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Article ; Online: Hiponatremia hipotónica. Diagnóstico diferencial.

Esparza Martín, Noemí

2016 Volume 147, Issue 11, Page(s) 507–510

Title translation	Hypotonic hiponatremia. Differential diagnosis.
Language	Spanish
Publishing date	2016-12-02
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2016.09.013
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Article: IgG4 related disease as a mimicker of metastatic pancreatic cancer.

Roa Esparza, Íñigo / Soto-Peleteiro, Adriana / Aberasturi Plata, Yoseba / Gendive Martín, Nerea

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2022 Volume 114, Issue 8, Page(s) 505–507

Abstract: A previously healthy 62-year-old female was referred to our hospital for epigastric discomfort in the previous month. Routine laboratory tests showed lipase and pancreatic isoamylase elevation. CT scan revealed an homogeneous mass arising from the ... ...

Abstract	A previously healthy 62-year-old female was referred to our hospital for epigastric discomfort in the previous month. Routine laboratory tests showed lipase and pancreatic isoamylase elevation. CT scan revealed an homogeneous mass arising from the pancreatic head-uncinate process in addition to multiple bilateral hypoattenuating lesions in the renal cortex and pulmonary nodules. US-guided biopsy of one of the kidney lesions was performed under the suspicion of pancreatic metastatic disease.
MeSH term(s)	Female ; Humans ; Immunoglobulin G4-Related Disease ; Lipase ; Middle Aged ; Pancreas/pathology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Tomography, X-Ray Computed
Chemical Substances	Lipase (EC 3.1.1.3)
Language	English
Publishing date	2022-03-28
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2022.8737/2022
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Article: Stability and Bioaccessibility of Phenolic Compounds in Rosehip Extracts during In Vitro Digestion.

Odriozola-Serrano, Isabel / Nogueira, Danielle P / Esparza, Irene / Vaz, Ana A / Jiménez-Moreno, Nerea / Martín-Belloso, Olga / Ancín-Azpilicueta, Carmen

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: Rosehips, particularly dog rose fruits ( ...

Abstract	Rosehips, particularly dog rose fruits (
Language	English
Publishing date	2023-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12051035
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Article ; Online: Kidney disease in pregnant patients.

Esparza Martín, Noemí / Esparza Martín, Miriam / García Cantón, César

Medicina clinica

2017 Volume 149, Issue 9, Page(s) 406–411

Title translation	Enfermedad renal en pacientes gestantes.
MeSH term(s)	Female ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/therapy
Language	Spanish
Publishing date	2017-07-25
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.06.013
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Book ; Online: Fast and Succinct Population Protocols for Presburger Arithmetic

Czerner, Philipp / Guttenberg, Roland / Helfrich, Martin / Esparza, Javier

2022

Abstract: ... predicates with coefficients in binary) runs in $\mathcal{O}(m \cdot n^2 \log n)$ expected number ... of interactions, which is almost optimal in $n$. However, the number of states of the protocol is exponential ... interactions, optimal in $n$, for all inputs of size $\Omega(m)$. For this we introduce population computers ...

Abstract	In their 2006 seminal paper in Distributed Computing, Angluin et al. present a construction that, given any Presburger predicate as input, outputs a leaderless population protocol that decides the predicate. The protocol for a predicate of size $m$ (when expressed as a Boolean combination of threshold and remainder predicates with coefficients in binary) runs in $\mathcal{O}(m \cdot n^2 \log n)$ expected number of interactions, which is almost optimal in $n$. However, the number of states of the protocol is exponential in $m$. Blondin et al. described in STACS 2020 another construction that produces protocols with a polynomial number of states, but exponential expected number of interactions. We present a construction that produces protocols with $\mathcal{O}(m)$ states that run in expected $\mathcal{O}(m^{7} \cdot n^2)$ interactions, optimal in $n$, for all inputs of size $\Omega(m)$. For this we introduce population computers, a carefully crafted generalization of population protocols easier to program, and show that our computers for Presburger predicates can be translated into fast and succinct population protocols. Comment: 58 pages, 7 figures, to be published in the Journal of Computer and System Sciences, Special Issue on SAND 2022
Keywords	Computer Science - Distributed ; Parallel ; and Cluster Computing ; F.1.1
Subject code	511
Publishing date	2022-02-23
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: [No title information]

Lozano-Esparza, Susana / Zazueta, Oscar E / Hernández-Ávila, Juan Eugenio / Lajous, Martín

Salud publica de Mexico

2022 Volume 64, Issue 1, Page(s) 96–99

Abstract: ... We selected all reported deaths (n=581) and 575 alive participants in an epidemiologic cohort with active ...

