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Article ; Online: L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-Dependent Autophagy.

Jahani, Mozhgan / Yarani, Reza / Rezazadeh, Davood / Tahmasebi, Hadis / Hoseinkhani, Zohreh / Kiani, Sara / Mansouri, Kamran

Current cancer drug targets

2024

Abstract: Background: Doxorubicin (DOX) is a chemotherapy drug that is widely used in cancer therapy, especially in Triple-Negative Breast Cancer (TNBC) patients. Nevertheless, cytoprotective autophagy induction by DOX limits its cytotoxic effect and drug ... ...

Abstract	Background: Doxorubicin (DOX) is a chemotherapy drug that is widely used in cancer therapy, especially in Triple-Negative Breast Cancer (TNBC) patients. Nevertheless, cytoprotective autophagy induction by DOX limits its cytotoxic effect and drug resistance induction in patients. Therefore, finding a new way is essential for increasing the effectiveness of this drug for cancer treatment. Objective: This study aimed to investigate the effect of L-lysine on DOX cytotoxicity, probably through autophagy modulation in TNBC cell lines. Methods: We used two TNBC cell lines, MDA-MB-231 and MDA-MB-468, with various levels of autophagy activity. Cell viability after treatment with L-lysine alone and in combination therapy was evaluated by MTT assay. Reactive Oxygen Species (ROS), nitric oxide (NO) concentration, and arginase activity were assessed using flow cytometric analysis, Griess reaction, and arginase activity assay kit, respectively. Real-time PCR and western blot analysis were used to evaluate the L-lysine effect on the autophagy-related genes and protein expression. Cell cycle profile and apoptotic assay were performed using flow cytometric analysis. Results: The obtained data indicated that L-lysine in both concentrations of 24 and 32 mM increased the autophagy flux and enhanced the DOX cytotoxicity, especially in MDA-MB-231, which demonstrated higher autophagy activity than MDA-MB-468, by inducing ROS and NO production. Furthermore, L-lysine induced G2/M arrest autophagy cell death, while significant apoptotic changes were not observed. Conclusion: These findings suggest that L-lysine can increase DOX cytotoxicity through autophagy modulation. Thus, L-lysine, in combination with DOX, may facilitate the development of novel adjunct therapy for cancer.
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064824-8
ISSN	1873-5576 ; 1568-0096
ISSN (online)	1873-5576
ISSN	1568-0096
DOI	10.2174/0115680096288665240315072646
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Article ; Online: Physicochemical and Functional Characteristics of Saffron (Crocus sativus L.) Corm Starch: Gelling and Film-Forming Properties

Esmaeelian, Mozhgan / Jahani, Moslem / Feizy, Javad / Einafshar, Soodabeh

Food Biophysics. 2023 Mar., v. 18, no. 1 p.82-94

2023

Abstract: In the present study, isolated starch from the saffron corm (SS) was investigated for physicochemical and functional properties and compared with the potato (PS) and waxy rice starches (RS). The SS granules were irregular and heterogeneous in appearance ... ...

Abstract	In the present study, isolated starch from the saffron corm (SS) was investigated for physicochemical and functional properties and compared with the potato (PS) and waxy rice starches (RS). The SS granules were irregular and heterogeneous in appearance with bimodal particle size distribution. A mean granule size of 2.66, 8.87, and 32.27 μm (Dv50) was recorded for RS, SS, and PS granules, respectively. The lowest degree of crystallinity and the least gelatinization enthalpy of SS are linked to its high amylose/amylopectin ratio. The least swelling power was obtained for SS gel and followed by RS and PS gels. Also, SS and RS samples showed the most syneresis and paste turbidity. Higher viscoelastic solid properties, gel strength, and final viscosity were also observed in the SS gel. The elastic modulus of saffron corm starch gel was less frequency dependent than potato and waxy rice starches. The most heterogeneous film was prepared from SS with the least transparency and maximum thickness. Also, the lowest film transparency was obtained for the rice starch sample. The SS films had the highest maximum tensile strength and stiffness but the lowest film stretchability. So, the saffron corm starch can be used when higher gelling properties or less transparency and more rigid films or coatings are required.
Keywords	Crocus sativus ; amylopectin ; amylose ; biophysics ; corms ; crystal structure ; enthalpy ; gel strength ; gelatinization ; gelation ; gels ; glutinous rice ; modulus of elasticity ; particle size distribution ; potatoes ; rice starch ; saffron ; tensile strength ; turbidity ; viscoelasticity ; viscosity
Language	English
Dates of publication	2023-03
Size	p. 82-94.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	2238029-2
ISSN	1557-1866 ; 1557-1858
ISSN (online)	1557-1866
ISSN	1557-1858
DOI	10.1007/s11483-022-09753-8
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Article ; Online: Synthesis of a dual-functional terbium doped copper oxide nanoflowers for high-efficiently electrochemical sensing of ofloxacin, pefloxacin and gatifloxacin.

