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Article: Taste Sensitivity and Taste Preference among Malay Children Aged 7 to 12 Years in Kuala Lumpur-A Pilot Study.

Lim, Ler Sheang / Tang, Xian Hui / Yang, Wai Yew / Ong, Shu Hwa / Naumovski, Nenad / Jani, Rati

Pediatric reports

2021 Volume 13, Issue 2, Page(s) 245–256

Abstract: ... of Malay children aged 7 to 12 years. Seven solutions at different concentrations of 6-n-propylthiouracil ...

Abstract	The taste and food preferences in children can affect their food intake and body weight. Bitter and sweet taste sensitivities were identified as primary taste contributors to children's preference for consuming various foods. This pilot study aimed to determine the taste sensitivity and preference for bitter and sweet tastes in a sample of Malaysian children. A case-control study was conducted among 15 pairs of Malay children aged 7 to 12 years. Seven solutions at different concentrations of 6-n-propylthiouracil and sucrose were prepared for testing bitterness and sweet sensitivity, respectively. The intensity of both bitter and sweet sensitivity was measured using a 100 mm Labelled Magnitude Scale (LMS), while the taste preference was rated using a 5-point Likert scale. The participants were better at identifying bitter than sweet taste (median score 6/7 vs. 4/7). No significant differences were detected for both tastes between normal-weight and overweight groups (bitter: 350 vs. 413,
Language	English
Publishing date	2021-05-18
Publishing country	Switzerland
Document type	Journal Article
ISSN	2036-749X
ISSN	2036-749X
DOI	10.3390/pediatric13020034
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Article ; Online: Efficacy and safety of Prostate stereotactic body radiotherapy for metastatic castration-resistant prostate cancer: A prospective cohort study.

Li, Jun / Dai, JunYong / Xian, Peng / Xiong, Lin / Song, YanPing / Tang, XianLi / Li, Yuan / Wu, Yongzhong / Zhou, Hong / Liu, Nan

Cancer treatment and research communications

2021 Volume 27, Page(s) 100368

Abstract: ... group (n = 61) and 12.0 months in the control group (n = 64) (HR, 0.87; 95% CI, 0.61-1.24; P = 0.249 ...

Abstract	Background: The efficacy and safety of prostate SBRT in men with mCRPC is unknown. Materials and methods: A prospective cohort study was conducted with 125 men diagnosed with mCRPC. All patients received ADT plus chemotherapy. Patients were randomly assigned to receive daily prostate SBRT (36-48 Gy in 6-8 fractions). Patients who did not receive SBRT served as controls. Results: The primary endpoints were PFS and OS. After 89 months of total follow-up, the median PFS was 13.8 months in the SBRT group (n = 61) and 12.0 months in the control group (n = 64) (HR, 0.87; 95% CI, 0.61-1.24; P = 0.249). The OS was 25.7 months in the SBRT group and 23.8 months in the control group (HR, 0.93; 95% CI, 0.65-1.33; P = 0.230). A non-significant increase in the PSA response rate (50.8% vs. 43.7%) and time to PSA progression (8.3 months vs. 7.0 months) was observed in the SBRT group compared to the control group; however, the time to symptomatic progression was significantly prolonged in the SBRT group (11.3 months) compared to the control group (8.5 months) (HR, 0.76; 95% CI, 0.53-1.08; P = 0.019). There was an 11.5% incidence of radiation cystitis and radiation rectitis in the SBRT group, and the degree and incidence of hormone-related and chemotherapy-related adverse events were similar between the two groups. Conclusion: Adding prostate SBRT significantly prolonged the time to symptomatic progression and non-significantly prolonged PFS and OS among men with mCRPC compared to treatment with ADT plus chemotherapy alone.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cystitis/etiology ; Docetaxel/administration & dosage ; Dose Fractionation, Radiation ; Follow-Up Studies ; Gonadotropin-Releasing Hormone/agonists ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Humans ; Male ; Neoplasm Grading ; Orchiectomy ; Proctitis/etiology ; Progression-Free Survival ; Prospective Studies ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms, Castration-Resistant/blood ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/therapy ; Radiation Injuries/etiology ; Radiosurgery/adverse effects ; Random Allocation ; Survival Rate ; Tumor Burden
Chemical Substances	Docetaxel (15H5577CQD) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2021-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2021.100368
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Article ; Online: Crustal remelting origin of highly silicic magmatism on the Moon

