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  1. Article ; Online: Hypoxia signaling and metastatic progression.

    Schito, Luana / Rey-Keim, Sergio

    Seminars in cancer biology

    2023  Volume 97, Page(s) 42–49

    Abstract: Disruption of oxygen homeostasis, resulting from an imbalance between ... ...

    Abstract Disruption of oxygen homeostasis, resulting from an imbalance between O
    MeSH term(s) Humans ; Hypoxia ; Tumor Hypoxia ; Cell Hypoxia
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2023.11.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Hypoxia orchestrates the lymphovascular-immune ensemble in cancer.

    Schito, Luana / Rey, Sergio

    Trends in cancer

    2022  Volume 8, Issue 9, Page(s) 771–784

    Abstract: The lymphatic system is a major component of the tumor microenvironment, wherein lymphovascular remodeling occurs as a response to low ... ...

    Abstract The lymphatic system is a major component of the tumor microenvironment, wherein lymphovascular remodeling occurs as a response to low O
    MeSH term(s) Cell Hypoxia ; Humans ; Hypoxia ; Immunotherapy ; Neoplasms/metabolism ; Tumor Microenvironment
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Draft genome sequence of

    Silva-Bea, Sergio / García-Meniño, Isidro / Rey, Sonia / Romero, Manuel / Fernández, Javier / Hammerl, Jens A / Mora, Azucena / Otero, Ana

    Microbiology resource announcements

    2024  Volume 13, Issue 4, Page(s) e0119223

    Abstract: The emergence of ... ...

    Abstract The emergence of convergent
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.01192-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Spatial inequality and place mobility in Mexico: 2000-2015

    Rey, Sergio J. / Casimiro Vieyra, Esau

    Applied Geography. 2023 Mar., v. 152 p.102871-

    2023  

    Abstract: In this paper we examine the relationship between spatial inequality, place mobility, and spatial polarization in Mexico. We use data for 2457 Mexican municipios from 2000 to 2015. We apply classical and spatial Markov chains to measure spatial income ... ...

    Abstract In this paper we examine the relationship between spatial inequality, place mobility, and spatial polarization in Mexico. We use data for 2457 Mexican municipios from 2000 to 2015. We apply classical and spatial Markov chains to measure spatial income dynamics and we employ a decomposition of spatial inequality to measure spatial polarization. In doing so, we ask the following questions: Has spatial inequality increased across Mexican municipios since 2000? What has been the role of place mobility in any changes in overall spatial inequality? Finally, we examine what the main components of place mobility have been over this period. We find evidence of a strong spatial dependency between municipios that has increased over time but we find no clear pattern at the state scale. Intra-state municipal inequality has relatively declined while Inter-state municipal inequality polarization has increased. We also find clear evidence that transitional dynamics of municipio incomes are influenced by spatial context. Substantial evidence shows that municipio income mobility is driven by a growth component that could be likely reflecting the devaluation of the peso over this period. Exchange mobility is found to be a more important component of overall place mobility than dispersion (inequality) mobility.
    Keywords geography ; income ; Mexico ; Spatial inequality ; Place mobility ; Polarization
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ISSN 0143-6228
    DOI 10.1016/j.apgeog.2023.102871
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  5. Article ; Online: Microplastic pollution on island beaches, Oahu, Hawai`i.

    Rey, Savannah Franklin / Franklin, Janet / Rey, Sergio J

    PloS one

    2021  Volume 16, Issue 2, Page(s) e0247224

    Abstract: We report microplastic densities on windward beaches of Oahu, Hawai`i, USA, an island that received about 6 million tourist visits a year. Microplastic densities, surveyed on six Oahu beaches, were highest on the beaches with the coarsest sands, ... ...

    Abstract We report microplastic densities on windward beaches of Oahu, Hawai`i, USA, an island that received about 6 million tourist visits a year. Microplastic densities, surveyed on six Oahu beaches, were highest on the beaches with the coarsest sands, associated with high wave energy. On those beaches, densities were very high (700-1700 particles m-2), as high as those recorded on other remote island beaches worldwide. Densities were higher at storm tide lines than high tide lines. Results from our study provide empirical data on the distribution of microplastics on the most populated and visited of the Hawaiian islands.
    MeSH term(s) Bathing Beaches ; Environmental Monitoring ; Hawaii ; Microplastics/analysis ; Water Pollutants, Chemical/analysis
    Chemical Substances Microplastics ; Water Pollutants, Chemical
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0247224
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  6. Article ; Online: Microplastic pollution on island beaches, Oahu, Hawai`i.