Taherizadeh, Mozhgan / Jahani, Shohreh / Moradalizadeh, Mehran / Foroughi, Mohammad Mehdi

Talanta

2022 Volume 255, Page(s) 124216

Abstract: The current effort introduces a facile construction of peony-like CuO: ... ...

Abstract	The current effort introduces a facile construction of peony-like CuO:Tb
MeSH term(s)	Ofloxacin/chemistry ; Pefloxacin ; Gatifloxacin ; Copper/chemistry ; Terbium ; Oxides/chemistry ; Electrodes ; Electrochemical Techniques/methods
Chemical Substances	Ofloxacin (A4P49JAZ9H) ; Pefloxacin (2H52Z9F2Q5) ; Gatifloxacin (L4618BD7KJ) ; cupric oxide (V1XJQ704R4) ; cuprous oxide (T8BEA5064F) ; Copper (789U1901C5) ; Terbium (06SSF7P179) ; Oxides
Language	English
Publishing date	2022-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2022.124216
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Article: Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm.

Jahani, Mozhgan / Dokaneheifard, Sadat / Mansouri, Kamran

Journal of inflammation (London, England)

2020 Volume 17, Page(s) 33

Abstract: COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and results in lung pneumonia following acute ... ...

Abstract	COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and results in lung pneumonia following acute respiratory distress syndrome (ARDS) and patient's death in severe cases. ARDS is a severe form of acute lung injury that is caused by high inflammatory response of the innate immunity cells. Hypoxia is the common feature in the inflammatory sites with having various impacts on this condition by induction of some factors such as hypoxia inducible factor-1α (HIF-1α). HIF-1α regulates some important cellular processes including cell proliferation, metabolism and angiogenesis. Furthermore, this factor is activated during the immune responses and plays important roles in the inflammation site by inducing pro-inflammatory cytokines production through immune cells. So, in this study the possible effect of the HIF-1α on the COVID-19 pathogenesis with emphasizes on its role on innate immunity response has been discussed.
Keywords	covid19
Language	English
Publishing date	2020-10-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2164385-4
ISSN	1476-9255
ISSN	1476-9255
DOI	10.1186/s12950-020-00263-3
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Article ; Online: Effectiveness of Counseling Based on Functional Analytic Psychotherapy with Enhanced Cognitive Therapy on the Sexual Quality of Life of Married Adolescent Women.

Gholami, Maryam / Ahmadi, Atefeh / Taebi, Mozhgan / Jahani, Yunes / Alidousti, Katayoun

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

2021 Volume 43, Issue 7, Page(s) 513–521

Abstract: Objective: Early marriage has many deleterious effects on the health of girls, such as sexual dissatisfaction, an inevitable result of the lack of sufficient knowledge about sexual issues at the time of the marriage. The goal of the present study was ... ...

