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  1. Article ; Online: Toxic Leucoencephalopathy with Bilateral Optic Nerve Necrosis in Two Suspected Cases of Methanol Inhalational Poisoning.

    Ranjan, Rahul S / Singh, Anil K / Namrata / Singh, Shailesh K

    Neurology India

    2023  Volume 71, Issue 5, Page(s) 1052–1055

    MeSH term(s) Humans ; Methanol ; Optic Nerve ; Optic Nerve Diseases/chemically induced ; Alcoholism ; Leukoencephalopathies ; Necrosis/chemically induced
    Chemical Substances Methanol (Y4S76JWI15)
    Language English
    Publishing date 2023-11-01
    Publishing country India
    Document type Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.388093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 698: Show issues Location:
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  2. Article ; Online: Knowledge, awareness and practice of hand hygiene among healthcare workers for the prevention of infection

    Namrata Gaur / Dushyant Singh Gaur

    Journal of Medical Evidence, Vol 4, Iss 2, Pp 115-

    A cross-sectional study

    2023  Volume 118

    Abstract: Background: Hand hygiene protocols, if followed stringently reduce the possibility of the spread of infection from healthcare workers (HCWs) to patients, to almost 99%. However, in actual practice, compliance of these protocols is poor. Aims: (1) To ... ...

    Abstract Background: Hand hygiene protocols, if followed stringently reduce the possibility of the spread of infection from healthcare workers (HCWs) to patients, to almost 99%. However, in actual practice, compliance of these protocols is poor. Aims: (1) To observe the practice of hand hygiene among HCWs and (2) assess knowledge and awareness regarding hand hygiene protocol and identify the factors hampering its effective practice. Prospective observational study at an multispeciality hospital. Patients and Methods: Consultants, junior doctors, nursing in-charges and nurses and ancillary staff like ward attendants, ward secretaries, housekeeping staff and lift operators were (1) Observed during their hand hygiene practice and (2) 200 of these HCWs were provided a written questionnaire, in order to assess their depth of hand hygiene knowledge. Data were studied and analysed. Results: Female HCWs, right from consultants to ward attendants and ancillary workers showed better knowledge and compliance with hand hygiene practices. The junior nurses, interns and junior residents were more compliant with hand hygiene procedures in comparison to consultants and in-charge nurses. Hand hygiene compliance was poor in outpatient department, particularly on days with heavy workloads. Lack of knowledge regarding hand hygiene was observed amongst ancillary staff. Conclusions: The study emphasised stringent compliance and constant re-enforcement of protocol of correct hand hygiene practice amongst HCWs including ancillary staff.
    Keywords alcohol hand-rub ; fomites ; hand hygiene ; health-care workers ; scrub stations ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Molecular Pathway, Epidemiological Data and Treatment Strategies of Fungal Infection (Mycoses): A Comprehensive Review.

    Singh, Namrata / Kumari, Vibha / Agrawal, Karan / Kulshreshtha, Mayank

    Central nervous system agents in medicinal chemistry

    2024  

    Abstract: The recent increase in fungal infections is a health crisis. This surge is directly tied to the increase in immunocompromised people caused by changes in medical practice, such as the use of harsh chemotherapy and immunosuppressive medicines. ... ...

    Abstract The recent increase in fungal infections is a health crisis. This surge is directly tied to the increase in immunocompromised people caused by changes in medical practice, such as the use of harsh chemotherapy and immunosuppressive medicines. Immunosuppressive disorders such as HIV have exacerbated the situation dramatically. Subcutaneous or superficial fungal infections can harm the skin, keratinous tissues, and mucous membranes. This category includes some of the most common skin disorders that impact millions of people worldwide. Despite the fact that they are seldom fatal, they can have a catastrophic impact on a person's quality of life and, in rare situations, spread to other people or become obtrusive. The majority of fungal infections under the skin and on the surface are simply and quickly cured. An opportunistic organism that preys on a weak host or a natural intruder can both result in systemic fungal infections. Furthermore, it might be exceedingly lethal and dangerous to one's life. Dimorphic fungi may pose a hazard to healthy populations that are not exposed to endemic fungi. Increased surveillance, the availability of quick, noninvasive diagnostic tests, monitoring the emergence of antifungal medication resistance, and research on the pathophysiology, prevention, and management of fungal infections are just a few potential solutions to these new health problems. The goal of this review is to summarize the data available for fungal infections and the different therapies which are involved in their treatment. Additionally, it also summarizes the molecular and scientific data of the plants which contain anti-fungal activity. Data are acquired using Google, PubMed, Scholar, and other online sources.
    Language English
    Publishing date 2024-01-16
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2227560-5
    ISSN 1875-6166 ; 1871-5249
    ISSN (online) 1875-6166
    ISSN 1871-5249
    DOI 10.2174/0118715249274215231205062701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effectiveness of COVID-19 vaccination in immune-mediated inflammatory diseases.

    Sparks, Jeffrey A / Singh, Namrata / Wallace, Zachary S

    The Lancet. Rheumatology

    2022  Volume 4, Issue 6, Page(s) e380–e382

    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00109-6
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  5. Article ; Online: Response to Zhai and Tang.

    Grover, Indu / Gunjan, Deepak / Singh, Namrata / Saraya, Anoop

    The American journal of gastroenterology

    2022  Volume 116, Issue 10, Page(s) 2144

    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Response to Medda et al.

    Grover, Indu / Gunjan, Deepak / Singh, Namrata / Saraya, Anoop

    The American journal of gastroenterology

    2022  Volume 117, Issue 5, Page(s) 814

    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001715
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  7. Article ; Online: A Patient With Minimally Conscious Syndrome Due to Cerebrovascular Accident Whose Symptoms Resolved With Zolpidem.

