Article ; Online: The efficacy and safety of a Chinese herbal product (Xiao-Feng-San) for the treatment of refractory atopic dermatitis: a randomized, double-blind, placebo-controlled trial.
International archives of allergy and immunology
2011 Volume 155, Issue 2, Page(s) 141–148
Abstract: ... Xiao-Feng-San (XFS; 47 patients) or placebo (24 patients). Total lesion score, erythema score, surface ...
| Abstract | Background: Severe and widespread atopic dermatitis often fails to respond adequately to topical steroids and oral antihistamines and requires immunomodulatory drugs which, although effective, have undesirable toxic effects. Methods: In this prospective, randomized, double-blind, placebo-controlled trial, 71 patients with severe intractable atopic dermatitis were given an 8-week treatment with oral Xiao-Feng-San (XFS; 47 patients) or placebo (24 patients). Total lesion score, erythema score, surface damage score, pruritus score and sleep score were measured at 4-week intervals. Results: Fifty-six patients completed both the treatment and follow-up periods. The decrease in the total lesion score in the treatment group at 8 weeks was significantly greater than that of the placebo group (79.7 ± 5.8% vs. 13.5 ± 7.64%; p < 0.001). There was also a statistically significant difference between the treatment and placebo groups with regard to erythema, surface damage, pruritus and sleep scores. The difference between the 2 groups was still significant for all outcome measures except the erythema score at the 12-week follow-up, 4 weeks after the 8-week treatment had ended. Patients reported no side effects from treatment, although some commented on the unpalatability of the medication. Conclusion: Our study results suggest that the traditional Chinese herbal medicine XFS may be an alternative choice of therapy for severe, refractory, extensive and nonexudative atopic dermatitis. |
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| MeSH term(s) | Adolescent ; China ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/physiopathology ; Disease Progression ; Drug Resistance ; Erythema ; Female ; Follow-Up Studies ; Humans ; Male ; Medicine, Chinese Traditional ; Plants, Medicinal/immunology ; Pruritus ; Severity of Illness Index ; Young Adult |
| Language | English |
| Publishing date | 2011 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1108932-5 |
| ISSN | 1423-0097 ; 1018-2438 |
| ISSN (online) | 1423-0097 |
| ISSN | 1018-2438 |
| DOI | 10.1159/000318861 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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