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  1. Article ; Online: Neurological manifestations of SARS-CoV-2 infections: towards quantum dots based management approaches.

    Almasi, Faezeh / Mohammadipanah, Fatemeh

    Journal of drug targeting

    2022  Volume 31, Issue 1, Page(s) 51–64

    Abstract: Developing numerous nanotechnological designed tools to monitor the existence of SARS-CoV-2, and modifying its interactions address the global needs for efficient remedies required for the management of COVID-19. Herein, through a multidisciplinary ... ...

    Abstract Developing numerous nanotechnological designed tools to monitor the existence of SARS-CoV-2, and modifying its interactions address the global needs for efficient remedies required for the management of COVID-19. Herein, through a multidisciplinary outlook encompassing different fields such as the pathophysiology of SARS-CoV-2, analysis of symptoms, and statistics of neurological complications caused by SARS-CoV-2 infection in the central and peripheral nervous systems have been testified. The anosmia (51.1%) and ageusia (45.5%) are reported the most frequent neurological manifestation. Cerebrovascular disease and encephalopathy were mainly related to severe clinical cases. In addition, we focus especially on the various concerned physiological routes, including BBB dysfunction, which transpired due to SARS-CoV-2 infection, direct and indirect effects of the virus on the brain, and also, the plausible mechanisms of viral entry to the nerve system. We also outline the characterisation, and the ongoing pharmaceutical applications of quantum dots as smart nanocarriers crossing the blood-brain barrier and their importance in neurological diseases, mainly SARS-CoV-2 related manifestations Moreover, the market status, six clinical trials recruiting quantum dots, and the challenges limiting the clinical application of QDs are highlighted.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Quantum Dots ; Nervous System Diseases ; Brain
    Language English
    Publishing date 2022-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2022.2110252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms.

    Almasi, Faezeh / Dang, Wen / Mohammadipanah, Fatemeh / Li, Ning

    Archives of pharmacal research

    2022  Volume 45, Issue 12, Page(s) 909–937

    Abstract: In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the ... ...

    Abstract In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the pathophysiological mechanisms and related therapeutic methods remain obscure. Considering the increased concerns of SARS-CoV-2 potential for more serious neuroinvasion conditions, the present review attempts to focus on the neuroprotective effects of natural compounds as the principle source of therapeutics inhibiting multiple steps of the SARS-CoV-2 infection cycle. The great majority of the natural products with anti-SARS-CoV-2 activity mainly inhibit the attachment, entry and gene expression rather than the replication, assembly, or release. Although microbial-derived natural products comprise 38.5% of the known natural products with neuroprotective effects following viral infection, the neuroprotective potential of the majority of microorganisms is still undiscovered. Among natural products, chrysin, huperzine A, ginsenoside Rg1, pterostilbene, and terrein have shown potent in vitro neuroprotective activity and can be promising for new or repurpose drugs for neurological complications of SARS-CoV-2.
    Language English
    Publishing date 2022-11-28
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-022-01420-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hypothetical targets and plausible drugs of coronavirus infection caused by SARS‐CoV‐2

    Almasi, Faezeh / Mohammadipanah, Fatemeh

    Transboundary and emerging diseases. 2021 Mar., v. 68, no. 2

    2021  

    Abstract: The world is confronting a dire situation due to the recent pandemic of the novel coronavirus disease (SARS‐CoV‐2) with the mortality rate passed over 470,000. Attaining efficient drugs evolve in parallel to the understanding of the SARS‐CoV‐2 ... ...

