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  1. Book: Zhong yao yin pian jian bie ying yong tu pu

    Li, Xingguang

    Zhongyao yinpian jianbie yingyong tupu

    2010  

    Title variant Zhongyao yinpian jianbie yingyong tupu
    Author's details zhu bian Li Xingguang ; fu zhu bian Tian Pengfei, Zhang Shan
    MeSH term(s) Materia Medica ; Medicine, Chinese Traditional
    Language Chinese
    Size 4, 241 p. :, col. ill. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Ren min jun yi chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787509137413 ; 7509137411
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book: Xin Ma Yin Tai si guo Zhong yao shi hua

    Li, Jinlong

    (Yi xue cong kan, Di 2 ji ; 9)

    2007  

    Author's details Li Jinlong zhu
    Series title Yi xue cong kan, Di 2 ji ; 9
    MeSH term(s) Medicine, Chinese Traditional/history ; History, Early Modern 1451-1600 ; History, Modern 1601-
    Keywords Asia, Southeastern
    Language Chinese
    Size 68 p. :, ill., ports.
    Publisher Xinjiapo Zhonghua yi xue hui
    Publishing place Singapore
    Document type Book
    ISBN 9789810585501 ; 9810585500
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article ; Online: Blood Loss in Operation Is Independently Predictive of Postoperative Ventriculoperitoneal Shunt in Pediatric Patients With Posterior Fossa Tumors.

    Hu, Sheng-Qi / Guo, Zhong-Yin / Wan, Li-Jun / Chen, Zi-Rong / Wan, Feng

    Pediatric neurology

    2023  Volume 144, Page(s) 119–125

    Abstract: Background: To identify the risk factors for postoperative hydrocephalus and the need for ventriculoperitoneal (VP) shunt after posterior fossa tumor (PFT) resection in pediatric patients and establish a predictive model.: Methods: A total of 217 ... ...

    Abstract Background: To identify the risk factors for postoperative hydrocephalus and the need for ventriculoperitoneal (VP) shunt after posterior fossa tumor (PFT) resection in pediatric patients and establish a predictive model.
    Methods: A total of 217 pediatric patients (≤14 years old) with PFTs who underwent tumor resection from November 2010 to December 2020 were divided into a VP shunt group (n = 29) and non-VP shunt group (n = 188). Univariate and multivariate logistic regression were performed. A predictive model was established based on the independent predictors. Receiver operating characteristic curves were generated to determine the cutoff values and areas under the curve (AUCs). The Delong test was performed to compare the AUCs.
    Results: Age less than three years (P = 0.015, odds ratio [OR] = 3.760), blood loss (BL) (P = 0.002, OR = 1.601), and locations at fourth ventricle (P < 0.001, OR = 7.697) were the independent predictors. The predictive model was as follows: total score = age (<3; yes = 2, no = 0) + BL + tumor locations (fourth ventricle; yes = 5, no = 0). The AUC of our model was higher than those of age less than three years, BL, locations at the fourth ventricle, and compound factors (age <3 + locations) (0.842 vs 0.609, 0.734, 0.732, and 0.788, respectively). The cutoff values of the model and BL were 7.5 points and 2.75 U, respectively.
    Conclusions: BL, age less than three years, and tumors at the fourth ventricle were independent predictors. Model scores over 7.5 points predict a high risk.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Adolescent ; Ventriculoperitoneal Shunt/adverse effects ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Retrospective Studies ; Brain Neoplasms/surgery ; Brain Neoplasms/complications ; Infratentorial Neoplasms/surgery ; Infratentorial Neoplasms/complications ; Hydrocephalus/surgery ; Hydrocephalus/etiology ; Hemorrhage/complications
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2023.04.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia

    Colin Carlock / Yunpeng Bai / Allison Paige-Hood / Qinglin Li / Frederick Nguele Meke / Zhong-Yin Zhang

    JCI Insight, Vol 8, Iss

    2023  Volume 19

    Abstract: Overexpression of phosphatases of regenerating liver 2 (PRL2), detected in numerous diverse cancers, is often associated with increased severity and poor patient prognosis. PRL2-catalyzed tyrosine dephosphorylation of the tumor suppressor PTEN results in ...

