant biomechanical properties of light-weight (LW) and heavy-weight (HW) monofilament polypropylene (PP) meshes with different knitting patterns in an animal model in vivo. Methods: Forty-five adult female Wistar rats were divided into three groups and randomly implanted with 32 × 32 mm HW-PP (62 gm Results: LW-PP meshes implanted in the LWT fashion (vaginal transverse plane) showed comparable maximum load and stiffness to HW-PP meshes, and LW-PP meshes implanted in the LWL fashion (vaginal longitudinal plane) presented lower maximum load and stiffness than the HW-PP meshes. There were no significant differences in the values of deflection at maximum load between the studied meshes as a function of time. Conclusions: The final mechanical behavior of PP mesh can be changed by its weight and knitting pattern. These properties may be useful in making more biocompatible prostheses for pelvic organ prolapse (POP) with less foreign material to maintain longitudinal vaginal elasticity and minimize sexual symptoms while maintaining transverse resistance (i.e., between vaginal fornixes) to prevent POP recurrence. Neurourol. Urodynam. 36:73-79, 2017. © 2015 Wiley Periodicals, Inc.
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.22890
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