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Article ; Online: I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People.

Pietrobon, Anna Julia / Teixeira, Franciane Mouradian Emidio / Sato, Maria Notomi

2020 Volume 11, Page(s) 579220

Abstract: Old individuals are more susceptible to various infections due to immunological changes that occur during the aging process. These changes named collectively as "immunosenescence" include decreases in both the innate and adaptive immune responses in ... ...

Abstract	Old individuals are more susceptible to various infections due to immunological changes that occur during the aging process. These changes named collectively as "immunosenescence" include decreases in both the innate and adaptive immune responses in addition to the exacerbated production of inflammatory cytokines. This scenario of immunological dysfunction and its relationship with disease development in older people has been widely studied, especially in infections that can be fatal, such as influenza and, more recently, COVID-19. In the current scenario of SARS-CoV-2 infection, many mechanisms of disease pathogenesis in old individuals have been proposed. To better understand the dynamics of COVID-19 in this group, aspects related to immunological senescence must be well elucidated. In this article, we discuss the main mechanisms involved in immunosenescence and their possible correlations with the susceptibility of individuals of advanced age to SARS-CoV-2 infection and the more severe conditions of the disease.
MeSH term(s)	Aging/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/virology ; Humans ; Immunosenescence ; Pandemics ; Risk Factors ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology
Keywords	covid19
Language	English
Publishing date	2020-10-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.579220
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: I mmunosenescence and Inflammaging

Pietrobon, Anna Julia / Teixeira, Franciane Mouradian Emidio / Sato, Maria Notomi

Frontiers in Immunology

Risk Factors of Severe COVID-19 in Older People

2020 Volume 11

Keywords	covid19
Publisher	Frontiers Media SA
Publishing country	ch
Document type	Article ; Online
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.579220
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: I mmunosenescence and Inflammaging

Anna Julia Pietrobon / Franciane Mouradian Emidio Teixeira / Maria Notomi Sato

Frontiers in Immunology, Vol

Risk Factors of Severe COVID-19 in Older People

2020 Volume 11

Abstract: Old individuals are more susceptible to various infections due to immunological changes that occur during the aging process. These changes named collectively as “immunosenescence” include decreases in both the innate and adaptive immune responses in ... ...

Abstract	Old individuals are more susceptible to various infections due to immunological changes that occur during the aging process. These changes named collectively as “immunosenescence” include decreases in both the innate and adaptive immune responses in addition to the exacerbated production of inflammatory cytokines. This scenario of immunological dysfunction and its relationship with disease development in older people has been widely studied, especially in infections that can be fatal, such as influenza and, more recently, COVID-19. In the current scenario of SARS-CoV-2 infection, many mechanisms of disease pathogenesis in old individuals have been proposed. To better understand the dynamics of COVID-19 in this group, aspects related to immunological senescence must be well elucidated. In this article, we discuss the main mechanisms involved in immunosenescence and their possible correlations with the susceptibility of individuals of advanced age to SARS-CoV-2 infection and the more severe conditions of the disease.
Keywords	COVID-19 ; coronavirus ; aging ; immunosenescence ; inflammaging ; SARS-CoV-2 ; Immunologic diseases. Allergy ; RC581-607 ; covid19
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of Histamine in Modulating the Immune Response and Inflammation.

Branco, Anna Cláudia Calvielli Castelo / Yoshikawa, Fábio Seiti Yamada / Pietrobon, Anna Julia / Sato, Maria Notomi

Mediators of inflammation

2018 Volume 2018, Page(s) 9524075

Abstract: Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or ... ...

Abstract	Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects.
MeSH term(s)	Adaptive Immunity/immunology ; Animals ; Cytokines/metabolism ; Histamine/metabolism ; Humans ; Immunity, Innate/immunology ; Inflammation/immunology ; Inflammation/metabolism ; Receptors, Histamine/immunology ; Receptors, Histamine/metabolism
Chemical Substances	Cytokines ; Receptors, Histamine ; Histamine (820484N8I3)
Language	English
Publishing date	2018-08-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2018/9524075
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Article: LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression.

Teixeira, Franciane Mouradian Emidio / Oliveira, Luana de Mendonça / Pietrobon, Anna Julia / Salles, Érika Machado de / D'Império Lima, Maria Regina / Viana, Isabelle Freire Tabosa / Lins, Roberto Dias / Rigato, Paula Ordonhez / Marques, Ernesto Torres de Azevedo / da Silva Duarte, Alberto José / Sato, Maria Notomi

Vaccines

2022 Volume 10, Issue 8

Abstract: Neonates have a limited adaptive response of plasma cells, germinal center (GC) B cells, and T follicular helper cells ( ... ...

