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Article: Evaluation of Individualized Pain Plans for Children With Sickle Cell Disease Admitted for Vaso-occlusive Crisis at Riley Hospital for Children.

Arends, Alexandria M / Perez, Anne / Wilder, Christina / Jacob, Seethal A

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

2022 Volume 27, Issue 4, Page(s) 312–315

Abstract: Objective: Vaso-occlusive crisis (VOC) is the most common problem reported by patients with sickle cell disease (SCD). The objective of this study was to evaluate the impact of individualized pain plans in pediatric patients with SCD admitted for VOC.!## ...

Abstract	Objective: Vaso-occlusive crisis (VOC) is the most common problem reported by patients with sickle cell disease (SCD). The objective of this study was to evaluate the impact of individualized pain plans in pediatric patients with SCD admitted for VOC. Methods: This was a pre- and post-study of patients with SCD admitted to Riley Hospital for Children for VOC from July 1, 2019, through July 1, 2020. The primary outcome was length of inpatient stay for VOC. Secondary outcomes included final pain score, days on scheduled opioids, days on breakthrough opioids, and average morphine milligram equivalents (MME) used per day. Results: Nine patients were included. The mean age was 16 years (range, 10-20 years). Key clinical findings were decreases in median [IQR] for final pain scores (7 [4.5-9] vs 6 [2.5-8], p = 0.396) and number of days of breakthrough opioid use (5 [3-8] vs 4 [2.5-5.5], p = 0.233). Following implementation of an individualized pain plan, there was an increase in median average MME per day (65.94 [53.1-97.7] vs 82.85 [41-114.3], p = 0.844). Median length of stay and days on scheduled opioids remained the same. Conclusions: This study demonstrated that use of individualized pain plans in a small population of patients with SCD might result in decreased pain scores and decreased days on breakthrough opioids.
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028543-4
ISSN	1551-6776
ISSN	1551-6776
DOI	10.5863/1551-6776-27.4.312
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction to: National burden of pediatric abusive injuries: patterns vary by age.

Huerta, Carlos Theodore / Perez, Eduardo A / Quiroz, Hallie / Quinn, Kirby / Thorson, Chad M / Hogan, Anthony R / Brady, Ann-Christina / Sola, Juan E

Pediatric surgery international

2022 Volume 38, Issue 3, Page(s) 521–522

Language	English
Publishing date	2022-01-22
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-022-05072-8
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Zs.A 2138: Show issues

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Article: An Unusual Case of Severe Cystic Lung Disease: A Case Report and Review of the Literature.

Lakhdar, Sofia / Shah, Deesha / Guzman Perez, Laura M / Sneed, Christina / Trandafirescu, Theo

Cureus

2022 Volume 14, Issue 3, Page(s) e23442

Abstract: Cystic lung diseases are a heterogeneous group of disorders with varying presentations and pathophysiology. They present as air-filled lung cysts that are prone to rupture and result in spontaneous pneumothoraxes. While pulmonary cysts are not uncommon, ... ...

Abstract	Cystic lung diseases are a heterogeneous group of disorders with varying presentations and pathophysiology. They present as air-filled lung cysts that are prone to rupture and result in spontaneous pneumothoraxes. While pulmonary cysts are not uncommon, cysts presenting later in life with unclear etiology are rare and result in both a diagnostic and therapeutic challenge. In this report, we present a case of an 82-year-old female presenting with shortness of breath and hemoptysis. Computed tomography (CT) angiogram showed multiple pulmonary cysts with one of the cysts containing an air-fluid level suspicious of superimposed infection. Pulmonary cysts are characteristic of different diseases that include but are not limited to Langerhans cell histiocytosis (LCH), lymphangioleiomyomatosis (LAM), and Birt-Hogg-Dube (BHD) syndrome. The differential diagnosis of cystic lung disease over the years has become more complex. Clinical context and radiological findings are essential for diagnosis.
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.23442
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Article ; Online: Outcomes Associated with ICU Telemedicine and Other Risk Factors in a Multi-Hospital Critical Care System: A Retrospective, Cohort Study for 30-Day In-Hospital Mortality.

Udeh, Chiedozie / Perez-Protto, Silvia / Canfield, Christina M / Sreedharan, Roshni / Factora, Faith / Hata, J Steven

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2022 Volume 28, Issue 10, Page(s) 1395–1403

Abstract: ... Introduction: ... Intensive care unit telemedicine (ICU-TM) is expanding due to increasing demands for critical care, but impact on outcomes remains controversial. This study evaluated the association of ICU-TM and other clinical factors with ... ...

