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Article ; Online: Prognostic Significance and Determinants of the 6-Min Walk Test in Patients With Heart Failure and Preserved Ejection Fraction.

Zotter-Tufaro, Caroline / Mascherbauer, Julia / Duca, Franz / Koell, Benedikt / Aschauer, Stefan / Kammerlander, Andreas A / Panzenboeck, Adelheid / Sadushi-Kolici, Roela / Bangert, Christine / Laimer, Daniela / Ristl, Robin / Lang, Irene M / Bonderman, Diana

JACC. Heart failure

2015 Volume 3, Issue 6, Page(s) 459–466

Abstract: ... of the 6-min walk distance (6-MWD) in affected patients.: Background: Symptoms of exertional fatigue and ...

Abstract	Objectives: This study sought to define the prognostic significance and clinical determinants of the 6-min walk distance (6-MWD) in affected patients. Background: Symptoms of exertional fatigue and dyspnea, as well as a reduced exercise tolerance, are cardinal features of pulmonary hypertension associated with heart failure and preserved ejection fraction (PH-HFpEF). Mechanisms limiting exercise capacity in this specific entity remain incompletely understood. Methods: Consecutive patients with PH-HFpEF, as confirmed by right heart catheter, were enrolled in our prospective registry. Hospitalization for HF and/or death for cardiac reasons were defined as primary outcome. Multiple regression models were constructed to establish determinants of the 6-MWD. For quantification of left ventricular (LV) extracellular matrix (ECM), myocardial biopsies were taken from 18 patients. Results: Between December 2010 and July 2013, 142 PH-HFpEF patients were included in the study. After a mean follow-up of 14.0 ± 10.0 months, 43 patients (30.3%) reached the combined endpoint. The 6-MWD was found to be an independent predictor of outcome and was influenced by a variety of clinical, echocardiographic, hemodynamic, laboratory, and pulmonary parameters. There was a significant inverse correlation between the 6-MWD and the extent of ECM in the LV myocardium. Conclusions: Impaired exercise capacity in PH-HFpEF patients is explained by cardiac and noncardiac factors. The 6-MWD predicts outcome and may be a useful endpoint in clinical trials.
MeSH term(s)	Aged ; Cardiac Catheterization ; Exercise Test ; Female ; Heart Failure/diagnosis ; Heart Failure/pathology ; Heart Failure/physiopathology ; Heart Ventricles/pathology ; Humans ; Male ; Prognosis ; Prospective Studies ; Stroke Volume/physiology ; Ventricular Dysfunction, Left/physiopathology ; Walking/physiology
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2015.01.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Zhong guo shao shu min zu ying xiong shi shi "ma na si"

Lang, Ying

(Zhong guo min jian wen hua cong shu ; 中国民间文化丛书)

1996

Author's details	Lang ying
Series title	Zhong guo min jian wen hua cong shu 中国民间文化丛书
Language	Chinese
Dates of publication	1996-1995
Size	10, 3, 188 p, Ill
Edition	Di 2 ban, di 3 ci yin shua
Publisher	Zhe jiang jiao yu chu ban she
Publishing place	Hang zhou
Document type	Book
ISBN	7533821742 ; 9787533821746
Database	Former special subject collection: coastal and deep sea fishing

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Book: A er tai yu xi min zu xu shi wen xue yu sa man wen hua

Lang, Ying / Rincindorji, J

(Zhong guo shao shu min zu shi shi yan jiu cong shu ; 中国少数民族史诗研究丛书)

1990

Title variant	Xu shi wen xue yu sa man wen hua ; 叙事文学与萨满文化
Author's details	Ren qin dao er ji, lang ying bian
Series title	Zhong guo shao shu min zu shi shi yan jiu cong shu 中国少数民族史诗研究丛书
Keywords	Folk literature, Altaic/History and criticism ; Shamanism ; Shamanism in literature
Language	Chinese ; English
Size	2, 342 p, 21 cm
Edition	Di 1 ban
Publisher	Nei meng gu da xue chu ban she
Publishing place	Hu he hao te
Document type	Book
Note	Table of contents also in English ; "Ben shu wei guo jia she ke 'qi wu' gui hua zhong dian yan jiu ke ti, ci xiang yan jiu shou guo jia she hui ke xue ji jin zi zhu ; Includes bibliographical references
ISBN	7810151169 ; 9787810151160
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Quantitative Label-Free Chemical Imaging of PLGA Nanoparticles in Cells and Tissues with Single-Particle Sensitivity.

