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  1. Article ; Online: ICODE: the international COVID-19 thrombosis biomarkers colloquium-novel soluble biomarkers: circulating cell-free nucleic acids and other molecules.

    Krauel, Krystin / Duerschmied, Daniel

    Journal of thrombosis and thrombolysis

    2021  Volume 53, Issue 1, Page(s) 83–87

    Abstract: This article summarizes the evidence derived from clinical (observational) studies describing novel soluble biomarkers in COVID-19. Our goal was to stimulate further research (preclinical as well as clinical studies) and therefore we discuss potential ... ...

    Abstract This article summarizes the evidence derived from clinical (observational) studies describing novel soluble biomarkers in COVID-19. Our goal was to stimulate further research (preclinical as well as clinical studies) and therefore we discuss potential prognostic value, but also technical details, such as sample preparation. A table provides an overview of the described biomarkers measured in plasma, serum or other (namely bronchoalveolar) fluids.
    MeSH term(s) Biomarkers/blood ; COVID-19/diagnosis ; Cell-Free Nucleic Acids/blood ; Humans ; Observational Studies as Topic ; Thrombosis/diagnosis
    Chemical Substances Biomarkers ; Cell-Free Nucleic Acids
    Language English
    Publishing date 2021-05-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02468-6
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  2. Article ; Online: Thromboinflammation as a Driver of Venous Thromboembolism.

    Gauchel, Nadine / Krauel, Krystin / Hamad, Muataz Ali / Bode, Christoph / Duerschmied, Daniel

    Hamostaseologie

    2021  Volume 41, Issue 6, Page(s) 428–432

    Abstract: Thrombus formation has been identified as an integral part in innate immunity, termed immunothrombosis. Activation of host defense systems is known to result in a procoagulant environment. In this system, cellular players as well as soluble mediators ... ...

    Abstract Thrombus formation has been identified as an integral part in innate immunity, termed immunothrombosis. Activation of host defense systems is known to result in a procoagulant environment. In this system, cellular players as well as soluble mediators interact with each other and their dysregulation can lead to the pathological process of thromboinflammation. These mechanisms have been under intensified investigation during the COVID-19 pandemic. In this review, we focus on the underlying mechanisms leading to thromboinflammation as one trigger of venous thromboembolism.
    MeSH term(s) COVID-19 ; Humans ; Immunity, Innate ; Inflammation ; Pandemics ; SARS-CoV-2 ; Thromboinflammation ; Thrombosis ; Venous Thromboembolism
    Language English
    Publishing date 2021-12-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1661-0257
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  3. Article: Decreased Platelet Aggregation in Patients with Decompensated Liver Cirrhosis and TIPS Implantation.

    Nassar, Asala / Huber, Jan Patrick / Stallmann, Daniela / Sharipova, Diana / Hamad, Muataz Ali / Schultheiss, Michael / Thimme, Robert / Duerschmied, Daniel / Scharf, Rüdiger Eberhard / Bettinger, Dominik / Krauel, Krystin

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an effective treatment of portal hypertension in patients with decompensated liver cirrhosis. However, some patients develop TIPS thrombosis with recurrence of portal hypertension. The ... ...

    Abstract Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an effective treatment of portal hypertension in patients with decompensated liver cirrhosis. However, some patients develop TIPS thrombosis with recurrence of portal hypertension. The role of platelets in TIPS thrombosis and the necessity of antiplatelet therapy is unclear. Therefore, we aimed to study platelet function in patients with liver cirrhosis prior to and after TIPS implantation. Platelet aggregation was tested in peripheral and portal-vein blood patient samples on the day (D) of TIPS implantation (D0), D4 and D30 following the procedure (platelet count above 100 × 10
    Language English
    Publishing date 2023-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11072057
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  4. Article: Platelet Subtypes in Inflammatory Settings.

    Hamad, Muataz Ali / Krauel, Krystin / Schanze, Nancy / Gauchel, Nadine / Stachon, Peter / Nuehrenberg, Thomas / Zurek, Mark / Duerschmied, Daniel

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 823549

    Abstract: In addition to their essential role in hemostasis and thrombosis, platelets also modulate inflammatory reactions and immune responses. This is achieved by specialized surface receptors as well as secretory products including inflammatory mediators and ... ...

