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Article ; Online: Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients.

Yucel, Kamile / Fuat Gurbuz, Ali

Hormone molecular biology and clinical investigation

2022

Abstract: Objectives: In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is ... ...

Abstract	Objectives: In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1α and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature. Methods: A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study. Results: When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1α and IMA (r: 0.320). However, there were statistically significant differences in HIF-1α and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1α and 0.937 for IMA. Conclusions: The HIF-1α and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1α and IMA levels can be used as reliable markers for the prognosis of COVID-19.
Language	English
Publishing date	2022-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2536635-X
ISSN	1868-1891 ; 1868-1883
ISSN (online)	1868-1891
ISSN	1868-1883
DOI	10.1515/hmbci-2022-0024
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Article ; Online: The effect of lactate/albumin ratio on mortality in patients with sepsis

Kamile Yucel / Ali Fuat Gurbuz

Medicine Science, Vol 10, Iss 3, Pp 939-

2021 Volume 45

Abstract: The aim of study was to evaluate the lactate/ albumin ratio, procalcitonin (ProCT) and C reactive protein (CRP) levels in patients with sepsis. For the study, 207 patients with sepsis who were treated in intensive care between January 1st, 2016 and ... ...

Abstract	The aim of study was to evaluate the lactate/ albumin ratio, procalcitonin (ProCT) and C reactive protein (CRP) levels in patients with sepsis. For the study, 207 patients with sepsis who were treated in intensive care between January 1st, 2016 and January 1st, 2021 were analyzed retrospectively. The patients age, sex, diagnosis for hospitalization, lactate levels during the admission (lactate 1) and discharge (lactate 2), CRP, ProCT and albumin, levels registered in patients files were recorded from the hospital automation system and their effect on the mortality was statistically analyzed. The patients were grouped as those aged older than 65 and younger than 65, and those with and without mortality. The study included 207 patients diagnosed with sepsis (96 female, 111 male). ProCT levels were found significantly higher in the group older than 65 in the present study. In this study, according to the data obtained, there was no difference in lactate1/albumin and lactate2/albumin ratio in terms of age groups and sex. However, lactate1/albumin and lactate2/ albumin ratio were significantly higher in the group with mortality than the group without mortality. According to our ROC analysis results; The AUC for lactate1, lactate2, lactate1/albumin and lactate2/albumin ratio was 0.649, 0.680, 0.690, 0.771, respectively. The lactate/albumin ratio is a readily available parameter with consistently better prognostic performance than initial serum lactate for in-hospital mortality in adult patients with sepsis. Raised lactate/albumin ratio showed significant association with increased mortality in patients with sepsis. [Med-Science 2021; 10(3.000): 939-45]
Keywords	c-reactive protein ; lactate/ albumin ratio ; mortality ; procalcitonin ; sepsis ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
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Article ; Online: Evaluation of vitamin D, vitamin B12 and Hemoglobin HbA1c levels in patients with type 1 diabetes mellitus

Kamile Yucel / Berna Bayir / Hatice Yildirim

Medicine Science, Vol 11, Iss 4, Pp 1603-

2022 Volume 7

Abstract: We aimed to evaluate the Vitamin D, Vitamin B12 and Hemoglobin A1c Levels in patients with T1DM. This study is a retrospective cross-sectional study. We classified patients as [Med-Science 2022; 11(4.000): 1603-7] ...

Abstract	We aimed to evaluate the Vitamin D, Vitamin B12 and Hemoglobin A1c Levels in patients with T1DM. This study is a retrospective cross-sectional study. We classified patients as [Med-Science 2022; 11(4.000): 1603-7]
Keywords	hba1c ; type 1 diabetes mellitus ; vitamin b12 ; vitamin d ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
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Article ; Online: Hypoxia induced factor-1α levels in patients undergoing adenoidectomy.

Yucel, Kamile / Aydin, Isa / Erdem, Said Sami

Scandinavian journal of clinical and laboratory investigation

2020 Volume 81, Issue 1, Page(s) 34–38

Abstract: Among the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study ... ...

Abstract	Among the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study included a total of 86 participants: 39 patients with AH and 47 healthy individuals. Serum HIF-1α levels (ng/mL) were measured by ELISA. HIF-1α concentrations were compared to the adenoid-nasopharyngeal ratio (ANR) of patients with AH, as recorded in the medical records. We found significantly higher concentrations of HIF-1α (0.30 ± 0.47 ng/mL) in patients with AH as compared to healthy controls (0.24 ± 0.07 ng/mL,
MeSH term(s)	Adenoidectomy ; Adenoids/pathology ; Adenoids/surgery ; Child ; Female ; Hemoglobins/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male ; Nasopharynx/pathology ; ROC Curve
Chemical Substances	HIF1A protein, human ; Hemoglobins ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2020.1849786
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Article: Comparison of Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry Methods in the Measurement of Serum Androstenedione Levels.

