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  1. Article ; Online: Human Schistosomiasis Vaccines as Next Generation Control Tools.

    Hotez, Peter J / Bottazzi, Maria Elena

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 3

    Abstract: Human schistosomiasis remains one of the most important yet neglected tropical diseases, with the latest estimates from the Global Burden of Disease Study indicating that over 140 million people are infected with schistosomes [ ... ]. ...

    Abstract Human schistosomiasis remains one of the most important yet neglected tropical diseases, with the latest estimates from the Global Burden of Disease Study indicating that over 140 million people are infected with schistosomes [...].
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8030170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: I Never Thought I Had "Moral Courage," until COVID-19 Happened.

    Bottazzi, Maria Elena

    The American journal of tropical medicine and hygiene

    2020  Volume 103, Issue 2, Page(s) 551

    MeSH term(s) Betacoronavirus ; Biomedical Research/trends ; COVID-19 ; COVID-19 Vaccines ; Communication ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Courage ; Humans ; Morals ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Viral Vaccines
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.61: Show issues Location:
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  3. Article ; Online: Inspiring women scientists in Honduras.

    Bottazzi, Maria Elena

    EBioMedicine

    2019  Volume 49, Page(s) 21

    MeSH term(s) Female ; Health Personnel ; Honduras ; Humans
    Language English
    Publishing date 2019-10-18
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  4. Article ; Online: Global regulatory reforms to promote equitable vaccine access in the next pandemic.

    Mahoney, Richard / Hotez, Peter J / Bottazzi, Maria Elena

    PLOS global public health

    2023  Volume 3, Issue 10, Page(s) e0002482

    Abstract: There is broad consensus that the global response to the Covid-19 pandemic was inadequate, leading to unacceptable levels of avoidable morbidity and mortality. Three strategic missteps led to the lack of equitable vaccine access: The heavy reliance on ... ...

    Abstract There is broad consensus that the global response to the Covid-19 pandemic was inadequate, leading to unacceptable levels of avoidable morbidity and mortality. Three strategic missteps led to the lack of equitable vaccine access: The heavy reliance on commercial vaccine manufacturers in high-income countries (HICs) versus low- and middle-income countries (LMICs); the emergence of vaccine nationalism restricting and delaying the supply of vaccines to LMICs; and an inadequate support or recognition for LMIC national regulatory authorities. To avoid these inequities in a future pandemic, we focus on three successful vaccine development and technology transfer case studies-the Hepatitis B vaccine produced in South Korea in the 1980s; the Meningitis A vaccine for Africa led by Program for Appropriate Technologies in Health (PATH) and the World Health Organization (WHO) in the 2000s; and a recombinant SARS CoV-2 protein-based vaccine technology from the Texas Children's Hospital transferred to India and to Indonesia. In addition to expanding support for academic or non-profit product development partnerships, our analysis finds that an essential step is the strengthening of selected LMIC regulatory systems to become Stringent Regulatory Authorities (SRAs), together with a re-prioritization of the WHO Prequalification (PQ) system to ensure early vaccine availability in LMICs especially during pandemics. Advancing LMIC National Regulatory Authorities (NRAs) to Stringent Regulatory Authorities (SRAs) status will require substantial resources, but the benefits for future pandemic control and for health in LMIC would be immense. We call on the WHO, United Nation (UN) agencies and SRAs, to collaborate and implement a comprehensive roadmap to support LMIC regulators to achieve stringent status by 2030.
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0002482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human Schistosomiasis Vaccines as Next Generation Control Tools

    Peter J. Hotez / Maria Elena Bottazzi

    Tropical Medicine and Infectious Disease, Vol 8, Iss 170, p

    2023  Volume 170

    Abstract: Human schistosomiasis remains one of the most important yet neglected tropical diseases, with the latest estimates from the Global Burden of Disease Study indicating that over 140 million people are infected with schistosomes [.] ...

    Abstract Human schistosomiasis remains one of the most important yet neglected tropical diseases, with the latest estimates from the Global Burden of Disease Study indicating that over 140 million people are infected with schistosomes [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: I Never Thought I Had "Moral Courage," until COVID-19 Happened

    Bottazzi, Maria Elena

    Am. j. trop. med. hyg

    Abstract: I Never Thought I Had "Moral Courage," until COVID-19 Happened. ...

    Abstract I Never Thought I Had "Moral Courage," until COVID-19 Happened.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32588797
    Database COVID19

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  7. Article ; Online: Whole Inactivated Virus and Protein-Based COVID-19 Vaccines.