Title translation	Comparing the usefulness of two mortality registries for data-linkage for prospective cohorts in Mexico.
Abstract	Objective: To estimate the sensitivity and specificity of two Mexican death registries for the identification of vital status using a publicly available record-linkage tool. Materials and methods: We selected all reported deaths (n=581) and 575 alive participants in an epidemiologic cohort with active follow-up. Individual records were cross-linked to two mortal-ity registries. Results: A sensitivity of 87.2% (95%CI: 84.7, 90.2) and specificity of 99.3% (95%CI: 98.2, 99.8) were jointly achieved with both registries. Major discrepancies in cause of death were observed in 10.8% of deaths. Conclusion: There is initial evidence that Mexican death registries are a valuable resource for mortality follow-up in epidemiologic studies.
MeSH term(s)	Cohort Studies ; Data Collection ; Humans ; Mexico/epidemiology ; Prospective Studies ; Registries
Language	Spanish
Publishing date	2022-02-25
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	954220-6
ISSN	1606-7916 ; 0036-3634
ISSN (online)	1606-7916
ISSN	0036-3634
DOI	10.21149/13384
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Article ; Online: Hypouricemia and tubular transport of uric acid.

Esparza Martín, N / García Nieto, V

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2011 Volume 31, Issue 1, Page(s) 44–50

Abstract: Hypouricemia is defined when a serum urate concentration is less than or equal 2.0mg/dl. Differential diagnosis is made by fractional uric acid excretion with the identification of urate transporters and intracellular proteins involved in the tubular ... ...

Abstract	Hypouricemia is defined when a serum urate concentration is less than or equal 2.0mg/dl. Differential diagnosis is made by fractional uric acid excretion with the identification of urate transporters and intracellular proteins involved in the tubular transport of uric acid. This review examines current knowledge on uric acid tubular transport and the various clinical situations of hypouricemia.
MeSH term(s)	Absorption ; Biological Transport ; Diabetes Complications/metabolism ; Diagnosis, Differential ; Fluid Therapy/adverse effects ; Glucose Transport Proteins, Facilitative/genetics ; Glucose Transport Proteins, Facilitative/metabolism ; Humans ; Kidney Tubules, Proximal/metabolism ; Models, Biological ; Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism ; Organic Cation Transport Proteins/genetics ; Organic Cation Transport Proteins/metabolism ; Prevalence ; Renal Tubular Transport, Inborn Errors/chemically induced ; Renal Tubular Transport, Inborn Errors/diagnosis ; Renal Tubular Transport, Inborn Errors/epidemiology ; Renal Tubular Transport, Inborn Errors/genetics ; Renal Tubular Transport, Inborn Errors/metabolism ; Uric Acid/metabolism ; Urinary Calculi/chemically induced ; Urinary Calculi/diagnosis ; Urinary Calculi/epidemiology ; Urinary Calculi/genetics ; Urinary Calculi/metabolism ; Xanthine/urine ; Xanthine Oxidase/deficiency ; Xanthine Oxidase/genetics
Chemical Substances	Glucose Transport Proteins, Facilitative ; Organic Anion Transporters ; Organic Cation Transport Proteins ; SLC22A12 protein, human ; SLC2A9 protein, human ; Xanthine (1AVZ07U9S7) ; Uric Acid (268B43MJ25) ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2011
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
DOI	10.3265/Nefrologia.pre2010.Oct.10588
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Article ; Online: suPAR and WT1 modify the adhesion of podocytes and are related to proteinuria in class IV lupus nephritis.

Bollain-Y-Goytia, Juan-José / Torres-Del-Muro, Felipe-de-Jesús / Hernández-Martínez, Sara-Paola / Avalos-Díaz, Esperanza / Herrera-Esparza, Rafael

Journal of translational autoimmunity

2023 Volume 7, Page(s) 100216

Abstract: ... a cross-sectional study of cases and controls. We studied patients with SLE without renal involvement (n = 12), SLE and LN ... class IV with proteinuria ≤0.5 g/24 h (n = 12), LN class IV with proteinuria ≥0.5 g/24 h (n = 12) and ... compared them with renal tissue control (CR) (n = 12) and control sera (CS) (n = 12). The CR was integrated ...

Abstract	Introduction: Lupus nephritis (LN) affects up to 60 % of the patients with Systemic Lupus Erythematosus (SLE) and renal damage progression is associated with proteinuria, caused in part by the integrity of the glomerular basement membrane (GBM) and by podocyte injury. The soluble urokinase plasminogen activator receptor (suPAR) and Wilms Tumor 1 (WT1) have been related to podocyte effacement and consequently with proteinuria which raises questions about its pathogenic role in LN. Objective: Define whether suPAR levels and WT1 expression influence in podocyte anchorage destabilization in LN class IV. Materials and methods: This is a cross-sectional study of cases and controls. We studied patients with SLE without renal involvement (n = 12), SLE and LN class IV with proteinuria ≤0.5 g/24 h (n = 12), LN class IV with proteinuria ≥0.5 g/24 h (n = 12) and compared them with renal tissue control (CR) (n = 12) and control sera (CS) (n = 12). The CR was integrated by cadaveric samples without SLE or renal involvement and the CS was integrated by healthy participants. The expression and cellular localization of WT1, urokinase-type plasminogen activator receptor (uPAR), ac-α-tubulin, vimentin, and β3-integrin was assessed by immunohistochemistry (IHC). The concentration of suPAR in serum was analyzed by enzyme-linked immunosorbent assay (ELISA). Results: In patients with LN, the activation of anchoring proteins was increased, such as podocyte β3-integrin, as well as the acetylation of alpha-acetyl-tubulin and uPAR, in contrast to the decrease in vimentin; interestingly, the cellular localization of WT1 was cytoplasmic and the number of podocytes per glomerulus decreased. The concentrations of suPAR was increased in patients with LN. Conclusion: The destabilization of podocyte anchorage modulated by β3-integrin activation, and tubulin acetylation, associated with decreased WT1 cytoplasmic expression, and increased suPAR levels could be involved in kidney damage in patients with LN class IV.
Language	English
Publishing date	2023-10-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2589-9090
ISSN (online)	2589-9090
DOI	10.1016/j.jtauto.2023.100216
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Article ; Online: Optimization of peritoneal fluid and leukocyte collection in patients with endometriosis.