Yucel, Kamile / Abusoglu, Sedat / Unlu, Ali

Clinical laboratory

2018 Volume 64, Issue 1, Page(s) 69–75

Abstract: Background: Recent reports have described inherent problems with androgen immunoassays compared with mass spectrometry analyses. In this study, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed according to CLSI rules. ...

Abstract	Background: Recent reports have described inherent problems with androgen immunoassays compared with mass spectrometry analyses. In this study, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed according to CLSI rules. The developed method was compared with two immunoassay methods, the enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA). Methods: After liquid-liquid extraction, a Shimadzu Prominence LC unit coupled to an ABSCIEX API 3200 mass spectrometer with atmospheric pressure chemical ionization was used to quantify serum androstenedione levels. Serum androstenedione results taken from tandem mass spectrometry were compared with the immunoassays. Results: The androstenedione assay was linear up to 50 ng/mL. Lower limit of quantitation and lower limit of detection were 0.195 ng/mL and 0.097 ng/mL, respectively. This method was not affected by matrix effect and other steroid hormone interferences. In this study, the obtained recovery was 69 - 99%, carryover value was determined as 0.026 ng/mL. According to the results of an interference study, androstenedione bias % did not exceed the limit of allowable bias % and 88.7% recovery was acquired for androstenedione. In the LC-MS/MS and ELISA comparison study, the slope value was found as 18.412, intercept -22.87, and r2 value as 0.1033. In the LC-MS/MS and RIA comparison study, slope value was found as 1.085, intercept 0.4541, and r2 value as 0.3712. In the RIA and ELISA comparison study, slope value was found as 9.57, intercept -15.5, and r2 value as 0.19. Conclusions: The LC-MS/MS provides agreement with the results of radioimmunoassay but not with ELISA. This method offers better selectivity compared to immunoassay systems.
MeSH term(s)	Androstenedione/blood ; Calibration ; Chromatography, Liquid/methods ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Immunoassay/methods ; Male ; Radioimmunoassay/methods ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
Chemical Substances	Androstenedione (409J2J96VR)
Language	English
Publishing date	2018-03-02
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2017.170612
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Article ; Online: Defective Treg generation and increased type 3 immune response in leukocyte adhesion deficiency 1.

Erdem, Serife / Haskologlu, Sule / Haliloglu, Yesim / Celikzencir, Huriye / Arik, Elif / Keskin, Ozlem / Eltan, Sevgi Bilgic / Yucel, Esra / Canatan, Halit / Avcilar, Huseyin / Yilmaz, Ebru / Ozcan, Alper / Unal, Ekrem / Karakukcu, Musa / Celiksoy, Mehmet Halil / Kilic, Sara Sebnem / Demir, Ayca / Genel, Ferah / Gulez, Nesrin /

Koker, Mustafa Yavuz / Ozen, Ahmet Oguzhan / Baris, Safa / Metin, Ayse / Guner, Sukru Nail / Reisli, Ismail / Keles, Sevgi / Dogu, Esin Figen / Ikinciogullari, Kamile Aydan / Eken, Ahmet

Clinical immunology (Orlando, Fla.)

2023 Volume 253, Page(s) 109691

Abstract: In 15 Turkish LAD-1 patients and controls, we assessed the impact of pathogenic ITGB2 mutations on Th17/Treg differentiation and functions, and innate lymphoid cell (ILC) subsets. The percentage of peripheral blood Treg cells, in vitro-generated induced ... ...

Abstract	In 15 Turkish LAD-1 patients and controls, we assessed the impact of pathogenic ITGB2 mutations on Th17/Treg differentiation and functions, and innate lymphoid cell (ILC) subsets. The percentage of peripheral blood Treg cells, in vitro-generated induced Tregs differentiated from naive CD4
MeSH term(s)	Humans ; T-Lymphocytes, Regulatory ; Immunity, Innate ; CD4-Positive T-Lymphocytes ; Leukocyte-Adhesion Deficiency Syndrome ; Th17 Cells
Language	English
Publishing date	2023-07-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2023.109691
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Article: fNIRS dataset during complex scene analysis.

Ning, Matthew / Duwadi, Sudan / Yücel, Meryem A / von Lühmann, Alexander / Boas, David A / Sen, Kamal

Frontiers in human neuroscience

2024 Volume 18, Page(s) 1329086

Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2024.1329086
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Article: fNIRS Dataset During Complex Scene Analysis.

Ning, Matthew / Duwadi, Sudan / Yücel, Meryem A / Von Lühmann, Alexander / Boas, David A / Sen, Kamal

bioRxiv : the preprint server for biology

2024

Abstract: When analyzing complex scenes, humans often focus their attention on an object at a particular spatial location. The ability to decode the attended spatial location would facilitate brain computer interfaces for complex scene analysis (CSA). Here, we ... ...