Title translation	Eficácia do aconselhamento baseado em psicoterapia analítica funcional – Com abordagem de terapia cognitiva aprimorada (FECT) na qualidade de vida sexual de mulheres adolescentes casadas.
Abstract	Objective: Early marriage has many deleterious effects on the health of girls, such as sexual dissatisfaction, an inevitable result of the lack of sufficient knowledge about sexual issues at the time of the marriage. The goal of the present study was to determine the effectiveness of counseling based on functional analytic psychotherapy with enhanced cognitive therapy (FECT) on the sexual quality of life of married adolescent women. Methods: This clinical trial was conducted between July and October 2019 on 150 married adolescent women who met the inclusion criteria. In the intervention group, FECT was conducted in sixteen 90-minute sessions twice a week. The Sexual Quality of Life-Female (SQOL-F) questionnaire was used. When the study ended, the control group was given the choice of receiving the same intervention as the intervention group. Results: The paired Conclusion: The results showed that counseling based on FECT improved the sexual quality of life in all dimensions in married adolescent women.
MeSH term(s)	Adolescent ; Cognitive Behavioral Therapy ; Counseling ; Female ; Humans ; Marriage ; Quality of Life ; Sexual Behavior
Language	English
Publishing date	2021-08-30
Publishing country	Brazil
Document type	Clinical Trial ; Journal Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0041-1733914
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Article ; Online: Hypoxia

Mozhgan Jahani / Sadat Dokaneheifard / Kamran Mansouri

Journal of Inflammation, Vol 17, Iss 1, Pp 1-

A key feature of COVID-19 launching activation of HIF-1 and cytokine storm

2020 Volume 10

Abstract: Abstract COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and results in lung pneumonia following ... ...

Abstract	Abstract COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and results in lung pneumonia following acute respiratory distress syndrome (ARDS) and patient’s death in severe cases. ARDS is a severe form of acute lung injury that is caused by high inflammatory response of the innate immunity cells. Hypoxia is the common feature in the inflammatory sites with having various impacts on this condition by induction of some factors such as hypoxia inducible factor-1α (HIF-1α). HIF-1α regulates some important cellular processes including cell proliferation, metabolism and angiogenesis. Furthermore, this factor is activated during the immune responses and plays important roles in the inflammation site by inducing pro-inflammatory cytokines production through immune cells. So, in this study the possible effect of the HIF-1α on the COVID-19 pathogenesis with emphasizes on its role on innate immunity response has been discussed.
Keywords	COVID-19 ; Hypoxia ; HIF-1α ; Cytokine storm ; Therapeutics. Pharmacology ; RM1-950 ; covid19
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Engineering of a decellularized bovine skin coated with antibiotics-loaded electrospun fibers with synergistic antibacterial activity for the treatment of infectious wounds.

Alizadeh, Sanaz / Majidi, Jila / Jahani, Mozhgan / Esmaeili, Zahra / Nokhbedehghan, Zeinab / Aliakbar Ahovan, Zahra / Nasiri, Hajar / Mellati, Amir / Hashemi, Ali / Chauhan, Narendra Pal Singh / Gholipourmalekabadi, Mazaher

Biotechnology and bioengineering

2024 Volume 121, Issue 4, Page(s) 1453–1464

Abstract: An ideal antibacterial wound dressing with strong antibacterial behavior versus highly drug-resistant bacteria and great wound-healing capacity is still being developed. There is a clinical requirement to progress the current clinical cares that fail to ... ...

Abstract	An ideal antibacterial wound dressing with strong antibacterial behavior versus highly drug-resistant bacteria and great wound-healing capacity is still being developed. There is a clinical requirement to progress the current clinical cares that fail to fully restore the skin structure due to post-wound infections. Here, we aim to introduce a novel two-layer wound dressing using decellularized bovine skin (DBS) tissue and antibacterial nanofibers to design a bioactive scaffold with bio-mimicking the native extracellular matrix of both dermis and epidermis. For this purpose, polyvinyl alcohol (PVA)/chitosan (CS) solution was loaded with antibiotics (colistin and meropenem) and electrospun on the surface of the DBS scaffold to fabricate a two-layer antibacterial wound dressing (DBS-PVA/CS/Abs). In detail, the characterization of the fabricated scaffold was conducted using biomechanical, biological, and antibacterial assays. Based on the results, the fabricated scaffold revealed a homogenous three-dimensional microstructure with a connected pore network, a high porosity and swelling ratio, and favorable mechanical properties. In addition, according to the cell culture result, our fabricated two-layer scaffold surface had a good interaction with fibroblast cells and provided an excellent substrate for cell proliferation and attachment. The antibacterial assay revealed a strong antibacterial activity of DBS-PVA/CS/Abs against both standard strain and multidrug-resistant clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli. Our bilayer antibacterial wound dressing is strongly suggested as an admirable wound dressing for the management of infectious skin injuries and now promises to advance with preclinical and clinical research.
MeSH term(s)	Animals ; Cattle ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Skin ; Wound Healing ; Chitosan/chemistry ; Polyvinyl Alcohol/chemistry ; Wound Infection/drug therapy ; Nanofibers/chemistry
Chemical Substances	Anti-Bacterial Agents ; Chitosan (9012-76-4) ; Polyvinyl Alcohol (9002-89-5)
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.28659
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Article ; Online: Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules,