    Abstract In addition to their essential role in hemostasis and thrombosis, platelets also modulate inflammatory reactions and immune responses. This is achieved by specialized surface receptors as well as secretory products including inflammatory mediators and cytokines. Platelets can support and facilitate the recruitment of leukocytes into inflamed tissue. The various properties of platelet function make it less surprising that circulating platelets are different within one individual. Platelets have different physical properties leading to distinct subtypes of platelets based either on their function (procoagulant, aggregatory, secretory) or their age (reticulated/immature, non-reticulated/mature). To understand the significance of platelet phenotypic variation, qualitatively distinguishable platelet phenotypes should be studied in a variety of physiological and pathological circumstances. The advancement in proteomics instrumentation and tools (such as mass spectrometry-driven approaches) improved the ability to perform studies beyond that of foundational work. Despite the wealth of knowledge around molecular processes in platelets, knowledge gaps in understanding platelet phenotypes in health and disease exist. In this review, we report an overview of the role of platelet subpopulations in inflammation and a selection of tools for investigating the role of platelet subpopulations in inflammation.
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.823549
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  5. Book ; Online ; Thesis: Interaktionen von Thrombozytenproteinen mit Bakterien als Brücke zwischen unspezifischer und spezifischer Immunabwehr

    Krauel, Krystin [Verfasser]

    2012  

    Author's details Krystin Krauel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Greifswald
    Publishing place Greifswald
    Document type Book ; Online ; Thesis
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  6. Article ; Conference proceedings: Platelet function testing in patients with liver cirrhosis and TIPS implantation

    Patrick, Huber / Asala, Nassar / Daniela, Stallmann / Diana, Sharipova / Muataz, AliHamad / Marlene, Reincke / Lukas, Sturm / Michael, Schultheiß / Daniel, Duerschmied / Robert, Thimme / Krystin, Krauel / Dominik, Bettinger

    Zeitschrift für Gastroenterologie

    2022  Volume 60, Issue 01

    Event/congress 38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber, Mannheim, 2022-01-28
    Language English
    Publishing date 2022-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0041-1740692
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  7. Article ; Online: Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding.

    Hoch, Johannes / Burkhard, Niklas / Zhang, Shanshan / Rieder, Marina / Marchini, Timoteo / Geest, Vincent / Krauel, Krystin / Zahn, Timm / Schommer, Nicolas / Hamad, Muataz Ali / Bauer, Carolina / Gauchel, Nadine / Stallmann, Daniela / Normann, Claus / Wolf, Dennis / Scharf, Rüdiger Eberhard / Duerschmied, Daniel / Schanze, Nancy

    Frontiers in immunology

    2023  Volume 14, Page(s) 1184010

    Abstract: Introduction: Serotonin is involved in leukocyte recruitment during inflammation. Deficiency of the serotonin transporter (SERT) is associated with metabolic changes in humans and mice. A possible link and interaction between the inflammatory effects of ...

    Abstract Introduction: Serotonin is involved in leukocyte recruitment during inflammation. Deficiency of the serotonin transporter (SERT) is associated with metabolic changes in humans and mice. A possible link and interaction between the inflammatory effects of serotonin and metabolic derangements in SERT-deficient mice has not been investigated so far.
    Methods: SERT-deficient (
    Results: After 19 weeks of high-fat diet,
    Discussion: Our observations suggest that SERT deficiency in mice is associated with inflammatory processes that manifest as increased adipose tissue inflammation upon chronic high-fat diet feeding due to enhanced leukocyte recruitment.
    MeSH term(s) Humans ; Animals ; Mice ; Diet, High-Fat/adverse effects ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Serotonin/metabolism ; Inflammation/metabolism ; Obesity/metabolism ; Adipose Tissue/metabolism ; Weight Gain ; RNA, Messenger/metabolism
    Chemical Substances Serotonin Plasma Membrane Transport Proteins ; Serotonin (333DO1RDJY) ; RNA, Messenger
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1184010
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  8. Article: Thromboinflammation as a Driver of Venous Thromboembolism

    Gauchel, Nadine / Krauel, Krystin / Hamad, Muataz Ali / Bode, Christoph / Duerschmied, Daniel

    Hämostaseologie

    2021  Volume 41, Issue 06, Page(s) 428–432

    Abstract: Thrombus formation has been identified as an integral part in innate immunity, termed immunothrombosis. Activation of host defense systems is known to result in a procoagulant environment. In this system, cellular players as well as soluble mediators ... ...