Abstract	When analyzing complex scenes, humans often focus their attention on an object at a particular spatial location. The ability to decode the attended spatial location would facilitate brain computer interfaces for complex scene analysis (CSA). Here, we investigated capability of functional near-infrared spectroscopy (fNIRS) to decode audio-visual spatial attention in the presence of competing stimuli from multiple locations. We targeted dorsal frontoparietal network including frontal eye field (FEF) and intra-parietal sulcus (IPS) as well as superior temporal gyrus/planum temporal (STG/PT). They all were shown in previous functional magnetic resonance imaging (fMRI) studies to be activated by auditory, visual, or audio-visual spatial tasks. To date, fNIRS has not been applied to decode auditory and visual-spatial attention during CSA, and thus, no such dataset exists yet. This report provides an open-access fNIRS dataset that can be used to develop, test, and compare machine learning algorithms for classifying attended locations based on the fNIRS signals on a single trial basis.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.23.576715
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Article ; Online: Homocysteine levels in patients with masked hypertension.

Yücel, Kamile / Bekçi, Taha Tahir / Taner, Alparslan / Kayrak, Mehmet / Korucu, Emine Nedime / Unlü, Ali

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology

2014 Volume 14, Issue 4, Page(s) 357–362

Abstract: Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the ... ...

Abstract	Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the pathophysiology. Plasma total homocysteine levels are accepted as a major independent biomarker for endothelial dysfunction and/or a contributor to hypertension and coronary artery disease. In this study, we aimed to measure the level of serum homocysteine and to evaluate the relationship between the parameters of ambulatory blood pressure monitoring in patients with masked hypertension. Methods: This cross-sectional observational study included 37 subjects with normal blood pressure, 30 with masked-hypertension and 27 patients with obvious hypertension. Masked hypertension (MHT) was defined as office blood pressure <140/90 mm Hg and mean daytime ambulatory systolic blood pressure in 24 hours monitoring ≥135/85 mm Hg. Homocysteine levels of the subjects were measured by using HPLC system with fluorescent detector. Lipid parameters were measured by routine methods. Mann-Whitney U test was used for statistical analysis. Results: In the analysis of homocysteine, it was observed that there was no difference between the control group and patients with MHT. Patients with high blood pressure showed higher homocysteine levels when compared to MHT (p=0.02). Homocysteine levels showed a weak positive correlation with average systolic blood pressure (r=0.335, p=0.043). Homocysteine levels were higher in smokers than non-smokers. compared with non-smokers group in all participants (p=0.036). Conclusion: We have reached the opinion that in the individuals with no obvious health problems but with MHT, homocysteine levels may not have any significant effect upon high blood pressure levels.
MeSH term(s)	Biomarkers/blood ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Case-Control Studies ; Cholesterol/blood ; Cross-Sectional Studies ; Female ; Homocysteine/blood ; Humans ; Male ; Masked Hypertension/blood ; Masked Hypertension/diagnosis ; Middle Aged
Chemical Substances	Biomarkers ; Homocysteine (0LVT1QZ0BA) ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2014-06
Publishing country	Turkey
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2278670-3
ISSN	1308-0032 ; 1302-8723
ISSN (online)	1308-0032
ISSN	1302-8723
DOI	10.5152/akd.2014.4689
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Article: Mapping the research landscape of bauxite by-products (red mud): An evolutionary perspective from 1995 to 2022.

Svobodova-Sedlackova, Adela / Calderón, Alejandro / Fernandez, A Inés / Chimenos, Josep Maria / Berlanga, Carlos / Yücel, Onuralp / Barreneche, Camila / Rodriguez, Rafael

Heliyon

2024 Volume 10, Issue 3, Page(s) e24943

Abstract: The global population growth has significantly impacted energy and raw material consumption, unmatched since the Industrial Revolution. Among metals, aluminium ranks second only to steel, with annual production exceeding 69 million tonnes. Due to its ... ...

Abstract	The global population growth has significantly impacted energy and raw material consumption, unmatched since the Industrial Revolution. Among metals, aluminium ranks second only to steel, with annual production exceeding 69 million tonnes. Due to its high demand, bauxite, the primary ore from which aluminium is extracted, is now classified as a critical material in the EU and the US, given the potential risk of supply shortages for essential applications. Geographical and production challenges surround bauxite, presenting geo-economic and environmental challenges. A critical concern in aluminium production is managing by-products, notably red mud, a bauxite residue, generating over 175 million tonnes annually worldwide. Comprehensive bibliometric research is imperative due to the high amount of bibliographical resources related to this topic, encompassing circular economy, re-valorisation, sustainability, and disposal. This study employs bibliometric methods to assess red mud valorisation, offering insights into research topics, influential authors, and key journals, shedding light on the past, present, and future of red mud research. Such bibliometric analysis not only highlights the current state of the field but also serves as a valuable tool for decision-making, enabling researchers and policymakers to identify trends, gaps, and areas for further exploration, fostering informed and sustainable advancements in the by-products of the aluminium industry.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24943
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