Aramesh-Boroujeni, Zahra / Jahani, Shohreh / Khorasani-Motlagh, Mozhgan / Kerman, Kagan / Noroozifar, Meissam

RSC advances

2020 Volume 10, Issue 39, Page(s) 23002–23015

Abstract: To determine the chemotherapeutic and pharmacokinetic aspects of an ytterbium complex containing 2,9-dimethyl-1,10-phenanthroline ( ... ...

Abstract	To determine the chemotherapeutic and pharmacokinetic aspects of an ytterbium complex containing 2,9-dimethyl-1,10-phenanthroline (Me
Language	English
Publishing date	2020-06-17
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d0ra03895d
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Article ; Online: A developed composite hard-gelatin capsules: delayed-release enteric properties

Nezhad Mohseni, Mozhgan / Najafpour-Darzi, Ghasem / Ramezani, Ramin / Jahani, Azin

Heliyon. 2022 Dec., v. 8, no. 12 p.e12265-

2022

Abstract: Present study focused on improvement of the formulation of conventional hard gelatin capsules using gastric acid-resistant polymers. We have utilized the same approach of making conventional drug capsules to develop novel capsules with delayed release ... ...

Abstract	Present study focused on improvement of the formulation of conventional hard gelatin capsules using gastric acid-resistant polymers. We have utilized the same approach of making conventional drug capsules to develop novel capsules with delayed release properties. For this purpose, delayed-release capsules were produced by improving the formulation of hard gelatin capsules. In addition, the effect of adding intestinal polymers such as Hydroxy propyl methyl cellulose phthalate, Glucomannan, and Polyvinyl alcohol to hard gelatin capsules were investigated. The capsules' release rate was determined. The degradation tests in an acidic environment were performed and the results were recorded. In fact, the delayed-release hard gelatin capsules pass through the stomach with small amount of the drug release; but their shell remains intact and dissolves as it enters the intestine environment. This article shows that enteric polymers with out interactions, only by changing the formulations will have delayed release properties. this makes sensitive drugs pass through stomach environment and have higher absorption.
Keywords	absorption ; acid tolerance ; drugs ; gelatin ; glucomannans ; intestines ; methylcellulose ; phthalates ; polyvinyl alcohol ; stomach ; Delayed-release ; Hard gelatin capsules ; Hydroxy propyl methyl cellulose phthalate ; Glucomannan
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12265
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Article: Regenerative Medicine and Angiogenesis; Challenges and Opportunities.

Jahani, Mozhgan / Rezazadeh, Davood / Mohammadi, Parisa / Abdolmaleki, Amir / Norooznezhad, Amir / Mansouri, Kamran

Advanced pharmaceutical bulletin

2020 Volume 10, Issue 4, Page(s) 490–501

Abstract: Blood vessel development is one of the most prominent steps in regenerative medicine due to the restoration of blood flow to the ischemic tissues and providing the rapid vascularization in clinical-sized tissue-engineered grafts. However, currently ... ...

Abstract	Blood vessel development is one of the most prominent steps in regenerative medicine due to the restoration of blood flow to the ischemic tissues and providing the rapid vascularization in clinical-sized tissue-engineered grafts. However, currently tissue engineering technique is restricted because of the inadequate
Language	English
Publishing date	2020-08-09
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2020.061
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