    Savannah Franklin Rey / Janet Franklin / Sergio J Rey

    PLoS ONE, Vol 16, Iss 2, p e

    2021  Volume 0247224

    Abstract: We report microplastic densities on windward beaches of Oahu, Hawai`i, USA, an island that received about 6 million tourist visits a year. Microplastic densities, surveyed on six Oahu beaches, were highest on the beaches with the coarsest sands, ... ...

    Abstract We report microplastic densities on windward beaches of Oahu, Hawai`i, USA, an island that received about 6 million tourist visits a year. Microplastic densities, surveyed on six Oahu beaches, were highest on the beaches with the coarsest sands, associated with high wave energy. On those beaches, densities were very high (700-1700 particles m-2), as high as those recorded on other remote island beaches worldwide. Densities were higher at storm tide lines than high tide lines. Results from our study provide empirical data on the distribution of microplastics on the most populated and visited of the Hawaiian islands.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Hypoxia: Turning vessels into vassals of cancer immunotolerance.

    Schito, Luana / Rey, Sergio

    Cancer letters

    2020  Volume 487, Page(s) 74–84

    Abstract: Hypoxia is a universal feature of solid cancers caused by a mismatch between cellular oxygen supply and consumption. To meet the increased demand for oxygen, hypoxic cancer cells (CCs) induce a multifaceted process known as angiogenesis, wherein new ... ...

    Abstract Hypoxia is a universal feature of solid cancers caused by a mismatch between cellular oxygen supply and consumption. To meet the increased demand for oxygen, hypoxic cancer cells (CCs) induce a multifaceted process known as angiogenesis, wherein new vessels are formed by the sprouting of pre-existing ones. In addition to providing oxygen for growth and an exit route for dissemination, angiogenic vessels and factors are co-opted by CCs to enable the generation of an immunotolerant, hypoxic tumor microenvironment, leading to therapeutic failure and mortality. In this review, we discuss how hypoxia-inducible factors (HIFs), the mechanistic target of rapamycin (mTOR), and the unfolded protein response (UPR) control angiogenic factors serving both vascular and immunomodulatory functions in the tumor microenvironment. Possible therapeutic strategies, wherein targeting oxygen sensing might enhance anti-angiogenic and immunologically-mediated anti-cancer responses, are suggested.
    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/genetics ; Blood Vessels/growth & development ; Blood Vessels/pathology ; Gene Expression Regulation, Neoplastic/genetics ; Gene Regulatory Networks/genetics ; Gene Regulatory Networks/immunology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/pathology ; TOR Serine-Threonine Kinases/genetics ; Tumor Hypoxia/genetics ; Tumor Hypoxia/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Unfolded Protein Response/genetics ; Unfolded Protein Response/immunology
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Hypoxia-Inducible Factor 1, alpha Subunit ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2020-05-26
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2020.05.015
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    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Chemometric and Physico-Chemical Characterization of Fruit and Olive Oils from Autochthonous Cultivars Grown in Aragon (Spain).

    Rey-Giménez, Raquel / Vázquez Ayala, Sergio / Laya Reig, Diego / Sánchez-Gimeno, Ana Cristina

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Olive tree crops and the olive oil market are becoming less and less diverse due to the rise of intensive growth varieties, with the consequent loss of varietal richness provided by oils from minority and autochthonous cultivars. "Royal de Calatayud" and ...

    Abstract Olive tree crops and the olive oil market are becoming less and less diverse due to the rise of intensive growth varieties, with the consequent loss of varietal richness provided by oils from minority and autochthonous cultivars. "Royal de Calatayud" and "Negral de Sabiñán" are two local minority cultivars in Aragon (Spain). Fruit parameters such as ripening, fresh weight, and oil yield were evaluated, as well as physico-chemical and chemical composition parameters in olive oil in comparison with "Arbequina", a cultivar widespread in Spain and other countries. Fruits were harvested from October to December in 2017 and 2019. Chemometric analysis revealed significant varietal differences among the three cultivars. In comparison with "Arbequina", higher oil yields were obtained in the two local cultivars. "Royal de Calatayud" has a higher oleic acid content and a greater quantity of phenolic compounds. It thus displays a better nutritional profile than "Arbequina". This preliminary study shows that "Royal de Calatayud" could be regarded as an excellent alternative to the "Arbequina" cultivar in the parameters analyzed.
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12040803
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  9. Article ; Online: Chemometric and Physico-Chemical Characterization of Fruit and Olive Oils from Autochthonous Cultivars Grown in Aragon (Spain)

    Rey-Giménez, Raquel / Vázquez Ayala, Sergio / Laya Reig, Diego / Sánchez-Gimeno, Ana Cristina

    Foods. 2023 Feb. 13, v. 12, no. 4

    2023  

    Abstract: Olive tree crops and the olive oil market are becoming less and less diverse due to the rise of intensive growth varieties, with the consequent loss of varietal richness provided by oils from minority and autochthonous cultivars. “Royal de Calatayud” and ...

