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Article ; Online: Is Fucus a suitable biomonitoring organism for polycyclic aromatic hydrocarbon contamination? A study from the Faroe Islands.

Knøfler, Ida Huusmann / Andersson, Kirstine Evald / Becker, Richard Leonard / Christiansen, Sigurd / Nielsen, Nikoline J / Christensen, Jan H

Environmental science and pollution research international

2024 Volume 31, Issue 18, Page(s) 26699–26712

Abstract: To evaluate seaweed as a biomonitoring organism, Fucus was sampled in the Faroe Islands. Nineteen PAHs, including the EPA 16, and four groups of alkylated PAHs were quantified using GC-MS analysis of extracts obtained using a modified QuEchERS method ... ...

Abstract	To evaluate seaweed as a biomonitoring organism, Fucus was sampled in the Faroe Islands. Nineteen PAHs, including the EPA 16, and four groups of alkylated PAHs were quantified using GC-MS analysis of extracts obtained using a modified QuEchERS method with ultrasonication in acetonitrile, back-extraction into hexane, and Florisil® cleanup. Samples from the harbor of Tórshavn collected at high tide were the most polluted with PAH concentrations between 1.3 × 10
MeSH term(s)	Polycyclic Aromatic Hydrocarbons/analysis ; Fucus ; Water Pollutants, Chemical/analysis ; Environmental Monitoring/methods ; Biological Monitoring ; Seaweed/chemistry ; Islands ; Gas Chromatography-Mass Spectrometry
Chemical Substances	Polycyclic Aromatic Hydrocarbons ; Water Pollutants, Chemical
Language	English
Publishing date	2024-03-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32658-7
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Article ; Online: Investigation of the spatial distribution of airborne polycyclic aromatic hydrocarbons using Rhytidiadelphus squarrosus in Tórshavn, Faroe Islands.

Cwalina, Eliza / Kilpinen, Kristoffer Skovlund / Ryde, Ingvild / Nielsen, Nikoline Juul / Christiansen, Sigurd / Christensen, Jan H

Environmental science and pollution research international

2023 Volume 30, Issue 35, Page(s) 84663–84673

Abstract: Due to adverse effects of Polycyclic Aromatic Hydrocarbons (PAHs) on human health, it is important to understand how airborne PAHs, are spatially distributed within urban areas. Moss has been shown to be a suitable material for biomonitoring of airborne ... ...

Abstract	Due to adverse effects of Polycyclic Aromatic Hydrocarbons (PAHs) on human health, it is important to understand how airborne PAHs, are spatially distributed within urban areas. Moss has been shown to be a suitable material for biomonitoring of airborne PAH pollution. In this study, the moss Rhytidiadelphus squarrosus was sampled throughout Tórshavn, Faroe Islands. 53 Rhytidiadelphus squarrosus samples were extracted using a matrix solid-phase dispersive extraction method and analysed for 19 parent PAHs and six groups of alkylated PAHs using gas chromatography mass-spectrometry. All PAHs were quantified in at least one Rhytidiadelphus squarrosus sample, and the sum of the EPA 16 PAHs (ƩPAH
MeSH term(s)	Humans ; Polycyclic Aromatic Hydrocarbons/analysis ; Chrysenes/analysis ; Pyrenes/analysis ; Anthracenes ; Phenanthrenes/analysis ; Environmental Monitoring/methods
Chemical Substances	Polycyclic Aromatic Hydrocarbons ; fluoranthene (360UOL779Z) ; chrysene (084HCM49PT) ; Chrysenes ; pyrene (9E0T7WFW93) ; Pyrenes ; Anthracenes ; Phenanthrenes
Language	English
Publishing date	2023-06-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-28423-x
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Article ; Online: Low skeletal muscle mass is predictive of dose-limiting toxicities in head and neck cancer patients undergoing low-dose weekly cisplatin chemoradiotherapy.

