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Article ; Online: Discovery and properties of novel analogues of the aphid pheromones nepetalactone and nepetalactol.

Lu, Yiming / Li, Zhong / Shao, Xusheng / Maienfisch, Peter

2024

Abstract: Background: Pheromones have unique advantages for pest control. Current aphid pheromone research focuses on alarm and sex pheromones. However, practical applications are limited so far, as (E)-β-farnesene has only been investigated to a small extent as ... ...

Abstract	Background: Pheromones have unique advantages for pest control. Current aphid pheromone research focuses on alarm and sex pheromones. However, practical applications are limited so far, as (E)-β-farnesene has only been investigated to a small extent as an alarm pheromone and only male aphids are targeted by sex pheromones. Previous literature reports electrophysiological responses and repellent behavior of asexual aphids to nepetalactone (1B), therefore our objective was to modify nepetalactone's structure to identify key fragments responsible for repellent effects, as guidance for subsequent modifications and further investigation. Results: In this study, seven derivatives were designed and synthesized based on nepetalactol (1A) and nepetalactone (1B) as lead compounds. Free-choice tests, conducted using cowpea aphids (Aphis craccivora), revealed that the lactone moiety was crucial for the repellent activity, and the removal of the carbonyl group eliminated the repelling effect. Compound (±)1I, an analogue of nepetalactone (1B), demonstrated a significantly higher repellent value than nepetalactone (1B) at three different concentrations, and even at 0.1 mg/mL it maintained a considerable repellent effect (26.5%). Electrostatic potential and density functional theory calculations supported the importance of the carbonyl group for the repellent effects. Conclusion: The newly discovered para-pheromone (±)1I shows improved repellent effects and potential for development as a novel biological control agent. Based on our innovative findings, analogues with improved efficacy and properties can be designed and prepared. Our research contributes to understanding the effects of structural modifications on pheromone activity and properties, which is crucial for exploring novel pheromone-based products for crop protection. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7984
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Article ; Online: An Effective Knowledgeable Label-Aware Approach for Sentential Relation Extraction

Binling Nie / Yiming Shao

Applied Sciences, Vol 13, Iss 21, p

2023 Volume 11929

Abstract: In recent years, sentential relation extraction has made remarkable progress with text and knowledge graphs (KGs). However, existing architectures ignore the valuable information contained in relationship labels, which KGs provide and can complement the ... ...

Abstract	In recent years, sentential relation extraction has made remarkable progress with text and knowledge graphs (KGs). However, existing architectures ignore the valuable information contained in relationship labels, which KGs provide and can complement the model with additional signals and prior knowledge. To address this limitation, we propose a neural architecture that leverages knowledgeable labels to enhance sentential relation extraction. We name our proposed method knowledge label-aware sensitive relation extraction (KLA-SRE). To achieve this, we combine pre-trained static knowledge graph embeddings with learned semantic embeddings from other tokens to efficiently represent relation labels. By combining static pre-trained graph embeddings with learned word embeddings, we mitigate the inconsistency between predicted relations and given entities. Experimental results on various relation extraction benchmarks in different fields show that knowledge labels improve the F1 score by 1.6% and 1.1% on average over the baseline on standard- and minority-shot benchmarks, respectively.
Keywords	sentential relation extraction ; knowledge graph ; label-aware ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	006
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Need for an international health emergency response force for future epidemic outbreaks.

Yiming, Shao

BMJ (Clinical research ed.)

2015 Volume 350, Page(s) h277

MeSH term(s)	Developing Countries ; Health Resources/supply & distribution ; Hemorrhagic Fever, Ebola/prevention & control ; Humans
Language	English
Publishing date	2015-01-20
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.h277
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Article ; Online: IDM editorial statement on the 2019-nCoV.

Shao, Yiming / Wu, Jianhong

Infectious Disease Modelling

2020 Volume 5, Page(s) 233–234

Keywords	covid19
Language	English
Publishing date	2020-01-24
Publishing country	China
Document type	Editorial
ZDB-ID	3015225-2
ISSN	2468-0427 ; 2468-2152
ISSN (online)	2468-0427
ISSN	2468-2152
DOI	10.1016/j.idm.2020.01.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development and validation of nomograms predicting overall and cancer-specific survival for non-metastatic primary malignant bone tumor of spine patients.

Shao, Yiming / Wang, Zhonghao / Shi, Xiaoya / Wang, Yexin

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3503

Abstract: At present, no study has established a survival prediction model for non-metastatic primary malignant bone tumors of the spine (PMBS) patients. The clinical features and prognostic limitations of PMBS patients still require further exploration. Data on ... ...