Gao, Xin / Lang, Xiaoqi / El Khoury, Elsy / Wei, Mian / Qian, Naixin / Min, Wei

Nano letters

2024 Volume 24, Issue 3, Page(s) 1024–1033

Abstract: Nanomedicine has brought significant advancements to healthcare by utilizing nanotechnology in medicine. Despite much promise, the further development of nanocarriers for clinical use has been hindered by a lack of understanding and visualization of nano- ...

Abstract	Nanomedicine has brought significant advancements to healthcare by utilizing nanotechnology in medicine. Despite much promise, the further development of nanocarriers for clinical use has been hindered by a lack of understanding and visualization of nano-bio interactions. Conventional imaging methods have limitations in resolution, sensitivity, and specificity. This study introduces a label-free optical approach using stimulated Raman scattering (SRS) microscopy to image poly(lactic-
MeSH term(s)	Animals ; Polylactic Acid-Polyglycolic Acid Copolymer ; Microscopy ; Polymers/chemistry ; Nanoparticles/chemistry
Chemical Substances	Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polymers
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c04463
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Article ; Online: Single-particle imaging of nanomedicine entering the brain.

Wei, Mian / Qian, Naixin / Gao, Xin / Lang, Xiaoqi / Song, Donghui / Min, Wei

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 5, Page(s) e2309811121

Abstract: Nanomedicine has emerged as a revolutionary strategy of drug delivery. However, fundamentals of the nano-neuro interaction are elusive. In particular, whether nanocarriers can cross the blood-brain barrier (BBB) and release the drug cargo inside the ... ...

Abstract	Nanomedicine has emerged as a revolutionary strategy of drug delivery. However, fundamentals of the nano-neuro interaction are elusive. In particular, whether nanocarriers can cross the blood-brain barrier (BBB) and release the drug cargo inside the brain, a basic process depicted in numerous books and reviews, remains controversial. Here, we develop an optical method, based on stimulated Raman scattering, for imaging nanocarriers in tissues. Our method achieves a suite of capabilities-single-particle sensitivity, chemical specificity, and particle counting capability. With this method, we visualize individual intact nanocarriers crossing the BBB of mouse brains and quantify the absolute number by particle counting. The fate of nanocarriers after crossing the BBB shows remarkable heterogeneity across multiple scales. With a mouse model of aging, we find that blood-brain transport of nanocarriers decreases with age substantially. This technology would facilitate development of effective therapeutics for brain diseases and clinical translation of nanocarrier-based treatment in general.
MeSH term(s)	Animals ; Mice ; Nanomedicine ; Brain/diagnostic imaging ; Blood-Brain Barrier/diagnostic imaging ; Brain Diseases ; Aging
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2309811121
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Zs.A 1148: Show issues

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Article: The homeostasis model assessment of insulin resistance is a judgment criterion for metformin pre-treatment before IVF/ICSI and embryo transfer cycles in patients with polycystic ovarian syndrome.

Gao, Rui / Qin, Lang / Li, Zhengyu / Min, Wenjiao

Frontiers in endocrinology

2023 Volume 14, Page(s) 1106276

Abstract: Purpose: The aim of this study was to explore the value of the homeostasis model assessment of IR (HOMA-IR) as a judgment criterion for metformin pre-treatment before : Materials and methods: The clinical and laboratory information of PCOS patients ... ...