Abstract	*Introduction:* Intensive care unit telemedicine (ICU-TM) is expanding due to increasing demands for critical care, but impact on outcomes remains controversial. This study evaluated the association of ICU-TM and other clinical factors with 30-day, in-hospital mortality. *Methods:* This retrospective, cohort study included 151,780 consecutive ICU patients admitted to nine hospitals in the Cleveland Clinic Health System from 2010 to 2020. Patients were identified from an institutional datamart and Acute Physiology and Chronic Health Evaluation IV (APACHE IV) registry. Primary outcome was 30-day in-hospital mortality. Analyses included multivariate logistic regression modeling, and survival analysis. *Results:* Overall, unadjusted 30-day, in-hospital mortality incidence was significantly different with (5.6%) or without ICU-TM (7.2%), and risk ratio was 0.78 (95% confidence interval [CI] 0.75-0.81) (p < 0.0001). Mortality rate for ICU-TM and no ICU-TM was 2.4/1,000 versus 3.2/1,000 patient days, respectively (p < 0.0001). Multivariate logistic regression showed that ICU-TM was associated with reduced 30-day mortality (odds ratio 0.78, 95% CI 0.72-0.83). Increased risk was seen with cardiac arrest admissions, males, acute stroke, weekend admission, emergency admission, race (non-white), sepsis, APACHE IV score, ICU length of stay (LOS), and the interaction term, emergency surgical admissions. Reduced risk was associated with hospital LOS, surgical admission, and the interaction terms (weekend admissions with ICU-TM and after-hour admissions with ICU-TM). The model c-statistic was 0.77. Median ICU and hospital lengths of stay were significantly reduced with ICU-TM, with no difference in 48-h mortality or 48-h mortality rate. *Conclusion:* ICU telemedicine exposure appears to be one of several operational and clinical factors associated with reduced 30-day, in-hospital mortality.
MeSH term(s)	Cohort Studies ; Critical Care ; Hospital Mortality ; Hospitals ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Retrospective Studies ; Risk Factors ; Telemedicine
Language	English
Publishing date	2022-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2021.0465
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Zs.A 4576: Show issues

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Article ; Online: Endocannabinoid signaling in the central nervous system.

Martinez Ramirez, César E / Ruiz-Pérez, Gonzalo / Stollenwerk, Todd M / Behlke, Christina / Doherty, Ashley / Hillard, Cecilia J

Glia

2022 Volume 71, Issue 1, Page(s) 5–35

Abstract: It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on central nervous system (CNS) function. In the 40 years since cannabinoids were found to trigger specific cell signaling cascades, studies of the ECS system continue ...

Abstract	It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on central nervous system (CNS) function. In the 40 years since cannabinoids were found to trigger specific cell signaling cascades, studies of the ECS system continue to cause amazement, surprise, and confusion! CB1 cannabinoid receptors are expressed widely in the CNS and regulate cell-cell communication via effects on the release of both neurotransmitters and gliotransmitters. CB2 cannabinoid receptors are difficult to detect in the CNS but seem to "punch above their weight" as compounds targeting these receptors have significant effects on inflammatory state and behavior. Positive and negative allosteric modulators for both receptors have been identified and examined in preclinical studies. Concentrations of the endocannabinoid ligands, N-arachidonoylethanolamine and 2-arachidonoylglycerol (2-AG), are regulated by a combination of enzymatic synthesis and degradation and inhibitors of these processes are available and making their way into clinical trials. Importantly, ECS regulates many essential brain functions, including regulation of reward, anxiety, inflammation, motor control, and cellular development. While the field is on the cusp of preclinical discoveries providing impactful clinical and therapeutic insights into many CNS disorders, there is still much to be learned about this remarkable and versatile modulatory system.
MeSH term(s)	Endocannabinoids/metabolism ; Receptors, Cannabinoid/metabolism ; Cannabinoids ; Signal Transduction ; Central Nervous System/metabolism ; Receptor, Cannabinoid, CB1
Chemical Substances	Endocannabinoids ; Receptors, Cannabinoid ; Cannabinoids ; Receptor, Cannabinoid, CB1
Language	English
Publishing date	2022-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639414-0
ISSN	1098-1136 ; 0894-1491
ISSN (online)	1098-1136
ISSN	0894-1491
DOI	10.1002/glia.24280
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Zs.A 2345: Show issues

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Article ; Online: The patient perspective on vaccine uptake in adults with psoriasis and eczema.

