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  1. Article ; Online: Upregulation of p67

    Zhao, Liang / Zhang, Rui / Zhang, Shuya / Zhang, Hualu / Yang, Qing / Xu, Zhelong

    Free radical research

    2022  Volume 56, Issue 1, Page(s) 115–126

    Abstract: While the zinc transporter ZIP2 (Slc39a2) is ... ...

    Abstract While the zinc transporter ZIP2 (Slc39a2) is upregulated
    MeSH term(s) Animals ; Mice ; Cation Transport Proteins ; Ischemia ; NADPH Oxidase 2/genetics ; NADPH Oxidase 2/metabolism ; NADPH Oxidases/metabolism ; Phosphoproteins ; Reactive Oxygen Species/metabolism ; Reperfusion ; Reperfusion Injury ; STAT3 Transcription Factor ; Up-Regulation
    Chemical Substances Cation Transport Proteins ; NADPH Oxidase 2 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-) ; neutrophil cytosol factor 67K ; Phosphoproteins ; Reactive Oxygen Species ; Slc39a2 protein, mouse ; Stat3 protein, mouse ; STAT3 Transcription Factor
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1194130-3
    ISSN 1029-2470 ; 1071-5762
    ISSN (online) 1029-2470
    ISSN 1071-5762
    DOI 10.1080/10715762.2022.2052057
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    Zs.A 2236: Show issues Location:
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  2. Article ; Online: Epicardial CCM2 Promotes Cardiac Development and Repair Via its Regulation on Cytoskeletal Reorganization.

    Wang, Rui / Lu, Dongbo / Song, Renhua / Du, Luping / Yang, Xi / Wu, Shi-Ting / Wang, Xiaohong / Wong, Justin / Xu, Zhelong / Zhao, Qiang / Liu, Renjing / Zheng, Xiangjian

    JACC. Basic to translational science

    2023  Volume 9, Issue 2, Page(s) 203–219

    Abstract: The epicardium provides epicardial-derived cells and molecular signals to support cardiac development and regeneration. Zebrafish and mouse studies have shown ... ...

    Abstract The epicardium provides epicardial-derived cells and molecular signals to support cardiac development and regeneration. Zebrafish and mouse studies have shown that
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.09.004
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  3. Article: Chlamydia pneumoniae

    Zhao, Xi / Miao, Guolin / Zhang, Lijun / Zhang, Yuke / Zhao, Huanhuan / Xu, Zhelong / Wang, Beibei

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 879023

    Abstract: Infection is closely related to atherosclerosis, which is a major pathological basis for cardiovascular diseases. Vascular smooth muscle cell (VSMC) migration is an important trigger in development of atherosclerosis that is associated ... ...

    Abstract Infection is closely related to atherosclerosis, which is a major pathological basis for cardiovascular diseases. Vascular smooth muscle cell (VSMC) migration is an important trigger in development of atherosclerosis that is associated with
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.879023
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  4. Article: Zinc dysregulation in cancers and its potential as a therapeutic target.

    Wang, Jie / Zhao, Huanhuan / Xu, Zhelong / Cheng, Xinxin

    Cancer biology & medicine

    2020  Volume 17, Issue 3, Page(s) 612–625

    Abstract: Zinc is an essential element and serves as a structural or catalytic component in many proteins. Two families of transporters are involved in maintaining cellular zinc homeostasis: the ZIP (SLC39A) family that facilitates zinc influx into the cytoplasm, ... ...