Abstract	Purpose: The aim of this study was to explore the value of the homeostasis model assessment of IR (HOMA-IR) as a judgment criterion for metformin pre-treatment before Materials and methods: The clinical and laboratory information of PCOS patients who received IVF/ICSI-ET from January 2017 to September 2021 was retrospectively analyzed. We compared the clinical pregnancy rate (primary outcome) and controlled ovarian stimulation (COS)-related parameters (secondary outcomes) between patients with and without metformin pre-treatment for all PCOS patients not grouped by HOMA-IR, PCOS patients with HOMA-IR < 2.71, and PCOS patients with HOMA-IR ≥ 2.71. Results: A total of 969 PCOS patients who received the GnRH-antagonist protocol were included in this study. For all PCOS patients, the metformin group showed comparable clinical pregnancy rates in fresh ET cycles and frozen ET cycles compared with the control group (55.9% vs. 57.1%, Conclusion: HOMA-IR is a judgment criterion for metformin pre-treatment before IVF/ICSI-ET in patients with PCOS. Metformin pre-treatment could be added for PCOS patients with HOMA-IR ≥ 2.71 during frozen IVF/ICSI-ET cycles to improve the clinical pregnancy rate.
MeSH term(s)	Female ; Humans ; Pregnancy ; Embryo Transfer ; Fertilization in Vitro ; Homeostasis ; Insulin Resistance ; Judgment ; Metformin/therapeutic use ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/drug therapy ; Retrospective Studies ; Semen ; Sperm Injections, Intracytoplasmic
Chemical Substances	Metformin (9100L32L2N)
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1106276
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Article: Comprehensive insights into the genetic background of Chinese populations using Y chromosome markers.

Li, Jienan / Song, Feng / Lang, Min / Xie, Mingkun

Royal Society open science

2023 Volume 10, Issue 9, Page(s) 230814

Abstract: China is located in East Asia. With a high genetic and cultural diversity, human migration in China has always been a hot topic of genetics research. To explore the origins and migration routes of Chinese males, 3333 Chinese individuals (Han, Hui, ... ...

Abstract	China is located in East Asia. With a high genetic and cultural diversity, human migration in China has always been a hot topic of genetics research. To explore the origins and migration routes of Chinese males, 3333 Chinese individuals (Han, Hui, Mongolia, Yi and Kyrgyz) with 27 Y-STRs and 143 Y-SNPs from published literature were analysed. Our data showed that there are five dominant haplogroups (O2-M122, O1-F265, C-M130, N-M231, R-M207) in China. Combining analysis of haplogroup frequencies, geographical positions and time with the most recent common ancestor (TMRCA), we found that haplogroups C-M130, N-M231 and R1-M173 and O1a-M175 probably migrated into China via the northern route. Interestingly, we found that haplogroup C*-M130 in China may originate in South Asia, whereas the major subbranches C2a-L1373 and C2b-F1067 migrated from northern China. The results of BATWING showed that the common ancestry of Y haplogroup in China can be traced back to 17 000 years ago, which was concurrent with global temperature increases after the Last Glacial Maximum.
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.230814
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Article ; Online: "Refusing appearance anxiety": A content analysis of body positive posts on Chinese social media.

Lang, Min / Chen, Peng / Li, Xinrui / Ye, Yiduo

Body image

2023 Volume 45, Page(s) 414–419

Abstract: Body positivity" is a global movement trending on social media. It aims to challenge predominant appearance ideals in media and encourage women to accept and appreciate all bodies regardless of appearance. In Western contexts, an increasing number of ... ...

Abstract	"Body positivity" is a global movement trending on social media. It aims to challenge predominant appearance ideals in media and encourage women to accept and appreciate all bodies regardless of appearance. In Western contexts, an increasing number of research has explored the potential of body positive social media to benefit young women's body image. However, similar research in China is lacking. This study aimed to explore the content of body positivity posts on Chinese social media. Eight hundred eighty-eight posts from Xiaohongshu (one of China's most popular social media platforms) were coded for positive body image themes, physical appearance-related attributes, and self-compassion themes. The results showed that these posts depicted diverse body sizes and appearances. Additionally, while over 40% of the posts conveyed appearance-focused messages, most contained positive body image themes, and nearly half contained self-compassion themes. The study clarified the content of body positivity posts on Chinese social media and provides theoretical support for future research on body positivity in social media content in China.
MeSH term(s)	Humans ; Female ; Social Media ; Body Image/psychology ; Anxiety ; Asian People ; China
Language	English
Publishing date	2023-05-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211449-X
ISSN	1873-6807 ; 1740-1445
ISSN (online)	1873-6807
ISSN	1740-1445
DOI	10.1016/j.bodyim.2023.04.002
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Zs.A 6252: Show issues

