LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 18

Search options

  1. Book ; Online ; Thesis: Diverse functions of Stat3 in intestinal epithelial cells during inflammation-associated and sporadic carcinogenesis

    Bollrath, Julia

    2010  

    Author's details Julia Bollrath
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 2010
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Immunology. Feed your Tregs more fiber.

    Bollrath, Julia / Powrie, Fiona

    Science (New York, N.Y.)

    2013  Volume 341, Issue 6145, Page(s) 463–464

    MeSH term(s) Animals ; Bacteria/metabolism ; Colon/microbiology ; Fatty Acids, Volatile/metabolism ; Homeostasis ; Humans ; Metagenome ; T-Lymphocytes, Regulatory/physiology
    Chemical Substances Fatty Acids, Volatile
    Language English
    Publishing date 2013-09-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1242674
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Controlling the frontier: regulatory T-cells and intestinal homeostasis.

    Bollrath, Julia / Powrie, Fiona M

    Seminars in immunology

    2013  Volume 25, Issue 5, Page(s) 352–357

    Abstract: The intestine represents one of the most challenging sites for the immune system as immune cells must be able to mount an efficient response to invading pathogens while tolerating the large number and diverse array of resident commensal bacteria. Foxp3(+) ...

    Abstract The intestine represents one of the most challenging sites for the immune system as immune cells must be able to mount an efficient response to invading pathogens while tolerating the large number and diverse array of resident commensal bacteria. Foxp3(+) regulatory T-cells (Tregs) play a non-redundant role at maintaining this balance. At the same time Treg cell differentiation and function can be modulated by the intestinal microbiota. In this review, we will discuss effector mechanisms of Treg cells in the intestine and how these cells can be influenced by the intestinal microbiota.
    MeSH term(s) Animals ; Bacteria/immunology ; Homeostasis ; Humans ; Intestines/immunology ; Intestines/microbiology ; Microbiota/immunology ; T-Lymphocytes, Regulatory/immunology ; Thymus Gland/immunology
    Language English
    Publishing date 2013-10-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2013.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Online ; Thesis: Diverse functions of Stat3 in intestinal epithelial cells during inflammation-associated and sporadic carcinogenesis

    Bollrath, Julia [Verfasser]

    2010  

    Author's details Julia Bollrath
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Controlling the frontier: Regulatory T-cells and intestinal homeostasis

    Bollrath, Julia / Powrie, Fiona M

    Seminars in immunology. 2013 Nov. 30, v. 25, no. 5

    2013  

    Abstract: The intestine represents one of the most challenging sites for the immune system as immune cells must be able to mount an efficient response to invading pathogens while tolerating the large number and diverse array of resident commensal bacteria. Foxp3⁺ ... ...

    Abstract The intestine represents one of the most challenging sites for the immune system as immune cells must be able to mount an efficient response to invading pathogens while tolerating the large number and diverse array of resident commensal bacteria. Foxp3⁺ regulatory T-cells (Tregs) play a non-redundant role at maintaining this balance. At the same time Treg cell differentiation and function can be modulated by the intestinal microbiota. In this review, we will discuss effector mechanisms of Treg cells in the intestine and how these cells can be influenced by the intestinal microbiota.
    Keywords T-lymphocytes ; bacteria ; cell differentiation ; homeostasis ; intestinal microorganisms ; intestines ; pathogens
    Language English
    Dates of publication 2013-1130
    Size p. 352-357.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2013.09.002
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Fed Your Tᵣₑgₛ More Fiber

    Bollrath, Julia / Fiona Powrie

    Science. 2013 Aug. 2, v. 341, no. 6145

    2013  

    Abstract: The human intestine harbors up to 10 ¹¹ bacteria per gram of intestinal content, comprising over 500 different species (1) that have coevolved with their hosts in a mutually beneficial relationship. These bacterial communities promote human health ... ...

    Abstract The human intestine harbors up to 10 ¹¹ bacteria per gram of intestinal content, comprising over 500 different species (1) that have coevolved with their hosts in a mutually beneficial relationship. These bacterial communities promote human health through effects on nutrition and immune system development and function, changing in distinct ways over time and in different disease states. Precisely how bacteria communicate with their hosts to promote immune function is poorly understood. On page 569 of this issue, Smith et al. (2) show that common bacterial metabolites—short-chain fatty acids—selectively expand regulatory T (T ᵣₑg) cells in the large intestine. T ᵣₑg cells suppress the responses of other immune cells, including those that promote inflammation. This finding provides a new link between bacterial products and a major anti-inflammatory pathway in the gut.
    Keywords bacteria ; bacterial communities ; coevolution ; hosts ; human health ; humans ; immune response ; immune system ; inflammation ; large intestine ; nutrition
    Language English
    Dates of publication 2013-0802
    Size p. 463-464.
    Publishing place American Association for the Advancement of Science
    Document type Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1242674
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 46/137: Show issues
    + C 27: Show issues
    Z50.00 SC01: Show issues
    Z 8.9: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells.

