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  1. Article ; Online: Redox regulation of m

    F De Jesus, Dario / Zhang, Zijie / Brown, Natalie K / Li, Xiaolu / Xiao, Ling / Hu, Jiang / Gaffrey, Matthew J / Fogarty, Garrett / Kahraman, Sevim / Wei, Jiangbo / Basile, Giorgio / Rana, Tariq M / Mathews, Clayton / Powers, Alvin C / Parent, Audrey V / Atkinson, Mark A / Dhe-Paganon, Sirano / Eizirik, Decio L / Qian, Wei-Jun /
    He, Chuan / Kulkarni, Rohit N

    Nature cell biology

    2024  Volume 26, Issue 3, Page(s) 421–437

    Abstract: Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we report that ... ...

    Abstract Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we report that N
    MeSH term(s) Animals ; Humans ; Mice ; Adenosine Deaminase/metabolism ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Immunity, Innate ; Insulin-Secreting Cells/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Oxidation-Reduction
    Chemical Substances ADAR1 protein, mouse (EC 3.5.4.4) ; Adenosine Deaminase (EC 3.5.4.4) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; Mettl3 protein, mouse (EC 2.1.1.-)
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-024-01368-0
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  2. Article: Redox Regulation of m

    De Jesus, Dario F / Zhang, Zijie / Brown, Natalie K / Li, Xiaolu / Gaffrey, Matthew J / Kahraman, Sevim / Wei, Jiangbo / Hu, Jiang / Basile, Giorgio / Xiao, Ling / Rana, Tariq M / Mathews, Clayton / Powers, Alvin C / Atkinson, Mark A / Eizirik, Decio L / Dhe-Paganon, Sirano / Parent, Audrey V / Qian, Wei-Jun / He, Chuan /
    Kulkarni, Rohit N

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Type 1 Diabetes (T1D) is characterized by autoimmune-mediated destruction of insulin-producing β-cells. Several observations have renewed interest in the innate immune system as an initiator of the disease process against β-cells. Here, we show that ... ...

    Abstract Type 1 Diabetes (T1D) is characterized by autoimmune-mediated destruction of insulin-producing β-cells. Several observations have renewed interest in the innate immune system as an initiator of the disease process against β-cells. Here, we show that N
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.16.528701
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  3. Article ; Online: Tribute: Marcus M. Reidenberg, MD.

    Atkinson, Arthur J

    Clinical pharmacology and therapeutics

    2020  Volume 108, Issue 4, Page(s) 697–698

    MeSH term(s) Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; Mentors/education ; Pharmacology, Clinical/history ; United States
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1940
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  4. Book ; Online: 30 m Map of Young Forest Age in China

    Xiao, Yuelong / Wang, Qunming / Tong, Xiaohua / Atkinson, Peter

    eISSN: 1866-3516

    2023  

    Abstract: ... and used to estimate young forest ages across China in 2020 at a spatial resolution of 30 m. First ... a 10 m spatial resolution land cover dataset (WorldCover2020) from the European Space Agency (ESA) was ...

    Abstract Young forest age mapping at a fine spatial resolution is important for increasing the accuracy of estimating land-atmosphere carbon fluxes and guiding forest management practices. In recent decades, China has actively conducted afforestation and forest protection projects, thereby, laying the foundation for the realization of carbon neutrality. However, very few studies have been conducted which map the ages of young forests for the whole of China at a fine spatial resolution. In this research, a continuous change detection and classification (CCDC)-based method suitable for large-scale forest age mapping is proposed, and used to estimate young forest ages across China in 2020 at a spatial resolution of 30 m. First, a 10 m spatial resolution land cover dataset (WorldCover2020) from the European Space Agency (ESA) was used to determine the forest cover areas in 2020. Then, the CCDC algorithm was used to identify stand-replacing disturbances to determine the stand age based on 436,967 Landsat tiles across China from 1990 to 2020. A validation sample set composed of multiple land use/land cover (LULC) products was used to calculate the overall accuracy (OA) of the 2020 young forest age (1–31 years) map of China, and the OA was 90.28 %. The reliability and applicability of the proposed CCDC-based forest age mapping method was validated by comparing the forest age map with Hansen’s forest change dataset, Max Planck Institute for Biogeochemistry (MPI-BGC) 1 km global forest age datasets and field measurements. The CCDC-based method has strong application potential in real-time mapping of the age of young forests at the global scale. The produced forest age map provides a basic dataset for research on the forest carbon cycle and forest ecosystem services, and important guidance for government departments, such as the National Forestry and Grassland Administration and National Development and Reform Commission in China.
    Subject code 333
    Language English
    Publishing date 2023-01-02
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Multiple anatomic sites of infarction in a pediatric patient with M. pneumoniae infection, a case report.