Becker, Jan-Niklas / Hermann, Robert / Wichmann, Jörn / Sonnhoff, Mathias / Christiansen, Hans / Bruns, Frank

PloS one

2023 Volume 18, Issue 2, Page(s) e0282015

Abstract: Background: The dose-limiting effect of CT-assessed low skeletal muscle mass (LSMM) measured at the level of the third cervical vertebra has been found in head and neck cancer patients receiving high-dose cisplatin chemoradiotherapy. The aim of this ... ...

Abstract	Background: The dose-limiting effect of CT-assessed low skeletal muscle mass (LSMM) measured at the level of the third cervical vertebra has been found in head and neck cancer patients receiving high-dose cisplatin chemoradiotherapy. The aim of this study was to investigate the predictive factors for dose-limiting toxicities (DLTs) using low-dose weekly chemoradiotherapy. Materials and methods: Head and neck cancer patients receiving definite chemoradiotherapy with weekly 40 mg/m2 body surface area (BSA) cisplatin or paclitaxel 45 mg/m2 BSA and carboplatin AUC2 were consecutively included and retrospectively analysed. Skeletal muscle mass was assessed using the muscle surface at the level of the third cervical vertebra in pretherapeutic CT scans. After stratification for LSMM DLT, acute toxicities and feeding status during the treatment were examined. Results: Dose-limiting toxicity was significantly higher in patients with LSMM receiving cisplatin weekly chemoradiotherapy. For paclitaxel/carboplatin, no significance regarding DLT and LSMM could be found. Patients with LSMM had significantly more dysphagia before treatment, although feeding tube placement before treatment was equal in patients with and without LSMM. Conclusions: LSMM is a predictive factor for DLT in head and neck patients treated with low-dose weekly chemoradiotherapy with cisplatin. For paclitaxel/carboplatin, further research must be carried out.
MeSH term(s)	Humans ; Cisplatin/adverse effects ; Carboplatin/adverse effects ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/chemically induced ; Chemoradiotherapy/adverse effects ; Paclitaxel/adverse effects ; Muscle, Skeletal/diagnostic imaging
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0282015
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Article ; Online: Low skeletal muscle mass is predictive of dose-limiting toxicities in head and neck cancer patients undergoing low-dose weekly cisplatin chemoradiotherapy.

Jan-Niklas Becker / Robert Hermann / Jörn Wichmann / Mathias Sonnhoff / Hans Christiansen / Frank Bruns

PLoS ONE, Vol 18, Iss 2, p e

2023 Volume 0282015

Abstract: Background The dose-limiting effect of CT-assessed low skeletal muscle mass (LSMM) measured at the level of the third cervical vertebra has been found in head and neck cancer patients receiving high-dose cisplatin chemoradiotherapy. The aim of this study ...

Abstract	Background The dose-limiting effect of CT-assessed low skeletal muscle mass (LSMM) measured at the level of the third cervical vertebra has been found in head and neck cancer patients receiving high-dose cisplatin chemoradiotherapy. The aim of this study was to investigate the predictive factors for dose-limiting toxicities (DLTs) using low-dose weekly chemoradiotherapy. Materials and methods Head and neck cancer patients receiving definite chemoradiotherapy with weekly 40 mg/m2 body surface area (BSA) cisplatin or paclitaxel 45 mg/m2 BSA and carboplatin AUC2 were consecutively included and retrospectively analysed. Skeletal muscle mass was assessed using the muscle surface at the level of the third cervical vertebra in pretherapeutic CT scans. After stratification for LSMM DLT, acute toxicities and feeding status during the treatment were examined. Results Dose-limiting toxicity was significantly higher in patients with LSMM receiving cisplatin weekly chemoradiotherapy. For paclitaxel/carboplatin, no significance regarding DLT and LSMM could be found. Patients with LSMM had significantly more dysphagia before treatment, although feeding tube placement before treatment was equal in patients with and without LSMM. Conclusions LSMM is a predictive factor for DLT in head and neck patients treated with low-dose weekly chemoradiotherapy with cisplatin. For paclitaxel/carboplatin, further research must be carried out.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Cytoplasmic mRNPs revisited: Singletons and condensates.