Noe, Megan H / Archila, Marjorie / Barbieri, John S / Goldman, Nathaniel / Lopez, Christina G / Mostaghimi, Arash / Scherer, Aaron M / Tan, Alice J / Perez-Chada, Lourdes M / Asgari, Maryam M / Gelfand, Joel M

Archives of dermatological research

2023 Volume 315, Issue 6, Page(s) 1583–1592

Abstract: Having a chronic disease is one of the most consistent factors associated with vaccine uptake for adults in the general population, but vaccination beliefs and behaviors specific to those with chronic skin diseases have not been explored. The objective ... ...

Abstract	Having a chronic disease is one of the most consistent factors associated with vaccine uptake for adults in the general population, but vaccination beliefs and behaviors specific to those with chronic skin diseases have not been explored. The objective of this study was to explore factors associated with vaccine uptake and barriers to vaccination in adults with psoriasis and eczema. Virtual, video-based semi-structured interviews were performed with adults who self-reported a diagnosis of psoriasis or eczema. Interviews explored themes around healthcare decision making, perceived risks/benefits to vaccination, barriers, and vaccine knowledge. Thematic analysis was used to analyze the data. Of 34 study participants, 25 participants (74%) were females and 9 (26%) were males, with a mean age of 50.8 years (SD: 16.4, range: 24-71 yrs). Half of participants (n = 17) had psoriasis, and half (n = 17) had eczema. Participants recognized both personal and societal benefits to vaccines. Common vaccination barriers identified were access to appointments, concerns about side effects, and misinformation. Physicians, friends/family, and media, including internet resources, were health information resources identified by patients. These results summarize the unique patient perspective around vaccine uptake in adults with eczema and psoriasis and represent an important first step in a multi-pronged approach to improve vaccination rates in adults with chronic skin diseases.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Eczema ; Health Knowledge, Attitudes, Practice ; Psoriasis ; Skin Diseases ; Vaccination ; Vaccines/adverse effects ; Young Adult ; Aged
Chemical Substances	Vaccines
Language	English
Publishing date	2023-02-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-023-02546-0
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Ui VI Zs.10: Show issues

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Article ; Online: Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed.

Bañuelos, Cristina / Kittleson, Joshua R / LaNasa, Katherine H / Galiano, Christina S / Roth, Stephanie M / Perez, Evelyn J / Long, Jeffrey M / Roberts, Mary T / Fong, Sania / Rapp, Peter R

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 49, Page(s) 8425–8441

Abstract: Basal forebrain (BF) projections to the hippocampus and cortex are anatomically positioned to influence a broad range of cognitive capacities that are known to decline in normal aging, including executive function and memory. Although a long history of ... ...

Abstract	Basal forebrain (BF) projections to the hippocampus and cortex are anatomically positioned to influence a broad range of cognitive capacities that are known to decline in normal aging, including executive function and memory. Although a long history of research on neurocognitive aging has focused on the role of the cholinergic basal forebrain system, intermingled GABAergic cells are numerically as prominent and well positioned to regulate the activity of their cortical projection targets, including the hippocampus and prefrontal cortex. The effects of aging on noncholinergic BF neurons in primates, however, are largely unknown. In this study, we conducted quantitative morphometric analyses in brains from young adult (6 females, 2 males) and aged (11 females, 5 males) rhesus monkeys (
MeSH term(s)	Animals ; Male ; Female ; Cognitive Aging ; Basal Forebrain/physiology ; Macaca mulatta ; Cholinergic Neurons ; Aging/physiology ; Cholinergic Agents
Chemical Substances	Cholinergic Agents
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0456-23.2023
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Zs.A 1668: Show issues

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Article: Ecology, behavior, and vocalizations of the Coiba Spinetail (Cranioleuca dissita), a Panama endemic

Blewett, Christina M. / Angehr, George R. / de Pérez, Isis Ochoa

Wilson journal of ornithology. 2021 Oct. 19, v. 133, no. 1

2021

Abstract: ... gleaning were also observed regularly. The most common foraging height was 7–10 m above the ground ... although they foraged as low as 2 m and as high as 25 m. The nest of Coiba Spinetail, which has not been previously ...