    Abstract Olive tree crops and the olive oil market are becoming less and less diverse due to the rise of intensive growth varieties, with the consequent loss of varietal richness provided by oils from minority and autochthonous cultivars. “Royal de Calatayud” and “Negral de Sabiñán” are two local minority cultivars in Aragon (Spain). Fruit parameters such as ripening, fresh weight, and oil yield were evaluated, as well as physico-chemical and chemical composition parameters in olive oil in comparison with “Arbequina”, a cultivar widespread in Spain and other countries. Fruits were harvested from October to December in 2017 and 2019. Chemometric analysis revealed significant varietal differences among the three cultivars. In comparison with “Arbequina”, higher oil yields were obtained in the two local cultivars. “Royal de Calatayud” has a higher oleic acid content and a greater quantity of phenolic compounds. It thus displays a better nutritional profile than “Arbequina”. This preliminary study shows that “Royal de Calatayud” could be regarded as an excellent alternative to the “Arbequina” cultivar in the parameters analyzed.
    Keywords Olea europaea ; chemometrics ; cultivars ; fruits ; indigenous species ; markets ; nutrient content ; oleic acid ; olive oil ; physicochemical properties ; Spain
    Language English
    Dates of publication 2023-0213
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12040803
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  10. Article ; Online: Cost-effectiveness analysis of dupilumab versus omalizumab, mepolizumab, and benralizumab added to the standard of care in adults with severe asthma in Colombia.

    Ali, Abraham / García, Elizabeth / Torres-Duque, Carlos A / Rey, Diana / Botero, Laura / Saenz, Stid / Avila, Maria Paula / Mazo, Elizabeth / Londoño, Sergio

    Expert review of pharmacoeconomics & outcomes research

    2024  Volume 24, Issue 3, Page(s) 361–374

    Abstract: Background: Cost-effectiveness studies evaluate health technologies and help choose treatments. The current study compared dupilumab to omalizumab, mepolizumab, and benralizumab in Colombian adults with severe uncontrolled type 2 asthma.: Methods: ... ...

    Abstract Background: Cost-effectiveness studies evaluate health technologies and help choose treatments. The current study compared dupilumab to omalizumab, mepolizumab, and benralizumab in Colombian adults with severe uncontrolled type 2 asthma.
    Methods: Over a 5-year period, a Markov model was utilized to assess the costs of biological treatments and management of exacerbations, comparing various doses of exacerbations, comparing various doses of dupilumab, omalizumab, mepolizumab, and benralizumab as add-on treatments. It included a 5% annual discount rate per local HTA, and set willingness-to-pay at three times GDP per capita per quality-adjusted life year (QALY) in Colombia.
    Results: Dupilumab (200 mg) exhibited greater QALYs and reduced overall costs compared to mepolizumab (100 mg), benralizumab (30 mg), and omalizumab (450 mg and 600 mg), with the incremental cost-effectiveness ratio (ICER) per QALYgained being -$5.429, -$6.269, -$196.567 and -$991.007, respectively. Dupilumab had greater QALYs and costs versus omalizumab 300 mg (ICERof $200.653 per QALY, above the willingness-to-pay threshold of 3 × GDP per capita). Sensitivity analyses were consistent with base case results.
    Conclusions: Dupilumab 200 mg was strongly dominant versus omalizumab 450 mg and 600 mg, mepolizumab 100 mg, and benralizumab 30 mg; however, cost-effectiveness was not demonstrated versus omalizumab 300 mg. These results could assist healthcare professionals in choosing an appropriate biologic for treating severe type 2 asthma.
    MeSH term(s) Adult ; Humans ; Omalizumab/therapeutic use ; Colombia ; Anti-Asthmatic Agents ; Cost-Effectiveness Analysis ; Standard of Care ; Asthma/drug therapy ; Antibodies, Monoclonal, Humanized
    Chemical Substances Omalizumab (2P471X1Z11) ; dupilumab (420K487FSG) ; benralizumab (71492GE1FX) ; mepolizumab (90Z2UF0E52) ; Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2208481-2
    ISSN 1744-8379 ; 1473-7167
    ISSN (online) 1744-8379
    ISSN 1473-7167
    DOI 10.1080/14737167.2023.2282668
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    Zs.A 6194: Show issues Location:
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