    Smack, Caleb / Johnson, Katherine / Meester, Noah / Shelton, Leah / Singh, Namrata

    Clinical neuropharmacology

    2024  Volume 47, Issue 2, Page(s) 59–61

    Abstract: Objective: In this report, we discuss the case of a patient with minimally conscious state (MCS) whose clinical condition significantly improved after Zolpidem therapy. We aim to provide supportive evidence for inclusion of zolpidem trials in patients ... ...

    Abstract Objective: In this report, we discuss the case of a patient with minimally conscious state (MCS) whose clinical condition significantly improved after Zolpidem therapy. We aim to provide supportive evidence for inclusion of zolpidem trials in patients with MCS.
    Methods: Our team used electronic medical records, direct patient care experiences, and literature review to obtain information for this case report.
    Results: Twice daily zolpidem therapy led to significant clinical improvement in our patient with MCS. In addition, this improvement was maintained throughout an increasingly arduous medical course.
    Conclusions: Minimally conscious state is a disorder with limited proven therapeutic options. Zolpidem administration has demonstrated immense benefit in a select population of patients, including ours. Given the potential for great improvement with limited downside, zolpidem trial presents an intriguing treatment option. Further clarification of prognostic features to stratify responders and nonresponders to therapy is needed.
    MeSH term(s) Humans ; Zolpidem/therapeutic use ; Pyridines/therapeutic use ; Persistent Vegetative State/drug therapy ; Persistent Vegetative State/etiology ; Stroke/complications
    Chemical Substances Zolpidem (7K383OQI23) ; Pyridines
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 199293-4
    ISSN 1537-162X ; 0362-5664
    ISSN (online) 1537-162X
    ISSN 0362-5664
    DOI 10.1097/WNF.0000000000000587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mechanistic insights into sodium ion-mediated ligand binding affinity and modulation of 5-HT2B GPCR activity: implications for drug discovery and development.

    Chauhan, Arushi / Singh, Jitender / Sangwan, Namrata / Avti, Pramod K

    Journal of receptor and signal transduction research

    2024  , Page(s) 1–11

    Abstract: Purpose: The G-protein coupled receptor (GPCR) family, implicated in neurological disorders and drug targets, includes the sensitive serotonin receptor subtype, 5-HT2B. The influence of sodium ions on ligand binding at the receptor's allosteric region ... ...

    Abstract Purpose: The G-protein coupled receptor (GPCR) family, implicated in neurological disorders and drug targets, includes the sensitive serotonin receptor subtype, 5-HT2B. The influence of sodium ions on ligand binding at the receptor's allosteric region is being increasingly studied for its impact on receptor structure.
    Methods: High-throughput virtual screening of three libraries, specifically the Asinex-GPCR library, which contains 8,532 compounds and FDA-approved (2466 compounds) and investigational compounds (2731)) against the modeled receptor [4IB4-5HT
    Results: This compound displayed strong interactions with the conserved active site. Ions influence ligand binding, with stronger interactions (3-H-bonds and 1-π-bond around 3.35 Å) observed when an agonist and ions are present. Ions entry is guided by conserved motifs in helices III, IV, and VII, which regulate the receptor. Dihydroergotamine, the selected drug, showed binding variance based on ions presence/absence, affecting amino acid residues in these motifs. DCCM and PCA confirmed the stabilization of ligands, with a greater correlation (∼46.6%-PC1) observed with ions. Dihydroergotamine-modified interaction sites within the receptor necessary for activation, serving as a potential 5HT
    Conclusion: Our study provides insights into sodium ion mobility's role in controlling ligand binding affinity in 5HT
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1230969-2
    ISSN 1532-4281 ; 1079-9893
    ISSN (online) 1532-4281
    ISSN 1079-9893
    DOI 10.1080/10799893.2024.2332886
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    Zs.A 1643: Show issues Location:
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  9. Article ; Online: Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next-Generation Therapeutics.

    Singh, Namrata / Sherin, G R / Mugesh, Govindasamy

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 33, Page(s) e202301232

    Abstract: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability to replace natural enzymes in various biomedical applications, such as biosensing, therapeutics, drug delivery, and ... ...

    Abstract Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability to replace natural enzymes in various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating the cellular redox status by mimicking the antioxidant enzymes in mammalian cells are of great therapeutic significance in oxidative-stress-mediated disorders. As the distinction of physiological oxidative stress (oxidative eustress) and pathological oxidative stress (oxidative distress) occurs at a fine borderline, it is a great challenge to design nanozymes that can differentially sense the two extremes in cells, tissues and organs and mediate appropriate redox chemical reactions. In this Review, we summarize the advances in the development of redox-active nanozymes and their biomedical applications. We primarily highlight the therapeutic significance of the antioxidant and prooxidant nanozymes in various disease model systems, such as cancer, neurodegeneration, and cardiovascular diseases. The future perspectives of this emerging area of research and the challenges associated with the biomedical applications of nanozymes are described.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Reactive Oxygen Species ; Oxidation-Reduction ; Nanostructures ; Oxidative Stress ; Catalysis ; Mammals
    Chemical Substances Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2023-05-09
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202301232
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  10. Article ; Online: Abnormal echocardiographic findings after COVID-19 infection: a multicenter registry.

    Singh, Namrata / Hani, Zeina Bani / AlRemeithi, Rashed

    The international journal of cardiovascular imaging

    2022  Volume 39, Issue 2, Page(s) 285–286

    MeSH term(s) Humans ; COVID-19 ; Predictive Value of Tests ; SARS-CoV-2 ; Registries ; Echocardiography
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Multicenter Study ; Letter
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-022-02732-7
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