    Abstract Zinc is an essential element and serves as a structural or catalytic component in many proteins. Two families of transporters are involved in maintaining cellular zinc homeostasis: the ZIP (SLC39A) family that facilitates zinc influx into the cytoplasm, and the ZnT (SLC30A) family that facilitates zinc efflux from the cytoplasm. Zinc dyshomeostasis caused by the dysfunction of zinc transporters can contribute to the initiation or progression of various cancers, including prostate cancer, breast cancer, and pancreatic cancer. In addition, intracellular zinc fluctuations lead to the disturbance of certain signaling pathways involved in the malignant properties of cancer cells. This review briefly summarizes our current understanding of zinc dyshomeostasis in cancer, and discusses the potential roles of zinc or zinc transporters in cancer therapy.
    MeSH term(s) Carrier Proteins/metabolism ; Cytoplasm/metabolism ; Homeostasis/genetics ; Homeostasis/physiology ; Humans ; Neoplasms/metabolism ; Repressor Proteins/metabolism ; Signal Transduction ; Zinc/metabolism
    Chemical Substances Carrier Proteins ; Repressor Proteins ; ZGPAT protein, human ; zinc-binding protein ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2020-09-14
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2676322-9
    ISSN 2095-3941
    ISSN 2095-3941
    DOI 10.20892/j.issn.2095-3941.2020.0106
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  5. Article ; Online: Apigenin delays postovulatory oocyte aging by reducing oxidative stress through SIRT1 upregulation.

    Yao, Xuerui / Guo, Panpan / Li, Ying-Hua / Guo, Hao / Jin, Zhelong / Lui, Wen / Yuan, Jianbin / Gao, Qingshan / Wang, Lin / Li, Yunxiao / Shi, Jiabin / Zhang, Xiwei / Cao, Qilong / Xu, Yong-Nan / Kim, Nam-Hyung

    Theriogenology

    2024  Volume 218, Page(s) 89–98

    Abstract: After ovulation, senescent oocytes inevitably experience reduced quality and defects in embryonic development. Apigenin (API) is a flavonoid with a wide range of pharmacological effects. Therefore, this study examined the protective effects of API on the ...

    Abstract After ovulation, senescent oocytes inevitably experience reduced quality and defects in embryonic development. Apigenin (API) is a flavonoid with a wide range of pharmacological effects. Therefore, this study examined the protective effects of API on the quality of porcine oocytes during in-vitro ageing and the underlying mechanisms. The results showed that API treatment could reduce the activation rate after aging for 48 h. In addition, API significantly reduced reactive oxygen species, abnormal distribution of mitochondria, early apoptosis in ageing oocytes, increased glutathione, and mitochondrial adenosine triphosphate levels in ageing oocytes. Importantly, API increased the embryonic development rate in aged oocytes. We also examined molecular changes, finding decreased sirtuin 1 expression in in-vitro postovulatory oocytes, but API reversed this effect. Our results suggest that API attenuates the deterioration of oocyte quality during in-vitro ageing, possibly by reducing oxidative stress through the upregulation of sirtuin 1.
    MeSH term(s) Female ; Animals ; Swine ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Apigenin/pharmacology ; Apigenin/metabolism ; Up-Regulation ; Cellular Senescence/physiology ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Oocytes/physiology
    Chemical Substances Sirtuin 1 (EC 3.5.1.-) ; Apigenin (7V515PI7F6) ; Reactive Oxygen Species
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2024.01.007
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    Zs.A 3929: Show issues Location:
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  6. Article ; Online: A new deep convolutional neural network incorporating attentional mechanisms for ECG emotion recognition.

    Fan, Tianqi / Qiu, Sen / Wang, Zhelong / Zhao, Hongyu / Jiang, Junhan / Wang, Yongzhen / Xu, Junnan / Sun, Tao / Jiang, Nan

    Computers in biology and medicine

    2023  Volume 159, Page(s) 106938

    Abstract: Using ECG signals captured by wearable devices for emotion recognition is a feasible solution. We propose a deep convolutional neural network incorporating attentional mechanisms for ECG emotion recognition. In order to address the problem of ... ...