    Abstract The world is confronting a dire situation due to the recent pandemic of the novel coronavirus disease (SARS‐CoV‐2) with the mortality rate passed over 470,000. Attaining efficient drugs evolve in parallel to the understanding of the SARS‐CoV‐2 pathogenesis. The current drugs in the pipeline and some plausible drugs are overviewed in this paper. Although different types of anti‐viral targets are applicable for SARS‐CoV‐2 drug screenings, the more promising targets can be considered as 3C‐like main protease (3Cl protease) and RNA polymerase. The remdesivir could be considered the closest bifunctional drug to the provisional clinical administration for SARS‐CoV‐2. The known molecular targets of the SARS‐CoV‐2 include fourteen targets, while four molecules of angiotensin‐converting enzyme 2 (ACE2), cathepsin L, 3Cl protease and RNA‐dependent RNA polymerase (RdRp) are suggested as more promising potential targets. Accordingly, dual‐acting drugs as an encouraging solution in drug discovery are suggested. Emphasizing the potential route of SARS‐CoV‐2 infection and virus entry‐related factors like integrins, cathepsin and ACE2 seems valuable. The potential molecular targets of each phase of the SARS‐CoV‐2 life cycle are discussed and highlighted in this paper. Much progress in understanding the SARS‐CoV‐2 and molecular details of its life cycle followed by the identification of new therapeutic targets are needed to lead us to an efficient approach in anti‐SARS‐CoV‐2 drug discovery.
    Keywords Coronavirus infections ; DNA-directed RNA polymerase ; RNA-directed RNA polymerase ; Severe acute respiratory syndrome coronavirus 2 ; cathepsin L ; drugs ; integrins ; mortality ; pandemic ; pathogenesis ; peptidyl-dipeptidase A ; therapeutics ; viruses
    Language English
    Dates of publication 2021-03
    Size p. 318-332.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; REVIEW
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.13734
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Prominent and emerging anti-diabetic molecular targets.

    Almasi, Faezeh / Mohammadipanah, Fatemeh

    Journal of drug targeting

    2020  Volume 29, Issue 5, Page(s) 491–506

    Abstract: Diabetes is on the rise across the globe affecting more than 463 million people and crucially increasing morbidities of diabetes-associated diseases. Urgent and immense actions are needed to improve diabetes prevention and treatment. Regarding the ... ...

    Abstract Diabetes is on the rise across the globe affecting more than 463 million people and crucially increasing morbidities of diabetes-associated diseases. Urgent and immense actions are needed to improve diabetes prevention and treatment. Regarding the correlation of diabetes with many associated diseases, inhibition of the disease progression is more crucial than controlling symptoms. Currently, anti-diabetic drugs are accompanied by undesirable side-effects and target confined types of biomolecules. Thus, extensive research is demanding to identify novel disease mechanisms and molecular targets as probable candidates for effective treatment of diabetes. This review discusses the conventional molecule targets that have been applied for their therapeutic rationale in treatment of diabetes. Further, the emerging and prospective molecular targets for the future focus of library screenings are presented.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Drug Delivery Systems/methods ; Drug Delivery Systems/trends ; High-Throughput Screening Assays/methods ; High-Throughput Screening Assays/trends ; Hormones/metabolism ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/metabolism ; Membrane Transport Proteins/metabolism
    Chemical Substances Hormones ; Hypoglycemic Agents ; Membrane Transport Proteins
    Language English
    Publishing date 2020-12-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2020.1859517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
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  5. Article ; Online: Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms

    Almasi, Faezeh / Dang, Wen / Mohammadipanah, Fatemeh / Li, Ning

    Arch. Pharm. Res.. 2022 Dec., v. 45, no. 12 p.909-937

    2022  

    Abstract: In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the ... ...

    Abstract In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the pathophysiological mechanisms and related therapeutic methods remain obscure. Considering the increased concerns of SARS-CoV-2 potential for more serious neuroinvasion conditions, the present review attempts to focus on the neuroprotective effects of natural compounds as the principle source of therapeutics inhibiting multiple steps of the SARS-CoV-2 infection cycle. The great majority of the natural products with anti-SARS-CoV-2 activity mainly inhibit the attachment, entry and gene expression rather than the replication, assembly, or release. Although microbial-derived natural products comprise 38.5% of the known natural products with neuroprotective effects following viral infection, the neuroprotective potential of the majority of microorganisms is still undiscovered. Among natural products, chrysin, huperzine A, ginsenoside Rg1, pterostilbene, and terrein have shown potent in vitro neuroprotective activity and can be promising for new or repurpose drugs for neurological complications of SARS-CoV-2.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; chrysin ; gene expression ; ginsenosides ; nerve tissue ; neuroprotective effect ; pterostilbene ; therapeutics
    Language English
    Dates of publication 2022-12
    Size p. 909-937.
    Publishing place Pharmaceutical Society of Korea
    Document type Article ; Online
    Note Review
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-022-01420-3
    Database NAL-Catalogue (AGRICOLA)