    Hotez, Peter J / Bottazzi, Maria Elena

    Annual review of medicine

    2021  Volume 73, Page(s) 55–64

    Abstract: The rapid development and deployment of mRNA and adenovirus-vectored vaccines against coronavirus disease 2019 (COVID-19) continue to astound the global scientific community, but these vaccine platforms and production approaches have still not achieved ... ...

    Abstract The rapid development and deployment of mRNA and adenovirus-vectored vaccines against coronavirus disease 2019 (COVID-19) continue to astound the global scientific community, but these vaccine platforms and production approaches have still not achieved global COVID-19 vaccine equity. Immunizing the billions of people at risk for COVID-19 in the world's low- and middle-income countries (LMICs) still relies on the availability of vaccines produced and scaled through traditional technology approaches. Vaccines based on whole inactivated virus (WIV) and protein-based platforms, as well as protein particle-based vaccines, are the most produced by LMIC vaccine manufacturing strategies. Three major WIV vaccines are beginning to be distributed widely. Several protein-based and protein particle-based vaccines are advancing with promising results. Overall, these vaccines are exhibiting excellent safety profiles and in some instances have shown their potential to induce high levels of virus neutralizing antibodies and T cell responses (and protection) both in nonhuman primates and in early studies in humans. There is an urgent need to continue accelerating these vaccines for LMICs in time to fully vaccinate these populations by the end of 2022 at the latest. Achieving these goals would also serve as an important reminder that we must continue to maintain expertise in producing multiple vaccine technologies, rather than relying on any individual platform.
    MeSH term(s) Animals ; COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccines, Inactivated
    Chemical Substances COVID-19 Vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-042420-113212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.321: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Neglected tropical disease vaccines: hookworm, leishmaniasis, and schistosomiasis.

    Hotez, Peter J / Bottazzi, Maria Elena / Kaye, Paul M / Lee, Bruce Y / Puchner, Karl Philipp

    Vaccine

    2023  Volume 41 Suppl 2, Page(s) S176–S179

    MeSH term(s) Animals ; Humans ; Ancylostomatoidea ; Neglected Diseases/epidemiology ; Neglected Diseases/prevention & control ; Schistosomiasis/epidemiology ; Schistosomiasis/prevention & control ; Leishmaniasis/epidemiology ; Leishmaniasis/prevention & control ; Vaccines ; Tropical Medicine
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-10-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.04.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 458: Show issues

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  9. Article ; Online: Developing a low-cost and accessible COVID-19 vaccine for global health.

    Hotez, Peter J / Bottazzi, Maria Elena

    PLoS neglected tropical diseases

    2020  Volume 14, Issue 7, Page(s) e0008548

    MeSH term(s) Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/economics ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Cross Protection ; Developing Countries ; Global Health ; Humans ; Neutralization Tests ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Protein Interaction Domains and Motifs ; SARS Virus/immunology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/prevention & control ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology ; Technology Transfer ; Vaccines, Subunit/adverse effects ; Vaccines, Subunit/economics ; Vaccines, Subunit/immunology ; Vaccines, Subunit/supply & distribution ; Vaccines, Synthetic/adverse effects ; Vaccines, Synthetic/economics ; Vaccines, Synthetic/immunology ; Viral Vaccines/adverse effects ; Viral Vaccines/economics ; Viral Vaccines/immunology ; Viral Vaccines/supply & distribution
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Vaccines, Subunit ; Vaccines, Synthetic ; Viral Vaccines ; spike glycoprotein, SARS-CoV ; spike protein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0008548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With

    Zhan, Bin / Bottazzi, Maria Elena / Hotez, Peter J / Lustigman, Sara

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 869039

    Abstract: Human onchocerciasis is a devastating neglected tropical disease caused by infection of the filarial ... ...

    Abstract Human onchocerciasis is a devastating neglected tropical disease caused by infection of the filarial nematode
    MeSH term(s) Animals ; Blindness/chemically induced ; Blindness/drug therapy ; Cattle ; Humans ; Intestinal Volvulus/chemically induced ; Ivermectin/pharmacology ; Ivermectin/therapeutic use ; Onchocerca ; Onchocerciasis/drug therapy ; Onchocerciasis/prevention & control ; Onchocerciasis/veterinary ; Vaccines
    Chemical Substances Vaccines ; Ivermectin (70288-86-7)
    Language English
    Publishing date 2022-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.869039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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