    Abstract Using ECG signals captured by wearable devices for emotion recognition is a feasible solution. We propose a deep convolutional neural network incorporating attentional mechanisms for ECG emotion recognition. In order to address the problem of individuality differences in emotion recognition tasks, we incorporate an improved Convolutional Block Attention Module (CBAM) into the proposed deep convolutional neural network. The deep convolutional neural network is responsible for capturing ECG features. Channel attention in CBAM is responsible for adding weight information to ECG features of different channels and spatial attention is responsible for the weighted representation of ECG features of different regions inside the channel. We used three publicly available datasets, WESAD, DREAMER, and ASCERTAIN, for the ECG emotion recognition task. The new state-of-the-art results are set in three datasets for multi-class classification results, WESAD for tri-class results, and ASCERTAIN for two-category results, respectively. A large number of experiments are performed, providing an interesting analysis of the design of the convolutional structure parameters and the role of the attention mechanism used. We propose to use large convolutional kernels to improve the effective perceptual field of the model and thus fully capture the ECG signal features, which achieves better performance compared to the commonly used small kernels. In addition, channel attention and spatial attention were added to the deep convolutional model separately to explore their contribution levels. We found that in most cases, channel attention contributed to the model at a higher level than spatial attention.
    MeSH term(s) Neural Networks, Computer ; Algorithms ; Emotions ; Wearable Electronic Devices ; Electrocardiography
    Language English
    Publishing date 2023-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.106938
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    Zs.A 653: Show issues Location:
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  7. Article ; Online: Chlamydia pneumoniae Infection Induces Vascular Smooth Muscle Cell Migration and Atherosclerosis Through Mitochondrial Reactive Oxygen Species-Mediated JunB-Fra-1 Activation

    Xi Zhao / Guolin Miao / Lijun Zhang / Yuke Zhang / Huanhuan Zhao / Zhelong Xu / Beibei Wang

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: Infection is closely related to atherosclerosis, which is a major pathological basis for cardiovascular diseases. Vascular smooth muscle cell (VSMC) migration is an important trigger in development of atherosclerosis that is associated with Chlamydia ... ...

    Abstract Infection is closely related to atherosclerosis, which is a major pathological basis for cardiovascular diseases. Vascular smooth muscle cell (VSMC) migration is an important trigger in development of atherosclerosis that is associated with Chlamydia pneumoniae (C. pneumoniae) infection. However, the mechanism of VSMC migration remains unclear, and whether antioxidant could be a therapeutic target for C. pneumoniae infection-induced atherosclerosis also remains unknown. The results showed that C. pneumoniae infection mainly impaired mitochondrial function and increased the level of mitochondrial reactive oxygen species (mtROS). The expressions of protein JunB, Fra-1 and Matrix metalloproteinase 2 (MMP) evidently increased after C. pneumoniae infection, and the interaction between JunB and Fra-1 was also enhanced. After scavenging mtROS by antioxidant Mito-TEMPO, the increasing expressions of JunB, Fra-1, MMP2 and the capacity of VSMC migration induced by C. pneumoniae infection were all inhibited. In comparison with infected ApoE-/- mice, the level of ROS in atherosclerotic lesion in ApoE-/-TLR2-/- mice with C. pneumoniae infection decreased. Knocking out TLR2 suppressed the expressions of JunB, Fra-1 and MMP2 in VSMCs and the formation of atherosclerotic lesion after C. pneumoniae infection. Furthermore, after using small interfering RNA to inhibit the expression of TLR2, the level of mtROS and the expressions of JunB, Fra-1 and MMP2 apparently decreased. Taken together, C. pneumoniae infection may promote VSMC migration and atherosclerosis development by increasing the level of mtROS through TLR2 to activate the JunB-Fra-1/MMP2 signaling pathway. The data provide the first evidence that antioxidant could reduce C. pneumoniae infection-induced VSMC migration and atherosclerosis.
    Keywords atheroclerosis ; Chlamydia pneumloniae ; vascular smooth muscle cell ; Activator protein 1 ; mitochondrial reactive oxygen species ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Point convolutional neural network algorithm for Ising model ground state research based on spring vibration.