    Abstract Overexpression of phosphatases of regenerating liver 2 (PRL2), detected in numerous diverse cancers, is often associated with increased severity and poor patient prognosis. PRL2-catalyzed tyrosine dephosphorylation of the tumor suppressor PTEN results in increased PTEN degradation and has been identified as a mechanism underlying PRL2 oncogenic activity. Overexpression of PRL2, coincident with reduced PTEN protein, is frequently observed in patients with acute myeloid leukemia (AML). In the current study, a PTEN-knockdown AML animal model was generated to assess the effect of conditional PRL2 inhibition on the level of PTEN protein and the development and progression of AML. Inhibition of PRL2 resulted in a significant increase in median animal survival, from 40 weeks to greater than 60 weeks. The prolonged survival reflected delayed expansion of aberrantly differentiated hematopoietic stem cells into leukemia blasts, resulting in extended time required for clinically relevant leukemia blast accumulation in the BM niche. Leukemia blast suppression following PRL2 inhibition was correlated with an increase in PTEN and downregulation of AKT/mTOR-regulated pathways. These observations directly established, in a disease model, the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and potentially other PTEN-deficient cancers by slowing cancer progression.
    Keywords Hematology ; Therapeutics ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Novel peripheral blood mononuclear cell mRNA signature for IFN-beta therapy responsiveness prediction in multiple sclerosis.

    Xue, Yang / Yin, Pengqi / Chen, Hongping / Li, Guozhong / Zhong, Di

    Autoimmunity

    2024  Volume 57, Issue 1, Page(s) 2332340

    Abstract: Interferon-beta (IFN- ...

    Abstract Interferon-beta (IFN-
    MeSH term(s) Humans ; Multiple Sclerosis ; RNA, Messenger/genetics ; Leukocytes, Mononuclear ; Interferon-beta/therapeutic use ; Interferon-beta/genetics ; Multiple Sclerosis, Relapsing-Remitting/diagnosis ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/genetics
    Chemical Substances RNA, Messenger ; Interferon-beta (77238-31-4)
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1025450-x
    ISSN 1607-842X ; 0891-6934
    ISSN (online) 1607-842X
    ISSN 0891-6934
    DOI 10.1080/08916934.2024.2332340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2777: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia.

    Carlock, Colin / Bai, Yunpeng / Paige-Hood, Allison / Li, Qinglin / Nguele Meke, Frederick / Zhang, Zhong-Yin

    JCI insight

    2023  Volume 8, Issue 19

    Abstract: Overexpression of phosphatases of regenerating liver 2 (PRL2), detected in numerous diverse cancers, is often associated with increased severity and poor patient prognosis. PRL2-catalyzed tyrosine dephosphorylation of the tumor suppressor PTEN results in ...

    Abstract Overexpression of phosphatases of regenerating liver 2 (PRL2), detected in numerous diverse cancers, is often associated with increased severity and poor patient prognosis. PRL2-catalyzed tyrosine dephosphorylation of the tumor suppressor PTEN results in increased PTEN degradation and has been identified as a mechanism underlying PRL2 oncogenic activity. Overexpression of PRL2, coincident with reduced PTEN protein, is frequently observed in patients with acute myeloid leukemia (AML). In the current study, a PTEN-knockdown AML animal model was generated to assess the effect of conditional PRL2 inhibition on the level of PTEN protein and the development and progression of AML. Inhibition of PRL2 resulted in a significant increase in median animal survival, from 40 weeks to greater than 60 weeks. The prolonged survival reflected delayed expansion of aberrantly differentiated hematopoietic stem cells into leukemia blasts, resulting in extended time required for clinically relevant leukemia blast accumulation in the BM niche. Leukemia blast suppression following PRL2 inhibition was correlated with an increase in PTEN and downregulation of AKT/mTOR-regulated pathways. These observations directly established, in a disease model, the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and potentially other PTEN-deficient cancers by slowing cancer progression.
    MeSH term(s) Animals ; Humans ; Signal Transduction ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Hematopoietic Stem Cells/metabolism
    Chemical Substances PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.170065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation