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Article ; Online: Prospective Identification of Prognostic Hot-Spot Mutant Gene Signatures for Leukemia: A Computational Study Based on Integrative Analysis of TCGA and cBioPortal Data.

Zhang, Min / Lang, Xianghua / Chen, Xinyi / Lv, Yuke

Molecular biotechnology

2023 Volume 65, Issue 11, Page(s) 1898–1912

Abstract: The advantage of an increasing amount of bioinformatics data on leukemias intrigued us to explore the hot-spot mutation profiles and investigate the implications of those hot-spot mutations in patient survival. We retrieved somatic mutations and their ... ...

Abstract	The advantage of an increasing amount of bioinformatics data on leukemias intrigued us to explore the hot-spot mutation profiles and investigate the implications of those hot-spot mutations in patient survival. We retrieved somatic mutations and their distribution in protein domains through data analysis of The Cancer Genome Atlas and cBioPortal databases. After determining differentially expressed mutant genes related to leukemia, we further conducted principal component analysis and single-factor Cox regression analyses. Moreover, survival analysis was performed for the obtained candidate genes, followed by a multi-factor Cox proportional hazard model method for the impacts of the candidate genes on the survival and prognosis of patients with leukemia. At last, the signaling pathways involved in leukemia were investigated by gene set enrichment analysis. There were 223 somatic missense mutation hot-spots identified with pertinence to leukemia, which were distributed in 41 genes. Differential expression in leukemia was witnessed in 39 genes. We found a close correlation between seven genes and the prognosis of leukemia patients, among which, three genes could significantly influence the survival rate. In addition, among these three genes, CD74 and P2RY8 were highlighted due to close pertinence with survival conditions of leukemia patients. Finally, data suggested that B cell receptor, Hedgehog, and TGF-beta signaling pathways were enriched in low-hazard patients. In conclusion, these data underline the involvement of hot-spot mutations of CD74 and P2RY8 genes in survival status of leukemia patients, highlighting their as novel therapeutic targets or prognostic indicators for leukemia patients. Summary of Graphical Abstract: We identified 223 leukemia-associated somatic missense mutation hotspots concentrated in 41 different genes from 2297 leukemia patients in the TCGA database. Differential analysis of leukemic and normal samples from the TCGA and GTEx databases revealed that 39 of these 41 genes showed significant differential expression in leukemia. These 39 genes were subjected to PCA analysis, univariate Cox analysis, survival analysis, multivariate Cox regression analysis, GSEA pathway enrichment analysis, and then the association with leukemia survival prognosis and related pathways were investigated.
MeSH term(s)	Humans ; Prognosis ; Prospective Studies ; Leukemia/genetics ; Computational Biology
Language	English
Publishing date	2023-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-023-00704-3
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Zs.A 4031: Show issues

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Article: Validation of the Chinese Version of the Self-Objectification Beliefs and Behaviors Scale.

Lang, Min / Ye, Yiduo

Frontiers in psychology

2021 Volume 12, Page(s) 724187

Abstract: Given the limitations of the existing tools used for measuring self-objectification in China, this study aims to validate the Chinese version of the self-objectification beliefs and behaviors scale (C-SOBBS). In this study, we first translated and ... ...

Abstract	Given the limitations of the existing tools used for measuring self-objectification in China, this study aims to validate the Chinese version of the self-objectification beliefs and behaviors scale (C-SOBBS). In this study, we first translated and culturally adopted SOBBS to the Chinese context. We conducted two wave surveys. In the first-wave survey, we recruited 331 female college students whose age ranged from 18 to 35 (
Language	English
Publishing date	2021-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.724187
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