    Abstract Thrombus formation has been identified as an integral part in innate immunity, termed immunothrombosis. Activation of host defense systems is known to result in a procoagulant environment. In this system, cellular players as well as soluble mediators interact with each other and their dysregulation can lead to the pathological process of thromboinflammation. These mechanisms have been under intensified investigation during the COVID-19 pandemic. In this review, we focus on the underlying mechanisms leading to thromboinflammation as one trigger of venous thromboembolism.
    Keywords thromboinflammation ; immunothrombosis ; innate immunity ; venous thromboembolism ; COVID-19 ; Thromboinflammation ; Immunthrombose ; angeborene Immunität ; venöse Thromboembolien ; COVID-19
    Language English
    Publishing date 2021-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1661-0257
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  9. Article ; Online: Early SARS-CoV-2 infection: Platelet-neutrophil complexes and platelet function.

    Rieder, Marina / Baldus, Niklas / Stallmann, Daniela / Jeserich, Maren / Goller, Isabella / Wirth, Luisa / Pollmeier, Luisa / Hofmann, Maike / Bode, Christoph / Busch, Hans-Joerg / Schmid, Bonaventura / Gauchel, Nadine / Scharf, Rüdiger E / Duerschmied, Daniel / Lother, Achim / Krauel, Krystin

    Research and practice in thrombosis and haemostasis

    2022  Volume 7, Issue 1, Page(s) 100025

    Abstract: Background: Conflicting results have been reported on platelet activity : Objectives: To assess platelet reactivity in patients with moderate disease at early stages of COVID-19.: Methods: We performed a prospective, descriptive analysis of 100 ... ...

    Abstract Background: Conflicting results have been reported on platelet activity
    Objectives: To assess platelet reactivity in patients with moderate disease at early stages of COVID-19.
    Methods: We performed a prospective, descriptive analysis of 100 consecutive patients presenting with suspected SARS-CoV-2 infection at University Medical Center Freiburg during the first or second wave of the pandemic. Following polymerase chain reaction testing and compliance with study inclusion criteria, 20 SARS-CoV-2-positive and 55 SARS-CoV-2-negative patients (serving as patient controls) were enrolled. In addition, 15 healthy subjects were included. Platelet reactivity was assessed using whole-blood impedance aggregometry and flow cytometry in response to various agonists.
    Results: Platelet aggregation was significantly impaired in the patients with COVID-19 compared with that in the patient controls or healthy subjects. The reduced platelet responsiveness in the patients with COVID-19 was associated with impaired activation of GPIIb/IIIa (α
    Conclusion: Despite reduced platelet responsiveness, platelet-neutrophil complexes are increased at early stages of moderate disease. Thus, this cellular interaction may occur during COVID-19 without preceding platelet activation.
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2022.100025
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  10. Article ; Online: Peripheral serotonin lacks effects on endothelial adhesion molecule expression in acute inflammation.

    Mauler, Maximilian / Schanze, Nancy / Krauel, Krystin / Schoenichen, Claudia / Glatzki, Franziska / Poeschl, Susanna / Stallmann, Daniela / Mezger, Julius / Gauchel, Nadine / Sharipova, Diana / Rieder, Marina / Hilgendorf, Ingo / Witsch, Thilo / Bode, Christoph / Duerschmied, Daniel

    Journal of thrombosis and haemostasis : JTH

    2021  Volume 20, Issue 1, Page(s) 222–229

    Abstract: Background: Peripheral, non-neuronal serotonin promotes the recruitment of neutrophils to sites of acute inflammation and tissue damage. Direct effects of serotonin on neutrophil function were shown to be involved. However, the influence of serotonin on ...

    Abstract Background: Peripheral, non-neuronal serotonin promotes the recruitment of neutrophils to sites of acute inflammation and tissue damage. Direct effects of serotonin on neutrophil function were shown to be involved. However, the influence of serotonin on the endothelial counterpart is unknown.
    Objectives: To investigate whether serotonin alters the function of endothelial cells in leukocyte recruitment during acute inflammation.
    Methods: We used two murine models of acute inflammation: intraperitoneal lipopolysaccharide (LPS) injection and mesenteric ischemia/reperfusion injury (I/R). To study effects of peripheral serotonin, leukocyte recruitment and endothelial adhesion molecule expression were compared in wild type (WT) and tryptophan hydroxylase 1 deficient (Tph1
    Results: As expected, neutrophil transmigration into the peritoneal cavity following LPS injection was impaired in Tph1
    Conclusions: The inflammatory release of peripheral serotonin is dispensable for the regulation of endothelial adhesion molecules.
    MeSH term(s) Animals ; Cell Adhesion ; Endothelium, Vascular/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation/metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Leukocytes ; Mice ; Mice, Inbred C57BL ; Neutrophils/metabolism ; Serotonin/metabolism
    Chemical Substances Intercellular Adhesion Molecule-1 (126547-89-5) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15541
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