    Guimei Yu / Yunpeng Bai / Kunpeng Li / Ovini Amarasinghe / Wen Jiang / Zhong-Yin Zhang

    iScience, Vol 24, Iss 11, Pp 103310- (2021)

    2021  

    Abstract: Summary: VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of VCP dodecamer, an ... ...

    Abstract Summary: VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of VCP dodecamer, an understudied state of VCP. The structure revealed an apo nucleotide status that has rarely been captured, a tail-to-tail assembly of two hexamers, and the up-elevated N-terminal domains akin to that seen in the ATP-bound hexamer. Further analyses elucidated a nucleotide status-dependent dodecamerization mechanism, where nucleotide dissociation from the D2 AAA domains induces and promotes VCP dodecamerization. In contrast, nucleotide-free D1 AAA domains are associated with the up-rotation of N-terminal domains, which may prime D1 for ATP binding. These results therefore reveal new nucleotide status-dictated intra- and interhexamer conformational changes and suggest that modulation of D2 domain nucleotide occupancy may serve as a mechanism in controlling VCP oligomeric states.
    Keywords Biological sciences ; Biochemistry ; Structural biology ; Science ; Q
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article: Brucine suppresses proliferation and promotes apoptosis of human cholangiacarcinoma cells via the inhibition of COX2 expression.

    Kang, Qiang / Zheng, Kai / Jiang, Gai-Ming / Li, Yu-Kai / Liang, Yu-Bo / Geng, Qin / Qian, Chun-Hang / Wang, Qing-Bo / He, Zhong-Yin / Huang, Song-Quan / Yang, Chen / Li, Jing / Li, Yue-Hua / Ke, Yang

    Journal of Cancer

    2023  Volume 14, Issue 14, Page(s) 2700–2706

    Abstract: ... ...

    Abstract Aims
    Language English
    Publishing date 2023-09-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.87514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Effect of

    Lin, Qianmin / Song, Bingbing / Zhong, Yingxiong / Yin, Huan / Li, Ziyu / Wang, Zhuo / Cheong, Kit-Leong / Huang, Riming / Zhong, Saiyi

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: As an acidic polysaccharide, the formation ... ...

    Abstract As an acidic polysaccharide, the formation of
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12071400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation.

    Yu, Guimei / Bai, Yunpeng / Li, Kunpeng / Amarasinghe, Ovini / Jiang, Wen / Zhang, Zhong-Yin

    iScience

    2021  Volume 24, Issue 11, Page(s) 103310

    Abstract: VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of VCP dodecamer, an ... ...

    Abstract VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of VCP dodecamer, an understudied state of VCP. The structure revealed an apo nucleotide status that has rarely been captured, a tail-to-tail assembly of two hexamers, and the up-elevated N-terminal domains akin to that seen in the ATP-bound hexamer. Further analyses elucidated a nucleotide status-dependent dodecamerization mechanism, where nucleotide dissociation from the D2 AAA domains induces and promotes VCP dodecamerization. In contrast, nucleotide-free D1 AAA domains are associated with the up-rotation of N-terminal domains, which may prime D1 for ATP binding. These results therefore reveal new nucleotide status-dictated intra- and interhexamer conformational changes and suggest that modulation of D2 domain nucleotide occupancy may serve as a mechanism in controlling VCP oligomeric states.
    Language English
    Publishing date 2021-10-16
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.103310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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