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  1. Article ; Online: Cancer neoepitopes viewed through negative selection and peripheral tolerance: a new path to cancer vaccines.

    Srivastava, Pramod K

    The Journal of clinical investigation

    2024  Volume 134, Issue 5

    Abstract: A proportion of somatic mutations in tumors create neoepitopes that can prime T cell responses that target the MHC I-neoepitope complexes on tumor cells, mediating tumor control or rejection. Despite the compelling centrality of neoepitopes to cancer ... ...

    Abstract A proportion of somatic mutations in tumors create neoepitopes that can prime T cell responses that target the MHC I-neoepitope complexes on tumor cells, mediating tumor control or rejection. Despite the compelling centrality of neoepitopes to cancer immunity, we know remarkably little about what constitutes a neoepitope that can mediate tumor control in vivo and what distinguishes such a neoepitope from the vast majority of similar candidate neoepitopes that are inefficacious in vivo. Studies in mice as well as clinical trials have begun to reveal the unexpected paradoxes in this area. Because cancer neoepitopes straddle that ambiguous ground between self and non-self, some rules that are fundamental to immunology of frankly non-self antigens, such as viral or model antigens, do not appear to apply to neoepitopes. Because neoepitopes are so similar to self-epitopes, with only small changes that render them non-self, immune response to them is regulated at least partially the way immune response to self is regulated. Therefore, neoepitopes are viewed and understood here through the clarifying lens of negative thymic selection. Here, the emergent questions in the biology and clinical applications of neoepitopes are discussed critically and a mechanistic and testable framework that explains the complexity and translational potential of these wonderful antigens is proposed.
    MeSH term(s) Animals ; Mice ; Cancer Vaccines ; Antigens, Neoplasm/genetics ; Peripheral Tolerance ; Neoplasms/genetics ; Neoplasms/therapy ; Epitopes
    Chemical Substances Cancer Vaccines ; Antigens, Neoplasm ; Epitopes
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI176740
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  2. Book ; Online ; E-Book: Heat shock proteins in the immune system

    Binder, Robert J. / Srivastava, Pramod K.

    2018  

    Author's details Robert J. Binder, Pramod K. Srivastava editors
    Keywords biological pathways ; heat shock proteins ; immune system ; infectious diseases ; innate T cells ; HSP inhibitors ; Vascular Normalization
    Subject code 610
    Language English
    Size 1 Online-Ressource (x, 185 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019709231
    ISBN 978-3-319-69042-1 ; 9783319690407 ; 3-319-69042-6 ; 331969040X
    DOI 10.1007/978-3-319-69042-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Assays to Detect Cross-Dressing by Dendritic Cells In Vivo and In Vitro.

    Mohapatra, Alok Das / Srivastava, Pramod K

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2618, Page(s) 251–264

    Abstract: The presentation of peptides derived from exogenous antigens on major histocompatibility complex (MHC) class I molecules of antigen-presenting cells (APCs), termed cross-presentation, is crucial for the activation of cytotoxic T-lymphocytes during cell- ... ...

    Abstract The presentation of peptides derived from exogenous antigens on major histocompatibility complex (MHC) class I molecules of antigen-presenting cells (APCs), termed cross-presentation, is crucial for the activation of cytotoxic T-lymphocytes during cell-mediated immune response. Typically, the APCs acquire exogenous antigens by (i) endocytosis of soluble antigens present in their external milieu, or (ii) through phagocytosis of dying/dead cancer cells or infected cells, followed by intracellular processing, before presentation by MHC I on the surface, or (iii) uptake of heat shock protein-peptide complexes generated in the antigen donor cells (3). In a fourth new mechanism, preformed peptide-MHC complexes can be directly transferred from the surface of antigen donor cells (i.e., cancer cells or infected cells) to that of APCs, without the need of further processing, in a process referred to as cross-dressing. Recently, the importance of cross-dressing in dendritic cell-mediated antitumor immunity and antiviral immunity has been demonstrated. Here, we describe a protocol to study cross-dressing of dendritic cells with tumor antigens.
    MeSH term(s) Antigen Presentation ; Dendritic Cells ; Histocompatibility Antigens Class I ; Antigens ; Peptides ; Bandages ; Histocompatibility Antigens Class II
    Chemical Substances Histocompatibility Antigens Class I ; Antigens ; Peptides ; Histocompatibility Antigens Class II
    Language English
    Publishing date 2023-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2938-3_18
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  4. Article ; Online: George Klein (1925-2016) A Prescient, Luminous Voice.