Bin Su / Yi Chen / Zongyu Yue / Lin Chen / Ross N. Mitchell / Ming Tang / Wei Yang / Guangyu Huang / Jinghui Guo / Xian-Hua Li / Fu-Yuan Wu

Communications Earth & Environment, Vol 4, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract Orbital observations of non-mare, highly silicic volcanic constructs on the Moon challenge the conventional view of the formation of silicic crusts in the presence of water and plate tectonics—the former the Moon has in very short supply and the ...

Abstract	Abstract Orbital observations of non-mare, highly silicic volcanic constructs on the Moon challenge the conventional view of the formation of silicic crusts in the presence of water and plate tectonics—the former the Moon has in very short supply and the latter it likely never ever had. Revealing the silica-rich magma origin may reshape our understanding of early planetary crust formation. However, the cause of lunar silicic magmatism remains enigmatic. Here we conduct phase equilibrium simulations for potential lunar igneous lithologies that demonstrate that the compositions of silicic volcanic constructs can be produced by partial melting of KREEP (potassium, rare earth elements, and phosphorus) basalts. Either internal radiogenic heating or external impact bombardment can provide the heat needed for KREEP basalt melting. Combined with silica-rich materials identified on other rocky planets, we suggest that highly evolved crusts might be more prevalent in the early solar system than anticipated as they can originate from crustal remelting in the absence of water and plate tectonics.
Keywords	Geology ; QE1-996.5 ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Precise Synthesis of Fe-N

Qiu, Yue / Fan, Lishuang / Wang, Maoxu / Yin, Xiaoju / Wu, Xian / Sun, Xun / Tian, Da / Guan, Bin / Tang, Dongyan / Zhang, Naiqing

ACS nano

2020 Volume 14, Issue 11, Page(s) 16105–16113

Abstract: ... are greatly desired. Herein, we construct an Fe-NC material with uniform and stable Fe-N ...

Abstract	Precisely tuning the coordination environment of the metal center and further maximizing the activity of transition metal-nitrogen carbon (M-NC) catalysts for high-performance lithium-sulfur batteries are greatly desired. Herein, we construct an Fe-NC material with uniform and stable Fe-N
Language	English
Publishing date	2020-10-20
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c08056
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Article ; Online: Transcranial direct current stimulation for upper extremity motor dysfunction in poststroke patients: A systematic review and meta-analysis.

Tang, Xian / Zhang, Nan / Shen, Zhiyuan / Guo, Xin / Xing, Jun / Tian, Shujuan / Xing, Yuan

Clinical rehabilitation

2024 , Page(s) 2692155241235336

Abstract: Objective: To evaluate the efficacy and safety of transcranial direct current stimulation in poststroke patients with upper extremity motor dysfunction using a systematic review and meta-analysis.: Data sources: We searched the Web of Science, ... ...

Abstract	Objective: To evaluate the efficacy and safety of transcranial direct current stimulation in poststroke patients with upper extremity motor dysfunction using a systematic review and meta-analysis. Data sources: We searched the Web of Science, Cochrane Library, EMBASE, and PubMed for randomized controlled trials investigating the effects of both active and sham stimulation up until January 27, 2024. Review methods: Efficacy, including the upper extremity Fugl-Meyer Assessment, Action Research Arm Test, Barthel Index, and safety, were assessed. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool and the Physiotherapy Evidence Database Scale. Meta-analysis was performed using the RevMan 5.4 software. Results: Forty-four studies with 1555 participants were included. Transcranial direct current stimulation proved effective in improving upper extremity motor function (standardized mean difference = 0.22, 95% confidence interval: 0.12-0.32, Conclusions: Our findings suggest that both anodal and cathodal stimulation were significantly effective in subacute stroke patients, particularly when preceding other treatments and when C3/C4 is targeted.
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	639276-3
ISSN	1477-0873 ; 0269-2155
ISSN (online)	1477-0873
ISSN	0269-2155
DOI	10.1177/02692155241235336
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Article ; Online: Transient gene therapy using cell cycle factors reverses renin-angiotensin-aldosterone system activation in heart failure rat model.