Mateu-Regué, Àngels / Nielsen, Finn Cilius / Christiansen, Jan

BioEssays : news and reviews in molecular, cellular and developmental biology

2020 Volume 42, Issue 12, Page(s) e2000097

Abstract: Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are ... ...

Abstract	Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.
Language	English
Publishing date	2020-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	50140-2
ISSN	1521-1878 ; 0265-9247
ISSN (online)	1521-1878
ISSN	0265-9247
DOI	10.1002/bies.202000097
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Article: Socioeconomic Disparity Trends in End-of-Life Care for Cancer and Non-Cancer Patients: Are We Closing the Gap?

Vestergaard, Anne Høy Seemann / Christiansen, Christian Fynbo / Neergaard, Mette Asbjoern / Valentin, Jan Brink / Johnsen, Søren Paaske

Clinical epidemiology

2022 Volume 14, Page(s) 653–664

Abstract: Purpose: Socioeconomic disparities in end-of-life care have been reported across underlying diseases, but there is a paucity of information on potential time trends. Thus, we aimed to examine time trends in use of health-care services at the end of life ...

Abstract	Purpose: Socioeconomic disparities in end-of-life care have been reported across underlying diseases, but there is a paucity of information on potential time trends. Thus, we aimed to examine time trends in use of health-care services at the end of life according to socioeconomic position in patients dying from cancer and non-cancer diseases. Materials and methods: We conducted a nationwide registry-based study among adults dying from cancer or non-cancer diseases (diabetes, dementia, heart failure, ischemic heart disease, stroke, chronic liver disease, and chronic obstructive pulmonary disease) in Denmark in 2006-2016. We obtained data on patients' educational level and income level and use of health-care services within three months before death. Use of health-care services according to educational level and income level was plotted by calendar year of death and compared by regression analyses adjusting for age, sex, comorbidity, cohabitation, and municipality. Results: In both cancer (n = 169,694) and non-cancer patients (n = 180,350), we found limited socioeconomic disparities and no clear temporal trends in use of hospital, intensive care, emergency room, general practice, home care nurse, and hospice. In 2006/2007, one percentage point more cancer patients with high income level compared with low income level were affiliated with hospital-based specialist palliative care (adjusted mean difference: 0.01 (95% confidence interval (CI): 0.01; 0.02)), whereas this was 12 percentage points in 2016 (adjusted mean difference: 0.12 (95% CI: 0.09; 0.14)). Conclusion: Socioeconomic disparities in specialist palliative care tended to increase over time among cancer patients but were limited and without clear time trends in use of other health-care services in both cancer and non-cancer patients.
Language	English
Publishing date	2022-05-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494772-6
ISSN	1179-1349
ISSN	1179-1349
DOI	10.2147/CLEP.S362170
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Article ; Online: Healthcare Costs at the End of Life for Patients with Non-cancer Diseases and Cancer in Denmark.

Vestergaard, Anne Høy Seemann / Ehlers, Lars Holger / Neergaard, Mette Asbjoern / Christiansen, Christian Fynbo / Valentin, Jan Brink / Johnsen, Søren Paaske

PharmacoEconomics - open

2023 Volume 7, Issue 5, Page(s) 751–764

Abstract: Objectives: To examine costs of care from a healthcare sector perspective within 1 year before death in patients with non-cancer diseases and patients with cancer.: Methods: This nationwide registry-based study identified all Danish citizens dying ... ...