Abstract	At present, no study has established a survival prediction model for non-metastatic primary malignant bone tumors of the spine (PMBS) patients. The clinical features and prognostic limitations of PMBS patients still require further exploration. Data on patients with non-metastatic PBMS from 2004 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariate regression analysis using Cox, Best-subset and Lasso regression methods was performed to identify the best combination of independent predictors. Then two nomograms were structured based on these factors for overall survival (OS) and cancer-specific survival (CSS). The accuracy and applicability of the nomograms were assessed by area under the curve (AUC) values, calibration curves and decision curve analysis (DCA). Results: The C-index indicated that the nomograms of OS (C-index 0.753) and CSS (C-index 0.812) had good discriminative power. The calibration curve displays a great match between the model's predictions and actual observations. DCA curves show our models for OS (range: 0.09-0.741) and CSS (range: 0.075-0.580) have clinical value within a specific threshold probability range compared with the two extreme cases. Two nomograms and web-based survival calculators based on established clinical characteristics was developed for OS and CSS. These can provide a reference for clinicians to formulate treatment plans for patients.
MeSH term(s)	Humans ; Nomograms ; Area Under Curve ; Calibration ; Databases, Factual ; Bone Neoplasms
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30509-y
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Article ; Online: Comparison of presepsin and Mid-regional pro-adrenomedullin in the diagnosis of sepsis or septic shock: a systematic review and meta-analysis.

Liang, Jun / Cai, Yingli / Shao, Yiming

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 288

Abstract: Background: The early diagnosis of sepsis is hampered by the lack of reliable laboratory measures. There is growing evidence that presepsin and Mid-regional pro-adrenomedullin (MR-proADM) are promising biomarkers in the diagnosis of sepsis. This study ... ...

Abstract	Background: The early diagnosis of sepsis is hampered by the lack of reliable laboratory measures. There is growing evidence that presepsin and Mid-regional pro-adrenomedullin (MR-proADM) are promising biomarkers in the diagnosis of sepsis. This study was conducted to evaluate and compare the diagnostic value of MR-proADM and presepsin in sepsis patients. Methods: We searched Web of Science, PubMed, Embase, China national knowledge infrastructure, and Wanfang up to 22th July, 2022, for studies evaluating the diagnosis performance of presepsin and MR-proADM in adult sepsis patients. Risk of bias was assessed using quadas-2. Pooled sensitivity and specificity were calculated using bivariate meta-analysis. Meta-regression and subgroup analysis were used to find source of heterogeneity. Results: A total of 40 studies were eventually selected for inclusion in this meta-analysis, including 33 for presepsin and seven for MR-proADM. Presepsin had a sensitivity of 0.86 (0.82-0.90), a specificity of 0.79 (0.71-0.85), and an AUC of 0.90 (0.87-0.92). The sensitivity of MR-proADM was 0.84 (0.78-0.88), specificity was 0.86 (0.79-0.91), and AUC was 0.91 (0.88-0.93). The profile of control group, population, and standard reference may be potential sources of heterogeneity. Conclusions: This meta-analysis demonstrated that presepsin and MR-proADM exhibited high accuracy (AUC ≥ 0.90) in the diagnosis of sepsis in adults, with MR-proADM showing significantly higher accuracy than presepsin.
MeSH term(s)	Adult ; Humans ; Shock, Septic/diagnosis ; Adrenomedullin ; Prognosis ; Protein Precursors ; Sepsis/diagnosis ; Sepsis/epidemiology ; Biomarkers ; Peptide Fragments ; Lipopolysaccharide Receptors
Chemical Substances	Adrenomedullin (148498-78-6) ; Protein Precursors ; Biomarkers ; Peptide Fragments ; presepsin protein, human ; Lipopolysaccharide Receptors
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08262-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of Immunocyte Infiltration Regulatory Network Based on hdWGCNA and Single-Cell Bioinformatics Analysis in Intervertebral Disc Degeneration.

Shao, Tuo / Gao, Qichang / Tang, Weilong / Ma, Yiming / Gu, Jiaao / Yu, Zhange

Inflammation

2024

Abstract: Immune infiltration plays a crucial role in intervertebral disc degeneration (IDD). In this study, we explored the immune microenvironment of IDD through single-cell bioinformatics analysis. Three single-cell datasets were integrated into this study. ... ...

Abstract	Immune infiltration plays a crucial role in intervertebral disc degeneration (IDD). In this study, we explored the immune microenvironment of IDD through single-cell bioinformatics analysis. Three single-cell datasets were integrated into this study. Nucleus pulposus cells (NPCs) were divided into subgroups based on characteristic genes, and the role of each subgroup in the IDD process was analyzed through pseudo-time trajectory analysis. The hub genes were obtained using hdWGCNA, further identified by bulk datasets and pseudo-time sequence. The expression of the hub genes defined the NPCs related to immune infiltration, and the interaction between these NPCs and immunocytes was explored. The NPCs were divided into four subgroups: reserve NPCs, HCL-NPCs, response NPCs, and support NPCs, which, respectively, dominate the four processes of IDD: non, mild, moderate, and severe degeneration. SPP1 and ICAM1 were identified as the nucleus pulposus immune infiltration hub genes. Macrophages and myelocytes played pro-inflammatory roles in the SPP1-ICAM both-up NPC group through the SPP1-CD44 pathway and ICAM1-ITGB2 ligand-receptor pathway, respectively. At the same time, both-up NPCs sought self-help inflammation remission from neutrophils through the ANXA1-FPR1 pathway. The systematic analysis of the differentiation and immune infiltration landscapes helps to understand IDD's overall development process. Our data suggest that SPP1 and ICAM1 may be new targets for the treatment of inflammatory infiltration in IDD.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-024-02020-7
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Article ; Online: A novel web-based dynamic prognostic nomogram for gastric signet ring cell carcinoma: a multicenter population-based study.