Salama, Abou Bakr M / Abouleisa, Riham R E / Ou, Qinghui / Tang, Xian-Liang / Alhariry, Nashwah / Hassan, Sarah / Gebreil, Ahmad / Dastagir, Muzammil / Abdulwali, Fareeha / Bolli, Roberto / Mohamed, Tamer M A

Molecular and cellular biochemistry

2022 Volume 478, Issue 6, Page(s) 1245–1250

Abstract: ... after treatment, N-terminal pro-brain natriuretic peptide, plasma renin activity, and aldosterone levels returned ...

Abstract	The loss of cardiomyocytes after myocardial infarction (MI) leads to heart failure. Recently, we demonstrated that transient overexpression of 4 cell cycle factors (4F), using a polycistronic non-integrating lentivirus (TNNT2-4F-NIL) resulted in significant improvement in cardiac function in a rat model of MI. Yet, it is crucial to demonstrate the reversal of the heart failure-related pathophysiological manifestations, such as renin-angiotensin-aldosterone system activation (RAAS). To assess that, Fisher 344 rats were randomized to receive TNNT2-4F-NIL or control virus seven days after coronary occlusion for 2 h followed by reperfusion. 4 months after treatment, N-terminal pro-brain natriuretic peptide, plasma renin activity, and aldosterone levels returned to the normal levels in rats treated with TNNT2-4F-NIL but not in vehicle-treated rats. Furthermore, the TNNT2-4F-NIL-treated group showed significantly less liver and kidney congestion than vehicle-treated rats. Thus, we conclude that in rat models of MI, TNNT2-4F-NIL reverses RAAS activation and subsequent systemic congestion.
MeSH term(s)	Animals ; Rats ; Aldosterone/metabolism ; Cell Cycle ; Heart Failure/genetics ; Heart Failure/therapy ; Heart Failure/metabolism ; Kidney/metabolism ; Myocardial Infarction/metabolism ; Renin/genetics ; Renin/metabolism ; Renin-Angiotensin System
Chemical Substances	Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
Language	English
Publishing date	2022-10-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-022-04590-2
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Article: Biomechanical stability of oblique lateral interbody fusion combined with four types of internal fixations: finite element analysis.

Hao, Jiayu / Tang, XianSheng / Jiang, Nizhou / Wang, Hong / Jiang, Jian

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1260693

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-09-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1260693
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Article ; Online: A nonsensory odorant-binding protein plays an important role in the larval development and adult mating of Spodoptera frugiperda.

Han, Wei-Kang / Tang, Feng-Xian / Yu, Na / Zhang, Yi-Xi / Liu, Ze-Wen

Insect science

2023 Volume 30, Issue 5, Page(s) 1325–1336

Abstract: Odorant-binding proteins (OBPs) play key roles in the perception of semiochemicals in insects. Several OBPs in insect olfactory systems have been functionally characterized, and they provide excellent targets for pest control. The functions of some OBPs ... ...

Abstract	Odorant-binding proteins (OBPs) play key roles in the perception of semiochemicals in insects. Several OBPs in insect olfactory systems have been functionally characterized, and they provide excellent targets for pest control. The functions of some OBPs that are highly expressed in the nonsensory organs of insects remain unclear. Here, the physiological function of an OBP (OBP27) that was highly expressed in the nonsensory organs of Spodoptera frugiperda was studied. OBP27 was nested within the Plus-C cluster according to phylogenetic analysis. The transcription of OBP27 steadily increased throughout the development of S. frugiperda, and transcripts of this gene were abundant in the fat body and male reproductive organs. An OBP27 knockout strain with an early frameshift mutation was obtained using the clustered regularly interspaced palindromic repeats (CRISPR) / CRISPR-associated protein 9 (Cas9) system. The development time of OBP27
Language	English
Publishing date	2023-02-28
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179775-4
ISSN	1744-7917 ; 1672-9609
ISSN (online)	1744-7917
ISSN	1672-9609
DOI	10.1111/1744-7917.13178
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Article ; Online: A Novel Polysaccharide Separated from Panax Notoginseng Residue Ameliorates Restraint Stress- and Lipopolysaccharide-induced Enteritis in Mice.