Abstract	Objectives: To examine costs of care from a healthcare sector perspective within 1 year before death in patients with non-cancer diseases and patients with cancer. Methods: This nationwide registry-based study identified all Danish citizens dying from major non-cancer diseases or cancer in 2010-2016. Applying the cost-of-illness method, we included costs of somatic hospitals, including hospital-based specialist palliative care, primary care, prescription medicine and hospice expressed in 2022 euros. Costs of patients with non-cancer diseases and cancer were compared using regression analyses adjusting for sex, age, comorbidity, residential region, marital/cohabitation status and income level. Results: Within 1 year before death, mean total healthcare costs were €27,185 [95% confidence interval (CI) €26,970-27,401] per patient with non-cancer disease (n = 109,723) and €51,348 (95% CI €51,098-51,597) per patient with cancer (n = 108,889). The adjusted relative total healthcare costs, i.e. the ratio of the mean costs, of patients with non-cancer diseases was 0.64 (95% CI 0.63-0.66) at 12 months before death and 0.91 (95% CI 0.90-0.92) within 30 days before death compared with patients with cancer. Mean costs of hospital-based specialist palliative care and hospice in the year leading up to death were €17 (95% CI €13-20) and €90 (95% CI €77-102) per patient with non-cancer disease but €1552 (95% CI €1506-1598) and €3411 (95% CI €3342-3480) per patient with cancer. Conclusions: Within 1 year before death, total healthcare costs, mainly driven by hospital costs, were substantially lower for patients with non-cancer diseases compared with patients with cancer. Moreover, the costs of hospital-based specialist palliative care and hospice were minimal for patients with non-cancer diseases.
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2874287-4
ISSN	2509-4254 ; 2509-4262
ISSN (online)	2509-4254
ISSN	2509-4262
DOI	10.1007/s41669-023-00430-1
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Article ; Online: Utilisation of hospital-based specialist palliative care in patients with gynaecological cancer: Temporal trends, predictors and association with high-intensity end-of-life care.

Vestergaard, Anne Høy Seemann / Neergaard, Mette Asbjoern / Fokdal, Lars Ulrik / Christiansen, Christian Fynbo / Valentin, Jan Brink / Johnsen, Søren Paaske

Gynecologic oncology

2023 Volume 172, Page(s) 1–8

Abstract: Objective: To examine hospital-based specialist palliative care (SPC) utilisation among patients with gynaecological cancer, including temporal trends, predictors and associations with high-intensity end-of-life care.: Methods: We conducted a ... ...

Abstract	Objective: To examine hospital-based specialist palliative care (SPC) utilisation among patients with gynaecological cancer, including temporal trends, predictors and associations with high-intensity end-of-life care. Methods: We conducted a nationwide registry-based study for all patients dying from gynaecological cancer in Denmark during 2010-2016. We estimated the proportions of patients receiving SPC by year of death and used regression analyses to examine predictors of SPC utilisation. Use of high-intensity end-of-life care according to SPC utilisation was compared by regression analyses adjusting for type of gynaecological cancer, year of death, age, comorbidities, residential region, marital/cohabitation status, income level and migrant status. Results: Among 4502 patients dying from gynaecological cancer, the proportion of patients receiving SPC increased from 24.2% in 2010 to 50.7% in 2016. Young age, three or more comorbidities, residence outside the Capital Region and being immigrant/descendant were associated with increased SPC utilisation, whereas income, cancer type and stage were not. SPC was associated with lower high-intensity end-of-life care utilisation. Particularly, when compared with patients not receiving SPC, patients who accessed SPC >30 days before death had 88% lower risk of intensive care unit admissions within 30 days before death (adjusted relative risk: 0.12 (95% CI: 0.06; 0.24)) and 96% lower risk of surgery within 14 days before death (adjusted relative risk: 0.04 (95% CI: 0.01; 0.31)). Conclusions: Among patients dying from gynaecological cancer, SPC utilisation increased over time and age, comorbidities, residential region and migrant status were associated with access to SPC. Furthermore, SPC was associated with lower use of high-intensity end-of-life care.
MeSH term(s)	Female ; Humans ; Palliative Care ; Terminal Care ; Hospice Care ; Genital Neoplasms, Female/therapy ; Neoplasms ; Hospitals
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2023.02.019
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Article ; Online: A comparative analysis of movement and physical activity in early childhood teacher education policy in five Nordic countries.

