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Article ; Online: Revisiting the role of ischaemia in familial cardiomyopathy: insights from an NRAP gene-related cardiomyopathy.

AbdelMassih, Antoine Fakhry / Al Ali, Alyaa / Musleh, Afnan Sameer / Ramsi, Musaab

BMJ case reports

2023 Volume 16, Issue 9

MeSH term(s)	Humans ; Cardiomyopathies/genetics ; Ischemia ; Muscle Proteins
Chemical Substances	NRAP protein, human ; Muscle Proteins
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-256111
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Article ; Online: Off-label use of muscular VSD device for closure of a rare congenital portosystemic shunt.

Agha, Hala Mounir / Mashoor, Shady / Ghobashy, Mohamed / AbdelMassih, Antoine / Gaber, Hanya / El-Karaksy, Hanaa

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

2024 Volume 76, Issue 1, Page(s) 34

Abstract: Background: Congenital portosystemic shunt (CPSS) is a vascular malformation in which portal blood drains toward the systemic circulation, leading to pulmonary hypertension.: Case presentation: A 10-year-old patient was brought for evaluation because ...

Abstract	Background: Congenital portosystemic shunt (CPSS) is a vascular malformation in which portal blood drains toward the systemic circulation, leading to pulmonary hypertension. Case presentation: A 10-year-old patient was brought for evaluation because of dyspnea on exertion. Echocardiography revealed a pulmonary hypertension of 75 mmHg, and multi-slice CT angiography revealed the presence of a CPSS. Closure was finally implemented using a muscular ventricular septal defect device. Follow-up of the patient revealed a gradual decline in pulmonary hypertension. Conclusions: CPSS is an overlooked cause of reversible pulmonary hypertension (PH). Closure of such lesions and reversal pulmonary hypertension are possible via catheterization. The preferred device type depends largely on the intervening team. Plugs are the first choice for interventional radiologists, while ventricular and atrial septal occluder devices and duct occluders are preferred by pediatric cardiologists.
Language	English
Publishing date	2024-03-23
Publishing country	Germany
Document type	Journal Article
ISSN	2090-911X
ISSN (online)	2090-911X
DOI	10.1186/s43044-024-00467-5
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Article ; Online: RSV-induced LV dysfunction, what can be the underlying cause?

AbdelMassih, Antoine Fakhry / Ismail, Habiba-Allah / Nabil, Fatima Mohamed / Mabrouk, Aliaa Ibrahim / Abdel Aziz, Faten

Pediatric pulmonology

2022 Volume 58, Issue 4, Page(s) 991–995

MeSH term(s)	Humans ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Function, Left ; Reproducibility of Results
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26290
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Article ; Online: New Strategies in the Treatment of Advanced Heart Failure in Children and the Current Consensus of Cairo University Children Hospital Heart Failure Working Group.

El-Saiedi, Sonia A / Fathalla, Amr / Gaber, Hanya / El Shershaby, Meryam / AbdelMassih, Antoine F

Current problems in cardiology

2022 Volume 48, Issue 1, Page(s) 101389

Abstract: The long-term treatment of congestive heart failure (CHF) in children includes digoxin, diuretics and afterload reduction with angiotensin-converting enzyme (ACE) inhibitors. In spite of the wide use of these drugs being the standard, yet, pediatric ... ...

Abstract	The long-term treatment of congestive heart failure (CHF) in children includes digoxin, diuretics and afterload reduction with angiotensin-converting enzyme (ACE) inhibitors. In spite of the wide use of these drugs being the standard, yet, pediatric heart failure (PHF) continued to be an important cause of morbidity and mortality in childhood. Introduction of new drugs has elevated the level of tolerance of these patients and played a role in delaying their urgent need to have heart transplant or Mechanical circulatory support (MCS). Together with a patient by patient tailored combination of different diuretics. We aim to present and discuss these new drugs and the combinations of regular drugs to reach the best outcome, as well as the consensus of our pediatric heart failure working group in Egypt.
MeSH term(s)	Humans ; Child ; Consensus ; Universities ; Heart Failure/drug therapy ; Diuretics/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Hospitals
Chemical Substances	Diuretics ; Angiotensin-Converting Enzyme Inhibitors
Language	English
Publishing date	2022-09-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2022.101389
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Article ; Online: JAK out of the Box; The Rationale behind Janus Kinase Inhibitors in the COVID-19 setting, and their potential in obese and diabetic populations.

Menshawey, Rahma / Menshawey, Esraa / Alserr, Ayman H K / Abdelmassih, Antoine Fakhry

Cardiovascular endocrinology & metabolism

2020 Volume 10, Issue 2, Page(s) 80–88

Abstract: The adaptive use of Janus kinase (JAK)-inhibitors has been suggested by rheumatology experts in the management of COVID-19. We recount the rationale behind their use in this setting, and the current evidence for and against their use in this review. JAK- ... ...