    Srivastava, Pramod K

    Cancer immunology research

    2017  Volume 5, Issue 4, Page(s) 272

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-17-0105
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  5. Article ; Online: Unique Fiber Morphologies from Emulsion Electrospinning—A Case Study of Poly(ε-caprolactone) and Its Applications

    Sagnik Ghosh / Anilkumar Yadav / Pramod M. Gurave / Rajiv K. Srivastava

    Colloids and Interfaces, Vol 7, Iss 19, p

    2023  Volume 19

    Abstract: The importance of electrospinning to produce biomimicking micro- and nano-fibrous matrices is realized by many who work in the area of fibers. Based on the solubility of the materials to be spun, organic solvents are typically utilized. The toxicity of ... ...

    Abstract The importance of electrospinning to produce biomimicking micro- and nano-fibrous matrices is realized by many who work in the area of fibers. Based on the solubility of the materials to be spun, organic solvents are typically utilized. The toxicity of the utilized organic solvent could be extremely important for various applications, including tissue engineering, biomedical, agricultural, etc. In addition, the high viscosities of such polymer solutions limit the use of high polymer concentrations and lower down productivity along with the limitations of obtaining desired fiber morphology. This emphasizes the need for a method that would allay worries about safety, toxicity, and environmental issues along with the limitations of using concentrated polymer solutions. To mitigate these issues, the use of emulsions as precursors for electrospinning has recently gained significant attention. Presence of dispersed and continuous phase in emulsion provides an easy route to incorporate sensitive bioactive functional moieties within the core-sheath fibers which otherwise could only be hardly achieved using cumbersome coaxial electrospinning process in solution or melt based approaches. This review presents a detailed understanding of emulsion behavior during electrospinning along with the role of various constituents and process parameters during fiber formation. Though many polymers have been studied for emulsion electrospinning, poly(ε-caprolactone) (PCL) is one of the most studied polymers for this technique. Therefore, electrospinning of PCL based emulsions is highlighted as unique case-study, to provide a detailed theoretical understanding, discussion of experimental results along with their suitable biomedical applications.
    Keywords emulsion ; electrospinning ; morphology ; fiber ; poly(ε-caprolactone) ; tissue engineering ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Heat-Shock Proteins.

    Hagymasi, Adam T / Dempsey, Joseph P / Srivastava, Pramod K

    Current protocols

    2022  Volume 2, Issue 11, Page(s) e592

    Abstract: Heat-shock proteins (HSPs), or stress proteins, are abundant and highly conserved, present in all organisms and in all cells. Selected HSPs, also known as chaperones, play crucial roles in folding and unfolding of proteins, assembly of multiprotein ... ...

    Abstract Heat-shock proteins (HSPs), or stress proteins, are abundant and highly conserved, present in all organisms and in all cells. Selected HSPs, also known as chaperones, play crucial roles in folding and unfolding of proteins, assembly of multiprotein complexes, transport and sorting of proteins into correct subcellular compartments, cell-cycle control and signaling, and protection of cells against stress and apoptosis. More recently, HSPs have been shown to be key players in immune responses: during antigen presentation as well as cross-priming, they chaperone and transfer antigenic peptides to class I and class II molecules of the major histocompatibility complexes. In addition, extracellular HSPs can stimulate and cause maturation of professional antigen-presenting cells of the immune system, such as macrophages and dendritic cells. They also chaperone several toll-like receptors, which play a central role in innate immune responses. HSPs constitute a large family of proteins that are often classified based on their molecular weight as Hsp10, Hsp40, Hsp60, Hsp70, Hsp90, etc. This unit contains a table that lists common HSPs and summarizes their characteristics including (a) name, (b) subcellular localization, (c) known function, (d) chromosome assignment, (e) brief comments, and (f) references. © 2022 Wiley Periodicals LLC.
    MeSH term(s) Heat-Shock Proteins/metabolism ; HSP70 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/genetics ; Antigen Presentation ; Molecular Chaperones ; Antigen-Presenting Cells/metabolism
    Chemical Substances Heat-Shock Proteins ; HSP70 Heat-Shock Proteins ; HSP90 Heat-Shock Proteins ; Molecular Chaperones
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.592
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  7. Article: Virulence and pathogenicity determinants in whole genome sequence of

    Srivastava, Alok K / Srivastava, Ruchi / Yadav, Jagriti / Singh, Alok K / Tiwari, Praveen K / Srivastava, Anchal K / Sahu, Pramod K / Singh, Shiv M / Kashyap, Prem Lal

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1066096

    Abstract: The present study deals with whole genome analysis ... ...