Christiansen, Lars Breum / Ekberg, Jan-Eric / Soini, Anne / Larsen, Robert / Kristjánsdóttir, Gudrún / Froberg, Karsten / Sollerhed, Ann-Christin / Sääkslahti, Arja / Fjørtoft, Ingunn / Vilhjálmsson, Rúnar / Olesen, Line Grønholt

Frontiers in sports and active living

2024 Volume 6, Page(s) 1352520

Abstract: Introduction: The aim of this study is to investigate the integration of movement and physical activity (MoPA) within Early Childhood Teacher Education (ECTE) policies across Denmark, Finland, Iceland, Norway, and Sweden. This knowledge can inform the ... ...

Abstract	Introduction: The aim of this study is to investigate the integration of movement and physical activity (MoPA) within Early Childhood Teacher Education (ECTE) policies across Denmark, Finland, Iceland, Norway, and Sweden. This knowledge can inform the development of ECTE policies and practices that promote MoPA in Early Childhood Education and Care (ECEC) in Nordic countries and other countries worldwide. Methods: In this study, a Nordic cross-national network of researchers collaborated in investigating policy documents at the national and university levels, which govern the education of ECEC teachers. This study was inspired by the Non-affirmative Theory of Education, which provides a framework for understanding the various influences on curricular development in higher education. Based on this, a four-step comparative analytical process of national and university documents across the Nordic countries was conducted. It included keyword search for MoPA related courses and a qualitative description of MoPA in ECTE. Thus, a combination of investigations of policy documents at the national and university level and expert knowledge set a solid foundation for international comparison. Results: The comparative analysis of MoPA in ECTE reveals diverse approaches influenced by national and university policies. A central theme is the variability in MoPA integration across these nations. Finland and Norway prioritize MoPA with independent mandatory courses. In Iceland, compulsory MoPA courses exist at one of two universities, and in Sweden at three out of 19. All university colleges in Denmark offer an elective course. Furthermore, learning objectives related to MoPA are, to varying degrees, part of the internships in the countries, with Sweden being an exception. In the participating countries, the teachers decide the content of the MoPA courses with little guidance, support, and agreement on essential MoPA content within and across the ECTE's. Norway has established guidelines, and in Finland, there is a network of ECTE Physical Education (PE) educators, which, to some degree, increases the consistency and quality of MoPA in education. Discussion: The Nordic countries present diverse MoPA integration approaches rooted in national policies and educational traditions. The findings emphasize the necessity of independent and mandatory MoPA courses, integration of MoPA into internships and promoting networks across the educational and academic sectors to equip future early childhood educators with competencies for fostering physical activity, motor development and children's well-being.
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2024.1352520
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Book: Analysis of RNA protein complexes in vitro

Kjems, Jørgen / Egebjerg, Jan / Christiansen, Jan

(Laboratory techniques in biochemistry and molecular biology ; 26)

1998

Title variant	RNA-protein
Author's details	Jørgen Kjems ; Jan Egebjerg ; Jan Christiansen
Series title	Laboratory techniques in biochemistry and molecular biology ; 26
Collection
Keywords	RNS-Bindungsproteine ; Biochemische Analyse
Subject	Bioanalytische Chemie ; Bioanalytik ; Analytische Biochemie ; RNS-Proteinkomplex ; RNS-bindendes Protein ; RNA-bindendes Protein ; RNA-bindende Proteine ; RNA-Bindungsproteine ; RNA-Bindeproteine ; RNS-Bindeproteine
Language	English
Size	X, 237 S. : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT009512855
ISBN	0-444-82418-9 ; 0-444-82419-7 ; 978-0-444-82418-9 ; 978-0-444-82419-6
Database	Catalogue ZB MED Medicine, Health

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