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    Zs.B 3229: Show issues Location:
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  6. Article ; Online: Hypothetical targets and plausible drugs of coronavirus infection caused by SARS-CoV-2.

    Almasi, Faezeh / Mohammadipanah, Fatemeh

    Transboundary and emerging diseases

    2020  Volume 68, Issue 2, Page(s) 318–332

    Abstract: The world is confronting a dire situation due to the recent pandemic of the novel coronavirus disease (SARS-CoV-2) with the mortality rate passed over 470,000. Attaining efficient drugs evolve in parallel to the understanding of the SARS-CoV-2 ... ...

    Abstract The world is confronting a dire situation due to the recent pandemic of the novel coronavirus disease (SARS-CoV-2) with the mortality rate passed over 470,000. Attaining efficient drugs evolve in parallel to the understanding of the SARS-CoV-2 pathogenesis. The current drugs in the pipeline and some plausible drugs are overviewed in this paper. Although different types of anti-viral targets are applicable for SARS-CoV-2 drug screenings, the more promising targets can be considered as 3C-like main protease (3Cl protease) and RNA polymerase. The remdesivir could be considered the closest bifunctional drug to the provisional clinical administration for SARS-CoV-2. The known molecular targets of the SARS-CoV-2 include fourteen targets, while four molecules of angiotensin-converting enzyme 2 (ACE2), cathepsin L, 3Cl protease and RNA-dependent RNA polymerase (RdRp) are suggested as more promising potential targets. Accordingly, dual-acting drugs as an encouraging solution in drug discovery are suggested. Emphasizing the potential route of SARS-CoV-2 infection and virus entry-related factors like integrins, cathepsin and ACE2 seems valuable. The potential molecular targets of each phase of the SARS-CoV-2 life cycle are discussed and highlighted in this paper. Much progress in understanding the SARS-CoV-2 and molecular details of its life cycle followed by the identification of new therapeutic targets are needed to lead us to an efficient approach in anti-SARS-CoV-2 drug discovery.
    MeSH term(s) Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Drug Repositioning ; Humans ; Pandemics ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.13734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fruit wrapping kraft coated paper promotes the isolation of actinobacteria using ex situ and in situ methods.

    Almasi, Faezeh / Kafshnouchi, Maghsoud / Mohammadipanah, Fatemeh / Hamedi, Javad

    Folia microbiologica

    2021  Volume 66, Issue 6, Page(s) 1047–1054

    Abstract: Designing novel isolation methods could enhance the diversification of the available bacterial strains to biotechnology. In this study, the new ex situ and in situ cultivation methods are introduced for the isolation of actinobacteria. In the ex situ ... ...

    Abstract Designing novel isolation methods could enhance the diversification of the available bacterial strains to biotechnology. In this study, the new ex situ and in situ cultivation methods are introduced for the isolation of actinobacteria. In the ex situ experiments, the soil suspension was spread on the isolation media located above some ordinary papers in immediate contact with the slurry of soil substrate and incubated for 16 weeks. The paper was wholly immersed in the cave soil for in situ cultivations, and the containers were buried under layers of soil in Hampoeil cave for 10 weeks. Fruit wrapping kraft coated paper, with 68.8% recovery of isolates, was a better choice in isolation of actinobacteria than other studied filter paper. Based on the molecular identification results, 19% of the isolates obtained from the in situ cultivation method had less than 98.5% similarity to known taxa of actinobacteria and potentially may represent new species. In contrast, in the standard cultivation method, 1.3% of the isolates had less than 98.5% similarity 16Sr RNA gene. This data shows that the introduced cultivation method is a promising technique for isolating less culturable or new actinobacteria.
    MeSH term(s) Actinobacteria/genetics ; Bacteria ; Fruit ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Soil Microbiology
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 240503-9
    ISSN 1874-9356 ; 0015-5632
    ISSN (online) 1874-9356
    ISSN 0015-5632
    DOI 10.1007/s12223-021-00907-8
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  8. Article: Fruit wrapping kraft coated paper promotes the isolation of actinobacteria using ex situ and in situ methods