    Göktuna, Serkan I / Canli, Ozge / Bollrath, Julia / Fingerle, Alexander A / Horst, David / Diamanti, Michaela A / Pallangyo, Charles / Bennecke, Moritz / Nebelsiek, Tim / Mankan, Arun K / Lang, Roland / Artis, David / Hu, Yinling / Patzelt, Thomas / Ruland, Jürgen / Kirchner, Thomas / Taketo, M Mark / Chariot, Alain / Arkan, Melek C /
    Greten, Florian R

    Cell reports

    2022  Volume 38, Issue 9, Page(s) 110471

    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.110471
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis.

    Bollrath, Julia / Greten, Florian R

    EMBO reports

    2009  Volume 10, Issue 12, Page(s) 1314–1319

    Abstract: Our understanding of the molecular mechanisms that link inflammation and cancer has significantly increased in recent years. Here, we analyse genetic evidence indicating that the transcription factors nuclear factor-kappaB (NF-kappaB) and signal ... ...

    Abstract Our understanding of the molecular mechanisms that link inflammation and cancer has significantly increased in recent years. Here, we analyse genetic evidence indicating that the transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) have a central role in this context by regulating distinct functions in cancer cells and surrounding non-tumorigenic cells. In immune cells, NF-kappaB induces the transcription of genes that encode pro-inflammatory cytokines, which can act in a paracrine manner on initiated cells. By contrast, in tumorigenic cells, both NF-kappaB and STAT3 control apoptosis, and STAT3 can also enhance proliferation. Consequently, inflammation should be considered as a valuable target for cancer prevention and therapy.
    MeSH term(s) Animals ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Humans ; I-kappa B Kinase/genetics ; I-kappa B Kinase/metabolism ; I-kappa B Kinase/physiology ; Inflammation/pathology ; Inflammation/physiopathology ; Models, Biological ; NF-kappa B/genetics ; NF-kappa B/metabolism ; NF-kappa B/physiology ; Neoplasm Metastasis ; Neoplasms/etiology ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; STAT3 Transcription Factor/physiology ; Signal Transduction/genetics ; Signal Transduction/physiology
    Chemical Substances NF-kappa B ; STAT3 Transcription Factor ; I-kappa B Kinase (EC 2.7.11.10)
    Language English
    Publishing date 2009-11-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/embor.2009.243
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Correction: Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.

    Ilott, Nicholas Edward / Bollrath, Julia / Danne, Camille / Schiering, Chris / Shale, Matthew / Adelmann, Krista / Krausgruber, Thomas / Heger, Andreas / Sims, David / Powrie, Fiona

    The ISME journal

    2019  Volume 14, Issue 3, Page(s) 879

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2019-11-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2406536-5
    ISSN 1751-7370 ; 1751-7362
    ISSN (online) 1751-7370
    ISSN 1751-7362
    DOI 10.1038/s41396-019-0539-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7773: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Colorectal Cancer Organoid-Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses.

    Farin, Henner F / Mosa, Mohammed H / Ndreshkjana, Benardina / Grebbin, Britta M / Ritter, Birgit / Menche, Constantin / Kennel, Kilian B / Ziegler, Paul K / Szabó, Lili / Bollrath, Julia / Rieder, Dietmar / Michels, Birgitta E / Kress, Alena / Bozlar, Müge / Darvishi, Tahmineh / Stier, Sara / Kur, Ivan-Maximilano / Bankov, Katrin / Kesselring, Rebecca /
    Fichtner-Feigl, Stefan / Brüne, Bernhard / Goetze, Thorsten O / Al-Batran, Salah-Eddin / Brandts, Christian H / Bechstein, Wolf O / Wild, Peter J / Weigert, Andreas / Müller, Susanne / Knapp, Stefan / Trajanoski, Zlatko / Greten, Florian R

    Cancer discovery

    2023  Volume 13, Issue 10, Page(s) 2192–2211

    Abstract: In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical testing; however, cultured tumor cells lose important characteristics, ... ...

    Abstract In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical testing; however, cultured tumor cells lose important characteristics, including the consensus molecular subtypes (CMS). To better reflect the cellular heterogeneity, we established the colorectal cancer organoid-stroma biobank of matched PDTOs and cancer-associated fibroblasts (CAF) from 30 patients. Context-specific phenotyping showed that xenotransplantation or coculture with CAFs improves the transcriptomic fidelity and instructs subtype-specific stromal gene expression. Furthermore, functional profiling in coculture exposed CMS4-specific therapeutic resistance to gefitinib and SN-38 and prognostic expression signatures. Chemogenomic library screening identified patient- and therapy-dependent mechanisms of stromal resistance including MET as a common target. Our results demonstrate that colorectal cancer phenotypes are encrypted in the cancer epithelium in a plastic fashion that strongly depends on the context. Consequently, CAFs are essential for a faithful representation of molecular subtypes and therapy responses ex vivo.
    Significance: Systematic characterization of the organoid-stroma biobank provides a resource for context dependency in colorectal cancer. We demonstrate a colorectal cancer subtype memory of PDTOs that is independent of specific driver mutations. Our data underscore the importance of functional profiling in cocultures for improved preclinical testing and identification of stromal resistance mechanisms. This article is featured in Selected Articles from This Issue, p. 2109.
    MeSH term(s) Humans ; Biological Specimen Banks ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Tumor Cells, Cultured ; Cancer-Associated Fibroblasts/metabolism ; Organoids/pathology ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-23-0050
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top