    Jiang, Zhelong / Chen, Gang / Qiao, Ruixiu / Feng, Pengcheng / Chen, Yihao / Su, Junjia / Zhao, Zhiyuan / Jin, Min / Chen, Xu / Li, Zhigang / Lu, Huaxiang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2643

    Abstract: The ground state search of the Ising model can be used to solve many combinatorial optimization problems. Under the current computer architecture, an Ising ground state search algorithm suitable for hardware computing is necessary for solving practical ... ...

    Abstract The ground state search of the Ising model can be used to solve many combinatorial optimization problems. Under the current computer architecture, an Ising ground state search algorithm suitable for hardware computing is necessary for solving practical problems. Inspired by the potential energy conversion of the springs, we propose the Spring-Ising Algorithm, a point convolutional neural network algorithm for ground state search based on the spring vibration model. Spring-Ising Algorithm regards the spin as a moving mass point connected to a spring and establishes the equation of motion for all spins. Spring-Ising Algorithm can be mapped on AI chips through the basic structure of the neural network for fast and efficient parallel computing. The algorithm has shown promising results in solving the Ising model and has been tested in the recognized test benchmark K2000. The optimal results of this algorithm after 10,000 steps of iteration are 2.9% of all results. The algorithm introduces the concept of dynamic equilibrium to achieve a more detailed local search by dynamically adjusting the weight of the Ising model in the spring oscillation model. Spring-Ising Algorithm offers the possibility to calculate the Ising model on a chip which focuses on accelerating neural network calculations.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-49559-3
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  9. Article: Endoplasmic Reticulum Stress/Ca

    Zhao, Huanhuan / Liu, Dan / Yan, Qiumei / Bian, Xiyun / Yu, Jing / Wang, Jingjing / Cheng, Xinxin / Xu, Zhelong

    Frontiers in physiology

    2022  Volume 12, Page(s) 736920

    Abstract: Zinc homeostasis has been known to play a role in myocardial ischemia/reperfusion (I/R) injury, but the precise molecular mechanisms regulating the expression of ZIP transporters during reperfusion are still unclear. The aim of this study was to ... ...

    Abstract Zinc homeostasis has been known to play a role in myocardial ischemia/reperfusion (I/R) injury, but the precise molecular mechanisms regulating the expression of ZIP transporters during reperfusion are still unclear. The aim of this study was to determine whether ER Stress/CaMKII/STAT3 pathway plays a role in the regulation of cellular zinc homeostasis. Zinc deficiency increased mRNA and protein expressions of the ER stress relevant markers Chop and Bip, and STAT3 phosphorylation in H9c2 or HL-1 cells, an effect that was abolished by ZnCl
    Language English
    Publishing date 2022-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.736920
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  10. Article: Adrenocorticotropic Hormone-Producing Paraganglioma With Low Plasma ACTH Level: A Case Report and Review of the Literature.

    Liu, Siyue / Liu, Zhelong / Chen, Fuqiong / Xu, Weijie / Yuan, Gang

    Frontiers in endocrinology

    2020  Volume 10, Page(s) 936

    Abstract: Ectopic adrenocorticotropic hormone (ACTH) syndrome caused by paraganglioma is extremely rare. It usually accompanied by high or normal plasma ACTH level. Here we described a male who presented with ectopic ACTH-producing paraganglioma and a low plasma ... ...

    Abstract Ectopic adrenocorticotropic hormone (ACTH) syndrome caused by paraganglioma is extremely rare. It usually accompanied by high or normal plasma ACTH level. Here we described a male who presented with ectopic ACTH-producing paraganglioma and a low plasma ACTH level. Immunohistochemistry and immunofluorescence confirmed ACTH production in focal paraganglioma cells. This unusual case expanded the spectrum of ACTH-dependent Cushing's syndrome and revealed a potential mechanism of this unique clinical phenotype. Besides, the literature concerning ACTH-producing paraganglioma is reviewed.
    Language English
    Publishing date 2020-01-21
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00936
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