Luo, Bi / Yang, Fan / Chen, Peng / Zuo, Hao-Yu / Liang, Yun-Fei / Xian, Ming-Hua / Tang, Nan / Wang, Guo-En

Chemistry & biodiversity

2023 Volume 20, Issue 10, Page(s) e202300648

Abstract: Polysaccharides are rich in Panax notoginseng residue after extraction. This study aims to explore the structural characteristics of PNP-20, which is a homogeneous polysaccharide, separated from P. notoginseng residue by fractional precipitation and ... ...

Abstract	Polysaccharides are rich in Panax notoginseng residue after extraction. This study aims to explore the structural characteristics of PNP-20, which is a homogeneous polysaccharide, separated from P. notoginseng residue by fractional precipitation and evaluate the anti-enteritis effect of PNP-20. The structure of PNP-20 was determined by spectroscopic analyses. A mouse model with enteritis induced by restraint stress (RS) and lipopolysaccharide (LPS) was used to evaluate the pharmacological effect of PNP-20. The results indicated that PNP-20 consisted of glucose (Glc), galactose (Gal), Mannose (Man) and Rhamnose (Rha). PNP-20 was composed of Glcp-(1→, →4)-α-Glcp-(1→, →4)-α-Galp-(1→, →4,6)-α-Glcp-(1→, →4)-Manp-(1→ and →3)-Rhap-(1→, and contained two backbone fragments of →4)-α-Glcp-(1→4)- α-Glcp-(1→ and →4)-α-Galp-(1→4)-α-Glcp-(1→. PNP-20 reduced intestinal injury and inflammatory cell infiltration in RS- and LPS-induced enteritis in mice. PNP-20 decreased the expression of intestinal tumor necrosis factor-α, NOD-like receptor family pyrin domain containing 3, and nuclear factor-κB and increased the expression of intestinal superoxide dismutase 2. In conclusion, PNP-20 may be a promising material basis of P. Notoginseng for the treatment of inflammatory bowel disease.
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300648
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Article: Identification of Critical Biomarkers and Mechanisms of

Liang, Tian-Shan / Tang, Nan / Xian, Ming-Hua / Wen, Wei-Lun / Huang, Chang-Jin / Cai, Lan-Hua / Li, Qi-Lin / Wu, Yan-Hua

Clinical, cosmetic and investigational dermatology

2023 Volume 16, Page(s) 2061–2071

Abstract: Objective: Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes and results in patches of depigmentation that are visible as white spots. Recent research studies have yielded a strong mechanistic understanding of this ...

Abstract	Objective: Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes and results in patches of depigmentation that are visible as white spots. Recent research studies have yielded a strong mechanistic understanding of this disease. Methods: The expression profiles of GSE65127 and GSE75819 were downloaded from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) between the vitiligo and healthy samples. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of DEGs were performed using R analyses. We performed R to further understand the functions of the critical targets. Cytoscape tools have facilitated network topology analysis. Molecular docking was performed using Auto Dock Vina software. Results: The results showed that 13 DEGs were screened in vitiligo. Based on bioinformatics, network pharmacology and Western blot, we found that the critical targets of melanoma antigen recognized by 5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1) may be related to the mechanism of action of FLL in the treatment of vitiligo. Conclusion: TYRP1, as a melanocyte molecular biomarker, may be closely related to the underlying mechanism of FLL in the treatment of vitiligo via the inhibition of melanocyte death.
Language	English
Publishing date	2023-08-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S413733
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