Abstract	Neonates have a limited adaptive response of plasma cells, germinal center (GC) B cells, and T follicular helper cells (T
Language	English
Publishing date	2022-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10081246
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Article ; Online: Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients.

Pietrobon, Anna Julia / Andrejew, Roberta / Custódio, Ricardo Wesley Alberca / Oliveira, Luana de Mendonça / Scholl, Juliete Nathali / Teixeira, Franciane Mouradian Emidio / de Brito, Cyro Alves / Glaser, Talita / Kazmierski, Julia / Goffinet, Christine / Turdo, Anna Claudia / Yendo, Tatiana / Aoki, Valeria / Figueiró, Fabricio / Battastini, Ana Maria / Ulrich, Henning / Benard, Gill / Duarte, Alberto Jose da Silva / Sato, Maria Notomi

Frontiers in immunology

2022 Volume 13, Page(s) 1012027

Abstract: Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotide metabolism to COVID-19 severity in ... ...

Abstract	Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotide metabolism to COVID-19 severity in mild and severe cases of the disease. We verified that the gene expression of ectonucleotidases is reduced in the whole blood of patients with COVID-19 and is negatively correlated to levels of CRP, an inflammatory marker of disease severity. In line with these findings, COVID-19 patients present higher ATP levels in plasma and reduced levels of ADO when compared to healthy controls. Cell type-specific analysis revealed higher frequencies of CD39+ T cells in severely ill patients, while CD4+ and CD8+ expressing CD73 are reduced in this same group. The frequency of B cells CD39+CD73+ is also decreased during acute COVID-19. Interestingly, B cells from COVID-19 patients showed a reduced capacity to hydrolyze ATP into ADP and ADO. Furthermore, impaired expression of ADO receptors and a compromised activation of its signaling pathway is observed in COVID-19 patients. The presence of ADO in vitro, however, suppressed inflammatory responses triggered in patients' cells. In summary, our findings support the idea that alterations in the metabolism of extracellular purines contribute to immune dysregulation during COVID-19, possibly favoring disease severity, and suggest that ADO may be a therapeutic approach for the disease.
MeSH term(s)	Adenosine/metabolism ; Adenosine Diphosphate ; Adenosine Triphosphate/metabolism ; COVID-19 ; Humans ; Purines ; Severity of Illness Index ; Signal Transduction
Chemical Substances	Purines ; Adenosine Diphosphate (61D2G4IYVH) ; Adenosine Triphosphate (8L70Q75FXE) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1012027
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Article: Clinical Characteristics and Survival Analysis in Frequent Alcohol Consumers With COVID-19.

Alberca, Ricardo Wesley / Rigato, Paula Ordonhez / Ramos, Yasmim Álefe Leuzzi / Teixeira, Franciane Mouradian Emidio / Branco, Anna Cláudia Calvielli / Fernandes, Iara Grigoletto / Pietrobon, Anna Julia / Duarte, Alberto Jose da Silva / Aoki, Valeria / Orfali, Raquel Leão / Sato, Maria Notomi

Frontiers in nutrition

2021 Volume 8, Page(s) 689296

Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can generate a systemic disease named coronavirus disease-2019 (COVID-19). Currently, the COVID-19 pandemic has killed millions worldwide, presenting huge health and economic ... ...

Abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can generate a systemic disease named coronavirus disease-2019 (COVID-19). Currently, the COVID-19 pandemic has killed millions worldwide, presenting huge health and economic challenges worldwide. Several risk factors, such as age, co-infections, metabolic syndrome, and smoking have been associated with poor disease progression and outcomes. Alcohol drinking is a common social practice among adults, but frequent and/or excessive consumption can mitigate the anti-viral and anti-bacterial immune responses. Therefore, we investigated if patients with self-reported daily alcohol consumption (DAC) presented alteration in the immune response to SARS-CoV-2. We investigated 122 patients with COVID-19 (101 male and 46 females), in which 23 were patients with DAC (18 men and 5 women) and 99 were non-DAC patients (58 men and 41 women), without other infections, neoplasia, or immunodeficiencies. Although with no difference in age, patients with DAC presented an increase in severity-associated COVID-19 markers such as C-reactive protein (CRP), neutrophil count, and neutrophil-to-lymphocyte ratio. In addition, patients with DAC presented a reduction in the lymphocytes and monocytes counts. Importantly, the DAC group presented an increase in death rate in comparison with the non-DAC group. Our results demonstrated that, in our cohort, DAC enhanced COVID-19-associated inflammation, and increased the number of deaths due to COVID-19.
Language	English
Publishing date	2021-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2021.689296
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Article ; Online: Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes.