    Almasi, Faezeh / Kafshnouchi, Maghsoud / Mohammadipanah, Fatemeh / Hamedi, Javad

    Folia microbiologica. 2021 Dec., v. 66, no. 6

    2021  

    Abstract: Designing novel isolation methods could enhance the diversification of the available bacterial strains to biotechnology. In this study, the new ex situ and in situ cultivation methods are introduced for the isolation of actinobacteria. In the ex situ ... ...

    Abstract Designing novel isolation methods could enhance the diversification of the available bacterial strains to biotechnology. In this study, the new ex situ and in situ cultivation methods are introduced for the isolation of actinobacteria. In the ex situ experiments, the soil suspension was spread on the isolation media located above some ordinary papers in immediate contact with the slurry of soil substrate and incubated for 16 weeks. The paper was wholly immersed in the cave soil for in situ cultivations, and the containers were buried under layers of soil in Hampoeil cave for 10 weeks. Fruit wrapping kraft coated paper, with 68.8% recovery of isolates, was a better choice in isolation of actinobacteria than other studied filter paper. Based on the molecular identification results, 19% of the isolates obtained from the in situ cultivation method had less than 98.5% similarity to known taxa of actinobacteria and potentially may represent new species. In contrast, in the standard cultivation method, 1.3% of the isolates had less than 98.5% similarity 16Sr RNA gene. This data shows that the introduced cultivation method is a promising technique for isolating less culturable or new actinobacteria.
    Keywords Actinobacteria ; RNA ; biotechnology ; fruits ; genes ; new species ; paper ; slurries ; soil
    Language English
    Dates of publication 2021-12
    Size p. 1047-1054.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 240503-9
    ISSN 1874-9356 ; 0015-5632
    ISSN (online) 1874-9356
    ISSN 0015-5632
    DOI 10.1007/s12223-021-00907-8
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Hypothetical targets and plausible drugs of coronavirus infection caused by SARS‐CoV‐2

    Almasi, Faezeh / Mohammadipanah, Fatemeh

    Transboundary and Emerging Diseases ; ISSN 1865-1674 1865-1682

    2020  

    Keywords General Immunology and Microbiology ; General Veterinary ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/tbed.13734
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Pivotal role of cardiac magnetic resonance imaging in a new case of Takayasu arteritis.

    Almasi, Simin / Asadian, Sanaz / Tabesh, Faezeh / Rabiei, Parham / Rezaeian, Nahid

    Oxford medical case reports

    2021  Volume 2021, Issue 1, Page(s) omaa130

    Abstract: Takayasu arteritis (TA), also known as the pulseless disease, is a form of vasculitis of unknown cause that chiefly affects the aorta and its major branches, most frequently in young women. The earliest detectable abnormality in TA is a thickening of the ...

    Abstract Takayasu arteritis (TA), also known as the pulseless disease, is a form of vasculitis of unknown cause that chiefly affects the aorta and its major branches, most frequently in young women. The earliest detectable abnormality in TA is a thickening of the vessel wall, but diffuse aortic wall calcification is very rare and is a late manifestation. Besides, the involvement of the coronary arteries is not a common finding in TA and frequently involves the right coronary artery (RCA). Multi-modality imaging has a fundamental role in the diagnosis of vasculitis and its complications. In this report, we want to present an unusual case with TA, diffuse aortic wall calcification and left main coronary artery ostial lesion, which is a rare combination.
    Language English
    Publishing date 2021-01-23
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omaa130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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