    Hahn, Devon W / Atkinson, Claire E / Le, Matthew

    BMC pediatrics

    2021  Volume 21, Issue 1, Page(s) 372

    Abstract: Background: Although M. pneumoniae (M. pneumoniae) infections have been associated with various ... to contribute to the urgency of discovering the mechanism of the coagulopathy associated with M. pneumoniae ... of thrombotic events in multiple anatomic sites associated with M. pneumoniae infection. The mechanism ...

    Abstract Background: Although M. pneumoniae (M. pneumoniae) infections have been associated with various extrapulmonary manifestations, there have been very few documented cases of thrombotic events in pediatrics, and none to our knowledge with such extensive involvement as the patient described here. We aim to contribute to the urgency of discovering the mechanism of the coagulopathy associated with M. pneumoniae infections.
    Case presentation: This 10-year-old boy was admitted after 2 weeks of fever, sore throat, worsening cough, and progressive neck and back pain. During hospitalization, he developed clots in several different organs: bilateral pulmonary emboli, cardiac vegetations, multiple splenic infarcts, and deep venous thromboses in three of four extremities. He was treated with long-term antibiotics and anticoagulation, and fully recovered.
    Conclusions: This is the first case known to us of a child with an extensive number of thrombotic events in multiple anatomic sites associated with M. pneumoniae infection. The mechanism by which M. pneumoniae infection is related to thrombotic events is not fully understood, but there is evidence that the interplay between the coagulation pathways and the complement cascade may be significant. This patient underwent extensive investigation, and was found to have significant coagulopathy, but minimal complement abnormalities. By better understanding the mechanisms involved in complications of M. pneumoniae infection, the clinician can more effectively investigate the progression of this disease saving time, money, morbidity, and mortality.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Child ; Humans ; Infarction/drug therapy ; Male ; Mycoplasma pneumoniae ; Pediatrics ; Pneumonia, Mycoplasma/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-08-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-021-02845-3
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  6. Article ; Online: Unusual and Tunable Negative Linear Compressibility in the Metal-Organic Framework MFM-133(M) (M = Zr, Hf).

    Yan, Yong / O'Connor, Alice E / Kanthasamy, Gopikkaa / Atkinson, George / Allan, David R / Blake, Alexander J / Schröder, Martin

    Journal of the American Chemical Society

    2018  Volume 140, Issue 11, Page(s) 3952–3958

    Abstract: High-pressure single-crystal X-ray structural analyses of isostructural MFM-133(M) (M = Zr, Hf ...

    Abstract High-pressure single-crystal X-ray structural analyses of isostructural MFM-133(M) (M = Zr, Hf) of flu topology and incorporating the tetracarboxylate ligand TCHB
    Language English
    Publishing date 2018--21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.7b11747
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  7. Article ; Online: Active ascent accelerates the time course but not the overall incidence and severity of acute mountain sickness at 3,600 m.

    Beidleman, Beth A / Figueiredo, Peter S / Landspurg, Steven D / Femling, Jon K / Williams, Jason D / Staab, Janet E / Buller, Mark J / Karl, J Philip / Reilly, Aaron J / Mayschak, Trevor J / Atkinson, Emma Y / Mesite, Timothy J / Hoyt, Reed W

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Volume 135, Issue 2, Page(s) 436–444

    Abstract: ... residence, transported to Taos, NM (2,845 m), hiked ( ...

    Abstract Acute mountain sickness (AMS) typically peaks following the first night at high altitude (HA) and resolves over the next 2-3 days, but the impact of active ascent on AMS is debated. To determine the impact of ascent conditions on AMS, 78 healthy Soldiers (means ± SD; age = 26 ± 5 yr) were tested at baseline residence, transported to Taos, NM (2,845 m), hiked (
    MeSH term(s) Humans ; Young Adult ; Adult ; Altitude Sickness/epidemiology ; Incidence ; Acute Disease ; Exercise/physiology ; Time Factors ; Altitude
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00216.2023
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    Uc I Zs.249: Show issues Location:
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  8. Article ; Online: Sheila M. Innis, PhD, RD (1953-2016): A Pioneer and Innovator Influencing the Maternal and Infant Nutrition Field.

