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  1. Article: Immunological aspects of COVID-19: What do we know?

    Velikova, Tsvetelina Veselinova / Kotsev, Stanislav Vasilev / Georgiev, Daniel Stefanov / Batselova, Hristiana Momchilova

    World journal of biological chemistry

    2020  Volume 11, Issue 2, Page(s) 14–29

    Abstract: The newly emerged coronavirus (severe acute respiratory syndrome coronavirus 2 SARS-CoV-2) and the disease that it causes coronavirus disease 2019 (COVID-19) have changed the world we know. Yet, the origin and evolution of SARS-CoV-2 remain mostly vague. ...

    Abstract The newly emerged coronavirus (severe acute respiratory syndrome coronavirus 2 SARS-CoV-2) and the disease that it causes coronavirus disease 2019 (COVID-19) have changed the world we know. Yet, the origin and evolution of SARS-CoV-2 remain mostly vague. Many virulence factors and immune mechanisms contribute to the deteriorating effects on the organism during SARS-CoV-2 infection. Both humoral and cellular immune responses are involved in the pathophysiology of the disease, where the principal and effective immune response towards viral infection is the cell-mediated immunity. The clinical picture of COVID-19, which includes immune memory and reinfection, remains unclear and unpredictable. However, many hopes are put in developing an effective vaccine against the virus, and different therapeutic options have been implemented to find effective, even though not specific, treatment to the disease. We can assume that the interaction between the SARS-CoV-2 virus and the individual's immune system determines the onset and development of the disease significantly.
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2564793-3
    ISSN 1949-8454
    ISSN 1949-8454
    DOI 10.4331/wjbc.v11.i2.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hypotheses and facts for genetic factors related to severe COVID-19.

    Kotsev, Stanislav Vasilev / Miteva, Dimitrina / Krayselska, Stanislava / Shopova, Martina / Pishmisheva-Peleva, Maria / Stanilova, Spaska Angelova / Velikova, Tsvetelina

    World journal of virology

    2021  Volume 10, Issue 4, Page(s) 137–155

    Abstract: Genome-wide association analysis allows the identification of potential candidate genes involved in the development of severe coronavirus disease 2019 (COVID-19). Hence, it seems that genetics matters here, as well. Nevertheless, the virus's nature, ... ...

    Abstract Genome-wide association analysis allows the identification of potential candidate genes involved in the development of severe coronavirus disease 2019 (COVID-19). Hence, it seems that genetics matters here, as well. Nevertheless, the virus's nature, including its RNA structure, determines the rate of mutations leading to new viral strains with all epidemiological and clinical consequences. Given these observations, we herein comment on the current hypotheses about the possible role of the genes in association with COVID-19 severity. We discuss some of the major candidate genes that have been identified as potential genetic factors associated with the COVID-19 severity and infection susceptibility:
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2829019-7
    ISSN 2220-3249
    ISSN 2220-3249
    DOI 10.5501/wjv.v10.i4.137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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