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  1. Article ; Online: ITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation.

    Li, Guo-Wei / Jin, Yan-Ping / Qiu, Jian-Ping / Lu, Xiu-Fang

    Aging

    2024  Volume 16, Issue 3, Page(s) 3007–3020

    Abstract: Related studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. Based on these studies, we tried to construct a ... ...

    Abstract Related studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. Based on these studies, we tried to construct a mitochondrial glycolysis regulatory network and explored its effect on mitochondrial homeostasis and ovarian cancer cells' cancerous characteristics. Our research revealed a distinct increase in the expression of ITGB2 and associated signaling pathway elements (PI3K-AKT-mTOR) in cases of ovarian cancer. ITGB2 might control mTOR expression via the PI3K-AKT pathway, thus promote mitochondrial glycolysis transformation and cell energy supply in ovarian cancer. This pathway could also inhibit mitophagy, maintain mitochondrial stability, and enhance the cancerous characteristics in case of ovarian cancer cells by mediating mitochondrial glycolytic transformation. Thus, we concluded that ITGB2-associated signaling route (PI3K-AKT-mTOR) may contribute to the progression of cancerous traits in ovarian cancer via mediating mitochondrial glycolytic transformation.
    MeSH term(s) Humans ; Female ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Line, Tumor ; Ovarian Neoplasms/pathology ; TOR Serine-Threonine Kinases/metabolism ; Glycolysis ; Cell Proliferation
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-11
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Organocatalytic enantioselective decarboxylative protonation of α-alkyl-α-aryl malonate monoesters.

    Guo, Cong-Ying / Chen, Jia-Zheng / Liu, Wen-Ting / Mei, Hao / Meng, Jie / Chen, Jian-Ping

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 28, Page(s) 3854–3857

    Abstract: In contrast to the well-established enzymatic enantioselective decarboxylative protonation (EDP), the corresponding chemocatalytic reactions of acyclic malonic acid derivatives remain challenging. Herein, we developed a biomimetic EDP of α-alkyl-α-aryl ... ...

    Abstract In contrast to the well-established enzymatic enantioselective decarboxylative protonation (EDP), the corresponding chemocatalytic reactions of acyclic malonic acid derivatives remain challenging. Herein, we developed a biomimetic EDP of α-alkyl-α-aryl malonate monoesters using a chiral 1,2-
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc06018g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Astragalus membranaceus

    Yin, Jia-Ting / Zhang, Ming-Ruo / Zhang, Shu / Yang, Shu-Hui / Li, Jian-Ping / Liu, Yun / Duan, Jin-Ao / Guo, Jian-Ming

    The American journal of Chinese medicine

    2024  Volume 52, Issue 2, Page(s) 513–539

    Abstract: Aging can cause degenerative changes in multiple tissues and organs. Gastrointestinal diseases and dysfunctions are common in the elderly population. In this study, we investigated the effects ... ...

    Abstract Aging can cause degenerative changes in multiple tissues and organs. Gastrointestinal diseases and dysfunctions are common in the elderly population. In this study, we investigated the effects of
    MeSH term(s) Aged ; Humans ; Mice ; Male ; Female ; Animals ; Infant ; Child, Preschool ; Astragalus propinquus/chemistry ; Interleukin-22 ; Intestines ; Signal Transduction ; Intestine, Small ; Stem Cells ; Polysaccharides/pharmacology ; Aging ; Regeneration
    Chemical Substances Interleukin-22 ; Polysaccharides
    Language English
    Publishing date 2024-03-26
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 193085-0
    ISSN 1793-6853 ; 0090-2942 ; 0192-415X
    ISSN (online) 1793-6853
    ISSN 0090-2942 ; 0192-415X
    DOI 10.1142/S0192415X24500228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1110: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: The complete mitochondrial genome of the Baishanzu horned toad

    Wu, Jian-Ping / Wu, Jia-Lian / Chen, Yun-Bo / Xu, Wei-Hua / Xie, Wen-Qi / Tang, Zi-Qiang / Ding, Guo-Hua / Ma, Li

    Mitochondrial DNA. Part B, Resources

    2024  Volume 9, Issue 1, Page(s) 209–213

    Abstract: The mitochondrial genome (mitogenome) ... ...

    Abstract The mitochondrial genome (mitogenome) of
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2024.2307995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Han Chinese specific cytochrome P450 polymorphisms and their impact on the metabolism of anti-hypertensive drugs with adrenoreceptor blocking properties.

    Qian, Jian-Chang / Cai, Jian-Ping / Hu, Guo-Xin

    Expert opinion on drug metabolism & toxicology

    2021  Volume 17, Issue 6, Page(s) 707–716

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Adrenergic Antagonists/pharmacokinetics ; Adrenergic Antagonists/pharmacology ; Antihypertensive Agents/pharmacokinetics ; Antihypertensive Agents/pharmacology ; Asian Continental Ancestry Group/genetics ; Cytochrome P-450 Enzyme System/genetics ; Genotype ; Humans ; Polymorphism, Genetic
    Chemical Substances Adrenergic Antagonists ; Antihypertensive Agents ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2021.1921147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6264: Show issues Location:
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  6. Article: Genetic variants, haplotype determination, and function of novel alleles of

    Zhang, Li-Qun / Li, Xin-Yue / Chen, Lian-Guo / Chen, Zhe / Xu, Ren-Ai / Qian, Jian-Chang / Zhou, Xiao-Yang / Dai, Da-Peng / Hu, Guo-Xin / Cai, Jian-Ping

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28952

    Abstract: Amino acid variants in protein may result in deleterious effects on enzymatic activity. In this study we investigate the DNA variants on activity ... ...