    Abstract The present study deals with whole genome analysis of
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1066096
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  8. Article ; Online: Influence of Additives and Growth Inhibitors in Improving the Physicochemical Properties of Silicoaluminophosphate Molecular Sieve, SAPO-11.

    Manal, Arjun K / Advani, Jacky H / Kanna, Narasimharao / Kumar, Pramod / Srivastava, Rajendra

    Chemistry, an Asian journal

    2023  Volume 18, Issue 13, Page(s) e202300294

    Abstract: Silicoalumiophosphates (SAPOs) are microporous crystalline materials extensively utilized as adsorbents and catalysts. The present work utilized two strategies to synthesize nanocrystalline SAPO-11. The first strategy involves a surfactant as a ... ...

    Abstract Silicoalumiophosphates (SAPOs) are microporous crystalline materials extensively utilized as adsorbents and catalysts. The present work utilized two strategies to synthesize nanocrystalline SAPO-11. The first strategy involves a surfactant as a mesoporogen to reduce the crystallite size and increase the surface area for the materials synthesized at 200 °C in 2 days. In the second strategy, the synthesis temperature and time were significantly reduced to 160 °C and 3 h using propylene oxide as a pH accelerator. The reduction in the particle size and the improvement in the surface area were achieved using propyltriethoxysilane, which inhibited the growth of SAPO-11 particles. The materials were thoroughly characterized using XRD, N
    Language English
    Publishing date 2023-05-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300294
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  9. Article: Low-Level Inhibition of Hsp90 Forces Cells to Tip Their (Antigenic) Hand.

    Srivastava, Pramod K / Callahan, Margaret K

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2019  Volume 25, Issue 21, Page(s) 6277–6279

    Abstract: Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound ... ...

    Abstract Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound implications in protein trafficking and antigen presentation and suggest a novel way to enhance the potency of existing anticancer agents.
    MeSH term(s) Antigen Presentation ; Antigens, Neoplasm ; HSP90 Heat-Shock Proteins ; Humans ; Neoplasms ; Proteostasis
    Chemical Substances Antigens, Neoplasm ; HSP90 Heat-Shock Proteins
    Language English
    Publishing date 2019-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-2094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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  10. Article: The Psychological Impact of Rhino-Orbital Mucormycosis During the Second Wave of COVID-19 Pandemic From South East Asian Country.

    Srivastava, Shruti / Beri, Nitika / Das, Gopal K / Sahu, Pramod K / Singh, Ankur / Sharma, Isha

    Cureus

    2023  Volume 15, Issue 2, Page(s) e35349

    Abstract: Aim: The present study addressed overcoming the lacunae in the literature of psychiatric manifestations associated with rhino-orbital mucormycosis. The current study aimed to assess the symptoms of depression, anxiety, stress, coping measures, suicidal ... ...

    Abstract Aim: The present study addressed overcoming the lacunae in the literature of psychiatric manifestations associated with rhino-orbital mucormycosis. The current study aimed to assess the symptoms of depression, anxiety, stress, coping measures, suicidal intent, and visual disability in patients of rhino-orbital mucormycosis (ROM) during the epidemic of the disease at the nodal tertiary care center in North India.
    Methods: Fifty-four inpatients of laboratory-proven rhino-orbital mucor-mycosis (ROM) were included for an observational, cross-sectional study at nodal, designated COVID-19, and mucormycosis treating tertiary care hospital. Patients with Hindi Mini-Mental State Examination score <24, prior psychiatric illness, and severely ill requiring ventilator support were excluded. The psychological variables were assessed using Depression, Anxiety, and Stress Scale 21 (DASS 21), Beck's Suicide intent Scale, Coping Scale Questionnaire, and Visual disability scale (IND-VFQ33). Their socioeconomic status was assessed using the Modified Kuppuswamy Scale.
    Results: Ninety percent of patients with ROM had diabetes mellitus. The majority (44%) of patients belonged to lower socioeconomic strata. Higher frequencies of severe depression (28%), extremely severe anxiety (26%), and mild stress (17%) were noted in the study participants. On the Tukey test, depression score was higher in patients of ROM compared to COVID (with ROM) (p-value= 0.016). On Tukey analysis, anxiety score was significantly higher in ROM patients compared to COVID (with ROM) patients (p-value = 0.018). Coping scores were significantly higher in COVID (with ROM) patients compared to ROM patients (p value = 0.035). Mild to moderate visual disability was noted in the study participants.  Conclusion: The current study reflects the association of higher depression and anxiety scores in cases with ROM that indicated higher mental health needs. Early assessment, early detection, and early intervention for psychological help, along with the multidisciplinary team, helped to improve the overall psychological outcome of the affected patients.
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35349
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