Abstract	The adaptive use of Janus kinase (JAK)-inhibitors has been suggested by rheumatology experts in the management of COVID-19. We recount the rationale behind their use in this setting, and the current evidence for and against their use in this review. JAK-inhibitors role in COVID-19 infection appears to be multifaceted, including preventing viral endocytosis and dampening the effect of excessive chemokines. This drug class may be able to achieve these effects at already preapproved dosages. Concerns arise regarding reactivation of latent viral infections and the feasibility of their use in those with severe disease. Most interestingly, JAK-Inhibitors may also have an additional advantage for diabetic and obese populations, where the dysregulation of JAK-signal transducer and activator of transcription pathway may be responsible for their increased risk of poor outcomes. Targeting this pathway may provide a therapeutic advantage for these patient groups.
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2574-0954
ISSN (online)	2574-0954
DOI	10.1097/XCE.0000000000000237
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Article ; Online: Association of GDF-15, hs-cTnT and NT-proBNP with coronary artery disease in patients undergoing elective angiography.

Souaid, Tarek / Hijazi, Ziad / Barakett, Vanda / Sarkis, Antoine / Kadri, Zeina / Batra, Gorav / Lindbäck, Johan / Abdelmassih, Tony / Azar, Rabih R

Future cardiology

2022 Volume 18, Issue 8, Page(s) 635–646

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Biomarkers ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Growth Differentiation Factor 15 ; Humans ; Natriuretic Peptide, Brain ; Peptide Fragments ; Troponin T
Chemical Substances	Biomarkers ; Growth Differentiation Factor 15 ; Peptide Fragments ; Troponin T ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca-2021-0137
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Article ; Online: Low iron mitigates viral survival: insights from evolution, genetics, and pandemics-a review of current hypothesis.

Menshawey, Rahma / Menshawey, Esraa / Alserr, Ayman H K / Abdelmassih, Antoine Fakhry

The Egyptian journal of medical human genetics

2020 Volume 21, Issue 1, Page(s) 75

Abstract: Background: Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction.: Body: In this review, we summarize the ... ...

Abstract	Background: Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction. Body: In this review, we summarize the evolutionary and genetic perspectives pointing towards the hypothesis that low iron mitigates infection. The presence of infection promotes the generation of resistance alleles, and there are some evolutionary and genetic clues that suggest the presence of an iron deficiency phenotype that may have developed to protect against infection. Examples include the relative paucity of iron overload genes given the essential role of iron, as well as the persistence of iron deficiency among populations in spite of public health efforts to treat it. Additional examination of geographic areas with severe iron deficiency in the setting of pandemics including H1N1, SARS, and COVID-19 reveals that areas with higher prevalence of iron deficiency are less affected. RNA viruses have several evolutionary adaptations which suggest their absolute need for iron, and this dependency may be exploited during treatment. Conclusion: RNA viruses pose a unique challenge to modern healthcare, with an average of 2-3 new pathogens being discovered yearly. Their overarching requirements for iron, along with human evolutionary and genetic adaptations which favored an iron deficiency phenotype, ultimately suggest the potential need for iron control in these infections.
Language	English
Publishing date	2020-12-16
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2515357-2
ISSN	2090-2441 ; 2090-2441
ISSN (online)	2090-2441
ISSN	2090-2441
DOI	10.1186/s43042-020-00114-z
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Article ; Online: Advanced Echocardiography Techniques: The Future Stethoscope of Systemic Diseases.

Iskander, John / Kelada, Peter / Rashad, Lara / Massoud, Doaa / Afdal, Peter / Abdelmassih, Antoine Fakhry

Current problems in cardiology

2021 Volume 47, Issue 6, Page(s) 100847

Abstract: Cardiovascular disease (CVD) has been showing patterns of extensive rise in prevalence in the contemporary era, affecting the quality of life of millions of people and leading the causes of death worldwide. It has been a provocative challenge for modern ... ...

Abstract	Cardiovascular disease (CVD) has been showing patterns of extensive rise in prevalence in the contemporary era, affecting the quality of life of millions of people and leading the causes of death worldwide. It has been a provocative challenge for modern medicine to diagnose CVD in its crib, owing to its etiological factors being attributed to a large array of systemic diseases, as well as its non-binary hideous nature that gradually leads to functional disability. Novel echocardiography techniques have enabled the cardiac ultrasound to provide a comprehensive analysis of the heart in an objective, feasible, time- and cost-effective manner. Speckle tracking echocardiography, contrast echocardiography, and 3D echocardiography have shown the highest potential for widespread use. The uses of novel modalities have been elaborately demonstrated in this study as a proof of concept that echocardiography has a place in routine general practice with supportive evidence being as recent as its role in the concurrent COVID-19 pandemic. Despite such evidence, many uses remain off-label and unexploited in practice. Generalization of echocardiography at the point of care can become a much-needed turning point in the clinical approach to case management. To actualize such aspirations, we recommend further prospective and interventional studies to examine the effect of implementing advanced techniques at the point of care on the decision-making process and evaluate their effectiveness in prevention of cardiovascular morbidities and mortalities.
MeSH term(s)	COVID-19 ; Cardiovascular Diseases/diagnostic imaging ; Echocardiography/methods ; Humans ; Pandemics ; Quality of Life ; Stethoscopes
Language	English
Publishing date	2021-03-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2021.100847
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Article ; Online: The antibacterial activity of Libanstin from Ilex paraguariensis (Yerba Mate).