    Field, Catherine J / Devlin, Angela M / Atkinson, Stephanie

    The Journal of nutrition

    2020  Volume 150, Issue 7, Page(s) 1673–1675

    MeSH term(s) Female ; History, 20th Century ; History, 21st Century ; Humans ; Infant ; Infant Nutritional Physiological Phenomena/history ; Maternal Nutritional Physiological Phenomena ; Nutritional Sciences/history
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/nxaa078
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  9. Article: Characterising the land surface phenology of Africa using 500 m MODIS EVI

    Adole, Tracy / Jadunandan Dash / Peter M. Atkinson

    Applied geography. 2018 Jan., v. 90

    2018  

    Abstract: ... in different geographical sub-regions in Africa at a medium spatial resolution of 500 m using MODIS EVI ...

    Abstract Vegetation phenological studies at different spatial and temporal scales offer better understanding of the relationship between the global climate and the global distribution of biogeographical zones. These studies in the last few decades have focussed on characterising and understanding vegetation phenology and its drivers especially using satellite sensor data. Nevertheless, despite being home to 17% of the global forest cover, approximately 12% of the world's tropical mangroves, and a diverse range of vegetation types, Africa is one of the most poorly studied regions in the world. There has been no study characterising land surface phenology (LSP) of the major land cover types in the different geographical sub-regions in Africa, and only coarse spatial resolution datasets have been used for continental studies. Therefore, we aim to provide seasonal phenological pattern of Africa's vegetation and characterise the LSP of major land cover types in different geographical sub-regions in Africa at a medium spatial resolution of 500 m using MODIS EVI time-series data over a long temporal range of 15 years (2001–2015). The Discrete Fourier Transformation (DFT) technique was employed to smooth the time-series data and an inflection point-based method was used to extract phenological parameters such as start of season (SOS) and end of season (EOS). Homogeneous pixels from 12 years (2001–2012) MODIS land cover data (MODIS MCD12Q1) was used to describe, for the first time, the LSP of the major vegetation types in Africa. The results from this research characterise spatially and temporally the highly irregular and multi-annual variability of the vegetation phenology of Africa, and the maps and charts provide an improved representation of the LSP of Africa, which can serve as a pivot to filling other research gaps in the African continent.
    Keywords biogeography ; climate ; data collection ; forests ; geographical distribution ; land cover ; mangroves ; moderate resolution imaging spectroradiometer ; phenology ; satellites ; time series analysis ; Africa
    Language English
    Dates of publication 2018-01
    Size p. 187-199.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0143-6228
    DOI 10.1016/j.apgeog.2017.12.006
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Can Women Facilitate Men's Prostate Cancer Screening Informed Decision-Making? The M-PACT Trial.

    Holt, Cheryl L / Le, Daisy / Slade, Jimmie L / Muwwakkil, Bettye / Saunders, Darlene R / Williams, Ralph / Atkinson, Nancy L / Naslund, Michael

    Journal of health communication

    2017  Volume 22, Issue 12, Page(s) 964–973

    Abstract: The M-PACT study compared an all-male with a mixed-sex intervention to increase informed ...

    Abstract The M-PACT study compared an all-male with a mixed-sex intervention to increase informed decision-making for prostate cancer screening among African-American men in church settings. We recruited 262 men in 18 churches randomized to the two intervention approaches. Trained and certified lay peer community health advisors in each church led a series of four men's health workshops on informed decision-making for prostate cancer screening. African-American male workshop participants completed baseline, post-workshop, and 12-month follow-up surveys. Contrary to our expectations, including women in the workshops did not result in increased intervention efficacy for the informed decision-making outcomes as both groups showed significant improvement over time in several study outcomes including stage of decision-making for prostate cancer screening, preference for role in decision-making, prostate cancer knowledge, and self-reports of prostate specific antigen testing. Finally, men who attended multiple workshops had better informed decision-making outcomes on several indicators. The current findings suggest mixed results from including women in this men's health educational intervention. Future work should consider optimal ways of providing family support for African-American men's health promotion.
    MeSH term(s) African Americans/psychology ; African Americans/statistics & numerical data ; Aged ; Decision Making ; Early Detection of Cancer/psychology ; Early Detection of Cancer/utilization ; Faith-Based Organizations ; Female ; Follow-Up Studies ; Health Promotion/methods ; Humans ; Interpersonal Relations ; Male ; Middle Aged ; Program Evaluation ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/ethnology
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1427988-5
    ISSN 1087-0415 ; 1081-0730
    ISSN (online) 1087-0415
    ISSN 1081-0730
    DOI 10.1080/10810730.2017.1382616
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