Teixeira, Franciane Mouradian Emidio / Pietrobon, Anna Julia / Oliveira, Luana de Mendonça / Oliveira, Luanda Mara da Silva / Sato, Maria Notomi

Frontiers in immunology

2020 Volume 11, Page(s) 175

Abstract: During pregnancy, the organization of complex tolerance mechanisms occurs to assure non-rejection of the semiallogeneic fetus. Pregnancy is a period of vulnerability to some viral infections, mainly during the first and second trimesters, that may cause ... ...

Abstract	During pregnancy, the organization of complex tolerance mechanisms occurs to assure non-rejection of the semiallogeneic fetus. Pregnancy is a period of vulnerability to some viral infections, mainly during the first and second trimesters, that may cause congenital damage to the fetus. Recently, Zika virus (ZIKV) infection has gained great notoriety due to the occurrence of congenital ZIKV syndrome, characterized by fetal microcephaly, which results from the ability of ZIKV to infect placental cells and neural precursors in the fetus. Importantly, in addition to the congenital effects, studies have shown that perinatal ZIKV infection causes a number of disorders, including maculopapular rash, conjunctivitis, and arthralgia. In this paper, we contextualize the immunological aspects involved in the maternal-fetal interface and vulnerability to ZIKV infection, especially the alterations resulting in perinatal outcomes. This highlights the need to develop protective maternal vaccine strategies or interventions that are capable of preventing fetal or even neonatal infection.
MeSH term(s)	Female ; Fetus/immunology ; Fetus/virology ; Humans ; Maternal-Fetal Exchange/immunology ; Microcephaly/immunology ; Microcephaly/virology ; Placenta/immunology ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; Pregnancy Complications, Infectious/virology ; Zika Virus/immunology ; Zika Virus/physiology ; Zika Virus Infection/immunology ; Zika Virus Infection/virology
Language	English
Publishing date	2020-02-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.00175
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Perspective: The Potential Effects of Naringenin in COVID-19.

Alberca, Ricardo Wesley / Teixeira, Franciane Mouradian Emidio / Beserra, Danielle Rosa / de Oliveira, Emily Araujo / Andrade, Milena Mary de Souza / Pietrobon, Anna Julia / Sato, Maria Notomi

Frontiers in immunology

2020 Volume 11, Page(s) 570919

Abstract: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which ... ...

Abstract	Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/pathology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/pathology ; Cytokines/antagonists & inhibitors ; Cytokines/biosynthesis ; Disease Models, Animal ; Flavanones/therapeutic use ; Humans ; Macrophages/immunology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Virus Replication/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Antiviral Agents ; Cytokines ; Flavanones ; naringenin (HN5425SBF2)
Keywords	covid19
Language	English
Publishing date	2020-09-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.570919
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case Report.

Gozzi-Silva, Sarah Cristina / Benard, Gil / Alberca, Ricardo Wesley / Yendo, Tatiana Mina / Teixeira, Franciane Mouradian Emidio / Oliveira, Luana de Mendonça / Beserra, Danielle Rosa / Pietrobon, Anna Julia / Oliveira, Emily Araujo de / Branco, Anna Cláudia Calvielli Castelo / Andrade, Milena Mary de Souza / Fernandes, Iara Grigoletto / Pereira, Nátalli Zanete / Ramos, Yasmim Álefe Leuzzi / Lima, Julia Cataldo / Provenci, Bruna / Mangini, Sandrigo / Duarte, Alberto José da Silva / Sato, Maria Notomi

Tropical medicine and infectious disease

2021 Volume 6, Issue 1

Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has infected over 90 million people worldwide, therefore it is considered a pandemic. SARS-CoV-2 infection can lead to severe ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has infected over 90 million people worldwide, therefore it is considered a pandemic. SARS-CoV-2 infection can lead to severe pneumonia, acute respiratory distress syndrome (ARDS), septic shock, and/or organ failure. Individuals receiving a heart transplantation (HT) may be at higher risk of adverse outcomes attributable to COVID-19 due to immunosuppressives, as well as concomitant infections that may also influence the prognoses. Herein, we describe the first report of two cases of HT recipients with concomitant infections by SARS-CoV-2,
Language	English
Publishing date	2021-02-10
Publishing country	Switzerland
Document type	Case Reports
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed6010022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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