    Abstract Amino acid variants in protein may result in deleterious effects on enzymatic activity. In this study we investigate the DNA variants on activity of
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Determination of total phenol and six polyphenolic components in the polyphenol extract of

    Shi, Dan-Yang / Zheng, Yu / Guo, Qiang-Sheng / Gong, Can / Xu, Xu / Gao, Jian-Ping

    Analytical methods : advancing methods and applications

    2023  Volume 15, Issue 47, Page(s) 6561–6570

    Abstract: A quantitative nuclear magnetic resonance spectroscopy (qNMR) method was established for determining the total phenol and six polyphenolic components in the polyphenol extract ... ...

    Abstract A quantitative nuclear magnetic resonance spectroscopy (qNMR) method was established for determining the total phenol and six polyphenolic components in the polyphenol extract of
    MeSH term(s) Polyphenols/chemistry ; Catechin/chemistry ; Phenol ; Dimethyl Sulfoxide ; Magnetic Resonance Spectroscopy/methods ; Solvents/chemistry
    Chemical Substances Polyphenols ; cinnamomi cortex ; Catechin (8R1V1STN48) ; Phenol (339NCG44TV) ; Dimethyl Sulfoxide (YOW8V9698H) ; Solvents
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay01501g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Application of Femoral Nerve Block in Treating Great Saphenous Vein Insufficiency by Endovenous Radiofrequency Ablation Combined with Punctate Stripping.

    Li, Ying-Hao / Wang, Tao / Qian, Cheng / Chen, Guo-Ping / Lou, Wen-Sheng / Gu, Jian-Ping

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2023  Volume 29, Page(s) 10760296231220054

    Abstract: Purpose: To evaluate the efficacy and safety of ultrasound-guided femoral nerve block (FNB) in treating great saphenous vein (GSV) insufficiency by endovenous radiofrequency ablation (EVRA) combined with punctate stripping (PS).: Methods: This was a ... ...

    Abstract Purpose: To evaluate the efficacy and safety of ultrasound-guided femoral nerve block (FNB) in treating great saphenous vein (GSV) insufficiency by endovenous radiofrequency ablation (EVRA) combined with punctate stripping (PS).
    Methods: This was a single-center, retrospective cohort study. A total of 135 patients were divided into Group A (59 patients) and Group B (76 patients). All patients received tumescent anesthesia during the operation, and group A received an additional ultrasound-guided FNB before the procedure. Intraoperative and postoperative pain score, the volume of tumescent anesthesia solution (TAS), and other indicators were compared in two groups.
    Results: Group A had a significantly lower intraoperative pain visual analog scale than group B (2.7 ± 1.2 vs 5.2 ± 1.5,
    Conclusions: Ultrasound-guided FNB in treating GSV insufficiency by EVRA combined with PS significantly relieved intraoperative pain and reduced the dosage of TAS and the incidence of skin ecchymosis without increasing the complications of anesthesia or any other surgical complications.
    MeSH term(s) Humans ; Femoral Nerve ; Retrospective Studies ; Ecchymosis/complications ; Saphenous Vein/surgery ; Treatment Outcome ; Pain, Postoperative/etiology ; Radiofrequency Ablation/adverse effects ; Varicose Veins/complications ; Varicose Veins/surgery ; Venous Insufficiency/surgery ; Venous Insufficiency/complications
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296231220054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4370: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Iron-Catalyzed Aerobic α,β-Dehydrogenation.

    Jiang, Guo-Qing / Han, Bin-Hong / Cai, Xian-Peng / Qu, Jian-Ping / Kang, Yan-Biao

    Organic letters

    2023  Volume 25, Issue 24, Page(s) 4429–4433

    Abstract: An iron-catalyzed direct aerobic α,β-dehydrogenation of carbonyls has been reported. The combination ... ...

    Abstract An iron-catalyzed direct aerobic α,β-dehydrogenation of carbonyls has been reported. The combination of
    MeSH term(s) Iron ; Catalysis ; Transition Elements ; Lactams
    Chemical Substances Iron (E1UOL152H7) ; Transition Elements ; Lactams
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c01240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms.

    Guo, Kai-Kai / Liu, Chang-Ya / Li, Gao-Hui / Xiang, Jian-Ping / Leng, Xiao-Chang / Cai, Yi-Ke / Hu, Xue-Bin

    Current medical science

    2024  Volume 44, Issue 2, Page(s) 391–398

    Abstract: Objective: The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries, utilizing computational fluid dynamics as ... ...

    Abstract Objective: The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries, utilizing computational fluid dynamics as a tool for analysis.
    Methods: In line with the designated inclusion criteria, this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, China, from January 2021 to September 2022. Utilizing follow-up digital subtraction angiography (DSA) data, these cases were classified into two distinct groups: the sidewall aneurysm group and the bifurcation aneurysm group. Morphological and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction model.
    Results: No significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior circulation. However, pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel (D
    Conclusions: The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation aneurysms. Whether it is a bifurcation or sidewall aneurysm, these disparities should be considered. The morphological parameter SR has the potential to be a valuable clinical tool for promptly distinguishing the distinct rupture risks associated with sidewall and bifurcation aneurysms.
    MeSH term(s) Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/complications ; Aneurysm, Ruptured/complications ; Hemodynamics ; China
    Language English
    Publishing date 2024-03-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-024-2846-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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