Jiang, Yujuan / Hu, Haitao / Shao, Xinxin / Li, Weikun / Lu, Yiming / Liang, Jianwei / Tian, Yantao

Frontiers in immunology

2024 Volume 15, Page(s) 1365834

Abstract: Background: Gastric signet ring cell carcinoma (GSRCC) is a rare and highly malignant disease with a poor prognosis. To assess the overall survival (OS) and cancer-specific survival (CSS) of patients with GSRCC, prognostic nomograms were developed and ... ...

Abstract	Background: Gastric signet ring cell carcinoma (GSRCC) is a rare and highly malignant disease with a poor prognosis. To assess the overall survival (OS) and cancer-specific survival (CSS) of patients with GSRCC, prognostic nomograms were developed and validated using common clinical factors. Methods: This retrospective cohort study included patients diagnosed with GSRCC between 2011 and 2018 from the National Cancer Center (n = 1453) and SEER databases (n = 2745). Prognostic nomograms were established by identifying independent prognostic factors using univariate and multivariate Cox regression analyses. The calibration curve and C-index were used to assess the predictions. The clinical usefulness of the survival prediction model was further evaluated using the DCA and ROC curves. The models were internally validated in the training cohort and externally validated in the validation cohort. Two web servers were created to make the nomogram easier to use. Results: Patients with GSRCC were divided into training ( Conclusion: We developed web-based dynamic nomograms utilizing six independent prognostic variables that assist physicians in estimating the OS and CSS of patients with GSRCC.
MeSH term(s)	Humans ; Carcinoma, Signet Ring Cell/mortality ; Carcinoma, Signet Ring Cell/pathology ; Carcinoma, Signet Ring Cell/diagnosis ; Nomograms ; Stomach Neoplasms/mortality ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology ; Male ; Female ; Middle Aged ; Retrospective Studies ; Prognosis ; Aged ; Internet ; Neoplasm Staging ; Adult ; SEER Program
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Multicenter Study
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1365834
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Special Staining and Protein Expression of VEGF/EGFR and P53/NF-κB in Cryptorchid Tissue of Erhualian Pigs.

Liu, Penggang / Shao, Yiming / Liu, Caihong / Lv, Xiaoyang / Afedo, Seth Yaw / Bao, Wenbin

Life (Basel, Switzerland)

2024 Volume 14, Issue 1

Abstract: Erhualian pigs exhibit one of the highest reproductive rates globally, and cryptorchidism is a crucial factor affecting reproductive abilities of boars. This investigation focused on cryptorchid tissues from Erhualian pigs, where the histological ... ...

Abstract	Erhualian pigs exhibit one of the highest reproductive rates globally, and cryptorchidism is a crucial factor affecting reproductive abilities of boars. This investigation focused on cryptorchid tissues from Erhualian pigs, where the histological structure of cryptorchidism was observed using specialized staining. In addition, protein expression of P53/NF-κB in cryptorchid tissues was assessed using Western blot and immunohistochemistry. In comparison to normal Erhualian testes, Masson's trichrome staining indicated a reduction in collagen fibers in the connective tissue and around the basal membrane of the seminiferous tubules in cryptorchid testes. Moreover, collagen fiber distribution was observed to be disordered. Verhoeff Van Gieson (EVG) and argyrophilic staining demonstrated brownish-black granular nucleoli organized regions in mesenchymal cells and germ cells. When compared to normal testicles, the convoluted seminiferous tubules of cryptorchids exhibited a significantly reduced number and diameter (
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14010100
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ASO Author Reflections: Effect of the Number of Examined Lymph Nodes on Survival in Gastric Signet-Ring Cell Cancer.

Jiang, Yujuan / Shao, Xinxin / Li, Weikun / Hu, Haitao / Lu, Yiming / Li, Yang / Tian, Yantao

Annals of surgical oncology

2023 Volume 31, Issue 3, Page(s) 1791–1792

MeSH term(s)	Humans ; Stomach Neoplasms/pathology ; Carcinoma, Signet Ring Cell/pathology ; Lymph Nodes/pathology ; Lymph Node Excision
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-14647-1
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