Ramírez-Pavez, Tamara N / Machado-Linde, Francisco / García-Peñarrubia, Pilar / Nieto-Meca, Lucía / Martínez-Esparza, María / Marín-Sánchez, Pilar

Fertility and sterility

2023 Volume 120, Issue 4, Page(s) 917–919

Abstract: Objective: To propose a standardized protocol for peritoneal free fluid and leukocyte sample collection in women with endometriosis suitable for biomedical research on the basis of the surgical procedure, the clinical and technical conditions, and the ... ...

Abstract	Objective: To propose a standardized protocol for peritoneal free fluid and leukocyte sample collection in women with endometriosis suitable for biomedical research on the basis of the surgical procedure, the clinical and technical conditions, and the quality of the samples obtained. Design: Video showing the step-by-step collection procedure and the suitability of samples obtained for biomedical research. Subjects: This study included 103 women with confirmed endometriosis by pathology analysis, who signed informed consent and were recruited from the Hospital "Virgen de la Arrixaca", Murcia, Spain. The study was approved by the Ethics Committee of University of Murcia (CEI 3156/2020). Main outcome measures: We analyzed the presence of free fluid in the peritoneal cavity and its relationship with hormonal treatment intake. In addition, the presence of blood contamination, the number of viable leukocytes and macrophages in free peritoneal fluid and lavages as well as their relationship with the lavage volume used, the body mass index, and the age of patients were analyzed. Results: The presence of free peritoneal fluid, in which cells and molecules could be quantified, was scarce in the patients (21%), and it was not significantly related to hormonal treatment intake. The cell viability was higher than 98% in all collected samples; although 54% showed good quality and enough cellularity to be used in biomedical research, 40% were contaminated with blood and 6% had low cellularity. The number of leukocytes and macrophages recovered from the peritoneal lavages correlated positively with the lavage volume used and negatively with the body mass index and was independent of the age of the patients. Conclusion: We describe a standardized step-by-step procedure for peritoneal fluid and leukocyte collection in women with endometriosis, suitable for biomedical research, taking into account that not all women present free fluid in the peritoneal cavity. We propose to increase the lavage volume recommended by the World Endometriosis Research Foundation from 10 mL to at least 40 mL of sterile saline solution and its mobilization for at least 30 seconds within the peritoneal cavity, especially in patients with higher body mass index, to improve the efficiency of the procedure.
MeSH term(s)	Humans ; Female ; Endometriosis/metabolism ; Ascitic Fluid/metabolism ; Leukocytes/metabolism ; Peritoneum ; Macrophages/metabolism
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2023.06.030
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Article: Bio-Layer Interferometry Analysis of the Target Binding Activity of CRISPR-Cas Effector Complexes.

Müller-Esparza, Hanna / Osorio-Valeriano, Manuel / Steube, Niklas / Thanbichler, Martin / Randau, Lennart

Frontiers in molecular biosciences

2020 Volume 7, Page(s) 98

Abstract: CRISPR-Cas systems employ ribonucleoprotein complexes to identify nucleic acid targets with complementarity to bound CRISPR RNAs. Analyses of the high diversification of these effector complexes suggest that they can exhibit a wide spectrum of target ... ...

Abstract	CRISPR-Cas systems employ ribonucleoprotein complexes to identify nucleic acid targets with complementarity to bound CRISPR RNAs. Analyses of the high diversification of these effector complexes suggest that they can exhibit a wide spectrum of target requirements and binding affinities. Therefore, streamlined analysis techniques to study the interactions between nucleic acids and proteins are necessary to facilitate the characterization and comparison of CRISPR-Cas effector activities. Bio-layer Interferometry (BLI) is a technique that measures the interference pattern of white light that is reflected from a layer of biomolecules immobilized on the surface of a sensor tip (bio-layers) in real time and in solution. As streptavidin-coated sensors and biotinylated oligonucleotides are commercially available, this method enables straightforward measurements of the interaction of CRISPR-Cas complexes with different targets in a qualitative and quantitative fashion. Here, we present a general method to carry out binding assays with the Type I-Fv complex from
Language	English
Publishing date	2020-05-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2020.00098
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