El-Sawalhi, Sabah / Fayad, Elie / Porras, Gina / Fayad, Antoine Abou / Abdel-Massih, Roula M

Fitoterapia

2021 Volume 153, Page(s) 104962

Abstract: Infectious diseases are reported to be one of the major causes of death in the world. The World Health Organization (WHO) warns of an increase in the deaths number because of antibacterial resistance. Lately, a trend towards searching for new active ... ...

Abstract	Infectious diseases are reported to be one of the major causes of death in the world. The World Health Organization (WHO) warns of an increase in the deaths number because of antibacterial resistance. Lately, a trend towards searching for new active antibacterial compounds in plants has been observed. Ilex paraguariensis, known as Yerba Mate, is a plant known to be rich in numerous bioactive compounds that have an important role in human health. In this study, Yerba Mate was extracted with acetone: water (1:1) and further fractionated with hexane, chloroform and ethyl acetate. The obtained fractions were tested for antibacterial activity against Staphylococcus aureus and Salmonella species. The minimum inhibitory concentration (MIC) values on S. aureus ranged from 1.56 to 3.12 mg/mL for both the chloroform and ethyl acetate fractions. Whereas for the water fraction, the MIC values ranged from 0.78 to 3.12 mg/mL on S. aureus and ranged from 1.56 mg/mL to 3.12 mg/mL on Salmonella species. The aqueous fraction was further treated with different enzymes to mimic in vivo digestion and the fractions obtained were then tested for antibacterial activity. Furthermore, the Yerba Mate aqueous fraction was run on High Performance Liquid Chromatography (HPLC) and collected fractions were tested for antibacterial activity, to identify the active metabolite. Fraction 3 was tested on different strains of S. aureus and the MIC values ranged from 0.19 to 1.56 μg/mL. A novel pyrazinone, Libanstin, from Ilex paraguariensis was identified using NMR spectroscopy.
MeSH term(s)	Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Ilex paraguariensis/chemistry ; Microbial Sensitivity Tests ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Pyrazines/isolation & purification ; Pyrazines/pharmacology ; Salmonella/drug effects ; Staphylococcus aureus/drug effects
Chemical Substances	Anti-Bacterial Agents ; Phytochemicals ; Plant Extracts ; Pyrazines
Language	English
Publishing date	2021-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2021.104962
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Article ; Online: Is pulmonary vascular disease reversible with PPAR ɣ agonists?

Afdal, Peter / AbdelMassih, Antoine F

Microcirculation (New York, N.Y. : 1994)

2018 Volume 25, Issue 3, Page(s) e12444

Abstract: Severe angio-obliterative PAH remains a disease characterized by great morbidity and shortened survival. Unfortunately, the only currently available treatments for angio-obliterative changes are palliative in the form of pulmonary vasodilators evolving ... ...

Abstract	Severe angio-obliterative PAH remains a disease characterized by great morbidity and shortened survival. Unfortunately, the only currently available treatments for angio-obliterative changes are palliative in the form of pulmonary vasodilators evolving from the phosphodiesterase inhibitor sildenafil to endothelin receptor antagonist: Bosentan; while the only definitive treatment is lung transplantation which remains dependent on the availability of donors and the transplant policies which vary widely from a country to another. PPARs, especially the γ isoform, are largely expressed in pulmonary artery endothelial cells and smooth muscle cells. They are also found on endothelial progenitor cells. Several previous studies have highlighted the role of PPAR γ agonists in reversal of vascular remodeling especially in coronary, carotid and peripheral vascular disease atherosclerotic plaques. Experimental studies have also revealed that PPAR γ activation affects many different pathways; thus, the effect of PPAR γ is multifaceted, affecting almost every pathobiological pathway involved in the development of PAH simultaneously. We thereby hypothesize that PPAR γ agonists may play a key role in reversing severe pulmonary angio-obliterative changes and promote microvascular regeneration which may substitute the need for heart-lung transplantation in such patients.
MeSH term(s)	Humans ; Microvessels/physiology ; PPAR gamma/agonists ; Pulmonary Circulation/drug effects ; Regeneration/drug effects ; Vascular Diseases/drug therapy
Chemical Substances	PPAR gamma
Language	English
Publishing date	2018-03-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1217758-1
ISSN	1549-8719 ; 1073-9688
ISSN (online)	1549-8719
ISSN	1073-9688
DOI	10.1111/micc.12444
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