Title translation	Ecología, comportamiento y vocalizaciones del curutié Cranioleuca dissita, un endémico de Panamá
Abstract	The Coiba Spinetail (Cranioleuca dissita), endemic to Islas Coiba and Ranchería on the Pacific coast of Panama, was originally classified as a subspecies (C. d. dissita) of the geographically distant Rusty-backed Spinetail (C. vulpina) of South America, but its status has long been an enigma. The present study was conducted to obtain basic information on the ecology, behavior, and vocalizations of this species, which has previously been lacking. On both islands, Coiba Spinetail was found almost exclusively in forest and forest edge. Their most common foraging substrate was small-diameter (∼1 cm) branches or vines, although they also foraged on tree trunks. The foraging type most often observed was pecking, but probing and gleaning were also observed regularly. The most common foraging height was 7–10 m above the ground, although they foraged as low as 2 m and as high as 25 m. The nest of Coiba Spinetail, which has not been previously described, is a globe-shaped structure made mostly of plant fibers and built around a vertical support such as an upright branch or trunk or around several lianas or vines. The nest of Rusty-backed Spinetail instead is a globular mass of grass, roots, and sticks, wedged in the fork of a partly submerged sapling or bush. The song of Coiba Spinetail resembles typical Cranioleuca spp. in having several short introductory notes followed by a series of notes on one pitch. It differs from most species in the genus, however, in that the notes gradually become longer and slow down, rather than accelerating or being evenly spaced. The song differs markedly from that of Rusty-backed Spinetail in note structure and quality. These results coupled with previous findings that Coiba Spinetail is genetically distinct from Rusty-backed Spinetail indicate that it merits full species status. Considering its extremely small range, Coiba Spinetail qualifies for Near Threatened status under IUCN Red List criteria.
Keywords	coasts ; edge effects ; forests ; grasses ; nests ; ornithology ; trees ; Panama ; South America
Language	English
Dates of publication	2021-1019
Size	p. 11-21.
Publishing place	Wilson Ornithological Society
Document type	Article
ZDB-ID	2256217-5
ISSN	1938-5447 ; 1559-4491
ISSN (online)	1938-5447
ISSN	1559-4491
DOI	10.1676/20-00032
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Whole-body Magnetic Resonance Imaging as a Treatment Response Biomarker in Castration-resistant Prostate Cancer with Bone Metastases: The iPROMET Clinical Trial.

Garcia-Ruiz, Alonso / Macarro, Carlos / Zacchi, Francesca / Morales-Barrera, Rafael / Grussu, Francesco / Casanova-Salas, Irene / Sanguedolce, Francesco / Gonzalez, Macarena / Cresta-Morgado, Pablo / de Albert, Matias / Garcia-Bennett, Josep / Marmolejo, David / Planas, Jacques / Roche, Sarai / Mast, Richard / Zatse, Christina / Piulats, Josep M / Herrera-Imbroda, Bernardo / Regis, Lucas /

Agundez, Laura / Olmos, David / Calvo, Nahum / Escobar, Manuel / Carles, Joan / Mateo, Joaquin / Perez-Lopez, Raquel

European urology

2024

Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Letter
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2024.02.016
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article: Hippo Signaling Modulates the Inflammatory Response of Chondrocytes to Mechanical Compressive Loading.

Cai, Xiaomin / Warburton, Christopher / Perez, Olivia F / Wang, Ying / Ho, Lucy / Finelli, Christina / Ehlen, Quinn T / Wu, Chenzhou / Rodriguez, Carlos D / Kaplan, Lee / Best, Thomas M / Huang, Chun-Yuh / Meng, Zhipeng

bioRxiv : the preprint server for biology

2023

Abstract: Knee osteoarthritis (KOA) is a degenerative disease resulting from mechanical overload, where direct physical impacts on chondrocytes play a crucial role in disease development by inducing inflammation and extracellular matrix degradation. However, the ... ...

Abstract	Knee osteoarthritis (KOA) is a degenerative disease resulting from mechanical overload, where direct physical impacts on chondrocytes play a crucial role in disease development by inducing inflammation and extracellular matrix degradation. However, the signaling cascades that sense these physical impacts and induce the pathogenic transcriptional programs of KOA remain to be defined, which hinders the identification of novel therapeutic approaches. Recent studies have implicated a crucial role of Hippo signaling in osteoarthritis. Since Hippo signaling senses mechanical cues, we aimed to determine its role in chondrocyte responses to mechanical overload. Here we show that mechanical loading induces the expression of inflammatory and matrix-degrading genes by activating the nuclear factor-kappaB (NFκB) pathway in a Hippo-dependent manner. Applying mechanical compressional force to 3-dimensional cultured chondrocytes activated NFκB and induced the expression of NFκB target genes for inflammation and matrix degradation (i.e., IL1
Language	English
Publishing date	2023-06-11
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.09.544419
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